ライフサイエンスコーパス: stroma

1 ffects of P4 are mediated by the endometrial stroma.

2 and edematous changes within the vestibular stroma.

3 ed genes in CRC stroma as compared to normal stroma.

4 ent by inducing a novel reprogramming of the stroma.

5 d on the walls of tumor vessels and in tumor stroma.

6 lammatory, angiogenic, and immune-suppressed stroma.

7 llate cells (PSC), key mediators of the PDAC stroma.

8 d that have not invaded into the surrounding stroma.

9 ostasis and interactions between tumours and stroma.

10 nt myofibroblast-like cell foci in the tumor stroma.

11 em cells and Paneth cells, and in underlying stroma.

12 o fibronectin in the tumor vessels and tumor stroma.

13 omies, each with its immediately surrounding stroma.

14 sels against a background of low-signal iris stroma.

15 ated with increased tumour invasion into the stroma.

16 Fs) are the most abundant cells of the tumor stroma.

17 n the intercellular airspace and chloroplast stroma.

18 g high Kv1.3 preferentially localized in the stroma.

19 lagen that stiffens the extracellular matrix stroma.

20 and combination of epithelial cytoplasm and stroma.

21 inks (HLCCs), which generate a stiffer tumor stroma.

22 es are a major constituent of the intestinal stroma.

23 omprise the tumor and cells within the tumor stroma.

24 the basement membrane and reaching into the stroma.

25 gross morphological heterogeneities such as stroma.

26 cks, cells can migrate unimpeded through the stroma.

27 notypes expressed TNFalpha in the islets and stroma.

28 nded layer, which is adhesive to the corneal stroma.

29 ificant expansion of hyaluronic acid in PDAC stroma.

30 iding a positive biomechanical effect in the stroma.

31 signaling between the uterine epithelium and stroma.

32 tions between leukemic cells and bone marrow stroma.

33 eased adhesion molecule expression by thymic stroma.

34 anules, glial tissue (1 case), and a fibrous stroma.

35 the decidualisation response of the uterine stroma.

36 and suppression of tumor progression in the stroma.

37 -descemet's fluid and DM appeared apposed to stroma.

38 ular sub-groups because of the loss of human stroma.

39 is to modify, rather than deplete, the tumor stroma.

40 e also observed marked inflammation in tumor stroma.

41 in human MM cells that were cocultured on BM stroma.

42 OD3 might be a novel player in thyroid tumor stroma.

43 tion of NOTCH signaling from the surrounding stroma.

44 rganoid-activated CAFs produced desmoplastic stroma.

45 nular opacities are deposited in the corneal stroma.

46 g a contribution from the host-derived tumor stroma.

47 IL6, a cytokine also generated by the tumor-stroma.

48 l cornea to facilitate spread throughout the stroma.

49 Few human studies to date have focused on stroma.

50 ation ranges similar to those found in tumor stroma.

51 eration of both the epidermis and the dermal stroma.

52 suggesting that fibroblasts migrate to form stroma.

53 ed CD68+ macrophages compared to neighboring stroma.

54 ly hypermethylated and underexpressed in MDS stroma.

55 bulking of approximately 80% of the anterior stroma; (4) removal of the deep stroma (bubble roof) fro

56 ation and progression are independent of the stroma, accumulated disease burden leads to rapid, selec

57 Mechanistically, stroma-activated cancer cells show widespread increases

58 roenvironment marked by exacerbated lymphoid stroma activation and increased recruitment of T follicu

59 Accordingly, stroma adjacent to invading mammary ducts of Sharpin(cpd

60 Analogously, the stroma adjacent to skeletal metastases generated in mice

61 matrix that recapitulates the primary tumor stroma, adopt a basal-like phenotype.

62 ng of a stratified epithelium, a collagenous stroma and an innermost single-cell layered endothelium

63 ESV1 [LESV]) are located in the chloroplast stroma and are also bound into starch granules.

64 is a tyrosine kinase overexpressed by tumor stroma and cancer cells.

65 ke alters normal breast epithelial cells and stroma and contributes to tumor cell growth remains unde

66 pproaches for reshaping the pancreatic tumor stroma and discuss how these might improve patient outco

67 Low-density stroma and high lymphocyte levels showed increased overa

68 tio 0.322, P = 0.0219) as compared with high stroma and high lymphocyte levels.

69 A subgroup of tumors with less stroma and high numbers of immune cells showed high rate

70 Fibroblasts are common cell types in cancer stroma and lay down collagen required for survival and g

71 s in HA metabolism within both the peritumor stroma and parenchyma are linked to tumor initiation, pr

72 rcinoma (PDAC) is characterized by extensive stroma and pathogenic modifications to the peripheral ne

73 igration of paraganglionic cells passing the stroma and reaching the prostate ducts.

74 ires tumor cells to navigate through a stiff stroma and squeeze through confined microenvironments.

75 so orchestrate the communication between the stroma and the luminal compartment at all developmental

76 between a growing tumor and its surrounding stroma and their role in facilitating the emergence of d

77 tinels that convey signals to lymphoid organ stroma and thereby facilitate immune response initiation

78 ow that C1q, but not C4, is expressed in the stroma and vascular endothelium of several human maligna

79 he extracellular space and on the supporting stroma and with well characterized tumor-promoting roles

80 ing tumor-initiating cells (TICs), the tumor stroma, and chemokine receptors, as well as invasion and

81 Specifically, we integrate parenchyma, stroma, and endothelium into a single thick tissue by co

82 TR bone metastases and analyzed tumor cells, stroma, and microvesicles.

83 (n = 20) including tumor cells, lymphocytes, stroma, and necrosis to generate a multiagent spatial mo

84 d HGF were heterogeneously expressed in PDAC stroma, and only dual inhibition of these pathways could

85 were entirely derived from FOXD1-expressing stroma, and Phd2 inactivation alone induced renal Epo in

86 ce of targeting the tumor and its associated stroma, and prove the potency of a novel combined approa

87 haFAP- and FSP-1-positive cells in the tumor stroma, and their presence correlated with that of M2 tu

88 - complete with nephrons, collecting ducts, stroma, and vasculature - from induced pluripotent stem

89 Supplementing defined stroma- and serum-free culture conditions with recombina

90 igands, such as PD-L1/CD274 by the tumor and stroma are considered key factors limiting efficacy.

91 The intestinal epithelium and stroma are the major source of WNT ligands but their ori

92 ts is usually associated with the epithelium-stroma area mismatch leading to buckling.

93 ulated expression of tRNAi(Met) in the tumor stroma as a possible contributor to tumor progression.

94 the most significantly induced genes in CRC stroma as compared to normal stroma.

95 on detected on the tumour cells or in tumour stroma, as determined by immunohistochemistry.

96 and favors neutrophil arrest in the vaginal stroma; as a result, the vagina becomes more vulnerable

97 These effects were not observed in the stroma associated with the rare and much smaller metasta

98 R in myeloid cells from the colorectal tumor stroma associates with tumor progression and reduced sur

99 tumor were similar in gene expression space, stroma away from tumor was significantly different from

100 differentiate between tumour and uninvolved stroma based on intrinsic contrast could prove decisive

101 In the stroma-based conditions, the AML patient cells exhibited

102 These observations support the use of stroma-based strategies for the diagnosis and prognosis

103 n addition to its role in proteolysis in the stroma, biochemical and genetic evidence led to the hypo

104 rogen, luteotropin, and estrogen, on corneal stroma bioenergetics.

105 the anterior stroma; (4) removal of the deep stroma (bubble roof) from a central 6-mm optical zone; a

106 e points tested, infiltration of the corneal stroma by P. aeruginosa revealed a high degree of alignm

107 nventional ones with limited removal of deep stroma can improve visual and refractive outcomes of DAL

108 Thus, tumor stroma can make a significant contribution to tumor vers

109 levels of PD-L1, and contained within their stroma CD8(+) T cells and M1 (antitumor) macrophages.

110 at caspase-3 is activated in L88 bone marrow stroma cell-derived exosomes and identified 1 of the sub

111 mal niches, and we now find that bone marrow stroma cells (BMSCs) are severely and permanently damage

112 igen, they establish transient contacts with stroma cells as indicated by sporadic short-lived calciu

113 Cancer cells and stroma cells in tumors secrete chemotactic agonists that

114 ficient mice, suggesting other cells such as stroma cells may also be targeted by LECT2.

115 STAT3 signaling pathways in cancer cells and stroma cells of TME leading to a decrease in cancer cell

116 However, which stroma cells respond to IFNgamma and by which mechanism

117 Without ESR1 in neighboring stroma cells, epithelial cells that line the inside of t

118 als involve interaction with the surrounding stroma cells, in the presence or absence of autoantigens

119 hesion of HSPCs to primary human mesenchymal stroma cells.

120 This pro-tumor stroma, characterized by angiogenic remodelling, is asso

121 signature under supportive or nonsupportive stroma cocultures.

122 s, and large oncosomes are involved in tumor-stroma communication by shuttling signaling cargo and ot

123 d numbers of blood vessels in the esophageal stroma, compared with controls.

124 The thymic epithelium within the thymic stroma comprises highly specialized cells with a high de

125 The stroma conditioned by IL-1beta-expressing cancer cells s

126 ancer, a tumor characterized by desmoplastic stroma containing cancer-associated fibroblasts (CAF).

127 ysis revealed that the Hic-5(-/-);PyMT tumor stroma contains fewer CAFs and exhibits reduced ECM depo

128 ifferentiated neuroblasts and low schwannian stroma content.

129 The tumor stroma contributes to the suppression of tumor growth by

130 terior layer, whereas chronic changes in the stroma correlate with the cumulative dose and duration o

131 proaches to inactivate CAF and prevent tumor-stroma cross-talk may offer a viable strategy to treat p

132 ght increases H2O2 production in chloroplast stroma, cytosol and nuclei.

133 Stroma derived from 5-azacytidine-treated patients lacke

134 ex vivo responses of primary AML cells in BM stroma-derived and standard culture conditions.

135 In contrast, the stroma-derived conditions enhanced sensitivity to Janus

136 esistance to specific drug classes in the BM stroma-derived conditions was a result of activation of

137 Here, we demonstrate that stroma-derived Dickkopf-1 (Dkk1) targets beta-catenin in

138 our data suggest a critical role for reduced stroma-derived OPN for HSC aging and identify thrombin-c

139 epithelial compartment resulted from loss of stroma-derived paracrine signals that activate Yap1 and

140 Expression of both Axin2 and Lgr5 requires stroma-derived R-spondin 3 produced by gastric myofibrob

141 we targeted the PHD/HIF-2/EPO axis in FOXD1 stroma-derived renal interstitial cells and examined the

142 To specifically determine the impact of host/stroma-derived versican we therefore compared growth of

143 hown in our in vitro model of human lymphoid stroma differentiation and in an inducible mouse model o

144 nt intrauterine oxygenation for normal renal stroma differentiation, suggesting that chronic activity

145 nd provide a mechanism-based rationale for a stroma-directed therapy for PDAC.

146 Thus, SHARPIN is required in mammary gland stroma during development.

147 neal isolate of P. aeruginosa in the corneal stroma during infection of ex vivo and in vivo rabbit co

148 MMP-9 gene expression in the tumor-reactive stroma during late-stage metastasis in the lung.

149 r, in many tumor types, the influence of the stroma during preneoplastic stages is unknown.

150 ved between corneal epithelial cells and the stroma during wound healing after corneal epithelial deb

151 -mutated melanoma; the model describes tumor-stroma dynamics both with and without treatment.

152 results illuminate the integration of tumor-stroma dynamics with tissue plasticity in melanoma progr

153 Removal of stroma enables outgrowth of PKD cell lines, which exhibi

154 thylation and DNMTi treatment of primary MDS stroma enhanced its ability to support erythroid differe

155 In LLC-derived tumors, both the tumor and stroma expressed versican at high levels.

156 thematical modelling and layered or spheroid stroma-extracellular matrix-tumour cultures were used to

157 mor proteomes were apparent, attributable to stroma, extrinsic signaling, and growth conditions.

158 h epigenetic changes amenable to cancer- and stroma-focused intervention.

159 These vesicles were also found in the stroma following anterior stromal keratectomy, in which

160 cancer cells, it must also act on the tumour stroma for effective rejection of large, established tum

161 ntrinsic microglia, that create a supportive stroma for neoplastic cell expansion and invasion.

162 ge areas of nuclei, lumen, and cytoplasm and stroma for peripheral zone (PZ), transition zone (TZ), a

163 The effect of myeloid cells on reactive stroma formation in TN breast cancer is largely unknown.

164 The stiffened collagenous stroma fosters malignant transformation of the tissue by

165 al cells transplanted in vivo into wild-type stroma, fully repopulate the mammary gland fat pad, unde

166 cultured, BMSCs quantitatively reconstitutes stroma function in vivo, which is mediated by a multipot

167 , these data confirm the concept that normal stroma function is essential for normal tubular differen

168 We show that this requirement maps to thymic stroma, further underlining the key importance of this T

169 mbination arm, high expression of immune and stroma GSs were significantly associated with higher and

170 .2-4.0; interaction test P = .01), while the stroma GSs were significantly associated with higher pCR

171 er than mice given control agents; the tumor stroma had fewer activated pancreatic stellate cells, lo

172 therapies, and the dialog between tumor and stroma has been shown to modulate the response to molecu

173 ed proteins secreted by tumours and/or their stroma have been proposed to condition pre-metastatic si

174 scending limb of Henle, collecting duct, and stroma; however, it disappeared in mature NP-derived pro

175 5% CI 1.2-6.0), and invasion beyond the lung stroma (HR 3.0, 95% CI 1.4-6.1).

176 not in inflammatory cells or the surrounding stroma (IKKbetaca mice).

177 DPT knockdown in supportive stroma impaired HSC survival, whereas ectopic expression

178 ll sizes, challenging the paradigm that PDAC stroma imposes a critical barrier to drug delivery.

179 ng and therapeutic harnessing of the role of stroma in cancer restraint may hinge on our knowledge of

180 ese experiments illustrate the importance of stroma in cancer therapy and how its impact on treatment

181 vivo, P. aeruginosa traveled throughout the stroma in discrete regions or bands.

182 heterogeneity such as adjacent necrosis and stroma in HGSC.

183 ted by carcinoma cells to invade surrounding stroma in HNSCC.

184 etween pre-tumor cells and their surrounding stroma in malignant progression of the cerebellar tumor

185 Molecular analysis of the tumor stroma in neoadjuvant chemotherapy-treated human desmopl

186 AT3 and modification of the pancreatic tumor stroma in patients and mice.

187 In addition, the role of the bone marrow stroma in regulating clinical responses to DNA methyltra

188 acrophages (TAMs) are recruited to the tumor stroma in response to cytokines secreted by tumor cells,

189 ed the formation of a dense fibrocollagenous stroma in vitro that was associated with significant inc

190 tes to the tRNAi(Met)-driven pro-tumorigenic stroma in vivo.

191 The close overlap of stroma-induced changes in vitro with those previously sh

192 he potential of JAK inhibitors to counteract stroma-induced resistance to BCL2 inhibitors in AML.

193 ining protein 2 (BRD2) in particular, blocks stroma-inducible transcriptional regulation in vitro and

194 Tumor-stroma interactions contribute to tumorigenesis.

195 oteins play crucial roles in mediating tumor-stroma interactions during metastasis of cancer to diffe

196 shown a novel model recapitulating 3D tumor-stroma interactions for studies of real-time cell invasi

197 ital imaging enables to study dynamic tumour-stroma interactions within primary and metastatic sites,

198 t STAT4 might mediate EMT process via cancer-stroma interactions.

199 the adhesion-dependent events at the tumour-stroma interface that govern the collective mode of migr

200 a1 (TGFbeta1), a cytokine involved in cancer-stroma interplay.

201 astatic process such as invasion to adjacent stroma, intravasation and ultimately extravasation and s

202 In this study, to model 3D chemotactic tumor-stroma invasion in vitro, we developed an innovative mic

203 cy for adenocarcinoma versus the surrounding stroma is assessed.

204 We demonstrate that bone marrow stroma is capable of inducing Mcl-1 dependence through t

205 nerve-derived noradrenaline in the prostate stroma is critical for activation of an angiogenic switc

206 IL-33 produced by FALC stroma is crucial for pleural B1-cell activation and loc

207 The tumor stroma is no longer seen solely as physical support for

208 osteopontin (OPN) in the murine bone marrow stroma is reduced.

209 study, we show that Gli3 activity in the FL stroma is required for B cell development.

210 hose from wild type, we show that transgenic stroma is sufficient to reprogram wild-type keratinocyte

211 igated the transcriptome of tumor-associated stroma isolated from TNBC (n = 57).

212 ndings of smooth muscle cell hypertrophy and stroma-like cells, consistently observed in obstructing

213 keratoplasty (DALK) with removal of the deep stroma limited to the central 6-mm optical zone.

214 These findings indicate that the stroma may mediate the effects of iAs in tumor progressi

215 Consequently, strategies to target the tumor stroma might be used to treat patients with pancreatic c

216 These findings indicate that local stroma might control positional disease patterns not onl

217 therefore asked whether cells in the tumour stroma might explain the association between tumour form

218 anding question is how the local and distant stroma modulate MDSCs during tumor progression.

219 Contribution of tumor stroma obscured signatures of DNA mismatch repair identi

220 xpression of HPGDS in mast cells, present in stroma of both airway epithelia, lung as well as in othe

221 hologs was selectively enriched in the tumor stroma of breast cancer patients, and depletion of these

222 Moreover, POSTN was highly enriched in the stroma of cancer tissues and produced mainly by CAFs.

223 The uterine stroma of Fst-cKO mice also responds poorly to artificia

224 onectin was also detected in the peritumoral stroma of HPV8-positive skin SCC.

225 We detected EGFR in myeloid cells in the stroma of human colorectal tumors; myeloid cell expressi

226 eter laminas were obtained from the anterior stroma of human donor corneas and decellularized with a

227 in fusions showed that AtCPT7 resides in the stroma of mesophyll chloroplasts.

228 of PDGF-DD did not affect the vasculature or stroma of PanNET; instead, we found that PDGF-DD stimula

229 em cell recellularization within the corneal stroma of patients with advanced keratoconus.

230 tissue, Fbln5 is expressed abundantly in the stroma of PDA; however, the mechanisms underlying the st

231 liably report in vivo Ca(2+) dynamics in the stroma of root plastids in response to extracellular ATP

232 adult stem cells were found sparsely in the stroma of subcutaneous loose connective tissues.

233 owing exposure to tumor-derived factors, the stroma of TDLNs adapts on multiple levels to exhibit fea

234 hment of a favorable microenvironment in the stroma of the target organs.

235 ll infiltrate in the prostate epithelial and stroma of tumors from DKO mice.

236 tured regions of the cervical epithelium and stroma of untreated or estrogen-treated nontransgenic an

237 ris has radially oriented vessels within the stroma on OCTA.

238 om high-stage disease containing very little stroma or HBEGF expression.

239 l NP derivatives, ureteric bud, and cortical stroma; p-Creb was present in differentiated thick ascen

240 showed that a complex landscape with optimal stroma permeabilization and immune cell activation is ab

241 n under-studied cohort of the pancreas tumor stroma, play a significant role in the initiation and pr

242 trated that aberrant Notch activation in the stroma plays an important role in negatively regulating

243 ly unrecognized pathway involved in lymphoid stroma polarization and as a potential therapeutic targe

244 r and molecular effects on the human corneal stroma post CXL, and promises to establish optimized tre

245 In summary, tumors form their fibroblastic stroma predominantly from precursors present in the loca

246 ularized, immature APCs in the donor corneal stroma quickly mature and migrate to lymphoid tissues to

247 utant correlates with the redox state of the stroma rather than photodamage and that CGL71 functions

248 GFR by myeloid cells of the colorectal tumor stroma, rather than the cancer cells themselves, contrib

249 These data demonstrate the potential of stroma recovery to improve HSC transplantation.

250 lpha impairs chemotaxis and cell adhesion to stroma, reduces bone marrow and spleen colonization in x

251 levels of PD-L1, and contained within their stroma regulatory T cells, M2 (protumor) macrophages, an

252 ell and non-cell constituents of surrounding stroma remains incompletely understood.

253 x protein tenascin-C is part of the reactive stroma response, which has a critical role in prostate c

254 our studies deepen knowledge about reactive stroma responses in the bone endosteum that accompany pr

255 d molecular abnormalities in leukemia marrow stroma responsible for the suppression of normal hematop

256 Within this subtype, invasive, stroma-rich tumours with infiltration of inflammatory ce

257 e when measured to the border of the choroid stroma (SCT) than the vascular lumen (VCT) or sclera (TC

258 thin pancreatic ductal adenocarcinoma (PDAC) stroma secrete lumican and its presence is associated wi

259 Tumor stroma-secreted growth factors, cytokines, and reactive

260 which encode the characteristically abundant stroma seen in PDAC.

261 laries located in the normal human utricular stroma showed vascular endothelial cells with few pinocy

262 Stroma slowed down tumor growth in a lymphocyte-deprived

263 criminate between malignant and nonmalignant stroma spectra with high sensitivity (93.56%) and specif

264 Downregulation of IFNAR1 in tumor stroma stimulated CRC development and growth, played a k

265 lar choroidal thickness, VCT), outer choroid stroma (stromal choroidal thickness, SCT), or inner scle

266 rate that dynamic feedback between tumor and stroma subverts normal inflammatory responses by trigger

267 Engrafted cells could be localized to the stroma surrounding acini and ducts.

268 xert mastery over the local tumor-associated stroma (TAS) to configure protective immunity within the

269 uppressive cells and a uniquely desmoplastic stroma that functions as a barrier to T cell infiltratio

270 ncodes a matricellular protein found in PDAC stroma that has been associated with invasiveness, metas

271 c extensively programs an immune suppressive stroma that is obligatory for tumor progression.

272 nhydrase CAH6 is in the flagella, not in the stroma that surrounds the pyrenoid as in current models.

273 pression (ie, at least 1% of tumour cells or stroma that were PD-L1-positive by immunohistochemistry)

274 Fatty acids are de novo synthesized in the stroma, then converted into very-long-chain polyunsatura

275 fibroblasts (CAFs) that produce desmoplastic stroma, thereby modulating disease progression and thera

276 We demonstrate that the grana/stroma thylakoid connections have a helical character st

277 transcription in a panel of paired tumor and stroma tissues.

278 f ALCAM expressed in cells forming the tumor stroma to cancer progression has not been investigated.

279 ers interactions between tumor cells and the stroma to promote tumor progression.

280 proximately two protons from the chloroplast stroma to the lumen per electron transferred from ferred

281 nvironment, rather than specific bone marrow stroma, to combat the invasion by and survival of chemo-

282 ift in the balance of endogenous bone marrow stroma, towards a composition associated with less effic

283 mediators in the production of this fibrotic stroma, upon activation transitioning to a myofibroblast

284 Gross morphological heterogeneities due to stroma, vasculature, and noncancer cells were mapped in

285 epithelium, basement membrane, and anterior stroma was performed.

286 , to analyze the expression of SOD3 in tumor stroma, we characterized stromal cells from the thyroid.

287 ies to determine levels of EGFR in tumor and stroma; we also collected information on tumor stage and

288 patients with disorders of anterior corneal stroma were correlated to clinical outcome parameters of

289 as vessels, lymphocytes, nerves, mucosa, or stroma were more strongly labeled with the antagonist th

290 ssion of osteopontin in both tumor cells and stroma were significantly increased in BD-NFPAs.

291 , borderline ovarian tumours, normal ovarian stroma) were compared as were the carcinoma histotypes (

292 llagen (Col-I) promoter (COL-EGFP) had green stroma, whereas we could not find COL-EGFP(+) cells in t

293 ts of HIF activation in the developing renal stroma, which also essentially modulates nephron develop

294 ng pathways can induce hyperplasia of the MD stroma, which could play a significant role in the etiol

295 to a more oxidized state of the chloroplast stroma, which is caused by an increased mitochondrial el

296 expression was recorded on connective tissue stroma, which provided DR3-dependent release of chemokin

297 s to be related to inflammatory cells in the stroma, while cancerous areas were dominated by nonessen

298 tology might be mediated by Smo in the local stroma, with systemic Ptch1 required for ductal outgrowt

299 SFRP2 induction is remarkable in tumor stroma, with transcription mainly modulated by the nucle

300 of the thinnest epithelium and the thinnest stroma without any palisades of Vogt-like niche structur