ライフサイエンスコーパス: stress protein

1 doxin is a ubiquitous redox control and cell stress protein.

2 ng functional conservation of this important stress protein.

3 ession of the uspA gene encoding a universal stress protein.

4 presentative of a third and unique family of stress proteins.

5 ins including circulatory, cytoskeletal, and stress proteins.

6 stresses by producing a large set of general stress proteins.

7 half, a hallmark of the superfamily of small stress proteins.

8 ially enhanced accumulation of two oxidative stress proteins.

9 irect the synthesis of more than 100 general stress proteins.

10 ppaBalpha may be considered to be one of the stress proteins.

11 induced the synthesis of the hsp72 and hsp90 stress proteins.

12 e inosine shows reduced expression of folate stress proteins.

13 gest that Ty3 VLPs are destroyed by cellular stress proteins.

14 ons corresponding to in vivo induction of ER stress proteins.

15 of phase II defence enzymes and antioxidant stress proteins.

16 pB intergenic region, encoding two universal stress proteins.

17 r annotated with homologs encoding oxidative stress proteins.

18 itochondrial proteins and an upregulation of stress proteins.

19 nction and is known to occur in mechanically stressed proteins.

20 mmediate early response protein IEX-1, small stress protein 1 (HSPB8), and tumor necrosis factor-asso

21 Of these, Microtubule-Associated Stress Protein 1 (MASP1), an uncharacterized protein, in

22 e named PASS1 (protein associated with small stress proteins 1).

23 ased on the Haemophilus influenzae universal stress protein (1JMV), highly similar to E. coli UspA, w

24 f transgenic mice in which the heat shock or stress protein 70 is increased, there is a marked tolera

25 Known as osmotic stress protein 94, or Osp94, this 2935-base pair cDNA en

26 edoxins and several genes encoding Universal Stress Protein A domain proteins.

27 teins with similarity to the USPA (universal stress protein A of Escherichia coli) domain of bacteria

28 ng for ethanolamine utilization, a universal stress protein, a ferritin-like protein, and a phosphotr

29 o decreased heat-induced radical generation, stress protein accumulation, and cellular injury in the

30 a FAD-dependent, two-domain multifunctional stress protein acting as a Phase II enzyme, activating c

31 and temporal induction of some of these key stress proteins after ischemia.

32 and the drug was also found to induce key ER stress proteins, albeit in a manner dissimilar to, and a

33 A major stress protein, alpha-crystallin, functions as a chapero

34 tor homologue-HBZ17); and (5) genes encoding stress proteins (alphaB-crystallin and mu-crystallin).

35 hypothesis invoking RpoS and UspA (universal stress protein, also significantly elevated in minimal g

36 knockdown of Herp (Homocysteine-inducible ER stress protein), an ER stress-inducible protein with an

37 the chaperoning of antigenic peptide by the stress protein and (b) the binding of the stress protein

38 The stress protein and endoplasmic reticulum chaperone, immu

39 These results suggest that the stress protein and molecular chaperone alphaB-crystallin

40 -regulated protein 170 (Grp170), the largest stress protein and molecular chaperone, is highly effici

41 g of the key interaction between the sigma38 stress protein and the beta-flap of the bacterial core R

42 nce of an association between levels of this stress protein and the proinflammatory cytokine, TNFalph

43 reased ERAD, while increasing maladaptive ER stress proteins and cell death.

44 Viral infection can stimulate synthesis of stress proteins and particular associations of viral and

45 Many stress proteins and their cognates function as molecular

46 ity induces the expression of a novel set of stress proteins and triggers the general stress response

47 5 h later, includes the induction of various stress proteins and ubiquitin, which are important in pr

48 5 h later, includes the induction of various stress proteins and ubiquitin, which are important in pr

49 amycin, thapsigargin, or A23187 expressed ER stress proteins and were resistant to subsequent H2O2-in

50 n involves stimulation of the expression of 'stress proteins' and neurotrophic factors.

51 coding for cell-surface-maintenance enzymes, stress proteins, and generalized efflux pumps.

52 mycin increased ERAD, as well as adaptive ER stress proteins, and minimally affected cell death.

53 All organisms have stress proteins, and universally conserved stress protei

54 ependent classes of binding sites for LRP-2, stressed proteins, and unstressed ligands, respectively,

55 dehydrogenase, a glycolytic enzyme; HSP72, a stress protein; and glutamine synthetase, an excitotoxic

56 proteins, carbonic anhydrase, and oxidative stress proteins; and functional groups involved in prote

57 Attempts to model the other stress protein antibodies were not successful.

58 s and loss-of-function mutations of a key ER stress protein are associated with disruption of membran

59 superfamily of mammalian small heat shock or stress proteins are abundant in muscles where they play

60 Although extracellular stress proteins are considered as indicators of the stre

61 Multiple ER stress proteins are likely to be involved in this tolera

62 tes global protein synthesis, mRNAs encoding stress proteins are more efficiently translated.

63 Members of the Hsp100 family of heat stress proteins are present in species throughout the ba

64 Heat shock proteins (HSPs) or stress proteins are synthesized by cells in response to

65 Upon encountering oxidative stress, proteins are oxidized extensively by highly reac

66 ly, and (ii) the binding sites for LRP-2 and stressed proteins are likely to be in parts of the molec

67 isplay lower viability, and express elevated stress protein as they mature.

68 Using stress proteins as direct drug targets would be clinical

69 ovokes increased expression of 27- and 70-kD stress proteins as well as manganese superoxide dismutas

70 sion of different endoplasmic reticulum (ER) stress proteins associated with MPTP- and PD-related neu

71 03720 (similar to Escherichia coli universal stress protein); At3g54870 (armadillo-repeat containing

72 Acr is a stress protein believed to be involved in the bacillary

73 Following the demonstration that the stress protein, BiP, prevented induction of collagen-ind

74 the excess buildup of acetyl-CoA upregulates stress proteins but excess formate depletes acetyl-CoA a

75 The role of the pro-apoptotic stress protein C/EBP homologous protein (CHOP) in MCD-me

76 6 and greater increases in expression of ER stress proteins C/EBP homologous protein and spliced XBP

77 e stress proteins, and universally conserved stress proteins can be regarded as the minimal stress pr

78 When used as vaccines, tumor-derived stress proteins can elicit antitumor immune responses.

79 Several studies have confirmed that certain stress proteins can function as potent vaccines against

80 t demonstrates that Gadd45, a p53-responsive stress protein, can facilitate topoisomerase relaxing an

81 The absence of ER stress protein CCAAT enhancer-binding protein homologous

82 binds to a wide variety of partly unfolded, stressed proteins.Clusterin also binds to many different

83 The stress response and stress proteins confer protection against diverse forms

84 or 1 (IGF-1) and clusterin, an extracellular stress protein, constitute this regulatory system.

85 nducible members of the heat shock family of stress proteins correlates with increased cellular prote

86 ges in dopamine (DA) distribution, oxidative stress, protein damage, and cell death.

87 Instead, a combination of oxidative stress, protein damage, and prophage-mediated cell lysis

88 and reared them in normal (within hives) or stressed (protein-deficient, asocial) conditions.

89 colysis, translational inhibition, oxidative stress, protein degradation, and amino acid catabolism.

90 egin a molecular genetic analysis of a major stress protein, DnaK/Hsp70, to begin to understand how s

91 eins (ProX, OppA, DegQ, MalB, and MglB), and stress proteins (DsbA, Tig, and UspA).

92 gated the early expression of cytoprotective stress proteins during ischemia-reperfusion induced by P

93 hock proteins) and mitochondrial adaptive or stress proteins (e.g. manganese superoxide dismutase, mi

94 th tumor protein Ags (e.g., gp100) and large stress proteins (e.g., hsp110 and grp170) with exception

95 s well as laboratory progress on the role of stress proteins, estrogen and a few other potential adju

96 Associations between microbial virulence and stress protein expression have been identified in other

97 ted potential functions of DJ-1 in oxidative stress, protein folding, and degradation pathways.

98 ly related cellular processes of response to stress, protein folding, and ubiquitin-dependent protein

99 f cellular pathways that include response to stress, protein folding, microtubule stability, and cell

100 This suggests that domains exist on the stress protein for each function.

101 Stress proteins from autologous normal tissue components

102 Expression of the global stress protein gene (gspA) is induced during the intrace

103 st in strains harbouring a lesion in htrA, a stress protein gene.

104 The protective potential of stress proteins generated following 4-TBP exposure was e

105 ependent increase in expression of all major stress protein genes, including groES, dnaKJ, hsp18, and

106 General stress proteins, Gls24 and GlsB, were previously shown t

107 The glucose-regulated stress protein (GRP) chaperones are subsequently induced

108 Stress protein GRP78/BiP is highly induced in progressiv

109 s to the therapy of cancer via regulation of stress protein GRP78/BiP.

110 Prior ER stress induces expression of the ER stress proteins Grp78, Grp94, and calreticulin and rende

111 that overexpress Mr 78,000 glucose-regulated stress protein (GRP78) are resistant to topoisomerase II

112 Because the stress protein GRP94 can augment presentation of peptide

113 rly, the heterologous expression of two cold-stress proteins had no profound influence on stress tole

114 To determine if this unique stress protein has a critical role in meiosis, we used g

115 Recently Gadd45, a p53-regulated stress protein, has been implicated in the activation of

116 ins and particular associations of viral and stress proteins have been documented.

117 Several ER stress proteins have been suggested to counteract the de

118 Stress proteins have three immunological regulatory func

119 tly, heat shock proteins (also known as heat stress proteins) have mostly been regarded as intracellu

120 This study was focused on the role of stress protein heat shock protein (HSP)70 for translatin

121 The stress protein heat shock protein 60 (Hsp60) induces sec

122 Delivery of the CD8 peptide epitope by stress protein, heat shock protein (hsp)70, results in e

123 gous, but not identical, to an intracellular stress protein, heat shock protein 60.

124 studies of two long-recognized but unstudied stress proteins, heat shock protein (hsp) 110 and glucos

125 ry transferrin receptor, integrin beta7, the stress protein heme oxygenase and the lymphocyte-specifi

126 nstrate that selective overexpression of the stress protein heme oxygenase-1 (HO-1) in astrocytes of

127 The stress protein heme oxygenase-1 (HO-1) is induced in end

128 Expression of the antioxidative stress protein heme oxygenase-1 (HO-1) was determined by

129 The induction of the stress protein heme oxygenase-1 (HO-1) was studied in th

130 32,000, similar to the well-known oxidative stress protein heme oxygenase-1 (HO-1).

131 to c-jun in MAPK pathway that regulates the stress protein, HO-1, expression.

132 Stress proteins, however, may have extracellular functio

133 In this study, we show that cellular stress proteins HSF1 and hsp70 play a mechanistic role i

134 ations in TnI or SR gene expression, but the stress protein HSP-70 was variably induced.

135 tochemical staining for the non-constitutive stress protein HSP-72 or neuronal death by acid fuchsin

136 of stress; (iii) induction of heat shock or stress protein (HSP)70 by heat stress was defective in a

137 There is evidence that microbial heat shock (stress) proteins (Hsp) are immunodominant antigens of ma

138 The plant heat stress protein, Hsp101, and the yeast ortholog, Hsp104,

139 ynthesis of numerous proteins, including the stress proteins Hsp60 (GroEL homolog) and Hsp70 (DnaK ho

140 Stress protein HSP70 in turn induced membrane tumor necr

141 red without expression of the inducible heat stress protein, hsp70, as detected by immunocytochemistr

142 The role of the abundant stress protein Hsp90 in protecting cells against stress-

143 chaperones such as the heat shock family of stress proteins (HSPs) actively participate in an array

144 Heat shock, or stress, proteins (HSPs) are induced in response to condi

145 activity of alphaB crystallin, an important stress protein in humans, is regulated by physiological

146 t elevated levels of serum antibody to Hsp90 stress protein in individuals colonized with this microo

147 ese observations suggest a new role for this stress protein in protecting the plastid during the dism

148 cts overexpress significant amounts of these stress proteins in both rat neonatal cardiomyocytes and

149 d cell death and investigated the role of ER stress proteins in Ca2+ regulation and cytoprotection af

150 results in the elevated expression of folate stress proteins in Escherichia coli.

151 e initiated an investigation of the roles of stress proteins in eukaryotic viral life cycles using as

152 nity, thus bridging this ancient function of stress proteins in prokaryotes to their ability to elici

153 disease, it would appear that the role of ER stress proteins in protection from oxidant damage warran

154 as regulatory elements for the expression of stress proteins in the complex stress response network o

155 DHNs, and presumably somewhat similar plant stress proteins in the late embryogenesis abundant and c

156 e observations confirm the role of mammalian stress proteins in the recognition of abnormal proteins

157 However, demonstrations of functions for stress proteins in viral life cycles are few.

158 rted that electromagnetic (EM) fields induce stress proteins in vitro.

159 The folate stress proteins include the universal stress protein, th

160 creasing evidence for the roles of oxidative stress proteins including superoxide dismutase enzymes i

161 cription Factor 6) induces cytoprotective ER stress proteins, including GRP78 and GRP94.

162 a transcriptional inducer of genes encoding stress proteins, including those belonging to the heat s

163 Real-time PCR of ER stress proteins indicated that the expression of the hea

164 structurally and functionally related small stress proteins induced by a variety of insults, includi

165 A member of a gene family encoding stress proteins induced by heat and nitrogen limitation,

166 ssion in glial cells, that IkappaB-beta is a stress protein inducible by hyperthermia or proteasome i

167 pase activity; and (v) more activation of ER stress proteins inositol-requiring enzyme 1 and activati

168 h was accompanied by inhibition of oxidative stress, protein insolubilization, and caspase activity i

169 st that molecular chaperoning is involved in stress protein interactions with APCs, antigen binding,

170 In plants, FDH is regarded as a universal stress protein involved in responses to various abiotic

171 ng whether increased expression of these two stress proteins is able to protect myogenic cells agains

172 ce the signal for the up-regulation of these stress proteins is believed to be the accumulation of mi

173 ress responses, in which the entire array of stress proteins is induced, no increases in HSP40 and HS

174 show that the unfolding of the mechanically stressed protein is nonexponential due to static disorde

175 Parameters of retinal oxidative stress, protein kinase C activity, and nitric oxides rem

176 hibitors of NF-kappa B (Bay11-7082), oxidant stress, protein kinase C, ERK, and p38 MAPKs.

177 re blocked by specific inhibitors of oxidant stress, protein kinase C, ERK1/2, and p38 mitogen-activa

178 During apoptotic stress, protein kinase Pak2 is cleaved by caspase 3 to f

179 on of multiple signaling pathways, including stress protein kinases as well as certain caspases.

180 ated DCs, was associated with a reduction of stress protein kinases, and attenuated lipopolysaccharid

181 uscle, was reduced following exposure, while stress-protein levels (Hsp70) increased.

182 A novel 14-amino acid peptide, with stress-protein-like sequences, exhibiting neuroprotectio

183 Stress proteins located in the cytosol or endoplasmic re

184 lting in the induction of a collection of ER stress proteins, many of which are protective and functi

185 reased inflammation, and increased oxidative stress protein markers.

186 (4) Chaperones and stress proteins may play a critical role in transforming

187 The endoplasmic reticulum (ER) stress protein mesencephalic astrocyte-derived neurotrop

188 ed gene ontology terms including Response to Stress, Protein Metabolic Process, Protein Folding, Regu

189 -inflammatory, and anti-apoptotic microsomal stress protein, migrates to the nucleus in a truncated a

190 This task--complicated by cellular stresses, protein misfolding, aggregation, and degradati

191 Pag, also known as macrophage 23-kD stress protein (MSP23), is a member of a novel family of

192 The data support roles for oxidative stress, protein nitration and aggregation, and excitotox

193 Gls24 was previously identified as a general stress protein of Enterococcus faecalis.

194 BiP/GRP78 is a lumenal stress protein of the endoplasmic reticulum (ER) that in

195 B-stimulating "danger" signal into the large stress protein or chaperone Grp170 (HYOU1/ORP150) that w

196 ively mild insults through the expression of stress proteins or chaperones such as glucose-regulated

197 The expression of three stress proteins, OsmY, Dps, and UspA, is significantly a

198 aginyl endopeptidase family functioning as a stress protein, overexpressed by TAMs, provides an ideal

199 ein L25 (RplY), and the probable DNA-binding stress protein (PA0962).

200 The ER stress proteins PERK, ATF4, ATF6, IRE1alpha, and CHOP we

201 -months (n=10), changes in mitochondrial and stress proteins persisted whereas cytoskeletal proteins

202 Gadd45, a p53-regulated stress protein, plays an important role in the cell cycl

203 Following exposure to cell envelope stress, proteins present in the extracytoplasmic space b

204 ata support a model in which induction of ER stress proteins prevents disturbances of intracellular C

205 nificantly increased expression of CX3CL1, a stress protein produced by the injured enterocyte, NOD2

206 urrent progress in identifying mechanisms of stress protein protection from ischemia, in which new me

207 Herp, an ubiquitin-like domain containing ER stress protein, renders PC12 and MN9D cells vulnerable t

208 Activation of the stress protein response prevented the VEGF-mediated chan

209 icantly decreased by prior activation of the stress protein response with geldanamycin or pyrrolidine

210 These include enhanced stress protein response, attenuation of the inflammatory

211 attenuated in rats by the activation of the stress protein response.

212 An intriguing pattern emerges: stress proteins, ribosomal proteins and tRNA synthetases

213 f tyrosine phosphorylation of GRP-75-related stress protein(s) by alpha-thrombin and suggests that th

214 as relevant peptides from apoptotic and cell-stress proteins second mitochondria-derived activator of

215 The cytoplasmic superoxide stress protein SodB was induced by acid, possibly in res

216 hus, Osp94 is a new member of the hsp110/SSE stress protein subfamily and likely acts as a molecular

217 In contrast, calpain has no effect on other stress proteins such as GRP78 or HSP70.

218 nducible transcription factors 1alpha and 2, stress proteins such as heat shock protein 27, and vascu

219 Redox regulation of stress proteins, such as molecular chaperones, guarantee

220 together with the appearance of a universal stress protein suggested that the viability of these cel

221 For the late protection, stress protein synthesis may play a role.

222 leukin-10, in turn, induced heme oxygenase-1 stress protein synthesis via an autocrine mechanism.

223 Heme oxygenase-1 (HO-1) is a stress protein that has been suggested to participate in

224 Hsp27 is a small stress protein that has previously been shown to modulat

225 results support the hypothesis that Ub is a stress protein that plays an important role in protectin

226 ck proteins (sHSPs) are virtually ubiquitous stress proteins that are also found in many normal tissu

227 s controls the synthesis of over 100 general stress proteins that are induced by growth-limiting cond

228 ed eye lens alpha-crystallins are ubiquitous stress proteins that exhibit ATP-independent molecular c

229 ous family of low molecular mass (15-30 kDa) stress proteins that have been found in all organisms.

230 folate stress proteins include the universal stress protein, the ferric uptake regulatory repressor,

231 he stress protein and (b) the binding of the stress protein to receptor(s) on antigen-presenting cell

232 Li et al. now identify the pseudokinase stress protein TRIB3 as an important factor in APL disea

233 mitant ablation of the upregulated oxidative stress protein TXNIP substantially negated the effects o

234 Thrombospondin-1 is a stress protein typically secreted in response to hypoxia

235 ed that the high-level induction of the PspA stress protein under YidC depletion conditions is roughl

236 ses (CHT) and beta-1,3-glucanases (GLU), are stress proteins up-regulated as response to extrinsic en

237 in was identified that contained a Universal stress protein (Usp) domain present in bacteria, protozo

238 y techniques, we identify specific universal stress proteins (USP) as abundantly expressed cAMP-bindi

239 e of an acidic isoform of both the universal stress protein UspA and carbon starvation protein Csp15,

240 that includes the Escherichia coli universal stress protein UspA, for the MADS-box transcription regu

241 sferase (DGAT) (Rv3130c), and many universal stress proteins (USPs).

242 Four- and 10-fold activation of stress protein was detected by a consensus heat shock fa

243 s for CAP160 and CAP85, another spinach cold-stress protein, were introduced into tobacco (Nicotiana

244 ge foam cell formation, and downregulated ER stress proteins without changing blood pressure.

245 Furthermore, mRNAs encoding key soluble stress proteins (XBP-1 and ATF-4) were translated primar