ライフサイエンスコーパス: stringent

1 More stringent 95% and 98% diagnostic accuracy thresholds wer

2 e Cnm(+) native strain, OMZ175, Cnm mediates stringent adhesion to dentinal and root tissues as well

3 hat promote strong B cell pulling forces and stringent affinity discrimination.

4 finitions incorporating family history, more stringent age-based low-density lipoprotein cholesterol

5 the reduced acidification expected from more stringent air pollution policy.

6 From the 1970s to 1990s, more stringent air quality regulations were implemented acros

7 ge via a SNP-derived PAM was found to confer stringent allele-specific cleavage, while a guide-specif

8 A more stringent analysis indicated that 27 differentially expr

9 provides clear recommendations toward a more stringent and consistent use of terminology.

10 luenza A virus infection mouse model is more stringent and may thus be more suitable to select for hi

11 to define subcellular co-localization (i.e. stringent and relaxed), based on which to further derive

12 rs expand, the need for a more standardized, stringent, and informative characterization and validati

13 -knockout (Nrp1(myel-KO)) mice and applied 2 stringent animal models of sepsis: cecal ligation and pu

14 This finding suggests that stringent assemblage of Hsp90 keeps CRAF kinase equipped

15 tem cell transplantation to the embryo, is a stringent assessment of stem cell pluripotency.

16 ants or loci, but instead by those with less stringent association P-values.

17 replication links that was found under more stringent assumptions is the most probable.

18 t exception, existing solutions rely on some stringent assumptions.

19 techniques rely on specific recognition and stringent binding of proteins by antibodies.

20 formed in the human TLR9 dimer, with a very stringent binding site interacting with the 5' CpG motif

21 n control populations and the application of stringent bioinformatics analyses.

22 Using stringent break points, 93% of isolates were resistant t

23 low DOC concentrations, the new EQS is more stringent, but above 162 muM DOC it is higher than the p

24 nally, due in part to the presence of highly stringent checkpoints during male meiosis.

25 lesions in non-immunoglobulin genes and thus stringent checks are in place to constrain and restrict

26 Stringent chemical methods to profile RNA expression wit

27 isplayed outstanding in vivo activity in the stringent chronic model (up to 24-fold better than the d

28 ajority of SNPs (359 994 or 74%) fell in the stringent class of poly high resolution polymorphisms.

29 These studies employ stringent clinical standards to demonstrate that percept

30 ean Power Plan (CPP) and a hypothetical more stringent CO2 emission reduction target ("stronger CPP")

31 mcitabine, busulfan, and melphalan group had stringent complete remission compared with 22 of 174 pat

32 tabine, busulfan, and melphalan who achieved stringent complete remission in accordance with the Inte

33 ow cytometry, and the patient's MM entered a stringent complete remission that lasted for 17 weeks be

34 ete response or better; 14.1% and 4.3% had a stringent complete response).

35 l [CI], 73-94) among all evaluable patients (stringent complete response, 12%; complete response, 10%

36 rred in (29 [60%] of 48) patients, including stringent complete response/complete response (4 [8%]),

37 nths), overall response rate was 81%, with 8 stringent complete responses (25%), 3 complete responses

38 rtial responses, 4 complete responses, and 3 stringent complete responses.

39 After 20 rounds of selection under different stringent conditions, we identified the 10 most enriched

40 gs for inhibition of the hyphal switch under stringent conditions.

41 -scale sensitivity under experimentally less stringent conditions.

42 Water availability acts as the most stringent constraint for life on Earth.

43 Time-reversal symmetries impose stringent constraints on emission and absorption.

44 ort penetration depth of soft X-rays imposes stringent constraints on sample type, preparation, and a

45 y or saturation magnetization, and thus post stringent constraints on the adaptability in diverse app

46 rugs and one non-specific aptamer, tested as stringent control candidates, caused negligible response

47 Since stringent control is responsible for the survival of pat

48 l cells into a tight cellular sheet requires stringent control of cell packing and organization.

49 The stringent control of ethylene synthesis under active eth

50 of the secondary cleavage provide means for stringent control of SBT3 activity, to ensure that the a

51 In multicellular organisms, a stringent control of the transition between cell divisio

52 onclude that hCXCL1-GAG interactions provide stringent control over regulating chemokine levels and r

53 Stringent control represents a key bacterial stress resp

54 modification, the cyclopropanation, is under stringent control.

55 es typhoid fever cases when assessed using a stringent controlled model of typhoid infection.

56 howed a significant interaction effect after stringent correction for multiple testing in Hispanic Am

57 R] + very good PR + complete response [CR] + stringent CR).

58 5% CI 20.8-38.9)-three (2.8%, 0.6-8.0) had a stringent CR, ten (9.4%, 4.6-16.7) had a very good PR, a

59 Using stringent criteria (Fold change > 1.5; FDR < 0.05), thre

60 demic force, as well as with relaxed or more stringent criteria for defining inapparent DENV infectio

61 an acute myocardial infarction, comply with stringent criteria for product homogeneity, potency, and

62 ptibility, but maps of this phenomenon using stringent criteria in disease-relevant tissues remain sp

63 More stringent criteria should be used to determine when to o

64 ed hESC-derived trophoblasts in the light of stringent criteria that were proposed recently, such as

65 tive features of primate development provide stringent criteria to evaluate naive pluripotency in hum

66 eukaryotic tree allowing the application of stringent criteria to identify novel microRNA loci.

67 sons with early to intermediate AMD, even by stringent criteria.

68 short term and enrolled individuals meeting stringent criteria.

69 according to demyelinating activity based on stringent criteria.

70 operational taxonomy units, even at the most stringent cut-off can represent multiple bacterial speci

71 Stringent decontamination of wood surfaces combined with

72 We enrolled children who met a stringent definition of cerebral malaria (one that inclu

73 bly poor level of specificity, and that more stringent definitions are required to avoid misleading i

74 With more stringent deforestation regulations in some countries, w

75 olymeric self-assembled structures require a stringent degree of control over such aspects as functio

76 Following stringent denaturing washes, the resulting covalently li

77 However, the stringent dependence of such strategies on the inherentl

78 eve 90% coverage of all exonic regions using stringent design criteria.

79 s that transmit signals from a kinase show a stringent design tradeoff that hampers their ability to

80 P2013 is a rituximab biosimilar developed to stringent development guidelines, including non-clinical

81 lications of M. pneumoniae in children using stringent diagnostic criteria.

82 aps, concerns about error rates, low yields, stringent DNA requirements and uncertainty about best pr

83 ymerases replicate the damaged DNA, allowing stringent DNA synthesis by a replicative polymerase to r

84 ymerases to replicate a DNA lesion, allowing stringent DNA synthesis to resume beyond the offending d

85 rm of CrO4(2-), is being considered for more stringent drinking water standards by regulatory agencie

86 f underlying drug resistance or require more stringent DST prior to treatment initiation.

87 relatively greater reproducibility with more-stringent effect size thresholds with relaxed significan

88 combinatorial targeting strategy fulfilling stringent efficacy and safety criteria.

89 010 to 2030, as older vehicles built to less-stringent emission standards retire.

90 r emissions for newer vehicles that met more stringent emission standards.

91 ed cycle emissions for vehicles meeting more-stringent emission standards.

92 cles, including 8 GDIs certified to the most-stringent emissions standard, superultra-low-emission ve

93 lder vehicles with newer ones that meet more stringent emissions standards should reduce SOA levels i

94 A formation from newer vehicles meeting more stringent emissions standards.

95 plex-dependent oncogenic advantage in a more stringent environment.

96 clization step appears to be subject to less stringent enzyme control.

97 The results indicate that stringent ER retention requires the COPII coat machinery

98 tolerance tests (IVGTT) remains critical for stringent evaluation of novel replacement therapies in t

99 Stringent evidence of the direct detrimental contributio

100 As a result, some of the most stringent experimental conditions can be relaxed, and su

101 n efficiencies, has continued to necessitate stringent experimental conditions for the observation of

102 er, high costs, longer diagnostic times, and stringent expertise requirements limit the utility of re

103 The required stringent fabrication processes to obtain high quality M

104 When applying this stringent filter to patients, prevalence of monogenic NS

105 immunoprecipitation, mass spectrometry and a stringent filtering algorithm we identified 39 proteins

106 Stringent filtering for rare and potentially disease cau

107 we show that a conservative approach, using stringent filtering is required to generate valid identi

108 talogue of known human HLOF mutations; after stringent filtering of variants in our dataset, we ident

109 After stringent filtering, a total of 1297 non-recurrent exoni

110 ress this, we designed a novel pipeline with stringent filters and assembled a comprehensive Referenc

111 Following statistical analysis and stringent filtration, we identified 1429 PSSs, among whi

112 allow automakers that sell AFVs to meet less-stringent fleet efficiency targets, resulting in increas

113 with many nearly matched targets, rapid and stringent formation of stable products is challenging.

114 to Debye screening, nonspecific binding, and stringent functionalization requirements.

115 he form of a pi-helix, which is required for stringent gating and tight coupling of ion and substrate

116 rMATS-DVR combines a stringent GATK-based pipeline for calling SNVs including

117 totic gene bookmarking play pivotal roles in stringent gene regulation during lineage commitment and

118 ritized for future data collection, and more stringent guidance on acceptable practices is required i

119 and Drug Administration published new, more stringent guidelines for glucose meter manufacturers to

120 When tested in the stringent guinea pig model of EBOV disease, EBOTAb has b

121 d C60-based materials that typically require stringent high-temperature vaporization techniques, alon

122 ue features of S. Typhi pathogenesis and its stringent host specificity have been a long-standing puz

123 urrently recommended US regulations are less stringent; however, US regulatory agencies must act to e

124 eatures and performs better than mLASSO on a stringent human benchmark dataset.

125 This benefit threshold becomes more stringent if vaccine action is leaky (ie, the susceptibi

126 standard uptake value ratiohigh) are overly stringent in defining amyloid positivity.

127 plasma membrane with a t-SNARE that is more stringent in its localization to functional arbuscules.

128 With less stringent inclusion criteria (i.e., >/=85% of an axon's

129 regimens were tested in clinical trials with stringent inclusion criteria.

130 ity, and prevention of transmission requires stringent infection control measures, making C. auris a

131 ponses capable of conferring protection in a stringent influenza A virus challenge.

132 nd-user appealing as they often require very stringent installation of programming environments, thir

133 indings demonstrate the mechanistic value of stringent interrogation of well-defined sets of genes as

134 la in West Africa in 2014, comprehensive and stringent interventions have been implemented to deceler

135 identified conserved RIDD targets containing stringent IRE1 RNase target sequences.

136 The most stringent kinase client is the oncogenic kinase v-Src.

137 s of expression can successfully satisfy the stringent labelling demands of super-resolution SMLM.

138 h a previous diagnosis of type 1 VWD without stringent laboratory diagnostic criteria.

139 in which the different criteria are equally stringent, leading to a controllable number of false neg

140 duals identified no single variants reaching stringent levels of significance and, despite excellent

141 calculated TOTOX value of 50, which are less stringent limits used by the European and British Pharma

142 Herein, we combined the stringent linear geometric interaction constraints of ha

143 Thus, the stringent linearity of halogen bonding is a powerful too

144 cle was missed by Weyl because it breaks the stringent Lorentz symmetry in high-energy physics.

145 /6 in Balb/c) and highly (Balb/c in C57BL/6) stringent major histocompatibility complex fully mismatc

146 A stringent measure of clinical response was calculated th

147 To remedy this problem, we sought more stringent mechanisms of expressing defence proteins.

148 re cell type-specific and often require more stringent modes of activation.

149 Strikingly, this stringent motif is substantially enriched in the human (

150 Using a stringent mouse model of allogeneic kidney transplantati

151 interactions that can be tested induces very stringent multiple hypotheses corrections that limit the

152 To meet stringent NOx emission limits, selective catalytic reduc

153 Stringent numerical model shows that these observations

154 toward increased variation explained at more stringent P value cut points in the CAMP EA cohort (P<0.

155 We devised a more stringent pathogenicity filtering strategy, reducing bac

156 Achievement of the stringent per-protocol consumption target for the EIG pr

157 With less stringent perchlorate regulatory limits, ion exchange te

158 These results highlight the requirement for stringent pharmacogenetic approaches to separate specifi

159 ne a frequently occurring, very specific and stringent phosphorylation/O-GlcNAcylation interplay moti

160 n energy consumption and dissipation imposes stringent physical constraints on the information transp

161 51,485 functional interactions (7.94%), 869 stringent physical PPIs and 46,050 relaxed physical PPIs

162 Wnt signalling is subject to stringent positive and negative regulation to promote pr

163 This suggests that more stringent postprison parole supervision (relative to pro

164 ion followed by conventional therapy using a stringent primary endpoint (steroid-free clinical remiss

165 Each incident was then assessed in a stringent process of information-matching.

166 Implementation of more stringent progression criteria may also be warranted.

167 Long-lived organisms often feature more stringent protein and DNA quality control.

168 of the lower risk subjects exceeded the most stringent published cut-off for subtle parkinsonism of t

169 epresent potential tensions in trial design (stringent quality and highly efficient operations).

170 cells, secretory pathway proteins must pass stringent quality control checkpoints before exiting the

171 variants identified in Europeans, 96 passed stringent quality control in our African American data s

172 ral characterization of mAbs to ensure their stringent quality control.

173 nkage disequilibrium (LD)-aware methods with stringent quality control.

174 duplex strand exchange product could provide stringent recognition; however, we present experimental

175 More stringent referral criteria may reduce the cost per case

176 lytic function, including maintenance of the stringent regio- and stereo-selective cleavage activity,

177 and whose safety is derived from deliberate, stringent regulation of multiple replication-essential g

178 uitination and glycosylation pathways to the stringent regulation of PD-L1, which could lead to poten

179 Stringent regulation of tyrosine kinase activity is esse

180 dangerous goods and are therefore subject to stringent regulations and guidelines for certification f

181 However, protected areas with more stringent regulations had less anthropogenic noise.

182 sality is necessary before implementing more stringent regulations.

183 After the treatment target of stringent remission (or at least low disease activity) i

184 e in-orbit conditions and it can satisfy the stringent requirement for high-accuracy star trackers.

185 More stringent requirements exist for transfer of the substra

186 o address high prices include enforcing more stringent requirements for the award and extension of ex

187 natures, yet to approach the interface three stringent requirements have to be met: interface specifi

188 However, due to the stringent requirements of the transistors used in comple

189 time, it is this short wavelength that puts stringent requirements on X-ray optics and their metrolo

190 or high-temperature conditions have imposed stringent requirements that are currently limiting the r

191 g and authorities apply non-existing to most stringent requirements.

192 l antimicrobial regimen, without excessively stringent requirements.

193 fluent into aquatic bodies are becoming more stringent, requiring some treatment plants to reduce eff

194 Given the stringent resource constraints in quantum computing, inf

195 signal molecules play a central role in the stringent response (SR) to adapt to nutrient starvation

196 Mutants lacking elements of the stringent response - (p)ppGpp sythetases [RelA and SpoT]

197 BS cytotoxicity and that the pathway between stringent response activation and increased virulence is

198 rowth defects of GBS deficient in capsule or stringent response activation.

199 nes in the arginine deiminase pathway during stringent response activation.

200 Levels of the stringent response alarmone guanosine 3'-diphosphate 5'-

201 P. aeruginosa defective in the stringent response also had reduced ability to resuscita

202 of GltX inhibits translation and induces the stringent response and persistence.

203 Gene expression regulation by the stringent response effector, ppGpp, is facilitated by Dk

204 sly unidentified mechanism through which the stringent response functions in Gram-positive bacteria.

205 gic changes resulting from activation of the stringent response in B. burgdorferi may also be involve

206 itions as well as chemical activation of the stringent response induces capsule production in a numbe

207 Stringent response is a conserved bacterial stress respo

208 The stringent response is a survival mechanism used by bacte

209 sponds to Trp starvation in the absence of a stringent response is an intriguing question.

210 The stringent response is used to respond to amino acid star

211 To establish a mechanism by which the stringent response leads to increased cytotoxicity, we p

212 The stringent response mediated by the alarmone (p)ppGpp has

213 The stringent response modulators, guanosine tetraphosphate

214 However, FISH analysis of the starved stringent response mutant showed a bimodal response wher

215 ntification of seven target proteins for the stringent response nucleotides in the Gram-positive bact

216 e of ribosomes but strongly inhibited by the stringent response nucleotides.

217 ing (RNA-seq) on two GBS strains grown under stringent response or control conditions.

218 The stringent response regulates expression of a number of g

219 he guanosine pentaphosphate (ppGpp) alarmone/stringent response regulator.

220 er model bacterial systems, the logic of the stringent response remains remarkably conserved, while a

221 Our results indicate that the stringent response stimulates biofilm dispersal under nu

222 inoculation, suggesting that ppGpp-mediated stringent response temporarily limits cell growth, and m

223 pression of xdhABC is upregulated during the stringent response to promote purine salvage pathways, m

224 Furthermore, chemical activation of the stringent response with serine hydroxamate increased bet

225 This "stringent response" is critical for survival and antibio

226 Here, we show that the stringent response, a stress response pathway whose gene

227 Here we demonstrate that the stringent response, a ubiquitous bacterial stress respon

228 ) mutant strain of E. coli, deficient in the stringent response, by means of time-of-flight-secondary

229 e-cell sensing of nutrient depletion and the stringent response, the production of and response to ex

230 e whose activity is central to the bacterial stringent response-a conserved adaptation to environment

231 sine tetraphosphate and limited induction of stringent response-dependent gene expression in editing-

232 of the transcriptional profile known as the stringent response.

233 ivate synthesis of (p)ppGpp and initiate the stringent response.

234 ersister formation through relaxation of the stringent response.

235 ross-talk between c-di-AMP signaling and the stringent response.

236 d hflX are coregulated by general stress and stringent responses in a temperature-dependent manner.

237 protection against sporozoite challenge in a stringent rodent malaria model.

238 ned using rigid thermal cycling programs and stringent sample preparation procedures.

239 The more stringent SCABE acceptance criteria were met for all pro

240 ing the two methods in parallel and applying stringent selection criteria, we identified potentially

241 Through prioritization and stringent selection criteria, we selected 24 SNPs for fu

242 rs selected from the RMLM method with a less stringent selection criterion.

243 al and peripheral B cell checkpoints: a more stringent selection for central tolerance, resulting in

244 adaptation of these bacteria to reduced and stringent selection for endospore formation, as well as

245 Under stringent selection, they efficiently purge destabilizin

246 opmental changes when populations experience stringent selection.

247 heimer's amyloid beta peptide using weak and stringent selections for antibody specificity.

248 Antibody variants isolated using stringent selections for specificity were also enriched

249 s of attogram/liter in urine samples to meet stringent sensitivity requirements for internal dosimetr

250 coupling in PU.1's ability to enforce a more stringent sequence preference than Ets-1 and its proxima

251 pe mutants, the active-site residues exhibit stringent sequence requirements in that nearly all resid

252 ket is known to recognize selectively a very stringent set of aliphatic side chains such as valine, l

253 of different analyses allowed us to isolate stringent sets of target genes, including transcripts wi

254 is time-consuming to use in practice due to stringent significance criteria commonly seen in these a

255 trolled false positive rate, although a less stringent significance criterion was adopted.

256 Using a stringent significance threshold (P<7.1 x 10(-9)), GWAS

257 raged all variants (not just those that pass stringent significance thresholds) to analyze the functi

258 1-type magnesium-dependent endonuclease with stringent specificity for RNA:DNA hybrid duplexes.

259 to provide 100% sterile protection against a stringent sporozoite challenge in rodent models to malar

260 ric macrophage growth locus protein A (MglA)-stringent starvation protein A (SspA) complex and the DN

261 In silico analysis showed that the E. coli stringent starvation protein A (SspA) shares sequence an

262 ical states; only the genes that have passed stringent statistical criteria are considered in the sec

263 Applying stringent statistical criteria, we detected 1,886 genes

264 isual presentation of stimuli (P = .04), and stringent statistical threshold (P = .01) were used.

265 In addition to stringent sterile techniques, an efficacious way to prev

266 laboratory equipment, personnel, space, and stringent storage conditions for maintenance of sample i

267 th >/= 100 kb length were identified using a stringent strategy based on merging CNVs calls generated

268 A recent stringent study has shown that sphincterotomy is no bett

269 xperimental design that renders possible the stringent study of judgment propagation.

270 In this study we defined a stringent subset of Rab GTPases targeted by SidM and Lid

271 gical pH (pH 5.5-7.4), which also maintained stringent substrate selectivity toward endogenous nucleo

272 Based on our more stringent surrogate category analysis, to reach proporti

273 dentify patients with NAFLD who require more stringent surveillance in order to offer the most timely

274 investigation, including contact tracing and stringent surveillance.

275 his deficiency, we adapted and used a highly stringent Tandem Denaturing Affinity Purification (TDAP)

276 to achieve both high affinity binding and a stringent targeted absorption, distribution, metabolism,

277 This demands stringent techniques owing to the complicated nature of

278 polycrystalline states and hence provides a stringent test on the theory.

279 In this stringent test, these replicated VDR-BVs were significan

280 ing threshold that satisfies the third, most stringent test.

281 nd viscosities that vary 1000-fold, enabling stringent tests of bimolecular electron transfer models.

282 ns such as precision molecular spectroscopy, stringent tests of fundamental physics, quantum computin

283 at a stage where the WIMP scenario is facing stringent tests, and it can be expected that WIMPs will

284 nd enforcing next-generation standards (more stringent than Euro 6/VI) could nearly eliminate real-wo

285 for admission to OAT in California are more stringent than federal regulations.

286 that mediate NAHR may be significantly less stringent than previously believed.

287 To ensure stringent therapeutic testing conditions to replicate li

288 experimental data with cubic splines using a stringent thermodynamic criterion for mixing.

289 samples indicate that 8 OTUs replicate at a stringent threshold across all cohorts, while 49 OTUs ac

290 Antitumor efficacy required stringent Treg depletion combined with checkpoint inhibi

291 The most stringent twin differences estimates (monozygotic) were

292 raints as any other genetic study, including stringent type I error control.

293 Stringent validation identified 6 genes (BNIPL1, ROCK1,

294 ey yields high-resolution quantification and stringent validation of the number and spatial positions

295 Even though the protocol uses stringent washing to remove experimental noise, some of

296 (representing a progressive populace facing stringent water quality regulations) were interviewed.

297 nalyses showed that each model would be more stringent when evaluating food items that specifically t

298 y from the DNA damage checkpoint become more stringent with increased levels of damage and that Asf1

299 Here we report a stringent workflow for the interpretation of proteogenom

300 th negative and positive checkpoints ensures stringent yet efficient target degradation in type I CRI