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4 a) signaling through IL-1R and MyD88 in both stromal and immune cells drive inflammation in Ptpn6(spi
7 ls that separate HER2+ cancer cells from the stromal and immune microenvironment in HER2+ invasive br
8 utions of multiple tumor clones and assorted stromal and infiltrating cell populations to pooled geno
10 secreted by cancer cells, is abundant in the stromal and tumour compartments of aggressive ovarian ca
13 parated gene expression profiles from tumor, stromal, and immune cells using a non-negative matrix fa
14 icantly lower (vascular area: beta = -0.306, stromal area: beta = -0.377, both P < .001) than control
15 er adjusting for age, choroidal vascular and stromal areas were significantly lower (vascular area: b
16 ss, choroidal volume, choroidal vascular and stromal areas within the macular (6 mm) and foveal (1.5
19 method (STROMA4) assigns a score along each stromal axis for each patient and then combined the axis
22 signaling mediated IL-4-induced endometrial stromal cell (ESC) proliferation ex vivo, and that genit
27 ection of cytokines that improve mesenchymal stromal cell engraftment into the heart both in normal c
32 d promising results for HSCT and mesenchymal stromal cell therapy as alternatives to systemic therapi
34 cell transplantation (HSCT) and mesenchymal stromal cell therapy have been proposed for patients wit
36 ontent of many tumours associated immune and stromal cell types, their therapeutically relevant ratio
38 ered chemokine receptor CXCR7 and its ligand stromal cell-derived factor (SDF)-1 are known to be invo
40 on 1 (PLCepsilon1) as a crucial regulator of stromal cell-derived factor 1 alpha (SDF-1alpha)-induced
41 <em>CXCL12</em>, which encodes a chemokine, stromal cell-derived factor 1, that is expressed in card
42 r adhesion molecule 1; interleukin 6 [IL-6]; stromal cell-derived factor 1; tissue inhibitor of metal
44 r pathway may participate, together with the stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine re
45 L5551 inhibited CXCR4 binding to its ligand, stromal cell-derived factor-1alpha, and reduced hypoxia-
46 ived factor-1alpha, and reduced hypoxia- and stromal cell-derived factor-1alpha-mediated migration do
47 ly replication of certain prion strains upon stromal cell-derived follicular dendritic cells (FDC) in
48 port the application of adipose-derived stem/stromal cells (ASCs) for engineering the pulmonary vascu
49 dies have shown that bone marrow mesenchymal stromal cells (BM-MSC) protect AML blasts from spontaneo
50 tes superoxide, which stimulates bone marrow stromal cells (BMSC) to AML blast transfer of mitochondr
51 ifference in the metabolomics of bone marrow stromal cells (BMSCs) derived from hyperglycaemic (type
53 both ex vivo bone marrow-derived mesenchymal stromal cells (MSC) and in vitro 3T3-L1 preadipocytes si
55 been suggested to originate from mesenchymal stromal cells (MSC), but their relationship with MSCs is
61 -term passaged (P10) aging human mesenchymal stromal cells (MSCs) could be used for bone tissue regen
67 pathways mediated by factors secreted by BM stromal cells and involved a switch from BCL2 to BCLXL-d
68 ne CXCL13 is expressed by FDC and follicular stromal cells and modulates the homing of CXCR5-expressi
70 on upregulates Tgfbeta signaling in prostate stromal cells and promotes progression of a reactive str
72 ofibroblasts derive from Gli1(+) mesenchymal stromal cells and that a Gli inhibitor targets them for
73 s showed that the expression of caldesmon in stromal cells and the expression of osteopontin in both
75 xtensively, the contribution of fibroblastic stromal cells as portals of entry into the CNS was only
76 w that MDM cells contribute to the postnatal stromal cells at the dorsal aspect of the prostatic uret
77 selectively autoamplify its own synthesis in stromal cells by signaling transcriptional repression of
78 nvincingly in rodent models that mesenchymal stromal cells can prolong solid organ graft survival and
79 ion, maintenance, and metastatic progression.Stromal cells contribute to tumor development but the me
80 cale cell assemblages of encapsulated marrow stromal cells cultured in microwells, osteogenic differe
81 nsduction of bone marrow-derived mesenchymal stromal cells ex vivo, followed by intramyocardial cell
85 ps have observed increased nuclear CTNNB1 in stromal cells from a high frequency of MDS/AML patients,
86 NA methylome analysis of bone marrow-derived stromal cells from myelodysplastic syndrome (MDS) patien
91 te responses in lymph nodes, but the role of stromal cells in adipose tissue inflammation is unknown.
92 vered a pathogenic function for fibroblastic stromal cells in alloimmune reactivity that can be disso
95 resent over 90% of CRC, RSPO3 is produced by stromal cells in the tumor microenvironment and the acti
97 CXCL12 and reducing adhesion to mesenchymal stromal cells in vitro We also found that HIF-2alpha str
98 evaluate the effect of CXL on human corneal stromal cells in vitro, we developed a 3-D in vitro CXL
100 nous injection of singly encapsulated marrow stromal cells into mice delays clearance kinetics and su
101 pproach in a 3D carrier scaffold seeded with stromal cells is an effective in vivo niche model for st
102 ion of the Hh effector Smoothened (Smo) from stromal cells is associated with the loss of osteoblasto
103 pid mediator (LM) profiles of tendon-derived stromal cells isolated from healthy donors and patients
104 Since in patient-derived xenografts (PDXs) stromal cells of the human tumour are substituted by mur
106 ion at all gestational ages, associated with stromal cells or near blood vessels, but was absent in t
108 o-free human umbilical cord-mesenchymal stem/stromal cells reduce the severity of rodent E. coli-indu
113 is study, we investigate whether mesenchymal stromal cells that constitute a supportive microenvironm
114 itioning within the tissue are controlled by stromal cells that construct the barriers of the CNS.
115 r and molecular specialization within thymic stromal cells that enables their regulation of specific
116 ntly, 17f had minimal effects on bone marrow stromal cells that play vital functions in the microenvi
118 of Dll1 and Dll4 in subsets of fibroblastic stromal cells that were derived from chemokine Ccl19-exp
119 ontal transfer of genetic material from host stromal cells to cancer cells triggers the evolution of
120 iptional effector, acts within mouse mammary stromal cells to direct a hormone-responsive niche signa
122 otential for umbilical cord-mesenchymal stem/stromal cells to reduce E. coli-induced oxidant injury.
123 e separation of viable from non-viable human stromal cells using remote dielectrophoresis, in which a
125 rgeted disruption of both CRTC2 and CRTC3 in stromal cells with a mesenchymal Prx1-Cre transgene also
126 repressor, is down-modulated in skin cancer stromal cells, and Atf3 knockout mice develop aggressive
127 ation through endothelial cells, adhesion to stromal cells, and cell proliferation and display an inc
128 interactions between breast cancer cells and stromal cells, and iii) cancer-regulated angiogenesis.
129 and gradually degrade endosteal endothelium, stromal cells, and osteoblastic cells, whereas central m
130 ntiation and expansion of immune-suppressive stromal cells, and remodels the metabolic landscape to s
131 ensional culture, with or without supporting stromal cells, and under these conditions they give rise
132 requirement maps to IL-4Ralpha expression by stromal cells, and we provide evidence that it regulates
133 uingly, increased expression of Arf in tumor stromal cells, as in tumor keratinocytes themselves, con
134 t IRF-1 restricts CHIKV and RRV infection in stromal cells, especially muscle cells, and that this co
135 and other molecules between transformed and stromal cells, including fibroblasts, endothelial and im
136 d the number of bone marrow mesenchymal stem/stromal cells, likely due to decreased expression of PDG
139 alized channels lined with human bone marrow stromal cells, which adopt a mural cell-like phenotype t
140 imulated the production of the CXCL13 by TME stromal cells, which in turn promoted ILC3-stromal inter
156 PU-H71 induced apoptosis in the presence of stromal co-culture or cytoprotective survival signals.
159 c mice revealed high levels of CXCL12 in the stromal compartment as well as high staining for CXCR4 a
160 cant gene-expression changes in the proximal stromal compartment, and estrogen treatment uniquely aff
161 SerpinB2 expression, particularly in the stromal compartment, is associated with reduced metastas
163 ymic dendritic cells (DCs) and, in these two stromal compartments, TSSP edits the peptide repertoire
165 efined HNSCC subtypes by their malignant and stromal composition and established p-EMT as an independ
166 ay improve our understanding of how specific stromal composition could impact T-cell activity, with p
168 aring these alternative collagen sources for stromal contributions to stiffness, organization and ult
169 iR-221(hi) CAF microvesicles and established stromal CSC niches in experimental and patient-derived b
171 vation is the consequence of mutant Kras and stromal cues, providing insight into the role of the tum
172 the bone marrow retention signal provided by stromal-derived CXCL12, thereby enabling dissemination o
173 ed ROCK in LSK cells and sensitized them for stromal-derived factor-1alpha (SDF)-induced migration.
175 maintain HSPCs ex vivo, we demonstrate that stromal EVs play a critical role in the regulation of HS
177 , two pathologies characterized by excessive stromal expansion, we used mouse models to characterize
180 s process can expose epithelial cells to the stromal extracellular matrix (ECM), which is distinct fr
184 paired normal and prostate cancer-associated stromal fibroblasts (CAFs) derived from a coculture cell
185 Our study identifies a crosstalk between stromal fibroblasts and epithelial cells under starvatio
186 cies in the switching expression of MMP-3 in stromal fibroblasts and prostate cancer cells during tum
188 bligate component of the matrix assembled by stromal fibroblasts from head and neck squamous cell car
190 eal epithelium underlying the stimulation of stromal fibrosis and myofibroblast formation in corneal
191 ADCDTI and FA showed correlation only with stromal fraction (r = 0.512 and -0.413, respectively; P
192 lectron microscopy analysis of ADHE-enriched stromal fractions revealed fine spiral structures, simil
194 ssion profiles in the prostate and show that stromal gene signature changes ahead of the epithelial g
200 In this study, we use mice deficient in stromal interacting molecules 1 and 2, which are require
204 re fully reconstituted via two proteins, the stromal interaction molecule 1 (STIM1), a Ca(2+) sensor
205 amines this issue by focusing on the role of stromal interaction molecule 1 (STIM1), an endo/sarcopla
207 n the molecular machinery that mediate SOCE: stromal interaction molecule-1 (STIM1), which functions
209 insight into the HNSCC ecosystem and define stromal interactions and a p-EMT program associated with
210 E stromal cells, which in turn promoted ILC3-stromal interactions and production of the cancer cell m
211 reduce SOX11-enhanced MCL cell migration and stromal interactions and revert cell adhesion-mediated d
212 represents a central node in mediating tumor-stromal interactions that promote osteolytic bone metast
213 Taken together, our results illuminate tumor-stromal interactions, which drive metastasis, and provid
216 ancer patients whose tumors express both low stromal JAG1 and low stromal PTEN exhibit a shorter time
218 also found in the stroma following anterior stromal keratectomy, in which surgical removal of the ep
219 1-infected mice prevented the development of stromal keratitis lesions more effectively than did cont
220 t herpes epithelial keratitis without herpes stromal keratitis sequelae, possessed a significant leuk
221 to be highly plastic and capable of inducing stromal keratitis when adoptively transferred into Rag1(
223 ight foreshadow the partitioning of PSI into stromal lamellae in plants, similarly sustained by long-
225 strongly supporting the concept of targeting stromal LDH-A as an effective strategy to blunt tumoral
226 terogeneity in their adhesion strength under stromal-like conditions, unlike their nonmetastatic coun
227 taking advantage of two fetal liver-derived stromal lines with widely differing abilities to maintai
228 Together, our findings demonstrate that stromal lumican restrains PDAC cell growth through media
230 e to a chemoattractant gradient created from stromal, lymphoid, or antigen presenting cell interactio
232 e pro-TH2 cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) are associated with FA, and
234 red by an increased expression of the thymic stromal lymphopoietin (TSLP) proinflammatory cytokine.
235 n ILC2s were stimulated with IL-7 and thymic stromal lymphopoietin (TSLP), 2 ligands of IL-7 receptor
236 helial cell-derived cytokines such as thymic stromal lymphopoietin (TSLP), IL-33, and IL-25 may drive
237 ociated with an increase in levels of thymic stromal lymphopoietin (TSLP), IL-9, and IL-13, but not I
238 the epithelial-cell-derived cytokine thymic stromal lymphopoietin (TSLP), in patients whose asthma r
240 se dust mite (HDM)-induced release of thymic stromal lymphopoietin and GM-CSF from tracheal epithelia
242 markers (CCL2, CCL5, CCL11, IL-3, and thymic stromal lymphopoietin) at 3 time points (ie, during the
243 kines (interleukin [IL] 25, IL33, and thymic stromal lymphopoietin) by colon tissues, which activated
244 s, with an emphasis on the actions of thymic stromal lymphopoietin, IL-25, and IL-33 at the epithelia
245 gics similarly inhibit TH2 cytokines (thymic stromal lymphopoietin, IL-4, IL-5, IL-13, and the itch-s
246 iated cytokines (interleukin (IL)-33, thymic stromal lymphopoietin, IL-5 and IL-13), serum immunoglob
248 cells and promotes progression of a reactive stromal microenvironment in the Pten null prostate cance
254 stromal opacities persisting after DSAEK and stromal opacities occurring secondarily in post-DSAEK co
255 dications for DALK after DSAEK included both stromal opacities persisting after DSAEK and stromal opa
259 stic2 locus identified a previously unknown stromal protein that interacts physically with both ALB4
260 tumors express both low stromal JAG1 and low stromal PTEN exhibit a shorter time to recurrence than t
263 feration, epithelial-mesenchymal transition, stromal reaction, and angiogenesis through autocrine and
264 OSDI score, basal epithelial cells density, stromal reflectivity and sub-basal nerve tortuosity (p =
265 OSDI score, basal epithelial cells density, stromal reflectivity, sub-basal nerves tortuosity (p = 0
268 n all cells (Sharpin(cpdm)), and mice with a stromal (S100a4-Cre) deletion of Sharpin, have reduced m
269 80 consecutive keratoconic eyes without deep stromal scarring, with at least 1 postoperative examinat
272 in A2 (AnxA2) at Y23 and Y333 in response to stromal signals HGF and IGF-1, respectively, and IGF-1 e
276 al metabolic environment affects mesenchymal stromal/stem cells (MSCs) from umbilical cord's Wharton'
278 ry MCL tumors overexpress cell migration and stromal stimulation gene signatures compared with their
279 tissues of living animals, such as the inner stromal structure of a live mouse cornea, the fine struc
281 -thickness recipient cornea (up to the DSAEK stromal surface),7.0 mm in diameter, with a donor lamell
282 alized biomimetic colorectal tumouroids with stromal surrounds that comprised a range of ECM densitie
283 h multivariate Cox regression models fitting stromal TILs as a continuous variable (per 10% increment
284 icant loss of cells invading the surrounding stromal tissue and reduced HepG2 colonization into lung
285 d with an impaired early vascularization and stromal tissue growth as well as reduced glandular secre
288 , we reported that estrogen signaling in the stromal tumor microenvironment is associated with cervic
289 geted for cancer therapy in gastrointestinal stromal tumors (GISTs) and chronic myelogenous leukemia
291 ival (RFS) in patients with gastrointestinal stromal tumors (GISTs) treated with surgery and adjuvant
293 s, fostering hyperplasia in gastrointestinal stromal tumours (GISTs), and additional genetic alterati
294 grate the complexities of lymphatic biology, stromal variability, chemoattractant distribution, and f
297 lated miRNAs targeting growth factors in the stromal-vascular fraction (SVF) under conditions that pr
298 r data highlight the importance of balancing stromal versus adipogenic cell expansion during white ad
299 bit reduced thylakoid contents and increased stromal volume, indicative of defective development.
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