ライフサイエンスコーパス: striatopallidal

1 ation or focal AAV-Cre-mediated knockdown of striatopallidal A(2A)R in the DLS had relatively limited

2 Thus, the striatopallidal A(2A)R signaling in the DMS exerts inhib

3 demonstrated that optogenetic activation of striatopallidal A(2A)R signaling in the DMS suppressed g

4 d behaviors, as focally genetic knockdown of striatopallidal A(2A)Rs in the DMS enhanced goal-directe

5 the reward and specific contributions of the striatopallidal A(2A)Rs in the dorsolateral striatum (DL

6 r activity, have provided a means to dissect striatopallidal and cholinergic contributions to compuls

7 neurons (MSNs) at the origin of the indirect striatopallidal and direct striatonigral pathways.

8 endent information processing by the ventral striatopallidal and extended amygdala macrosystems, is r

9 characterize their properties in identified striatopallidal and striatonigral MSNs.

10 The majority of striatopallidal and striatonigral neurons were double-la

11 linergic stimulation has opposing effects on striatopallidal and striatonigral neurons.

12 GABA controls the polarity of STDP in both striatopallidal and striatonigral output neurons.

13 Transgenic fluorescent reporters identified striatopallidal and striatonigral projection neurons.

14 as an autoreceptor, but also on terminals of striatopallidal and striatonigral projections, where it

15 ical determinant of convergence for both the striatopallidal and subthalamopallidal projections, whil

16 wo main striatal pathways (striatonigral and striatopallidal) and identify novel (non)cell-autonomous

17 norphin (striatonigral) and >90% enkephalin (striatopallidal) and in interneurons that were 100% posi

18 spects of functional connectivity within the striatopallidal axis are dynamic and related to brain st

19 by a rapid functional reorganization of the striatopallidal axis.

20 ld be explained by retrograde stimulation of striatopallidal axons with consequent activation of inhi

21 c synapses specific to the striatonigral and striatopallidal basal ganglia pathways.

22 small-amplitude connections between pairs of striatopallidal cells.

23 ed involvement of neurons within the ventral striatopallidal complex in motivated behaviors.

24 s parallel, independent processing channels, striatopallidal convergence, and lateral integration wit

25 s inputs suggest that the BSTdm is part of a striatopallidal differentiation involved in coordinating

26 roups), suggests that the BSTam is part of a striatopallidal differentiation involved in coordinating

27 cephalon suggest that the BSTrh is part of a striatopallidal differentiation involved in modulating t

28 nglia-cortical pathways is maintained in the striatopallidal direction as described earlier.

29 eptors showed preferential colocalization in striatopallidal (enkephalin containing), or striatonigra

30 opioid receptors located presynaptically on striatopallidal enkephalinergic neurons and by delta opi

31 ) opioid receptors in the dorsal and ventral striatopallidal enkephalinergic system using fluorescenc

32 and ventral striatum resulted in labeling of striatopallidal fibers and pallidostriatal cell bodies,

33 in an interconnected network of cortical and striatopallidal forebrain structures.

34 Decreasing striatopallidal function in the dorsomedial striatum or

35 ke mice that hM4D activation by CNO inhibits striatopallidal function measured as disinhibited downst

36 onsistent with a selective inhibition of the striatopallidal GABAergic (indirect striatal output) pat

37 bition of striatonigral, and facilitation of striatopallidal, gene expression through activation of l

38 produce behavioral responses associated with striatopallidal Gs signaling and in this regard CNO dose

39 euron types (striatonigral direct pathway vs striatopallidal indirect pathway) differ in their input

40 ly affect striatonigral (direct pathway) and striatopallidal (indirect pathway) medium spiny neurons

41 ver, a precise understanding of the roles of striatopallidal (indirect) and striatonigral (direct) pa

42 indicate increased activity in nuclei of the striatopallidal (indirect) pathway, particularly in the

43 he balance of the striatonigral (direct) and striatopallidal (indirect) pathways.

44 Used as a therapeutic approach, striatopallidal inhibition should consider the risk of i

45 f levels in the striatonigral but not in the striatopallidal knock-out in response to l-DOPA treatmen

46 of l-DOPA reduces dyskinesia in animals with striatopallidal knock-out to wild-type levels, suggestin

47 the performance of learned sequences, while striatopallidal manipulations aborted ongoing performanc

48 dendritic spines in D(2) receptor-expressing striatopallidal medium spiny neurons (D(2) MSNs).

49 Recent work has implicated striatopallidal medium spiny neurons (MSNs) in this proc

50 onal activity and dendritic spine density in striatopallidal medium spiny neurons (MSNs).

51 oupled receptor, is selectively expressed in striatopallidal medium spiny neurons (MSNs).

52 they are concentrated in dendritic spines of striatopallidal medium spiny neurons and exist in a hete

53 how abundant expression in striatonigral and striatopallidal medium spiny neurons but not in several

54 ning of spines and glutamatergic synapses in striatopallidal medium spiny neurons, leaving striatonig

55 disease characterized in part by the loss of striatopallidal medium spiny projection neurons (MSNs).

56 trate a critical role for A(2A) receptors on striatopallidal medium spiny projection neurons in shapi

57 ressing (striatonigral) and Drd2-expressing (striatopallidal) medium spiny neurons.

58 ior was rescued by selectively enhancing the striatopallidal MSN activity via a Gq-coupled human M3 m

59 a new resource for elucidating the roles of striatopallidal MSN Galphas signaling in other neurobeha

60 loss of spines and glutamatergic synapses on striatopallidal MSNs but not on neighboring striatonigra

61 nhancement of postsynaptic responsiveness in striatopallidal MSNs controlling motor suppression.

62 tic spine formation and neuronal activity in striatopallidal MSNs of mice.

63 Striatopallidal MSNs showed profound defects, including

64 In addition, dendritic spine density in striatopallidal MSNs significantly increased following t

65 e to the activating, direct pathway MSNs and striatopallidal MSNs to the inhibitory, indirect pathway

66 bunits may cause larger tonic current in D2+ striatopallidal MSNs, and proper intracellular condition

67 ptor signaling exerts the opposite effect in striatopallidal MSNs.

68 eletion preferentially affects synapses onto striatopallidal MSNs.

69 This was true for both striatonigral and striatopallidal MSNs.

70 se pattern was the same in striatonigral and striatopallidal MSNs.

71 dopamine receptor D1+ striatonigral and D2+ striatopallidal MSNs.

72 tant huntingtin (mHdh) are believed to cause striatopallidal neuron vulnerability in early-stage Hunt

73 Thus, Gpr6 is the first striatopallidal neuron-specific genetic regulator of ins

74 Specifically, transiently disrupting striatopallidal neuronal activity facilitated behavioral

75 ypothesized that a D2 agonist would decrease striatopallidal neuronal activity, and hence regional ce

76 phai-coupled designer receptor hM4D in adult striatopallidal neurons and activated the receptor with

77 ceptors (A(2A)Rs) are highly enriched in the striatopallidal neurons and are implicated in instrument

78 It is highly enriched in striatopallidal neurons and can form functional heterome

79 sion of D(1a)R in striatonigral and D(2)R in striatopallidal neurons and the differential expression

80 of the D(2)R reduces coupling of A(2A)Rs on striatopallidal neurons and thereby responses to drugs t

81 elective viral-mediated knockdown of Penk in striatopallidal neurons attenuates heroin SA in adolesce

82 was then selectively and stably expressed in striatopallidal neurons by creating a transgenic mouse i

83 ted the increase in enkephalin expression in striatopallidal neurons caused by D(2)R deficiency.

84 erived neurotrophic factor/TrkB signaling in striatopallidal neurons controls inhibition of locomotor

85 In contrast, lack of CK2 in striatopallidal neurons enhances LID and ERK phosphoryla

86 position further, rendering Kir2 channels in striatopallidal neurons even more susceptible to modulat

87 mately 60% to 70% of either striatonigral or striatopallidal neurons expressed mGluR1a- or mGluR5-lik

88 onigral neurons for D1 dopamine receptors or striatopallidal neurons for D2 dopamine receptors and fo

89 The disconnection of striatopallidal neurons from motor command structures is

90 e CK2: knock-out of CK2 in striatonigral and striatopallidal neurons has opposing effects on LID.

91 ht activation of optoA(2A)R signaling in the striatopallidal neurons in 'time-locked' manner with the

92 eceptor Gpr6 is selectively expressed in the striatopallidal neurons in the striatum.

93 ference in pigeons between striatonigral and striatopallidal neurons in their dopaminergic innervatio

94 Recordings from striatopallidal neurons indicated that this is mediated

95 pattern of changes in both striatonigral and striatopallidal neurons is compatible with homeostatic m

96 otrophic factor signaling in enkephalinergic striatopallidal neurons is poorly understood.

97 ls in which the function of striatonigral or striatopallidal neurons is selectively disrupted due to

98 serpine (10 mg/kg) induces Fos expression in striatopallidal neurons of intact rats-an effect that is

99 medium spiny projection neurons (MSNs), the striatopallidal neurons of the so-called 'indirect' path

100 Conversely, the loss of DARPP-32 in striatopallidal neurons produced a robust increase in lo

101 input from IT-type cortical neurons, whereas striatopallidal neurons receive greater input from PT-ty

102 Blockade of the adenosine A2A receptor in striatopallidal neurons reduces postsynaptic effects of

103 the striatal circuitry and, particularly, in striatopallidal neurons severely affected in Huntington'

104 se making asymmetric axospinous contact with striatopallidal neurons were 0.69 microm.

105 to previous expectation, synapses formed by striatopallidal neurons were biophysically and pharmacol

106 ation of intrastriatal connections formed by striatopallidal neurons were examined.

107 Striatopallidal neurons were identified by rabbit anti-e

108 wn to induce apoptosis of a subpopulation of striatopallidal neurons which lie in the dorsomedial cau

109 neurons, and, instead, is largely present in striatopallidal neurons, (ii) displays a striking G prot

110 ation of reserpine induces Fos expression in striatopallidal neurons, an effect blocked by pretreatme

111 unctional D2 receptors are not segregated to striatopallidal neurons, but may be expressed in a highe

112 signaling through M1 muscarinic receptors in striatopallidal neurons, but not in striatonigral neuron

113 ive training was preferentially expressed in striatopallidal neurons, rather than striatonigral neuro

114 amine receptors located on striatonigral and striatopallidal neurons, respectively, has been postulat

115 eceptors are segregated to striatonigral and striatopallidal neurons, respectively.

116 In striatopallidal neurons, the G-protein alpha(olf) subtyp

117 rity of the FLI positive striatal cells were striatopallidal neurons, though some FLI positive striat

118 lly expressed genes in the striatonigral and striatopallidal neurons, two functionally and clinically

119 Rs) and adenosine A(2A)Rs are coexpressed on striatopallidal neurons, where they mediate opposing act

120 Specifically, enkephalin is expressed in striatopallidal neurons, whereas substance P and dynorph

121 rt differential effects on striatonigral and striatopallidal neurons, which comprise distinct output

122 auses a decrease in the synaptic strength of striatopallidal neurons, which in turn might lead to a i

123 e D2 receptor-mediated Fos expression in rat striatopallidal neurons.

124 er open probability for channels detected on striatopallidal neurons.

125 2-like receptors are, in fact, restricted to striatopallidal neurons.

126 ed preproenkephalin (PPE) gene expression in striatopallidal neurons.

127 pecifically identify either striatonigral or striatopallidal neurons.

128 2a receptors are preferentially expressed in striatopallidal neurons.

129 mouse model lacking NMDA-Rs specifically in striatopallidal neurons.

130 ically on intra-striatal collateral axons of striatopallidal neurons.

131 e of postsynaptic A2A receptors localized in striatopallidal neurons.

132 glutamatergic synaptic transmission in mouse striatopallidal neurons.

133 s of dopamine signaling in striatonigral and striatopallidal neurons.

134 ral connections could be distinguished among striatopallidal neurons.

135 phorylation selectively in striatonigral and striatopallidal neurons.

136 ) are reversed by decreasing function of the striatopallidal "no-go" pathway.

137 two intermingled subtypes (striatonigral and striatopallidal) of medium spiny neurons (MSNs) and syna

138 on the projection neurons giving rise to the striatopallidal or "indirect" pathway, they have been im

139 The percentage of double-labeled striatopallidal or striatonigral projection neurons did

140 ated activities of its two striatonigral and striatopallidal output pathways.

141 y slowed action initiation, and those of the striatopallidal pathway aborted action initiation.

142 irect striatonigral pathway and the indirect striatopallidal pathway are necessary for smooth initiat

143 essing medium-spiny neurons in the indirect, striatopallidal pathway in dorsolateral striatum.

144 tivity in the enkephalin-containing indirect striatopallidal pathway in the expression of parkinsonia

145 e hypothesis that activation of the indirect striatopallidal pathway, previously demonstrated using n

146 receptors in regulating the activity of the striatopallidal pathway.

147 istration suggests increased activity in the striatopallidal pathway.

148 also a large non-reciprocal component to the striatopallidal pathway.

149 es by modulating the activity of the ventral striatopallidal pathway.

150 he mammalian circuit or of the avian lateral striatopallidal pathway: some individual Area X neurons

151 n striatoentopeduncular/substantia nigra and striatopallidal pathways might tightly interact downstre

152 striatoentopeducuncular/substantia nigra or striatopallidal pathways, respectively.

153 g activity within both the striatonigral and striatopallidal pathways.

154 i.e., striatonigral) and the indirect (i.e., striatopallidal) pathways.

155 nsorimotor-striatum and in striatonigral and striatopallidal projecting segments.

156 alamic nuclei and lower PDE10A expression in striatopallidal projecting striatum was the strongest co

157 In striatopallidal-projecting medium spiny neurons, DA D(2)

158 We pay particular attention to striatopallidal projection neurons and their role in com

159 m were identified as either striatonigral or striatopallidal projection neurons by fluorescence retro

160 s at birth, in contrast to normal numbers of striatopallidal projection neurons expressing dopamine r

161 rease the activity of both striatonigral and striatopallidal projection neurons, and the relative act

162 as nearly equal numbers of striatonigral and striatopallidal projection neurons.

163 e may be subpopulations of striatonigral and striatopallidal projection neurons.

164 with the known topographical organization of striatopallidal projections indicated that the ITN-GP pr

165 g; conversely, the increase of PDE10A in the striatopallidal projections might lead to increased inte

166 anges of PDE10A in striatoentopeduncular and striatopallidal projections might result over time in an

167 tions in PV, and coordinated deformations of striatopallidal shape.

168 ection neurons (SPNs): the striatonigral and striatopallidal SPNs, which express dopamine D1 and D2 r

169 The striatopallidal (STP) and striatonigral (STN) neurons co

170 Modulation of the striatopallidal synapse has been proposed as a potential

171 luRs) play in modulating transmission at the striatopallidal synapse.

172 tyric acid in inhibiting transmission at the striatopallidal synapse.

173 in modulating GABAergic neurotransmission at striatopallidal synapses.

174 was to identify the crucial site within the striatopallidal system where lesions disrupt the syntax

175 he woolly fiber morphology characteristic of striatopallidal terminals.

176 g g-amino-n-butyric acid (GABA) release from striatopallidal terminals.

177 dus, suggesting a localization of mGluR4a on striatopallidal terminals.

178 the hypothesis of pathologic disruption of a striatopallidal-thalamo-cortical mesocircuit induced by

179 mediodorsal nucleus and with cortico-ventral striatopallidal-thalamocortical pathways that begin and

180 ABAA receptor-mediated tonic currents in D2+ striatopallidal than D1+ striatonigral medium spiny neur

181 This partial striatopallidal to striatonigral 'switching' phenotype i

182 Synaptic connections from striatopallidal to striatonigral neurons exhibited exclu

183 al ganglia and supported the grouping of the striatopallidal transition zone with the dorsal pallidum

184 finding that mGluR4 may selectively modulate striatopallidal transmission raises the interesting poss

185 Furthermore, the effect of L-AP4 on striatopallidal transmission was absent in mGluR4 knock-