ライフサイエンスコーパス: striatal

1 atients, and we observed significantly lower striatal (123)I-FP-CIT binding ratios in the caudate nuc

2 Striatal (123)I-FP-CIT binding to DAT and hypothalamic (

3 ubcortical and cortical brain regions and in striatal [(18)F]fluorodopa Ki compared with controls.

4 ism spectrum disorder, but a causal role for striatal 2-AG deficiency in phenotypes relevant to autis

5 In the violent offender group, striatal 5-HT1BR binding was positively correlated with

6 nificantly moderated the association between striatal 5-HT1BRs and trait anger (difference in slopes,

7 d inhibitory functional interactions between striatal A2AR and CB1R have been reported, and evidence

8 Previously reported striatal abnormalities in ADHD may be caused by comorbid

9 rgic transmission potentiated reward-related striatal activation and corticostriatal functional conne

10 r is characterized by reduced reward-related striatal activation and dysfunctional reward learning, p

11 ts receiving amisulpride exhibited increased striatal activation and potentiated corticostriatal func

12 nce and gambling addictions showed decreased striatal activation compared with healthy control indivi

13 d 4) greater ventromedial prefrontal/ventral striatal activation during emotional conflict regulation

14 tal activation for both groups and increased striatal activation only among ADHD smokers.

15 e that the coparental bond is underpinned by striatal activations and corticostriatal connectivity si

16 As hypothesized, striatal activity and pupil size reflected task-conditio

17 the impact of the parafascicular nucleus on striatal activity and some related behaviour critically

18 Importantly, striatal activity during generous decisions is directly

19 way is hypothesized to be a key regulator of striatal activity via modulation of synaptic plasticity

20 the shore and shelf and enhancer regions of striatal and cerebellar genes.

21 in mice does not disturb the development of striatal and cortical interneurons and does not lead to

22 Both the striatal and cortical networks encoded time, but the str

23 of Foxp1, a protein expressed selectively in striatal and cortical neurons that plays a neuroprotecti

24 The medial SN connects with limbic striatal and cortical regions and encodes value (greater

25 evented the migration of SD into subcortical striatal and hippocampal regions in the R192Q strain tha

26 inished BOLD activity in mesolimbic (ventral striatal and midbrain) and prefrontal cortical (dorsolat

27 endent on lateralization of structural nigro-striatal and nigro-motocortical pathways.

28 tes EP activity by differentially modulating striatal and pallidal GABAergic inputs.

29 e differentially innervated by subclasses of striatal and pallidal neurons.

30 hin previously identified, specific frontal, striatal and parietal networks we suggest that these str

31 tor decision making within specific frontal, striatal and parietal networks; we conclude that manual

32 Blunting in key frontal, cingulate, and striatal areas was evident in unaffected, at-risk indivi

33 oth segregated and integrative tracts in the striatal associative loop in chronic schizophrenia and t

34 s examined both types of input tracts in the striatal associative loop in chronic schizophrenia patie

35 on's disease, NeAL218 alone reprograms adult striatal astrocytes into iDANs that are excitable and co

36 connectivity was positively correlated with striatal atrophy, while striatum-retrosplenial cortex co

37 x connectivity is negatively correlated with striatal atrophy.

38 usion, pathological alpha-synuclein in nigro-striatal axonal terminals leads to early axonal patholog

39 hip between 4-year changes in free water and striatal binding ratio in a subgroup of Parkinson's dise

40 r was associated with the 4-year decrease in striatal binding ratio in the putamen.

41 structed with standardized parameters before striatal binding ratios were quantified against a normal

42 PA positron emission tomography to determine striatal blood flow during active atypical antipsychotic

43 Regional striatal blood flow was significantly higher during acti

44 the effect of a single dose of nalmefene on striatal blood oxygen level-dependent (BOLD) signal chan

45 We observed between-group differences in striatal BOLD responses to shock omission in Avoidance/E

46 the hypothesis that time course of return of striatal BPND to baseline differed between SZ and HCs, w

47 ies suggest glutamatergic deficits in fronto-striatal brain areas in both disorders, this is the firs

48 necting cortical areas to the striatum (e.g. striatal bundle and external capsule), but also in long

49 Here we report the critical role of ventral striatal cAMP-response element modulator (CREM) in media

50 or mHtt secretion in mouse neuroblastoma and striatal cell lines, as well as in primary neurons.

51 HDACIs on the regulation of PDH activity in striatal cells derived from HD knock-in mice and YAC128

52 e prevailing hypothesis of the centrality of striatal ChIs in opposing dopamine regulation of BG outp

53 basal ganglia, including a reduced number of striatal cholinergic interneurons (SCIN), are involved i

54 halamic) cholinergic pathways-as well as the striatal cholinergic interneurons.

55 c resonance imaging studies suggesting extra-striatal cholinergic projections from the pedunculoponti

56 These effects of chronic stress on prefronto-striatal circuit dynamics could be blocked or be mimicke

57 These data suggest that cortico-striatal circuit dysregulation drives maladaptive decisi

58 he contributions of striosomes and matrix to striatal circuit function.

59 ities in glutamate signaling and the cortico-striatal circuit.

60 acterize potential causal links between DUP, striatal circuitry and clinical outcomes.

61 e data also identified unique prefrontal and striatal circuitry as a putative marker of successful tr

62 sureable physiological alterations in limbic striatal circuitry that vary as a function of dopaminerg

63 d they are typically excluded from models of striatal circuitry.

64 rlies sustained reinforcement, and activates striatal circuitry.

65 al. find that stress disrupts inhibition of striatal circuits by prefrontal cortex, rendering animal

66 P and RRF neuronal populations can influence striatal circuits involved in associative learning.

67 D2L signaling is required for the control of striatal circuits regulating motor activity.

68 ural as well as functional changes in fronto-striatal circuits that might lead to enhanced multi-comp

69 astrocyte diversity between hippocampal and striatal circuits.

70 on error signal drives plasticity in frontal-striatal circuits.

71 hampered the study of the functions of these striatal compartments.

72 istration of cocaine could enduringly modify striatal connectivity.

73 Here, we evaluate how cortico-striatal, cortico-amygdalar, and amygdalo-striatal proje

74 Taken together, these results suggest that striatal CR+ interneurons comprise at least three molecu

75 gether, these results highlight that ventral striatal CREM mediates impulsivity related to substance

76 magnetic resonance imaging for assessment of striatal D1- and D2-type receptor availability and corti

77 eptor (D1) BAC MORF mice that label about 1% striatal D1-expressing medium spiny neurons and allow vi

78 Striatal D1-type but not D2-type BPnd was negatively ass

79 These results suggest a role of striatal D1-type receptors in cortical adaptation to chr

80 Nevertheless, interactions between striatal D2R and peripheral glucose have not been previo

81 h abstinence ex-smokers may recover from low striatal D2R availability and from increased behavioral

82 rmative markers significantly predict dorsal striatal D2R in 117 healthy ethnically diverse residents

83 in patients with SZ and HC, suggesting that striatal D2R internalization as measured by our imaging

84 Here we show that manipulations involving striatal D2R signaling coincide with perseverative and i

85 Instead, candidate gene associations with striatal D2R were diminished when correcting for ancestr

86 he relationship between genetic ancestry and striatal D2R.

87 Striatal DA D2 receptors (D2Rs) also regulate reinforcem

88 rminals, resulting in the rescue of aberrant striatal DA dynamics, reversal of characteristic phenoty

89 ohydrolase I (GCH1) transcription; increases striatal DA in vivo; and has symptomatic efficacy in two

90 ic neurons in SN, neuritic swelling, reduced striatal DA release, and impaired motor behavior.

91 , and decreased availability, and release of striatal DA, all of which correlated with symptoms of re

92 le, which prevents DAergic neuron demise and striatal DAergic denervation in vivo against PD-causing

93 ported ELA, there was no correlation between striatal DAT and D1 receptor binding (R(2)=0.07, p=0.33)

94 e (PD), we hypothesized that, in addition to striatal DAT binding, there would be differences in extr

95 ime after amphetamine significantly affected striatal DeltaBPND (F=1.38, P=0.26; F=0.51, P=0.61).

96 -syn-mediated deficits in forelimb akinesia, striatal denervation or loss of SNpc neuron, nor did STN

97 ling in governing the motor functions of the striatal direct and indirect pathways.

98 ) to determine the role of 2-AG signaling in striatal direct or indirect pathways, respectively.

99 Activity in striatal direct- and indirect-pathway spiny projection n

100 with broad reconfigurations of dorsolateral striatal (DLS) circuit properties that increase gain and

101 Glucose modulates striatal dopamine (DA) and regulates appetitive drive an

102 tantia nigra, and attenuated the decrease of striatal dopamine and metabolite levels in mice receivin

103 Furthermore, striatal dopamine changes have been linked to altered co

104 o the striatum and midbrain may underlie the striatal dopamine changes.

105 L- (eight repeats) and H- (nine repeats)] on striatal dopamine D2/D3 receptor (DRD2) availability and

106 epeat (VNTR) marker associated with baseline striatal dopamine D2/D3 receptor availability and with m

107 ) is a neural response that in part reflects striatal dopamine functioning.

108 mice, we found that endogenous GDNF affects striatal dopamine homeostasis and regulates amphetamine-

109 n of dopamine signaling by Akt1 kinase since striatal dopamine hyperstimulation is associated with ps

110 e traditionally associated with an excess of striatal dopamine in the basal ganglia.

111 ictions on the amount of tics generated when striatal dopamine increases and when the cortex is exter

112 vailability and with methylphenidate-induced striatal dopamine increases in healthy volunteers.

113 onic GDNF deletion in the CNS did not affect striatal dopamine levels or dopamine release, but dopami

114 Subregional estimates of striatal dopamine metabolism are presented.

115 singly, in unmated males but not in females, striatal dopamine neurotransmission was elevated after h

116 clusively to the mate's song, although their striatal dopamine neurotransmission was only slightly el

117 ur previous characterization of Slc6a15 as a striatal dopamine receptor 2 (D2)-neuron-enriched gene,

118 mission in hippocampal pyramidal neurons and striatal dopamine receptor D1-expressing neurons of Plcg

119 e densest and most widespread graft-mediated striatal dopamine reinnervation following a transplant p

120 comorbidity-is associated with a deficit in striatal dopamine release.

121 es rewarding phenotypes, social approach and striatal dopamine release.

122 e involvement of the AKT1 gene in modulating striatal dopamine signaling in the human brain.

123 There was a significant group difference in striatal dopamine synthesis capacity (Kicer) (F2,57 = 6.

124 , p=0.01) and was positively correlated with striatal dopamine synthesis capacity (r = 0.344, p=0.03)

125 at risk of schizophrenia have found elevated striatal dopamine synthesis capacity and increased dopam

126 lts provide empirical evidence for increased striatal dopamine synthesis in pathological gambling.

127 termine whether there are alterations in the striatal dopamine system in suicide, we conducted a quan

128 3)I-FP-CIT) SPECT can visualize and quantify striatal dopamine transporter (DAT) binding in vivo.

129 identified significant group differences in striatal dopamine transporter binding (all age ranges in

130 ifest Parkinson's disease (n=15) had reduced striatal dopamine transporter binding and (18)F-FDOPA up

131 Striatal dopamine transporter binding, VMAT2 binding, (1

132 Behaviorally, consistent with increased striatal dopamine, the PE group exhibited better behavio

133 isorders to a neural measure evoked during a striatal dopamine-related reward and punishment-based le

134 These behaviors were accompanied by striatal dopamine/serotonin abnormalities and cortical e

135 tanding of the physiological role of GDNF on striatal dopaminergic function.

136 onsistent evidence implicates disruptions of striatal dopaminergic indices in suicide and major depre

137 s in progressive forelimb asymmetry, loss of striatal dopaminergic terminal density and modest loss o

138 eeks post-surgery, showed asymmetric in vivo striatal DTBZ binding.

139 Striatal dysfunction has been strongly implicated in the

140 therapeutic gain to target both cortical and striatal dysfunction in dopamine neurotransmission and h

141 isrupted reward processing, mainly driven by striatal dysfunction, is a key characteristic of addicti

142 nfunctional GPR88 have been shown to present striatal dysfunctions and impaired learning.

143 gets proposed in the literature may modulate striatal dysregulation.

144 Excessive activity of striatal-enriched protein tyrosine phosphatase (STEP) in

145 However, prior investigations into striatal ERK/MAPK functions have yielded conflicting res

146 ed HSF1 and chaperone levels, maintenance of striatal excitatory synapses, clearance of Htt aggregate

147 euron targets and with decreased and delayed striatal fast-firing interneuron activity.

148 cy oscillations are shown to require pallido-striatal feedback, and occur with behaviourally relevant

149 the expression of Fgf2 in the DMS, and that striatal FGF2 promotes alcohol consumption, suggesting t

150 or, uncinate fasciculus, cingulum and fronto-striatal fibers).

151 dopaminergic transmission on reward-related striatal function and behavior, a monetary incentive del

152 Here we report male-specific deficits in striatal function important to reward learning in a mous

153 c symptoms and anhedonia are associated with striatal functioning, but few studies have linked risk f

154 mine (DA) system are positioned to influence striatal functions through mesolimbic DA-striatal pathwa

155 uring embryonic development and reduction of striatal GDNF levels in adult mice via AAV-Cre delivery.

156 , animal models of HD show aberrant cortical-striatal glutamate signaling.

157 d spine loss in cortical pyramidal cells and striatal hyperdopaminergia in mice.

158 In statistical parametric mapping, striatal hypometabolism was significantly correlated wit

159 Thus, manipulation of the function of the striatal indirect pathway may be a useful therapeutic ta

160 to produce either "hot spot" or "widespread" striatal innervation.

161 EP suggested that dopaminergic modulation of striatal inputs is mediated by postsynaptic receptors, a

162 R+) interneurons are the most common type of striatal interneuron in primates.

163 There was no significant difference in striatal Kicer between the bipolar and schizophrenia gro

164 pectedly found that Co neurons contribute to striatal-like projection neurons in the central extended

165 l subregions specifically involved in CEA-DA-striatal loops.

166 eraction of co-released dynorphin and KOR on striatal LTP.

167 an G-protein-coupled receptor that modulates striatal medium spiny neuron excitability.

168 dopamine subtype 2 (D2) receptor-expressing striatal medium spiny neurons (MSNs) by breeding transge

169 er46-ARPP-16 acts to basally control PP2A in striatal medium spiny neurons but that dopamine acting v

170 rotein ARPP-16, which is highly expressed in striatal medium spiny neurons, acts as a selective inhib

171 generation that preferentially occurs in the striatal medium spiny neurons.

172 s exacerbated mHTTx1-induced degeneration of striatal medium-sized spiny neurons.

173 s suggests that they play a critical role in striatal microcircuits.

174 RNA-sequencing analyses of cortical and striatal micropunches from Brd1(+/-) and wild-type mice

175 it was associated with specific reduction in striatal mitochondrial Complex-I (NDUFS4) in rotenone-tr

176 with SZ being a circuit disorder amenable to striatal modulation with DBS.

177 PET imaging has the potential to detect striatal molecular changes even at the early premanifest

178 aphy (PET) imaging studies have investigated striatal molecular changes in premanifest and manifest H

179 Dopamine depletion escalated striatal net output but had contrasting effects on "dire

180 umental learning as well as dopaminergic and striatal network function across many mammalian species.

181 and cortical networks encoded time, but the striatal network outperformed the orbitofrontal cortex,

182 The striatal network was also more reliable in predicting wh

183 control in these patients, or a known fronto-striatal networks hyperconnectivity in Tourette syndrome

184 ons in the functional connectivity of dorsal striatal networks relevant to food craving and weight ga

185 nflammation-associated reductions in ventral striatal neural responses to reward anticipation, decrea

186 hanism that may limit runaway enhancement of striatal neuron activity in response to drugs of abuse.

187 ased cholinergic tone creates alterations in striatal neuron functions that can promote the onset of

188 le is known about the response of individual striatal neuron types to HIV or how this disrupts functi

189 genes, which are enriched for expression in striatal neurons (p = 3 x 10(-3)), suggesting a path for

190 PDE10A is equally expressed in medium spiny striatal neurons and in their projections to entopeduncu

191 typically characterized by extensive loss of striatal neurons and the midlife onset of debilitating a

192 Ablation of CK2 in D1 receptor-positive striatal neurons caused enhanced locomotion and explorat

193 o the cerebellum, indicating that defects in striatal neurons favor the appearance of dystonia-like m

194 that can be used to track the conversion of striatal neurons from human fibroblasts in real time.

195 Our results support the view that striatal neurons integrate medial frontal activity and a

196 cuss how the pattern of connectivity between striatal neurons might give rise to the behaviorally obs

197 pathways coupled to mGluRI in D1R-containing striatal neurons of mice expressing EAAC1 leads to reduc

198 ic deletion of NMDA receptors on dopamine or striatal neurons or optogenetic manipulation of dopamine

199 ARPP-16 is expressed in striatal neurons where basal phosphorylation by MAST3 ki

200 Postsynaptically, i.e., in striatal neurons, D2R signaling controls complex functio

201 PHP.eB transduced 69% of cortical and 55% of striatal neurons, while 1 x 10(12) vg of AAV-PHP.S trans

202 vels restored long-term depression in YAC128 striatal neurons.

203 m, suggestive of basal inhibition of PP2A in striatal neurons.

204 disease, an archetypal disease that affects striatal neurons.

205 ction of Arc and its nuclear accumulation in striatal neurons.

206 rete patterns of dopamine neuron activity to striatal neurons.

207 ed thalamic inputs to the two populations of striatal neuropeptide Y (NPY) interneurons, plateau low

208 al striatum (VS) and are thought to modulate striatal neurotransmission.

209 persistent loss of dopaminergic neurons and striatal neurotransmitters, and continuous impairment of

210 Logistic regression tested whether striatal node strength, a measure of reward-related iFC,

211 ll decreased functional connectivity between striatal nodes and specific regions within frontal and p

212 ecifically the ventral striatum and caudate, striatal nodes implicated in motivational goal-directed

213 under full blocking conditions and comparing striatal nondisplaceable binding potential (BPND) using

214 In this regard, the co-occurrence of striatal novelty and retrieval success effects in indepe

215 frontal neurons that interface with distinct striatal or amygdalar targets.

216 mechanism by which PV interneurons modulate striatal output and selectively enhance performance earl

217 The prevailing view is that striatal parvalbumin (PV)-positive interneurons primaril

218 del of autism and indicate that the indirect striatal pathway disruption might play a causative role

219 isconnection of the PF-posterior dorsomedial striatal pathway produces a specific impairment in the a

220 ne-endocannabinoid signaling in the indirect striatal pathway, which may be relevant in motor functio

221 the existence of distinct changes between 2 striatal pathways in a mouse model of autism and indicat

222 and hippocampal areas, as well as in cortico-striatal pathways, emerges primarily via monosynaptic st

223 nce striatal functions through mesolimbic DA-striatal pathways.

224 dyskinesia reveals a central role for CK2 in striatal physiology and indicates that both pathways con

225 a signaling change associated with decreased striatal plasticity.

226 also modulate learning and addiction-related striatal plasticity.

227 ed tomography studies that have investigated striatal presynaptic dopamine function in Parkinson dise

228 ty both in ectopic expressing systems and in striatal primary neurons.

229 We show that hES-derived striatal progenitors can be transplanted in animal model

230 ased activity of their striosome-predominant striatal projection neuron targets and with decreased an

231 from the indirect (iSPNs) and direct pathway striatal projection neurons (dSPNs).

232 ine exposure produces new spine formation in striatal projection neurons (SPNs) of the nucleus accumb

233 Optogenetic activation of direct pathway striatal projection neurons inhibits LTP while reducing

234 hat glutamatergic synaptic transmission onto striatal projection neurons is weakened in mutant mice l

235 Striatal projection neurons of the direct pathway co-rel

236 res produces long-term potentiation (LTP) in striatal projection neurons when measured using whole-ce

237 ase-stimulatory G-protein highly enriched in striatal projection neurons, where it mediates the actio

238 al for activation of the cAMP pathway in the striatal projection neurons.

239 co-striatal, cortico-amygdalar, and amygdalo-striatal projections control extinction and relapse in a

240 AMP and cGMP catabolism, is downregulated in striatal projections to entopeduncular nucleus/substanti

241 sely, in DYT1 mice, PDE10A is upregulated in striatal projections to globus pallidus, preferentially

242 -modulated DA neurons give rise to canonical striatal projections.

243 genetic approaches to show that dorsolateral striatal PV interneurons influence the initial expressio

244 Finally, interval timing and striatal ramping activity are disrupted when the medial

245 Furthermore, we found that striatal ramping activity was correlated with and depend

246 Third, striatal ramping neurons are correlated with activity of

247 efene (18 mg) on changes in a priori defined striatal region of interest BOLD signal change during re

248 gnificantly reduced the BOLD response in the striatal region of interest compared with placebo.

249 measurements of cortico-cortical and cortico-striatal regions and their anatomical underpinnings.

250 en graph theoretical analysis disclosed that striatal regions constitute a cohesive module of the com

251 these results suggest that smaller volume in striatal regions critically implicated in reward process

252 namic positron emission tomography scans and striatal regions of interest that were hand-drawn based

253 additional frontal, temporal, occipital, and striatal regions showed decreased functional connectivit

254 ociations were observed with D2-type BPND in striatal regions, or with D1-type BPND in any region.

255 ron morphological types among species within striatal regions.

256 in the shell of mice and compared with other striatal regions.

257 osterior cingulate, sensory associative, and striatal regions.

258 consumption resulted in decreases in dorsal striatal response during receipt of the consumed beverag

259 MIDT, there was evidence of blunted ventral striatal response to reward in the poly-drug-dependent g

260 Short-latency (80-140 ms) striatal responses to a first target determined consciou

261 Men with and without PPU differed in their striatal responses to cues predicting erotic pictures bu

262 esonance imaging (fMRI), we examined ventral striatal responses to erotic and monetary stimuli, disen

263 litate dopaminergic transmission can enhance striatal responses to reward and improve reward learning

264 GSK598809 normalized ventral striatal reward response and enhanced response in the DR

265 Striatal ROI outcomes were confirmed by the voxel-based

266 on 1) were associated with decreased ventral striatal RPE signaling during reinforcement learning (se

267 data identify a novel link between IL-6 and striatal RPEs during reinforcement learning in the conte

268 l and a specific brain region, and highlight striatal signaling pathways as potential targets for the

269 nhibits PP2A and regulates key components of striatal signaling.

270 sticity of cortical excitatory synapses onto striatal spiny projection neurons (SPNs) early in the YA

271 Striatal spiny projection neurons (SPNs) receive converg

272 agonizing dopamine D2 receptors expressed by striatal spiny projection neurons (SPNs).

273 g in presynaptic terminals of direct pathway striatal spiny projections neurons.

274 mains, however, a pressing need to elucidate striatal SPN firing in the context of the synchronized n

275 After pretreatment, striatal SRTM BPND did not significantly differ from zer

276 Striatal SRTM BPND using midbrain or cerebellum as the r

277 We also reveal a role of Crem in regulating striatal structural plasticity.

278 cused on the functional role of dopamine and striatal structures in driving behavior on the basis of

279 Chemogenetic disruption of a striatal subcircuit in young mice reproduced age-related

280 (2) CRF content of the CEA-DA path; and (3) striatal subregions specifically involved in CEA-DA-stri

281 rval results in long-term changes in cortico-striatal synaptic efficacy under the control of the amyg

282 take after rotenone toxicity, due to reduced striatal synaptosomal mitochondria and synaptic vesicula

283 Compared with wild-type controls, striatal synaptosomes isolated from young mutant mice ex

284 In rat striatal synaptosomes, 6c was almost fivefold more poten

285 nner by AMPH and METH in model cells and rat striatal synaptosomes, and in striatum of rats given sub

286 ns enhanced cerebral blood volume signals in striatal target regions in a dopamine receptor-dependent

287 l death with concomitant significant loss of striatal terminals.

288 itive grafted cells per side with normalized striatal TH-immunoreactive fiber innervation and bidirec

289 The cortico-striatal-thalamo-cortical (CSTC) pathway is a brain circ

290 d activation and connectivity in the cortico-striatal-thalamo-cortical motor circuit in healthy contr

291 HD, we performed RNA-sequencing (RNA-seq) on striatal tissue from a cohort of 5-y-old OVT73-line shee

292 hibition dependent on thalamic activation of striatal tyrosine hydroxylase interneurons (THINs).

293 Here, we investigate striatal value representations by applying caudate elect

294 gaps, the current study investigated whether striatal volume predicted anhedonia severity in adolesce

295 p extends to adolescents and whether reduced striatal volume prospectively predicts anhedonia.

296 anhedonia is associated with reduced dorsal striatal volume, but it is unknown whether this relation

297 On T2-weighted MRI, lesion and striatal volumes were increased on day 3 and then decrea

298 appropriate models for (18)F-FPSCH (baseline striatal VT, 3.7 +/- 1.1) and (18)F-FESCH (baseline stri

299 l VT, 3.7 +/- 1.1) and (18)F-FESCH (baseline striatal VT, 5.0 +/- 2.0), respectively.

300 On day 3, with an increase in striatal water content, vasogenic oedema in the perihaem