ライフサイエンスコーパス: stress-inducible

1 mPing insertions that render adjacent genes stress inducible.

2 ls in the roots and it is neither wound- nor stress-inducible.

3 to barley HVA22, the yeast homologue is also stress-inducible.

4 ed encodes a novel Ag designated as L. major stress-inducible 1 (LmSTI1).

5 mutant plants that differ in their levels of stress-inducible 12-OPDA but display similar ABA levels.

6 Hspa1a and Hspa1b genes encode stress-inducible 70-kDa heat shock proteins (Hsp70) that

7 Here, we report that the stress-inducible 78-kDa glucose-regulated protein (GRP78

8 Class A HSFs are primarily responsible for stress-inducible activation of heat shock genes whereas

9 e distant MHC class I homologs that serve as stress-inducible Ags on epithelial and epithelially deri

10 and N. crassa proteins show homology with a stress-inducible alfalfa, G1.

11 Atf5 expression was stress inducible and enriched in beta cells.

12 sis revealed that the 68-kDa polypeptide was stress inducible and that a major band at 44 kDa and a m

13 enes, Ubb and Ubc, that are considered to be stress inducible and two constitutively expressed monoub

14 was observed to be constitutive rather than stress inducible and was distributed throughout most aer

15 It is stress-inducible and its up-regulation is associated wit

16 ion of many pathogen-, toxin-, and oxidative-stress-inducible and metabolic genes, as well as the act

17 se studies identify iex-1 as a biomechanical stress-inducible and NF-kappaB-dependent gene in cardiac

18 triction (CR) on expression of the oxidative stress-inducible and pro-apoptotic gene gadd153 (chop) i

19 eptor complex with NKG2D, a receptor for the stress-inducible and tumor-associated major histocompati

20 0]) is expressed in a variety of tissues, is stress inducible, and is a positive regulator of longevi

21 Heme oxygenase-1 (HO-1) is a stress-inducible, anti-inflammatory, and cytoprotective

22 x (MHC) class I homolog MIC-A functions as a stress-inducible antigen that is recognized by a subset

23 mplex class I chain-related gene A (MICA), a stress-inducible antigen, are also associated with sever

24 Peroxiredoxin I (Prx I) is an oxidative stress-inducible antioxidant protein with thioredoxin pe

25 Here we show that p8, a small stress-inducible basic helix-loop-helix protein, is requ

26 sigmaB activity in these mutants was stress inducible but transient, even in the absence of R

27 Hsp70 is stress-inducible, but paradoxically, we report here that

28 Our identification of a stress-inducible cDNA that encodes eIF1 suggests that mo

29 We have selected the stress-inducible cellular gene encoding the immediate-ea

30 xtract which interacts specifically with the stress-inducible change region (SICR) of the grp78 promo

31 unctional region in the 3' half of the core (stress-inducible change region [SICR]) which exhibits st

32 This evidence includes stress-inducible changes in 14-3-3 gene expression, inte

33 Our findings demonstrate long-lasting stress-inducible changes in AChE's promoter choices, ide

34 ducible change region [SICR]) which exhibits stress-inducible changes in stressed nuclei.

35 way of 1) decreased expression of the major stress-inducible chaperone Hsp72 with appearance of misf

36 The stress-inducible chaperone protein HSP70 (HSPA1) is impl

37 tional analyses indicate that in addition to stress-inducible chaperones that protect the cellular pr

38 those that prevent protein aggregation (heat stress-inducible chaperones) and eliminate damaged prote

39 sfunction, increased mitochondrial levels of stress-inducible chaperonins and a leucine-rich protein,

40 dentified as the ATF4 binding site in the ER stress-inducible chop promoter.

41 olysis was triggered by NKG2D recognition of stress-inducible class I major histocompatibility comple

42 spectively, we further discovered that an ER stress-inducible complex (ERSF) from HeLa nuclear extrac

43 The introduction of a stress-inducible component in these pathways has signifi

44 nd confirmed that NF-kappaB was activated by stress-inducible concentrations of copper.

45 of light, consistent with multiple consensus stress-inducible control sequences in the TKT promoter r

46 f mammalian Hsp gene expression involves the stress-inducible conversion of HSF1 from the inactive mo

47 The stress-inducible cytoprotective enzyme heme oxygenase-1

48 to ionizing radiation (IR) and H(2)O(2) on a stress-inducible domain.

49 hus, this study identifies SPRR1A as a novel stress-inducible downstream mediator of gp130 cytokines

50 de genetic and biochemical evidence that the stress-inducible dual specificity phosphatase, Sdp1, neg

51 phosphatase-1 (DUSP1/MKP-1) is a mitogen and stress-inducible dual specificity protein phosphatase, w

52 c endoplasmic reticulum kinase (PERK), an ER stress-inducible eIF2alpha kinase that is normally activ

53 Despite normal activity of the cognate stress-inducible eIF2alpha kinases PERK (also known as P

54 essential element for the assembly of an ER-stress-inducible enhanceosome that activates CHOP gene e

55 The mRNAs for two stress-inducible enzymes unrelated to amino acid biosynt

56 s of Nox4 and endoplasmic reticulum receptor stress-inducible Ero1beta generated reactive oxygen spec

57 on signature characterized by early and late stress-inducible expression in tolerant and intolerant g

58 is cis-acting motif mediates the nitrosative stress-inducible expression of cgb.

59 NA in the nucleus of the solitary tract, and stress-inducible expression of CRF-R1 transcripts in the

60 ck transcription factors (Hsfs) activate the stress-inducible expression of heat shock proteins (Hsps

61 als, HSF1 is the main factor controlling the stress-inducible expression of Hsp genes while the funct

62 Thus, stress-inducible expression of xCT is a two-step process

63 o -104 required for both constitutive and ER-stress-inducible expression.

64 s that are especially important for ABA- and stress-inducible expression.

65 angiogenesis, is also upregulated by several stress-inducible factors such as hypoxia and stimulation

66 The stress-inducible form of the gene is expressed from an i

67 G2A is a stress-inducible G protein-coupled receptor that is expr

68 ancer G protein-coupled receptor 1 family of stress-inducible G protein-coupled receptors.

69 mediate early response gene X-1 (IEX-1) is a stress-inducible gene abundantly expressed in macrophage

70 ctivating transcription factor 3 (ATF3) is a stress-inducible gene and encodes a member of the ATF/CR

71 (RAS1), revealed that it is an ABA- and salt stress-inducible gene and encodes a previously undescrib

72 SF-1), a master transcriptional regulator of stress-inducible gene expression and protein folding hom

73 , an ancient and highly conserved program of stress-inducible gene expression, to reestablish cellula

74 estigated the effects of BRCA1 on xenobiotic stress-inducible gene expression.

75 ented ABA responsiveness, thereby activating stress-inducible gene expression.

76 HVA22 is an ABA- and stress-inducible gene first isolated from barley (Hordeu

77 The stress-inducible gene heme oxygenase (HO-1) has previous

78 We conclude that SOCS3 is a mechanical stress-inducible gene in cardiac muscle cells and that i

79 The stress-inducible gene product, heme oxygenase-1, and car

80 ATF3 is a stress-inducible gene that encodes a member of the ATF/C

81 Induction of SSAT, a stress-inducible gene that encodes a rate-limiting polya

82 gadd153, also known as chop, is a highly stress-inducible gene that is robustly expressed followi

83 at BRCA1 induces GADD45, a p53-regulated and stress-inducible gene that plays an important role in ce

84 conducted a genetic screen based on ABA- and stress-inducible gene transcription.

85 ated significantly higher levels of ABA- and stress-inducible gene transcripts as compared to the wil

86 TF3 (activating transcription factor-3) is a stress-inducible gene, and the protein it encodes is a t

87 results indicate that expression of ATF3, a stress-inducible gene, in the heart leads to altered gen

88 etastatic lung were all dependent on Atf3, a stress-inducible gene, in the noncancer host cells.

89 Because ATF3 is a stress-inducible gene, our work provides a direct link t

90 Because ATF3 is a stress-inducible gene, these mice may provide a model to

91 Because ATF3 is a stress-inducible gene, these mice may represent a model

92 investigated the function of a cell envelope stress-inducible gene, yvrI, which encodes a 22.5 kDa pr

93 X-1 (immediate early response gene X-1) is a stress-inducible gene.

94 of BRCA1 induces GADD45, a p53-regulated and stress-inducible gene.

95 encing of HSP82, a transcriptionally potent, stress-inducible gene.

96 ect on the expression patterns of typical ER stress-inducible genes (AtBip2, AtPDI, AtCRT1, and AtCNX

97 ption inhibitors that prevented induction of stress-inducible genes during cell isolation procedures.

98 Stronger drought-stimulation of stress-inducible genes encoding late-embryogenesis-abund

99 to suppress the expression of cellular viral stress-inducible genes in cells of vertebrate origin.

100 Upon heat shock, transcription of many stress-inducible genes is rapidly and dramatically stimu

101 al translation repression with activation of stress-inducible genes such as ATF4, CHOP, and BiP in th

102 which is highly conserved in promoters of ER stress-inducible genes such as Grp78/BiP.

103 locally magnifies the specific activation of stress-inducible genes via counteraction of corepressors

104 n the posttranscriptional regulation of many stress-inducible genes via small noncoding RNAs.

105 morphisms (SNPs) from 41 disease and abiotic stress-inducible genes were tested for their genetic ass

106 ted in increased expression levels of two ER stress-inducible genes, BiP and Chop, consistent with th

107 ion, expression of heavy metal-inducible and stress-inducible genes, stress kinase cascades, and apop

108 tes to the nucleus and activates selected ER stress-inducible genes, such as GRP-78 and sarco/endopla

109 damage and are involved in the regulation of stress-inducible genes.

110 on factors are involved in the regulation of stress-inducible genes.

111 bly positioned in promoters upstream of most stress-inducible genes.

112 8 transgene induces a variety of heat and ER stress-inducible genes.

113 ed apoptosis and SC-specific upregulation of stress-inducible genes.

114 ion of HSP synthesis is tightly regulated by stress-inducible heat shock factors (HSF), which are par

115 Stress-inducible heat shock protein 70 (hsp70) interacts

116 o-terminal ubiquitin-like (UbL) region, four stress-inducible, heat shock chaperonin-binding motifs (

117 HO)-2, the constitutive cognate of oxidative stress inducible HO-1 (HSP32), degrades heme to biliverd

118 ces cerevisiae heat shock protein Hsp31 is a stress-inducible homodimeric protein that is involved in

119 plants with wounding and a range of rapidly stress-inducible hormones and detected a robust LUC acti

120 ble for HSF1 and RNA polymerase II, allowing stress-inducible Hsp expression.

121 for mammalian heat shock factor 1 (HSF1) in stress-inducible Hsp gene expression, resistance to stre

122 n of genes encoding thioredoxin (TRX2) and a stress-inducible HSP70 (SSA1) by H2O2.

123 , but not Hsc3p, results in induction of the stress-inducible Hsp70 at normal temperatures.

124 2 expression prompted the rapid induction of stress-inducible Hsp70 protein in neurons, and virally m

125 e have recently shown that expression of the stress-inducible Hsp70.3 gene in the myocardium in respo

126 promoter regions of some genes, such as the stress-inducible hsp70i gene that codes for a heat shock

127 Eukaryotes have constitutive (Hsc70) and stress-inducible (iHsp70) isoforms, but their functions

128 rpes simplex virus 1, the RNA encoded by the stress-inducible immediate early response gene IEX-1 was

129 f the up-regulated mRNAs, exemplified by the stress-inducible immediate-early 1 mRNA, is deadenylated

130 ected cells, the rates of degradation of the stress-inducible immediate-early response gene 1 and oth

131 r of p38 MAP kinase, SB203580, abolished the stress-inducible in vivo phosphorylation of CHOP.

132 An alternative, stress-inducible isoform of CAVI (CAVI-b) has been shown

133 rse senescence-inducing stimuli activate the stress-inducible kinase p38MAPK in normal human fibrobla

134 h Daxx, a Fas-binding protein that activates stress-inducible kinase pathways.

135 ay contribute to tumorigenesis by inhibiting stress-inducible kinase pathways.

136 PERK encodes an ER stress-inducible kinase that phosphorylates eukaryotic t

137 the PEPCK-C promoter and support a role for stress inducible kinases in the maintenance of PEPCK-C e

138 NF-kappaB inhibitor (IkappaB) by respective stress-inducible kinases (IKK) is a key event in NF-kapp

139 of the apoptosis signal-regulating kinase 1 stress-inducible kinases and Jun NH(2)-terminal kinase.

140 he shutoff of protein synthesis initiated by stress-inducible kinases.

141 ty complex (MHC) class I homolog, MICA, is a stress-inducible ligand for NKG2D, a C-type lectin-like

142 ted by activating receptors, which recognize stress-inducible ligands expressed on target cells and s

143 we revealed a molecular mechanism by which a stress-inducible, liver-enriched transcription factor, c

144 NKG2D ligands (NKG2DLs) are a group of stress-inducible major histocompatibility complex (MHC)

145 PP5 forms a complex with ATR in a genotoxic stress-inducible manner.

146 tg16 and LC3, and partially with DFCP1, in a stress-inducible manner.

147 Here we describe how the stress-inducible MAPK phosphatase, Sdp1, presents an unu

148 subjected to ex vivo I/R, the levels of 2 ER stress-inducible markers of the UPR, the ER-targeted cyt

149 These studies reveal a stress-inducible mechanism involved in the regulation of

150 detoxification gene through constitutive and stress-inducible mechanisms in the ASI chemosensory neur

151 Corticosterone upregulated the stress-inducible mechanistic target of rapamycin (mTOR)

152 , itself an inflammation-regulated and redox stress-inducible mediator of chondrocyte hypertrophic di

153 be due to expression of HSP70, the dominant stress-inducible member of the HSP70 family, rather than

154 rrent transcriptional activation of MKP-1, a stress-inducible member of the MAPK phosphatase (MKP) fa

155 The identification of CREBH as a stress-inducible metabolic regulator has important impli

156 Sestrins are stress-inducible metabolic regulators that suppress a wi

157 Sestrins are stress-inducible metabolic regulators with two seemingly

158 RA synoviocytes aberrantly expressed the stress-inducible MIC ligands of NKG2D, which stimulated

159 Stress-inducible MICA, a distant homolog of major histoc

160 ified miR-708, an endoplasmic reticulum (ER) stress-inducible miRNA whose expression is regulated by

161 Forced overexpression of stress-inducible miRNAs was sufficient to induce hypertr

162 summary, our study revealed that COX7AR is a stress-inducible mitochondrial COX subunit that facilita

163 We observe the activation of three stress-inducible mitogen-activated protein (MAP) kinases

164 Under physiologic or pharmacologic stress, inducible molecular chaperones provide additiona

165 The multifunctional, stress-inducible molecular chaperone HSP70 has important

166 enhanced expression of alphaB crystallin, a stress-inducible molecular chaperone of the small heat s

167 The stress-inducible molecular chaperone, HSP72, is an impor

168 We show here that the stress-inducible molecule, MICA, is induced on the surfa

169 The stress-inducible molecules GADD45beta and GADD45gamma ha

170 G mice exhibited increased levels of many ER stress-inducible mRNAs and proteins; for example, GRP78

171 enotypic analysis of knockout, knockdown and stress-inducible mutants for AtALN revealed that allanto

172 ngs demonstrate that aneuploidy is a form of stress-inducible mutation in eukaryotes, capable of fuel

173 tion between vascular territories exhibiting stress-inducible myocardial ischemia and those with norm

174 f cardiac flow in the presence or absence of stress-inducible myocardial ischemia.

175 Galanin is a stress-inducible neuropeptide and cotransmitter in serot

176 CHOP (also called GADD153) is a stress-inducible nuclear protein that dimerizes with mem

177 ess-inducible trimerization and DNA binding, stress-inducible nuclear translocation and Hsp gene tran

178 on signals in NEMO whose mutations disrupted stress-inducible nuclear translocation of NEMO and IKK/N

179 Induction of the stress-inducible p21(Waf1) protein in aggregates of neig

180 ethionylleucylphenylalanine-stimulatable and stress-inducible p38 MAPK activity as well as apoptosis

181 egulated by the unfolded protein response, a stress-inducible pathway used to monitor and maintain ER

182 suggests the existence of a number of other stress-inducible pathways that also affect the fidelity

183 The constitutive and stress-inducible patterns of the five Arabidopsis CYP86A

184 utively expressed member of type II MCPs, in stress-inducible PCD.

185 used to monitor the evolution of the cardiac stress-inducible phenotype.

186 Stress-inducible phosphoprotein 1 (STI1), an Hsp90 cocha

187 ted the cDNA for the murine homologue of the stress-inducible phosphoprotein STI1 (also known as IEF

188 ransformed cells through the activation of a stress inducible PI 3-kinase/Akt pathway and the hypoxia

189 UbC is one of two stress-inducible polyubiquitin genes in mammals and is t

190 ch for potential downstream mediators of the stress-inducible, pro-atrophy transcription factor ATF4.

191 activating transcription factor 3 (ATF3), a stress-inducible proapoptotic gene, downregulates the ex

192 ing a reporter construct generated using the stress-inducible promoter from the gene encoding a murin

193 rotein kinases (CDPK1 and CDPK1a) activate a stress-inducible promoter, bypassing stress signals.

194 gth-dependent cell death and activated an ER stress-inducible promoter.

195 ddition to mediating CRTC2 recruitment to ER stress inducible promoters, ATF6alpha also reduced hepat

196 The analogue also upregulated cell envelope stress-inducible promoters piniBAC and pclgR, implicatin

197 Here, we determined that ER stress inducible protein Mesencephalic Astrocyte-derived

198 By POD7, oxidative stress inducible protein tyrosine phosphatase and vascul

199 omocysteine-inducible, endoplasmic reticulum stress-inducible protein (HERP), and calnexin.

200 ntigens thiol-specific antioxidant, L. major stress-inducible protein 1 (LmSTI1), and Leishmania elon

201 specific antioxidant (TSA), Leishmania major stress-inducible protein 1 (LmSTI1), and Leishmania elon

202 find that the TPR domain-containing Hop-like stress-inducible protein 1 (Sti1p) cochaperone selective

203 is paper, the authors find that the Hop-like stress-inducible protein 1 (Sti1p) cochaperone selective

204 Heat shock protein 72 (HSP72) is a stress-inducible protein capable of protecting a variety

205 appear to be independent of Hsp104, another stress-inducible protein chaperone known to be involved

206 The stress-inducible protein heme oxygenase-1 provides prote

207 The stress-inducible protein heme oxygenase-1 provides prote

208 Stress-inducible protein kinases capable of activating c

209 Viral stress-inducible protein p56 is produced in response to

210 The stress-inducible protein Sestrin2 (Sesn2) plays an impor

211 We conclude that Mfn2 but not Mfn1 is an ER stress-inducible protein that is required for the proper

212 and its homologues encode a highly conserved stress-inducible protein which may play an important rol

213 cysteine-inducible ER stress protein), an ER stress-inducible protein with an ubiquitin-like (UBL) do

214 Heme oxygenase-1 (HO-1), a stress-inducible protein, also regulates IL-10 and TNF-a

215 A novel stress-inducible protein, Sestrin2 (Sesn2), declines in

216 78 (grp78) gene, which encodes an Mr 78,000 stress-inducible protein.

217 Metallothioneins (MTs) are thiol-rich, stress-inducible proteins that can afford protection aga

218 s motif and is highly related to a family of stress-inducible proteins that is conserved from yeast t

219 ctin cytoskeleton in regulating prions via a stress-inducible QN-rich protein.

220 ive roles of these constitutive and nutrient stress-inducible Rab5 proteins that ensure adaptable ves

221 ck transcription factor 1 (HSF1), the master stress-inducible regulator, and our current understandin

222 ubiquitous HSP family is further enhanced by stress-inducible regulatory networks, both at the transc

223 GADD34 is a stress-inducible regulatory subunit of a holophosphatase

224 growth arrest and DNA damage 34 (GADD34), a stress-inducible regulatory subunit of a phosphatase com

225 ted with a plasmid encoding ATF6-(1-373), ER stress-inducible reporter gene activation was high, but

226 ate an optical sensor cell line expressing a stress-inducible reporter protein.

227 We conclude that CMO is a stress-inducible representative of a new class of plant

228 ) stress as revealed by the activation of ER stress-inducible RNA-dependent protein kinase-like ER-in

229 Thrombospondins are a family of stress-inducible secreted glycoproteins that underlie ti

230 onstitute an operon that is expressed from a stress-inducible sigma(A)-type promoter located immediat

231 e/stress-activated protein kinase (JNK/SAPK) stress-inducible signaling pathway in the induction of t

232 se enzymes mediate the activation of several stress-inducible signaling pathways as well as micronucl

233 Osmotic stress inducible sorghum genes identified for the first

234 Stress-inducible Ssa3p and Ssa4p are 80% identical to Ss

235 Our work suggests that an alternative and stress-inducible strategy of translation initiation ensu

236 of the vertebrate HSF family that regulates stress-inducible synthesis of heat shock proteins (HSPs)

237 at shock transcription factor that regulates stress-inducible synthesis of heat shock proteins and is

238 Heat shock factor 1 (HSF1) is a stress-inducible transcription factor and has been descr

239 ithin 1 min, followed by induction of the ER stress-inducible transcription factor ATF4.

240 in disulfide isomerase) and induction of the stress-inducible transcription factor C/EBP-homologous p

241 The inhibition of the major stress-inducible transcription factor CHOP (CCAAT/enhanc

242 chronic hypoxia stimulates expression of the stress-inducible transcription factor gene c-jun and tra

243 The stress-inducible transcription factor known as growth an

244 The stress-inducible transcription factor, nuclear factor (N

245 ion factor 3 (ATF3), an NMD target and a key stress-inducible transcription factor, was stabilized in

246 The identity of oxidative stress-inducible transcription factors and their role in

247 tory activity, also functions as a potent ER stress-inducible transcriptional regulator.

248 we demonstrated that the function of ATF3, a stress-inducible transcriptional repressor, is negativel

249 s thaliana interacts with different selected stress-inducible transcripts targeting them for decappin

250 both cysteines were mutated are defective in stress-inducible trimerization and DNA binding, stress-i

251 ese HSFs nonetheless exhibit reversible heat stress-inducible trimerization.

252 pregulated PBMC gene expression of oxidative stress-inducible tyrosine phosphatase and Mn2+-superoxid

253 ting enzymes (UBC or E2) that belongs to the stress-inducible UBC4/5 class in yeast.

254 omocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 (HERP);

255 ted by a mitogenic pathway distinct from the stress-inducible UPR cascade and this probably controls

256 he single Arabidopsis (Arabidopsis thaliana) stress-inducible variant H1.3 occurs in plants in two se

257 Hsc70 is constitutively expressed and poorly stress-inducible, whereas Hsp70 is unabundant in normal

258 tein), which is the hamster homologue of the stress-inducible yeast gene, STI1, and clone H411, which