ライフサイエンスコーパス: stringently

1 light but axis alignment is determined less stringently.

2 nce are required to test the hypothesis more stringently.

3 y help define ovarian cancer stem cells more stringently.

4 hastic models to test biological models more stringently and make predictions for future experimental

5 We studied 184 stringently ascertained Caucasian multiple sclerosis fam

6 This allowed us to stringently assess the effects of recombinant caveolin-1

7 sis of chronic lymphocytic leukemia (CLL) is stringently associated with a tumor-supportive microenvi

8 ha1, alpha2, or alpha3 collagen isoforms are stringently associated with corneal stromal cell activat

9 athione S-transferase-30-kDa peptide remains stringently associated with ribosomes.

10 e analog discriminates at least 30-fold more stringently between the insulin receptor and mitogenic i

11 oneal) performed since 1995 was conducted to stringently categorize all identified biopsy procedure c

12 It is critical to stringently characterize iPS-RPE using standardized and

13 Using stringently characterized, homogeneous preparations of t

14 for every patient, we separately analyzed 55 stringently classified patients, and the results were si

15 echanism assumes nucleophilic catalysis by a stringently conserved active site Cys and general acid-g

16 and general acid-general base catalysis by a stringently conserved active site His.

17 A biologically important region is most stringently conserved among a smaller family of highly s

18 The KDO8PP and KDN9PP orthologs share a stringently conserved Arg residue that forms a salt brid

19 PPDK mutants, in which one of two stringently conserved docking residues located on the N-

20 ed in the protein data bank (PDB) identified stringently conserved elements that stabilize the trigon

21 oop-helix motif of the cap domain contains a stringently conserved Gly (within sequence motif 5), fla

22 residues Lys529 and Thr343, all of which are stringently conserved in the beetle luciferase sequences

23 her percentage of mutations occurred at less stringently conserved sites, including silent mutations

24 ithin the phosphonatase subfamily, Asp186 is stringently conserved, while either position 185 or posi

25 es of SIV replication in rhesus macaques and stringently control highly pathogenic SIV(MAC239) infect

26 function, TspO, together with FnrL and PrrA stringently control photopigment gene expression.

27 e employed multiple genetic mouse models for stringently controlled biochemical and immunostaining an

28 Gene expression in the IncP-1 plasmids is stringently controlled by a network of four global repre

29 This coordination is stringently controlled by gene networks that contain bot

30 cally localized HSP100/ClpB protein genes is stringently controlled by heat stress in both of the lab

31 p1 transcriptional activity is precisely and stringently controlled by heme.

32 ewal, proliferation, and differentiation are stringently controlled by numerous regulatory pathways.

33 As pyocyanin production is stringently controlled by QS, we examined the effect of

34 B lineage precursors into mature B cells is stringently controlled by stage-specific transcription f

35 ogression in osteoblasts and chondrocytes is stringently controlled by the cell-fate-determining tran

36 e membrane-embedded part of the molecule are stringently controlled by the cytoplasmic domain.

37 -tripods can be reliably synthesized through stringently controlled chemical synthesis and could serv

38 total cholesterol and CSF were assayed under stringently controlled conditions.

39 In Escherichia coli, stringently controlled genes are highly transcribed duri

40 show that the interactions between RNAP and stringently controlled promoters are intrinsically unsta

41 complexes is coupled to the transcription of stringently controlled promoters, and this unique featur

42 (RNAP) (both wild type and mutants) and four stringently controlled promoters.

43 This regulation is restricted to stringently controlled promoters.

44 vious small pilot studies, these elegant and stringently controlled results open a new era in leukemi

45 ; and (4) repression in mat1-P cells is less stringently controlled than in mat1-M cells.

46 Canonical BMP signaling is stringently controlled through reversible phosphorylatio

47 irus infection, and their activities must be stringently controlled to maintain immune homeostasis.

48 homeostasis and self-tolerance, but must be stringently controlled to permit expansion of protective

49 etween maternal and paternal chromosomes--is stringently controlled to restrict the number of crossov

50 results indicate that TBP binding in vivo is stringently controlled, and that the ability of activato

51 of microRNA (miR) biogenesis is complex and stringently controlled.

52 ication, and its level of expression must be stringently controlled.

53 ity of fibroblast growth factor 2 (FGF-2) is stringently controlled.

54 etics of the deposition of Al(III) were more stringently controlled.

55 y the multitiered regulatory mechanisms that stringently controls its expression and function.

56 FM is stringently coupled to the anagen stage of the hair cycl

57 To stringently define the mode of binding, a global fit of

58 ied by in vitro gel shift assays in order to stringently define their potential role in the ARE-media

59 ts were obtained when neurosyphilis was more stringently defined as a reactive CSF VDRL test result.

60 previous 12 mo; (b) recent condom use, less stringently defined as using a condom with the most rece

61 l plasma-cell [NPC]; n=22) and patients with stringently defined MGUS/smoldering MM (n=24) and sympto

62 Using stringently defined murine models of atopic, nonatopic a

63 nontypeable Haemophilus influenzae (NTHi) in stringently defined otitis-prone (sOP) and non-otitis-pr

64 tudy (GWAS) of anorexia nervosa (AN) using a stringently defined phenotype.

65 Operator recognition is stringently dependent not only on electropositive residu

66 to homeostatic stimuli does not appear to be stringently dependent on TCR-self peptide:MHC interactio

67 DSB unwinding by AdnAB in vitro is stringently dependent on the ATPase activity of the 'lea

68 ed evidence that PTEN-null myeloma cells are stringently dependent on the PI3K/Akt activation for cel

69 whose expression during productive infection stringently depends on ICP4, and positively affected the

70 Pheresis products were stringently depleted of T and B cells by immunomagnetic

71 Comparing the three clinical series: in the stringently diagnosed Manchester frontotemporal dementia

72 Therefore recombination machineries stringently discriminate between ssDNA and dsDNA lattice

73 sensitively signals target analytes but also stringently discriminates against analogous competing an

74 regulatory subunits (R(CE)) of PKAI(CE) and stringently discriminates against RIIalpha and RIIbeta s

75 used rosiglitazone and primary adipocytes to stringently evaluate a set of biomarkers for brite forma

76 ormation experiments, we find that, for even stringently filtered constraints, a large rigid componen

77 2,704 (1.5%) of our 183,605 informative and stringently filtered SNPs demonstrate an average relativ

78 It uses stringently hybridizing primers which carry a fluorescen

79 flow cytometry and serial transplantation to stringently identify HSCs, trafficking patterns of long-

80 ation of the subventricular zone lineage, we stringently identify lncRNAs with potential roles in adu

81 The myoglobin gene is regulated stringently in muscle fibers, such that high myoglobin e

82 could evolve a mechanism that discriminates stringently in their cellular responses between endogeno

83 Thus, the lanthanide ions have to be stringently kept at relatively low concentrations to min

84 ase (IN) transcription units into cells made stringently LEDGF/p75-deficient by RNAi resulted in much

85 chanism by which chronic transfusion of even stringently leukoreduced RBCs may result in sufficient m

86 otion that tissue-restricted stem cells have stringently limited lineage potential and prompts a re-e

87 rsensitive to hydrolysis, a feature that has stringently limited their utility in water.

88 rganized within the vectors in a manner that stringently maintains tetracycline-dependent regulation.

89 Studies in stringently matched patient cohorts suggest that an epis

90 ing institutional review board approval, two stringently matched subcohorts were derived.

91 t the immunosuppression activity of PD-L1 is stringently modulated by ubiquitination and N-glycosylat

92 repair of blunt and 5' overhang DSBs depends stringently on Ku and the LigD POL domain, but not on th

93 i, the etiologic agent of Lyme disease, rely stringently on regulatory events.

94 Under stringently optimized conditions, only the perfectly seq

95 .59; 95% CI, .35-1.01) and older individuals stringently or not stringently tested (RR, 0.88; 95% CI,

96 Surgical societies should stringently police for appropriate expert witness testim

97 d potent HSC activity that was comparable to stringently purified HSCs.

98 ds increase the efficiency of generating and stringently purifying iPSC-derived cardiomyocytes.

99 ive HIV infection (AHI) in whom RCI has been stringently quantified, we found that early ART reduced

100 egs have considerable potential as agents to stringently regulate antibody dynamics in vivo, resultin

101 y linked to the increased ability of IAPs to stringently regulate apoptosis in neuronally differentia

102 Bacteria stringently regulate the synthesis of their membrane pho

103 rlie discrimination of prospective mates and stringently regulate the transition to courtship in Dros

104 that expression of IgD in primary B cells is stringently regulated and closely linked to IgM expressi

105 s to newly replicated DNA, a process that is stringently regulated and intrinsically linked to replic

106 d walls, and their biosynthetic pathways are stringently regulated at both biochemical and genetic le

107 63 from chromosomal, repetitive genes is not stringently regulated at the protein level and can be su

108 bination by showing that Sir2 recruitment is stringently regulated by Fob1 phosphorylation at specifi

109 demonstrate that beta-catenin expression is stringently regulated by intrathymic signals, it is expr

110 PanK1beta (IC50 = 10 microm), and PanK3 was stringently regulated by long-chain acyl-CoA (IC50 = 2 m

111 The turnover of c-Myc protein is stringently regulated by post-transcriptional modificati

112 L gene with a C-terminal epitope tag that is stringently regulated by the Escherichia coli lac repres

113 Iron is stringently regulated by the iron regulatory proteins, I

114 st HMG-CoA reductase isozyme Hmg2p undergoes stringently regulated degradation by machinery that is a

115 in Xenopus eggs by a highly conservative and stringently regulated end-joining pathway, in which all

116 During amino acid starvation, P2 was stringently regulated in relA(+) and relA(S) cells, whil

117 to oligomerize, and finally to detach, in a stringently regulated mechanistic cycle.

118 f their expression involves an intricate and stringently regulated signaling cascade, initiated by re

119 e induction of autoimmune arthritis, is more stringently regulated than is processing of the nonglyco

120 -12 (IL-12) production by human monocytes is stringently regulated through the inducibility of both s

121 le, and it is critical that these enzymes be stringently regulated to avoid compromising the integrit

122 Normal DNA replication is stringently regulated to ensure a timely occurrence no m

123 Here, we show that Runx2 is stringently regulated with respect to cell cycle entry a

124 The PTS is stringently regulated, and a potential mechanism is the

125 during immune responses, IL-12 production is stringently regulated, in part through transcriptional c

126 Here we report the development of a stringently regulated, tetracycline-inducible, lung-spec

127 us, in which expression of the H2 protein is stringently regulated, was unable to replicate without i

128 heir activity at the synapse is likely to be stringently regulated.

129 ysiology, synthesis of PtdIns(4,5)P2 must be stringently regulated.

130 ovides a clear need for miR-155 itself to be stringently regulated.

131 omous induction of type I interferon must be stringently regulated.

132 lyzes sugar phosphorylation/transport and is stringently regulated.

133 A program of stringently-regulated gene expression is thought to be a

134 nger tugging forces on the BCR, thereby more stringently regulating antigen binding.

135 ing an inducible virus (iA6) that could more stringently repress A6 expression.

136 ia and cold shock, the Dan proteins are more stringently repressed by oxygen and insensitive to cold

137 nant vaccinia virus in which the A8L gene is stringently repressed by the Escherichia coli lac operat

138 , the hTERT, but not the mTert, reporter was stringently repressed in telomerase-negative human cells

139 LhGR-N was stringently repressed in the absence of exogenous glucoc

140 XRCC4/XLF complexes hold DNA ends together--stringently required for coding end joining, but dispens

141 inhibitors indicates that kinase activity is stringently required for heregulin-dependent, but not 12

142 vidence that the eIF4E-eIF4G complex is more stringently required for plasticity induced by initial l

143 hr209, Gly211, and Gly212 were identified as stringently required for recombinational events in bacte

144 ignificantly by mutations in helix 6 and was stringently required for SRP54M to associate.

145 hey demonstrate a novel mechanism by which a stringently required gene product can be bypassed, even

146 ce the efficiency of initiation, but are not stringently required in vitro.

147 vided evidence suggesting that Rad51 is more stringently required than Rad54 for intersister gene con

148 IP1 contributed to the synergy but were less stringently required than the N-terminal region of GRIP1

149 olic rather than catabolic pathways are more stringently required, likely due to functional redundanc

150 that, conversely, Myc-driven lymphomagenesis stringently requires two intact alleles of miR-17~92.

151 produces a single transcript of 2.3kb and is stringently restricted in expression to predominantly me

152 Participants were stringently screened for hypnotic susceptibility with tw

153 These findings indicate that the SMN complex stringently scrutinizes RNAs for specific structural fea

154 introduced to human hematopoietic cells and stringently selected for resistance to killing by the co

155 Differentially expressed genes stringently selected were used to construct multiple non

156 We found out that the most stringently sequence-based calls of X4 variants (Geno2Ph

157 tential of these new tools in activating the stringently silenced pluripotency gene Oct4 (Pou5f1) in

158 uences although locations of purines are not stringently specified.

159 Gene-expression studies and a stringently supervised analysis identified calreticulin

160 se (GVHD) by injecting the cells, along with stringently T cell-depleted donor marrow cells, into let

161 Protection was weaker in children not stringently tested (RR, 0.59; 95% CI, .35-1.01) and olde

162 01) and older individuals stringently or not stringently tested (RR, 0.88; 95% CI, .59-1.31 and RR, 0

163 This could be stringently tested by passive antibody transfer and oral

164 on cosmological length scales has yet to be stringently tested.

165 One novel gene is stringently testis specific and another is expressed exc

166 nd tamoxifen inhibited MCF7 cell growth more stringently than either agent alone.

167 We demonstrate that ClpB requires DnaK more stringently than Hsp104 requires Hsp70 for protein disag

168 yocardial infarction, which was defined less stringently than in previous trials.

169 ions that meet the input specifications more stringently than other published methods, SimBA is also

170 and IN interacts with exogenous donors less stringently than with endogenous elements.

171 not only mean response times but, much more stringently, the observed distribution of these times an

172 ants (RR, 0.1; 95% CI, .01-.77) and children stringently tuberculin tested (RR, 0.08; 95% CI, .03-.25

173 Protection appeared greatest in children stringently tuberculin tested, to try to exclude prior i

174 e PTMs were identified of which 106 could be stringently validated.

175 influence the CTD phosphatase sensitivity of stringently washed complexes.

176 labeled riboprobe complementary to B1R mRNA, stringently washed, and apposed to film and emulsion.

177 s complimentary to ER-alpha or ER-beta mRNA, stringently washed, and opposed to emulsion.