ライフサイエンスコーパス: striated muscle

1 of length dependence of force generation in striated muscle.

2 response factor (SRF) regulatory axis within striated muscle.

3 in contraction and regulation of vertebrate striated muscle.

4 growth cone guidance receptors expressed in striated muscle.

5 soforms play overlapping and unique roles in striated muscle.

6 ll death known to be abundantly expressed in striated muscle.

7 (myosin containing) filaments of vertebrate striated muscle.

8 itical role in regulating the contraction of striated muscle.

9 pregnancy induced adaptations in smooth and striated muscle.

10 otein associated with the thick filaments of striated muscle.

11 pal regulator of the contractile behavior of striated muscle.

12 periodic sarcomeric organization similar to striated muscle.

13 omponent of the membrane repair machinery in striated muscle.

14 xtend our understanding of titin function in striated muscle.

15 ogen accumulation in all tissues, especially striated muscle.

16 new opportunity for clonal analysis of adult striated muscle.

17 process of membrane fusion and exocytosis in striated muscle.

18 ling regulators as TNC expression targets in striated muscle.

19 ins that organizes contractile structures in striated muscle.

20 arcomeres are the basic contractile units of striated muscle.

21 e C-zeta/lambda and AMP-kinase activities in striated muscle.

22 channels, several of which are expressed in striated muscle.

23 P-C) is a component of the thick filament of striated muscle.

24 ein surrounding the contractile apparatus in striated muscle.

25 ocalization and potential function of CAP in striated muscle.

26 he structure and elasticity of sarcomeres in striated muscle.

27 allowing excitation-contraction coupling in striated muscle.

28 c protein that localizes to the costamere in striated muscle.

29 protein expressed in embryonic epithelia and striated muscle.

30 ding protein that is abundantly expressed in striated muscle.

31 localizes to the Z-disc/costameric region in striated muscle.

32 ics at the pointed end of actin filaments in striated muscle.

33 is creates a unique intracellular habitat in striated muscle.

34 ated to regulate growth of multiple types of striated muscle.

35 ing the cytoplasmic calcium concentration of striated muscle.

36 h, which are also expressed in the body-wall striated muscle.

37 drolysis to generate force and shortening in striated muscle.

38 C is a thick filament protein of vertebrate striated muscle.

39 e assembly of ryanodine receptor clusters in striated muscle.

40 sly reported to be specifically expressed in striated muscle.

41 indistinguishable from those in an arthropod striated muscle.

42 ve stress in a variety of tissues, including striated muscle.

43 filament pointed-end dynamics and length in striated muscle.

44 n, a major actin-binding filament protein of striated muscle.

45 b-Girdle muscular dystrophy 1B mainly affect striated muscle.

46 for excitation-contraction (EC) coupling in striated muscle.

47 RLC) also controls contraction of vertebrate striated muscle.

48 rganization of the sarcoplasmic reticulum in striated muscles.

49 that were co-opted for a similar purpose in striated muscles.

50 ement controlling active force generation in striated muscles.

51 processes, including the pathophysiology of striated muscles.

52 ure proper sarcomere-membrane interaction in striated muscles.

53 on of contractile and membrane structures in striated muscles.

54 ar muscle and at higher levels than in other striated muscles.

55 egulating membrane trafficking and fusion in striated muscles.

56 s in vertebrate smooth and many invertebrate striated muscles.

57 he smallest functional unit of myofibrils in striated muscles.

58 ent regulation of contraction by troponin in striated muscles.

59 are the primary actin isoforms expressed in striated muscles.

60 mooth muscles is also different from that in striated muscles.

61 Adjacent myosin filaments in striated muscle A-bands are cross-linked by the M-band.

62 Striated muscle activator of Rho signaling (STARS) is a

63 Furthermore, striated muscle activator of Rho signaling (STARS), an a

64 STARS (STriated muscle Activator of Rho Signaling) is a sarcome

65 uscle-specific actin-binding protein, STARS (striated muscle activator of Rho signaling), which direc

66 development and pregnancy mediate smooth and striated muscle adaptations through SMTNL1 and MYPT1.

67 To engineer gene vectors that target striated muscles after systemic delivery, we constructed

68 is caused by the progressive degeneration of striated muscles aggravated by sterile inflammation.

69 Mutations in striated muscle alpha-tropomyosin (alpha-TM), an essenti

70 heptad repeat positions were mutated in rat striated muscle alphaTm and expressed in Escherichia col

71 and challenges the paradigm that smooth and striated muscles always have distinctly different compon

72 st that Wingless-mediated cross-talk between striated muscle and adipose tissue controls obesity in D

73 ies, that affect distinct tissues, including striated muscle and adipose tissue.

74 anization of the central contractile unit of striated muscle and also as a mechanosensitive signaling

75 hildhood related to glycogen accumulation in striated muscle and an accompanying infantile-onset card

76 ntaining beta are expressed predominantly in striated muscle and brain and that splicing to include b

77 The ancient MYH7b gene, expressed in striated muscle and brain, encodes a sarcomeric myosin a

78 y of formins contributes to contractility of striated muscle and cell motility in several contexts.

79 e show that BAG3 is prominently expressed in striated muscle and colocalizes with Z-disks.

80 nodine receptor that is conserved throughout striated muscle and corresponds to a previously identifi

81 re of the 200 kDa alpha-actinin-2 dimer from striated muscle and explore its functional implications

82 adin (MYPN) is a Z-disc protein expressed in striated muscle and functions as a structural, signaling

83 However, cardiac muscle is also a subtype of striated muscle and is similarly affected in many of the

84 biomarker for a number of diseases affecting striated muscle and may also be a schizophrenia risk gen

85 highlights the central role of obscurin A in striated muscle and neural development.

86 eal the first direct mRNA targets of FXR1 in striated muscle and support translational repression as

87 keletal stiffness and mechanotransduction in striated muscle and that targeting this post-translation

88 ic fish, are unique in that they derive from striated muscle and they possess biochemical characteris

89 hesion plaques and dense bodies (Z-disks) of striated muscles and attachment plaques of smooth muscle

90 in protein present in the thick filaments of striated muscles and is involved in both sarcomere forma

91 orm lengths, including the thin filaments of striated muscles and the spectrin-based membrane skeleto

92 n complex in the Ca(2+)-regulatory system of striated muscle, and among their muscle type-specific is

93 ents of the sarcoglycan-sarcospan complex in striated muscle, and did not develop muscular dystrophy.

94 s, OXPAT is induced in mouse adipose tissue, striated muscle, and liver by physiological (fasting), p

95 could influence the mechanical properties of striated muscles, and Bianco et al. suggest that the int

96 assay and Western blot; AChR, MuSK, and anti-striated muscle antibodies were detected using a standar

97 The barbed ends of actin filaments in striated muscle are anchored within the Z-disc and cappe

98 Myosin folding and assembly in striated muscle are mediated by the general chaperones H

99 e physiological targets regulated by MEF2 in striated muscle are not completely known.

100 sin heavy chain (MHC) isoforms in vertebrate striated muscles are distinguished functionally by diffe

101 Striated muscles are relaxed under low Ca(2+) concentrat

102 eres, the functional units of contraction in striated muscle, are composed of an array of interdigita

103 s," mainly affect mesenchymal tissues (e.g., striated muscle, bone, and fibrous tissue).

104 ding cassette exons upregulated in brain and striated muscle but depleted in other tissues.

105 Multinucleated cells were characterized as striated muscles by electron microscopy and immunohistoc

106 In striated muscles, Ca(2+) release through RyRs controls m

107 Conditional deletion of LAP1 from striated muscle causes muscular dystrophy; this patholog

108 s troponin can be exchanged in permeabilized striated muscle cell preparations, and tested the hypoth

109 length dependence of tension differs between striated muscle cell types during submaximal activations

110 Caenorhabditis elegans striated muscle cells attach to basement membrane and tr

111 t the sarcolemma and within the cytoplasm of striated muscle cells from dystrophin-deficient mdx mice

112 We find that embryonic vertebrate striated muscle cells normally express receptors for glu

113 Mitochondrial dynamism is rare in striated muscle cells, so cardiac-specific genetic manip

114 s Xin and XIRP2 are exclusively expressed in striated muscle cells, where they are believed to play a

115 intolerance, and impaired glucose uptake in striated muscle cells.

116 maintains the lengths of actin filaments in striated muscle cells.

117 ent of the cell membrane repair machinery in striated muscle cells.

118 ate meshwork that organizes myofibers within striated muscle cells.

119 pen ER ryanodine-receptor Ca(2+) channels in striated-muscle cells.

120 Obscurin (approximately 800 kDa) in striated muscle closely surrounds sarcomeres at the leve

121 on actin are important for the regulation of striated muscle contraction and could also be important

122 The molecular regulation of striated muscle contraction couples the binding and diss

123 Striated muscle contraction in most animals is regulated

124 The regulation of vertebrate striated muscle contraction involves a number of differe

125 Striated muscle contraction is a highly cooperative proc

126 Activation of striated muscle contraction is a highly cooperative sign

127 Regulation of striated muscle contraction is achieved by Ca2+ -depende

128 Striated muscle contraction is regulated by the actin bi

129 Striated muscle contraction is regulated by the binding

130 n in regulating actin-myosin interactions in striated muscle contraction, and dephosphorylation of Ml

131 EGF receptor signaling, circadian exercise, striated muscle contraction, and lipid and carbohydrate

132 MyBP-C is a multidomain modulator of striated muscle contraction, interacting with myosin, ti

133 units of the troponin complex that regulates striated muscle contraction.

134 central to the control of calcium-regulated striated muscle contraction.

135 n C, troponin I, and tropomyosin to regulate striated muscle contraction.

136 s intracellular calcium release required for striated muscle contraction.

137 ficantly after PNT, indicating that urethral striated muscles contribute significantly to continence.

138 well as hind paw flinching, was observed in striated muscle control-transplanted rats, which were no

139 ribe a novel mechanism of nuclear spacing in striated muscles controlled by the cooperative activity

140 The Z-band in vertebrate striated muscle crosslinks actin filaments of opposite p

141 ity with exercise lead to protection against striated muscle damage, oxidative stress and injury.

142 In addition to striated muscle defects, double-null animals and LEM-2-n

143 The demonstration that both types of striated muscle derive from common progenitors comes fro

144 In striated muscle, desmin intermediate filaments interlink

145 scular dystrophy (DMD) is a fatal disease of striated muscle deterioration caused by lack of the cyto

146 critical determinant of cardiac and skeletal striated muscle development and function, with misexpres

147 Striated muscle development in vertebrates requires the

148 Striated muscle development requires the coordinated exp

149 scription factors that play pivotal roles in striated muscle differentiation, development, and metabo

150 lamins, or expression of variants that cause striated muscle disease, did not affect assembly of nesp

151 rmalities in nuclear envelope proteins cause striated muscle disease.

152 We find that LMNA mutations causing striated muscle diseases block actin-dependent nuclear m

153 remature aging syndromes, lipodystrophy, and striated muscle disorders.

154 All striated muscle display length-dependent activation prop

155 provides stability to the plasma membrane of striated muscle during muscle contraction.

156 ropose that neurons secrete vMSPs to promote striated muscle energy production and metabolism, in par

157 NA-1 (miR-1) is an evolutionarily conserved, striated muscle-enriched miRNA.

158 eceptor channels (RyR) are key components of striated muscle excitation-contraction coupling, and alt

159 In addition, vertebrate striated muscles exhibit two nonfocal neuromuscular patt

160 t myosin isoforms in the sarcomeres of adult striated muscle (fast IIa, IId, the slow/cardiac isoform

161 mily might function redundantly with MyoD in striated muscle fate specification in these organisms.

162 Striated muscle fibers are characterized by their tightl

163 al muscle constructs with parallel arrays of striated muscle fibers.

164 L1 is expressed in smooth muscle and type 2a striated muscle fibers.

165 Striated muscle fibres in the urethral rhabdosphincter a

166 In striated muscle fibres, the binding of myosin motors to

167 the cytoplasmic surface of the sarcolemma of striated muscle fibres.

168 were investigated in resting Rana temporaria striated muscle fibres.

169 ing dystrophin nonsense alleles, and rescued striated muscle function in mdx mice within 2-8 weeks of

170 al roles during embryonic development and in striated muscle gene expression.

171 role in some mammalian cellular systems, but striated muscle generally is not considered to be among

172 cts as a structural and signaling center for striated muscle, harbors factors that function as mechan

173 on of sarcoplasmic reticulum Ca2+ release in striated muscle has not been fully elucidated.

174 We identified mCRP in inflamed human striated muscle, human atherosclerotic plaque, and infar

175 sarcomeric protein exclusively localized in striated muscle in humans.

176 hondria and data on phosphate metabolites in striated muscle in vivo.

177 e suggest that the thixotropic properties of striated muscles in vivo are more likely to reflect dyna

178 is the principal regulator of contraction in striated muscle, in vitro evidence suggests that some ac

179 In striated muscle, including involuntary cardiac muscle, T

180 usually not seen as endocrine ones, bone and striated muscles, influence several physiological proces

181 Ca(2+)-dependent activation of striated muscle involves cooperative interactions of cro

182 hese results suggest that fast relaxation of striated muscle is an emergent property that reflects mu

183 Tarantula striated muscle is an outstanding system for understandi

184 ne microdomains whose major component in the striated muscle is caveolin-3, we hypothesized that muta

185 The scallop's large striated muscle is energy-dynamic but not fully differen

186 evelopment and early postnatal adaptation of striated muscle is largely unknown.

187 arcoplasmic reticulum (SR) Ca(2+) release in striated muscle is mediated by a multiprotein complex th

188 Contraction of striated muscle is tightly regulated by the release and

189 nds of contiguous tropomyosin (Tm) dimers in striated muscle is unknown.

190 Excitation-contraction (EC) coupling in striated muscles is mediated by the cardiac or skeletal

191 Contraction of striated muscles is regulated by tropomyosin strands tha

192 Troponin C (TnC), present in all striated muscle, is the Ca(2+)-activated trigger that in

193 a sarcomeric protein expressed primarily in striated muscles, is responsible for maintaining the str

194 tomyosin-based force production mechanism in striated muscle, it was originally proposed that contrac

195 schistosome muscles are hybrids, containing striated muscle-like myosin filaments and smooth muscle-

196 uscle-like contractile apparatuses, it has a striated muscle-like regulatory mechanism through tropon

197 re rapidly altered during the development of striated muscle, likely requiring a previously unrecogni

198 e indispensable for normal morphogenesis and striated muscle lineage specification.

199 l iPSC-derived progenitors (MiPs) toward the striated muscle lineages.

200 -1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant

201 The mechanism by which striated muscle loss occurs is the tumor release of pro-

202 nuclear membrane that has been implicated in striated muscle maintenance.

203 ata implicate that EC-coupling mechanisms in striated muscles may also broadly transduce diverse smoo

204 redictably affect the calcium sensitivity of striated muscle mechanics, providing a novel A-M kinetic

205 ion of this cascade and loop may account for striated muscle mitochondrial defects in mef2a null mice

206 gs are circulating hormones that pattern the striated muscle mitochondrial reticulum.

207 ted ends of actin filaments in sarcomeres of striated muscle myofibrils and in the erythrocyte membra

208 Vertebrate striated muscle myosin filaments have a 3-fold rotationa

209 erone UNC-45B is required for the folding of striated muscle myosin II.

210 sidues plus a leucine zipper) of the scallop striated muscle myosin isoform.

211 nd image processing of nucleotide-free (apo) striated muscle myosin-2 subfragment-1 (S1), possessing

212 A striated-muscle myosin (UNC-54) appears to provide parti

213 le-like myosin filaments containing MYO-3, a striated-muscle myosin isoform.

214 schistosome myosin II heavy chain and known striated muscle myosins.

215 ilament lattice in intact (i.e., nonskinned) striated muscle obeys constant volume.

216 Activation of thin filaments in striated muscle occurs when tropomyosin exposes myosin b

217 al rescued expression of the H77C protein in striated muscle of the alpha-sarcoglycan-deficient mice

218 reversed the established pathologies in the striated muscle of the KO mouse.

219 he outer edge of the A-band in the obliquely striated muscle of the nematode.

220 In striated muscles of Caenorhabditis elegans, reduction of

221 outh opening during feeding, and oesophageal striated muscle (OSM), which is crucial for voluntary sw

222 ilaments in both smooth and myosin-regulated striated muscles over a wide range of species.

223 n complex compared to 11 residues in the HMW striated muscle overlap complex.

224 ostnatal cardiac function and reinforces the striated muscle phenotype by regulating both transcripti

225 epair into the load-dependent control of the striated muscle phenotype.

226 l-linked glycoprotein expressed in liver and striated muscle, plays a central role in systemic iron b

227 ctly downstream of MEF2A at the costamere in striated muscle potentially playing a role in myofibrill

228 of MEF2A at the peripheral Z-disc complex in striated muscle potentially playing a role in regulating

229 Hoip is expressed in striated muscle precursors within the muscle lineage and

230 Striated muscle preferentially expressed protein kinase

231 e role of newly identified JMC protein SPEG (striated muscle preferentially expressed protein kinase)

232 ely induced apoptosis, we report evidence of striated muscle regeneration in vivo in mice by human Mi

233 etween calcium and the regulatory site(s) of striated muscle regulatory protein troponin switches on

234 The mechanisms that limit the speed at which striated muscles relax are poorly understood.

235 ebulin to reinforce and temporally fine-tune striated muscle relaxation-contraction cycles.

236 To generate force, striated muscle requires overlap between uniform-length

237 Excitation-contraction coupling in striated muscle requires proper communication of plasmal

238 h Sco1 was specifically deleted in heart and striated muscle, respectively.

239 All striated muscles respond to stretch by a delayed increas

240 cle-specific RING-finger (MuRF) proteins are striated muscle-restricted components of the sarcomere t

241 We show that striated muscle-restricted HA-TEAD-1 expression induced

242 ecific loss of the integrin beta1 subunit in striated muscle results in a near complete loss of integ

243 Physiologically, loss of Lmods in striated muscle results in cardiomyopathy or nemaline my

244 taining cytoplasmic tyrosine phosphatase, in striated muscle results in severe dilated cardiomyopathy

245 Genetic inactivation of murine E4f1 in striated muscles results in viable animals that show low

246 In striated muscle, sarcoglycans interact with dystrophin a

247 butes to the mechanical stabilization of the striated muscle sarcomere and cell contacts within the c

248 nderstood component of the thick filament in striated muscle sarcomeres.

249 sponges found to induce Ca(2+) release from striated muscle sarcoplasmic reticulum (SR).

250 II filament-based contractile structures in striated muscle, smooth muscle, and nonmuscle cells cont

251 Replacement of the striated muscle specific exon 9a-encoded C-terminus with

252 early myogenesis, but the functions of this striated muscle-specific enzyme in more differentiated s

253 rates, a general cell isoform, unc45a, and a striated muscle-specific isoform, unc45b.

254 Xin is a striated muscle-specific protein that is localized to th

255 ion of an unrelated peptide derived from the striated muscle-specific protein titin.

256 phosphorylation state of two Z-disc kinases (striated muscle-specific serine/threonine protein kinase

257 We have identified a novel striated muscle-specific splice variant of the formin FH

258 The striated muscle-specific tripartite motif (TRIM) protein

259 EG1 and SPEG, the human orthologue of murine striated-muscle-specific serine/threonine protein kinase

260 libut tissues, whereas capn3 was detected in striated muscles, spleen and ovary, but absent or relati

261 and the importance of the proteins in normal striated muscle structure and function.

262 axed, native myosin filaments from tarantula striated muscle, suggesting that such interactions are l

263 ffraction to study the contraction in living striated muscle, taking advantage of the paracrystalline

264 ( approximately 800-kDa), modular protein of striated muscle that concentrates around the M-bands and

265 t constitute a novel regulatory mechanism in striated muscles that acts independently of the well-kno

266 Striated muscles that enable mouth opening and swallowin

267 In striated muscle, the archetype P-type ATPase, SERCA (sar

268 In striated muscles, the actin filaments are anchored at Z-

269 Smooth muscle, striated muscle, their central and peripheral innervatio

270 similar in organization to the sarcomeres of striated muscle, there are intriguing differences in the

271 rotein C (MyBP-C) is an accessory protein of striated muscle thick filaments and a modulator of cardi

272 hat has been implicated in the regulation of striated muscle thin filament assembly; its physiologica

273 The striated muscle thin filament comprises actin, tropomyos

274 ys using protein extracts of hepatocytes and striated muscle tissue.

275 quantified for the first time the levels of striated muscle TM isoforms in human heart, including a

276 The force response of activated striated muscle to length perturbations includes the so-

277 ucose-regulated protein 94 (GRP94) in murine striated muscle to test the necessity of local IGFs for

278 dge) an atomic-level structure of alphaalpha-striated muscle tropomyosin bound to an actin filament t

279 MW overlap complex that is homologous to the striated muscle tropomyosin complex in which the ends ar

280 long the shaft of rotary-shadowed smooth and striated muscle tropomyosin molecules are equivalent to

281 Here, 40 nm long smooth and striated muscle tropomyosin molecules were rotary-shadow

282 Electron microscopy shows that striated muscle tropomyosin primarily consists of single

283 ccurs despite their weaker interactions with striated muscle tropomyosins.

284 rived progenitors (MiPs) can regenerate both striated muscle types simultaneously in mice.

285 Strategies to target multiple striated muscle types would provide a much-needed improv

286 es that enable regeneration of both of these striated muscle types.

287 we reassessed the abundance of dystrophin in striated muscle using full-length protein as the standar

288 scular dystrophy is a severe and progressive striated muscle wasting disorder that leads to premature

289 mine the specific role of Cypher isoforms in striated muscle, we generated two mouse lines in which e

290 rther understand the function of myospryn in striated muscle, we searched for additional myospryn par

291 e 427-kDa protein dystrophin is expressed in striated muscle where it physically links the interior o

292 n binding protein C (MyBP-C) is expressed in striated muscles, where it plays key roles in the modula

293 ivotal role in the structure and function of striated muscle, whereas the role of Enigma homolog prot

294 Titin is a giant protein of striated muscle with important roles in the assembly, in

295 Molecules from invertebrate striated muscles with phosphorylation-dependent regulati

296 toskeletal proteins originally identified in striated muscles with structural and regulatory roles.

297 In striated muscle, X-ROS is the mechanotransduction pathwa

298 endent activation is a universal property of striated muscle, yet the molecular mechanisms that under

299 ull repertoire of proteins that comprise the striated muscle Z-disc and peripheral structures, such a

300 In striated muscle Z-disks, alpha-actinin interacts with N-