ライフサイエンスコーパス: striatonigral

1 g for calbindin D(28K), a protein present in striatonigral afferent fibres.

2 d activity was only observed at the level of striatonigral afferents.

3 e cell type-specific expression of D(1a)R in striatonigral and D(2)R in striatopallidal neurons and t

4 r-mediated currents in dopamine receptor D1+ striatonigral and D2+ striatopallidal MSNs.

5 lates glutamatergic synapses specific to the striatonigral and striatopallidal basal ganglia pathways

6 odel and used to show abundant expression in striatonigral and striatopallidal medium spiny neurons b

7 This was true for both striatonigral and striatopallidal MSNs.

8 Again, this response pattern was the same in striatonigral and striatopallidal MSNs.

9 of LID, the kinase CK2: knock-out of CK2 in striatonigral and striatopallidal neurons has opposing e

10 is no evident difference in pigeons between striatonigral and striatopallidal neurons in their dopam

11 The overall pattern of changes in both striatonigral and striatopallidal neurons is compatible

12 upon D1 and D2 dopamine receptors located on striatonigral and striatopallidal neurons, respectively,

13 pamine D1 and D2 receptors are segregated to striatonigral and striatopallidal neurons, respectively.

14 set of differentially expressed genes in the striatonigral and striatopallidal neurons, two functiona

15 at these drugs exert differential effects on striatonigral and striatopallidal neurons, which compris

16 and target proteins of dopamine signaling in striatonigral and striatopallidal neurons.

17 s of DARPP-32 phosphorylation selectively in striatonigral and striatopallidal neurons.

18 ns through coordinated activities of its two striatonigral and striatopallidal output pathways.

19 DE10A in regulating activity within both the striatonigral and striatopallidal pathways.

20 confined in the sensorimotor-striatum and in striatonigral and striatopallidal projecting segments.

21 lockade should decrease the activity of both striatonigral and striatopallidal projection neurons, an

22 There may be subpopulations of striatonigral and striatopallidal projection neurons.

23 The striatum has nearly equal numbers of striatonigral and striatopallidal projection neurons.

24 sses of spiny projection neurons (SPNs): the striatonigral and striatopallidal SPNs, which express do

25 ontogeny of the two main striatal pathways (striatonigral and striatopallidal) and identify novel (n

26 mainly comprises two intermingled subtypes (striatonigral and striatopallidal) of medium spiny neuro

27 rojection neurons containing >55% dynorphin (striatonigral) and >90% enkephalin (striatopallidal) and

28 by cocaine occurred in both Drd1-expressing (striatonigral) and Drd2-expressing (striatopallidal) med

29 istinct efferent pathways, the direct (i.e., striatonigral) and the indirect (i.e., striatopallidal)

30 These data demonstrate an inhibition of striatonigral, and facilitation of striatopallidal, gene

31 We also detect reduced Golf levels in the striatonigral but not in the striatopallidal knock-out i

32 hat functional impairments of the prefrontal striatonigral circuit may be a common pathway linking th

33 putamen, indicates anterograde transport via striatonigral connections and is anticipated to occur in

34 rious brain regions in the two forms of MSA, striatonigral degeneration (SND) and olivopontocerebella

35 nical (MSA-P versus MSA-C) and pathological [striatonigral degeneration (SND) versus olivopontocerebe

36 neurodegenerative disorder characterized by striatonigral degeneration and olivo-pontocerebellar atr

37 ellar ataxia, which generally correlate with striatonigral degeneration and olivopontocerebellar atro

38 er the two striatal projection neuron types (striatonigral direct pathway vs striatopallidal indirect

39 e D1 receptor-mediated overactivation of the striatonigral direct pathway.

40 ow Shank3 mutation may differentially affect striatonigral (direct pathway) and striatopallidal (indi

41 stent with alterations in the balance of the striatonigral (direct) and striatopallidal (indirect) pa

42 the roles of striatopallidal (indirect) and striatonigral (direct) pathway neurons in regulating beh

43 impairment in the midbrain with concomitant striatonigral fiber degeneration and loss of dopamine ne

44 We demonstrate that striatonigral fibers originating in striosomes form high

45 P and SNr, consistent with activation of the striatonigral GABAergic (direct striatal output) pathway

46 results show that METH enhances D1-mediated striatonigral GABAergic transmission (1), which in turn

47 METH increased striatonigral GABAergic transmission, as evidenced by in

48 nic currents in D2+ striatopallidal than D1+ striatonigral medium spiny neurons (MSNs) are mediated b

49 oreover, inducible overexpression of FosB in striatonigral medium spiny neurons exacerbated dyskineti

50 triatopallidal medium spiny neurons, leaving striatonigral medium spiny neurons intact.

51 imilar locations in D(1) receptor-expressing striatonigral MSNs (D(1) MSNs).

52 Striatonigral MSNs give rise to the activating, direct p

53 excitability and glutamatergic signaling in striatonigral MSNs, whereas D2 receptor signaling exerts

54 on of the ERK/MSK1/CREB signaling pathway in striatonigral MSNs.

55 properties in identified striatopallidal and striatonigral MSNs.

56 striatopallidal MSNs but not on neighboring striatonigral MSNs.

57 ranscriptional programs normally specific to striatonigral neurons and in the acquisition of Drd1-ass

58 on resulted in a smaller striatum with fewer striatonigral neurons and reduced projections to the sub

59 mice, we found that the loss of DARPP-32 in striatonigral neurons decreased basal and cocaine-induce

60 of canonical G-protein-mediated signaling in striatonigral neurons during training.

61 Synaptic connections from striatopallidal to striatonigral neurons exhibited exclusively D(2)R-mediat

62 Second, we preferentially immunolabeled striatonigral neurons for D1 dopamine receptors or stria

63 tization, whereas decreasing excitability of striatonigral neurons impaired its persistence.

64 will prove useful to control the function of striatonigral neurons in the direct projection pathway.

65 behaviors or neuropeptide mRNA expression in striatonigral neurons in the rat striatum.

66 PPD) and substance P (SP) gene expression in striatonigral neurons induced by the indirect dopamine r

67 sults also show that accumulation of FosB in striatonigral neurons is causally related to the develop

68 t preferential expression of m4 receptors by striatonigral neurons may contribute to their differenti

69 odynorphin or substance P mRNA expression in striatonigral neurons on the side of injection.

70 These various results suggest that striatonigral neurons preferentially receive input from

71 A volkensin lesion of striatonigral neurons reduced striatal m4 mRNA by 63% an

72 We report here that knock-out of CK2 in striatonigral neurons reduces the severity of l-DOPA-ind

73 A potential way to control striatonigral neurons selectively is via M4 muscarinic r

74 Furthermore, the subtle activation of striatonigral neurons sustained the performance of learn

75 in the striatum to regulate the response of striatonigral neurons to D1 dopamine receptor stimulatio

76 ls making asymmetric axospinous contact with striatonigral neurons were 0.43 microm in mean diameter,

77 The majority of striatopallidal and striatonigral neurons were double-labeled for both mGluR

78 Among striatal projections neurons, 95% of striatonigral neurons, 96% of enkephalin-containing neur

79 atum functions to regulate dopamine input to striatonigral neurons, acting at both pre- and postsynap

80 absent from corticostriatal projections and striatonigral neurons, and, instead, is largely present

81 that were used occurs in enkephalin-negative striatonigral neurons, which show limited coexpression o

82 D1 receptors are preferentially expressed in striatonigral neurons, while adenosine A2a receptors are

83 preferential localization of m4 receptors to striatonigral neurons.

84 s substance P and dynorphin are expressed in striatonigral neurons.

85 has opposing effects on striatopallidal and striatonigral neurons.

86 ssed in striatopallidal neurons, rather than striatonigral neurons.

87 ptors in striatopallidal neurons, but not in striatonigral neurons.

88 n factor essential to the differentiation of striatonigral neurons.

89 d mRNA for M4 receptors is prevalent only in striatonigral neurons.

90 ted signaling selectively in direct-pathway (striatonigral) neurons of the dorsomedial striatum in Lo

91 cannabinoids act within the SNpr to modulate striatonigral neurotransmission presynaptically.

92 Approximately 60% to 70% of either striatonigral or striatopallidal neurons expressed mGluR

93 nt two mouse models in which the function of striatonigral or striatopallidal neurons is selectively

94 ade labeling to specifically identify either striatonigral or striatopallidal neurons.

95 from rat striatum were identified as either striatonigral or striatopallidal projection neurons by f

96 polarity of STDP in both striatopallidal and striatonigral output neurons.

97 latency for initiation: manipulations of the striatonigral pathway activity slowed action initiation,

98 each pathway and found that both the direct striatonigral pathway and the indirect striatopallidal p

99 Kainic acid lesions of the striatonigral pathway did not prevent the ability of qui

100 al capsule for the normal development of the striatonigral pathway involving PlexinD1-Semaphorin 3e (

101 ceptors increases the activity of the direct striatonigral pathway resulting in movement.

102 t is understood that supersensitivity of the striatonigral pathway underlies LID, however, D2 agonist

103 inforces strong cortical signals through the striatonigral pathway while inhibiting the weak, and may

104 ve rise to striatal neurons belonging to the striatonigral pathway.

105 adaptations within the dynorphin-expressing striatonigral pathway.

106 n of the indirect striatopallidal and direct striatonigral pathways.

107 nd a ventral region that receives a specific striatonigral projection but does not contain its recipr

108 centage of double-labeled striatopallidal or striatonigral projection neurons did not differ among st

109 a unveil a novel mechanism of development of striatonigral projection neurons involving retinoic acid

110 a subpopulation of GABAergic, Gad65-positive striatonigral projection neurons.

111 ent reporters identified striatopallidal and striatonigral projection neurons.

112 but also on terminals of striatopallidal and striatonigral projections, where it may modulate the rel

113 The striatopallidal (STP) and striatonigral (STN) neurons constitute the main neuronal

114 regulation of PDYN expression in mesolimbic striatonigral/striatomesencephalic circuits possibly con

115 orphin (PDYN) gene, which is enriched in the striatonigral/striatomesencephalic pathway, a key neuron

116 In 24 areas, chosen from both the striatonigral (StrN) and olivopontocerebellar (OPC) regi

117 striatopallidal (enkephalin containing), or striatonigral (substance P or dynorphin containing) cell

118 This partial striatopallidal to striatonigral 'switching' phenotype in mice indicates a

119 Then we demonstrate that CB1R at striatonigral synapses (basal ganglia direct pathway) me

120 of alpha-synuclein (alpha-syn) in limbic and striatonigral systems is associated with the neurodegene

121 e data and previous work, we have proposed a striatonigral-tectal-reticular neural pathway mediating

122 striatal projecting cells and its reciprocal striatonigral terminal fields, and a ventral region that

123 ing the response are not localized to either striatonigral terminals nor to the adjacent dopamine neu

124 a of substantia nigra (SNpr), could modulate striatonigral transmission, without affecting the respon