ライフサイエンスコーパス: stromal cell-derived factor 1

1 ling induced by the chemokine ligand CXCL12 (stromal cell-derived factor 1).

2 activation of MMP-9 and enhanced release of stromal cell-derived factor 1.

3 ble of inducing emigration, one of which was stromal cell-derived factor-1.

4 JVS-100 is a DNA plasmid encoding human stromal cell-derived factor-1.

5 (VEGF), inducible nitric oxide synthase, and stromal cell-derived factor-1.

6 (MMP)9 activity and decreased expression of stromal-cell-derived factor 1.

7 or ligands, such as CCR5-Delta32, CCR2-V64I, stromal cell-derived factor-1 3'alpha, and CCR5 promoter

8 ested the hypothesis that blockade of SDF-1 (stromal cell-derived factor 1), a key stem cell mobilize

9 n CXCR4, which binds the chemokine CXCL12 or stromal cell-derived factor-1, a chemokine that has been

10 Stromal cell-derived factor-1, a CXC chemokine, is the o

11 block CXCR4 usage and partially blocked with stromal cell-derived factor 1, all of which had no effec

12 The chemokine receptor CXCR4 and its ligand, stromal cell derived factor-1 alpha (SDF1 alpha) regulat

13 on 1 (PLCepsilon1) as a crucial regulator of stromal cell-derived factor 1 alpha (SDF-1alpha)-induced

14 Stromal cell-derived factor 1 alpha (SDF1 alpha) and its

15 hic factor (GDNF), sonic hedgehog (Shh), and stromal cell-derived factor 1 alpha (SDF1alpha), providi

16 y of CXCR4 antibodies to block chemotaxis to stromal cell-derived factor 1 alpha and to inhibit HIV-1

17 4) for the chemokine (C-X-C motif) ligand 12/stromal cell-derived factor-1 alpha (CXCL12/SDF-1 alpha)

18 ted by the chemokine (C-X-C motif) ligand 12/stromal cell-derived factor-1 alpha (CXCL12/SDF-1) via t

19 ross TNF-treated EC monolayers overlaid with stromal cell-derived factor-1 alpha (SDF-1 alpha) and su

20 Immobilized stromal cell-derived factor-1 alpha (SDF-1 alpha) has be

21 ence stimulates proliferation, survival, and stromal cell-derived factor-1 alpha (SDF-1 alpha)-induce

22 ed chemotactically to their cognate ligands, stromal cell-derived factor-1 alpha and secondary lympho

23 ate splice products are therefore functional stromal cell-derived factor-1 alpha receptors.

24 sustained delivery of a synthetic analog of stromal cell-derived factor 1-alpha (engineered stromal

25 Chemokine stromal cell derived factor-1 (also known as CXCL12) is

26 orphism in the 3' untranslated region of the stromal cell-derived factor 1 (also called pre-B-cell-st

27 to activate fibrocytes, probably by inducing stromal cell-derived factor-1 (also termed CXCL12), one

28 The chemokine stromal cell derived factor-1, also known as CXCL12, bin

29 or CXCR4 to induce chemotaxis in response to stromal cell derived factor 1 and abolished the activati

30 that interactions between the CXC chemokine stromal cell-derived factor 1 and its receptor CXC chemo

31 ith significantly upregulated mRNA levels of stromal cell-derived factor 1 and platelet-derived growt

32 many T lymphocytes migrate away than towards stromal cell-derived factor 1 and their directional migr

33 t to be involved in hemopoietic cell homing, stromal cell-derived factor-1 and its receptor CXC chemo

34 imals have increased chemotactic response to stromal cell-derived factor-1 and macrophage-inflammator

35 the levels of other DPP-4 substrates such as stromal cell-derived factor-1 and neuropeptide Y.

36 fibroblasts to secrete much higher levels of stromal-cell-derived factor 1 and vascular endothelial g

37 oid synoviocyte line, including a chemokine, stromal cell-derived factor 1, and several genes capable

38 scular endothelial growth factor-A [VEGF-A], stromal cell-derived factor-1, and matrix metalloproteas

39 in response to the chemokines MIP-3beta and stromal cell-derived factor-1; and 3) significantly incr

40 Like hemopoietic cell homing, levels of stromal cell-derived factor-1 are high at sites of breas

41 Chemokines such as CXCL12, previously called stromal cell-derived factor 1, are known to activate cel

42 The CXC chemokine ligand (CXCL12, or stromal cell-derived factor-1 as previously known) plays

43 otaxis toward the lymphoid tissue chemokines stromal cell-derived factor-1, B lymphocyte chemoattract

44 n expressions of mitochondrial cytochrome c, stromal cell-derived factor-1, C-X-C chemokine receptor

45 cent staining showed higher numbers of CD31+ stromal cell-derived factor-1+, chemokine receptor type

46 cell subsets revealed that migration toward stromal cell-derived factor 1/CXC ligand 12 (SDF-1/CXCL1

47 is usually stimulated by chemokines such as stromal cell-derived factor-1 (CXCL12) acting via G prot

48 ed that GC T cells would actively migrate to stromal cell-derived factor-1 (CXCL12), the CXCR4 ligand

49 condary lymphoid tissue chemokine, CCL21, or stromal cell-derived factor 1, CXCL12, which chemoattrac

50 sed CXCR4-mediated chemotaxis in response to stromal cell-derived factor 1/CXCL12 and abolished the p

51 CXCR4, a receptor for stromal cell-derived factor 1/CXCL12), was prominently u

52 e chemokine (SLC)/CC ligand (CCL)21), CXCR4 (stromal cell-derived factor-1/CXCL12), and CXCR5 (B cell

53 hypoxic preconditioning are mediated by the stromal cell-derived factor 1/CXCR4 axis, and that thera

54 Stromal cell-derived factor 1/CXCR4 inhibition impaired

55 hematopoietic compartment is associated with stromal cell-derived factor 1/CXCR4-dependent vasculogen

56 cally augmented along with downregulation of stromal cell-derived factor-1-degrading enzyme dipeptidy

57 eased vascular endothelial growth factor and stromal cell-derived factor 1 expression in fibroblasts;

58 s provided suggesting that downregulation of stromal cell-derived factor 1 expression in the bone mar

59 T cell expressed and secreted) (for HIVBaL), stromal cell-derived factor-1 (for HIVIIIB), or azidothy

60 ibility to T-tropic HIV-1; and (v) a ligand (stromal cell-derived factor 1) for or a monoclonal antib

61 ced molecule 1 ligand chemokine) and CXCL12 (stromal cell-derived factor 1) have not been established

62 Overexpression of stromal cell-derived factor-1 in injured tissue leads to

63 inting to the potential role of a chemokine (stromal cell-derived factor 1) in lymphomagenesis, and s

64 d CXCR4 (specific receptor for CXC chemokine stromal cell-derived factor-1) in CLL cells of a patient

65 FHL2 knockdown increased stromal cell-derived factor-1-induced EOC migration thro

66 CXCL12/stromal cell-derived factor 1 is a member of the CXC fam

67 upernatants but no increase in the cytokines stromal cell-derived factor 1, macrophage inflammatory p

68 and RYR3 that occurred after treatment with stromal cell-derived factor 1, macrophage-inflammatory p

69 /or RYR2 mRNA was found after treatment with stromal cell-derived factor 1, macrophage-inflammatory p

70 ically associate and form a heterodimer upon stromal cell-derived factor-1 or CXCL12 (SDF-1) stimulat

71 thymic stromal-derived lymphopoietin, flt3, stromal cell-derived factor-1, or IL-7R.

72 (P = 0.04), stem cell factor (P = 0.05), and stromal cell-derived factor 1 (P = 0.03) compared to tho

73 nished hypoxia response, including decreased stromal cell-derived factor 1 (P<0.005) and vascular end

74 n-1 receptor 2, programmed cell death-1, and stromal cell-derived factor-1) pathways, as was histolog

75 rn to that of CD34(+) cells, and opposite to stromal cell-derived factor 1 plasma levels and correspo

76 ophic effects of mesenchymal stem cell (MSC) stromal cell-derived factor-1 release on the effects of

77 ein 4], ANGPT1 [angiopoietin 1], and CXCL12 [stromal cell-derived factor 1], respectively).

78 chemotactic activity comparable with that of stromal cell derived factor 1 (SDF-1), a highly efficaci

79 Stromal cell derived factor-1 (SDF-1 or CXCL12) and its

80 The C-X-C chemokine receptor type 4 (CXCR4)/stromal cell derived factor-1 (SDF-1 or CXCL12) interact

81 ne inactivation studies have shown that both stromal cell derived factor-1 (SDF-1) and chemokine rece

82 The chemokine, stromal cell derived factor-1 (SDF-1) at high concentrat

83 The ligand, stromal cell derived factor-1 (SDF-1) stimulated higher

84 ypoxia-inducible factor-1alpha (HIF-1alpha), stromal cell derived factor-1 (SDF-1), matrix metallopro

85 s to varying concentrations of the chemokine stromal cell derived factor-1 (SDF-1).

86 cells express alpha-smooth muscle actin and stromal cell-derived factor 1 (SDF-1) and are tumorigeni

87 XCR4 is the receptor for the alpha-chemokine stromal cell-derived factor 1 (SDF-1) and has been shown

88 study was to analyze the role of a chemokine stromal cell-derived factor 1 (SDF-1) and its receptor C

89 bular joint (TMJ) and to explore the role of stromal cell-derived factor 1 (SDF-1) and regulated on a

90 ation-dependent chemotaxis to their ligands, stromal cell-derived factor 1 (SDF-1) and VCAM-1, which

91 Stromal cell-derived factor 1 (SDF-1) blocked HIV-1(LAI)

92 ned for associations of previously described stromal cell-derived factor 1 (SDF-1) chemokine and CCR5

93 Stromal cell-derived factor 1 (SDF-1) coordinates the re

94 hibit significantly enhanced chemotaxis to a stromal cell-derived factor 1 (SDF-1) gradient and adher

95 the chemokine receptor CXCR4 by its agonist stromal cell-derived factor 1 (SDF-1) has been associate

96 wn that T cells move away from the chemokine stromal cell-derived factor 1 (SDF-1) in a concentration

97 Stromal Cell-derived factor 1 (SDF-1) is a CXC chemokine

98 The chemokine stromal cell-derived factor 1 (SDF-1) is essential for p

99 ic chondrocytes, while its ligand, chemokine stromal cell-derived factor 1 (SDF-1) is expressed in th

100 Stromal cell-derived factor 1 (SDF-1) plays a major role

101 Here we show that the chemokine stromal cell-derived factor 1 (SDF-1) reduces the repell

102 scular endothelial growth factor (VEGF), and stromal cell-derived factor 1 (SDF-1) than cells from un

103 Binding of the natural ligand stromal cell-derived factor 1 (SDF-1) to CXCR4, which in

104 Recently, the CXC chemokine stromal cell-derived factor 1 (SDF-1) was identified as

105 Genotype data for CCR5, CCR2, and stromal cell-derived factor 1 (SDF-1) were obtained from

106 The interaction of the chemokine stromal cell-derived factor 1 (SDF-1) with its receptor

107 The chemokine CXCL12 (stromal cell-derived factor 1 (SDF-1)), abundantly produ

108 ndertaken to investigate the hypothesis that stromal cell-derived factor 1 (SDF-1), a CXC chemokine (

109 d murine MCP-1 and not to murine KC or human stromal cell-derived factor 1 (SDF-1), consistent with t

110 Therefore, we explored the possibility that stromal cell-derived factor 1 (SDF-1), the ligand for CX

111 mRNA for stromal cell-derived factor 1 (SDF-1), the only known li

112 opoietic progenitors, it (1) potentiates the stromal cell-derived factor 1 (SDF-1)-dependent chemotax

113 dly and dose-dependently inhibited basal and stromal cell-derived factor 1 (SDF-1)-induced BMC migrat

114 ween GPI+ and GPI(neg) NK cells and impaired stromal cell-derived factor 1 (SDF-1)-induced chemotaxis

115 is chemotactic activity revealed identity to stromal cell-derived factor 1 (SDF-1).

116 However, stromal cell-derived factor 1 (SDF-1)/CXCR4-mediated sig

117 tumor cells through their ability to secrete stromal cell-derived factor 1 (SDF-1); CAFs promote angi

118 ating evidence indicates that interaction of stromal cell-derived factor 1 (SDF-1/CXCL12 [CXC motif,

119 Stromal cell-derived factor 1 (SDF-1/CXCL12) is a multif

120 he hypothesis that chemokines in general and stromal cell-derived factor 1 (SDF-1; CXCL12) in particu

121 The human CXC chemokine, stromal cell-derived factor 1 (SDF-1alpha), is known to

122 In addition, the angiogenic factors stromal cell-derived factor 1 (SDF-1alpha), vascular end

123 CD20 is directly upregulated by CXCR4 ligand stromal cell-derived factor 1 (SDF-1alpha, CXCL12) produ

124 es even with stimulation by a CXCR4 agonist, stromal cell-derived factor-1 (SDF-1 [CXCL12]).

125 The chemokine stromal cell-derived factor-1 (SDF-1 or CXCL12) mediates

126 ment, where evidence points to the chemokine stromal cell-derived factor-1 (SDF-1 or CXCL12; expresse

127 is a specific receptor for the CXC chemokine stromal cell-derived factor-1 (SDF-1) and a coreceptor f

128 n (chemotaxis) in response to the chemokines stromal cell-derived factor-1 (SDF-1) and B-lymphocyte c

129 ediates lymphocyte chemotaxis in response to stromal cell-derived factor-1 (SDF-1) and functions as a

130 Stromal cell-derived factor-1 (SDF-1) and its receptor C

131 Stromal cell-derived factor-1 (SDF-1) and its receptor,

132 the interaction between the HIF-1-dependent stromal cell-derived factor-1 (SDF-1) and its receptor,

133 ression of both the EPC mobilizing chemokine stromal cell-derived factor-1 (SDF-1) and of vascular ep

134 The CXCR4/stromal cell-derived factor-1 (SDF-1) axis is essential

135 In humans, vitreal stromal cell-derived factor-1 (SDF-1) concentration incr

136 The chemokine stromal cell-derived factor-1 (SDF-1) controls T-cell re

137 We evaluated chimerism and stromal cell-derived factor-1 (SDF-1) expression in resp

138 Stromal cell-derived factor-1 (SDF-1) is a chemokine and

139 Stromal cell-derived factor-1 (SDF-1) is a chemokine con

140 Stromal cell-derived factor-1 (SDF-1) is a chemokine tha

141 Stromal cell-derived factor-1 (SDF-1) is a CXC chemokine

142 We recently found that the CXC-chemokine stromal cell-derived factor-1 (SDF-1) is a highly effica

143 Stromal cell-derived factor-1 (SDF-1) is a well-characte

144 The stromal cell-derived factor-1 (SDF-1) is an alpha chemok

145 The chemokine stromal cell-derived factor-1 (SDF-1) is constitutively

146 Stromal cell-derived factor-1 (SDF-1) is known to play a

147 Stromal cell-derived factor-1 (SDF-1) is the most promin

148 In addition, median stromal cell-derived factor-1 (SDF-1) levels were 43% hi

149 Increased local vascular stromal cell-derived factor-1 (SDF-1) levels were observ

150 Based on a short hairpin RNA library and stromal cell-derived factor-1 (SDF-1) migration screenin

151 towards a gradient of the chemotactic factor stromal cell-derived factor-1 (SDF-1) produced by stroma

152 In mammals, stromal cell-derived factor-1 (SDF-1) promotes hematopoi

153 Stromal cell-derived factor-1 (SDF-1) provides a potent

154 tion of chemokines, the role of signaling by stromal cell-derived factor-1 (SDF-1) through its recept

155 ly and reversibly antagonizes the binding of stromal cell-derived factor-1 (SDF-1) to its receptor CX

156 Basal and PTH-stimulated stromal cell-derived factor-1 (SDF-1) was decreased in m

157 Stromal cell-derived factor-1 (SDF-1) was elevated in DC

158 higher plasma levels of the chemokine CXCL12/stromal cell-derived factor-1 (SDF-1) were achieved in a

159 These cells also express stromal cell-derived factor-1 (SDF-1), a CXC chemokine t

160 eta-1, can strikingly stimulate secretion of stromal cell-derived factor-1 (SDF-1), also known as CXC

161 flammatory mediators, such as the chemokine, stromal cell-derived factor-1 (SDF-1), and factors that

162 FLSs constitutively expressed the chemokine stromal cell-derived factor-1 (SDF-1), and that pertussi

163 ets, the CXCR4 is the receptor for chemokine stromal cell-derived factor-1 (SDF-1), and the CCR4 is t

164 functional CXCR4 receptors for the chemokine stromal cell-derived factor-1 (SDF-1), as demonstrated b

165 ), a HIF-1alpha-independent up-regulation of stromal cell-derived factor-1 (SDF-1), as well as endoth

166 stology and immunohistochemical detection of stromal cell-derived factor-1 (SDF-1), beta-actin, vascu

167 compared with that of its only known ligand, stromal cell-derived factor-1 (SDF-1), by in situ hybrid

168 receptor 4 (CXCR4), the primary receptor for stromal cell-derived factor-1 (SDF-1), is involved in bo

169 Here, we show that its cognate chemokine, stromal cell-derived factor-1 (SDF-1), promotes the surv

170 The chemokine stromal cell-derived factor-1 (SDF-1), signaling through

171 Stromal cell-derived factor-1 (SDF-1), the ligand for th

172 endent cytokine transcription in response to stromal cell-derived factor-1 (SDF-1), the sole chemokin

173 Stromal cell-derived factor-1 (SDF-1), the unique agonis

174 stimulated immature B cells are defective in stromal cell-derived factor-1 (SDF-1)-induced calcium mo

175 al evaluation, 32 efficiently inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulatio

176 riety of substrates, including the chemokine stromal cell-derived factor-1 (SDF-1).

177 r pathway may participate, together with the stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine re

178 The stromal cell-derived factor-1 (SDF-1)/CXC chemokine rece

179 cells were found to upregulate production of stromal cell-derived factor-1 (SDF-1)/CXCL12 in human fi

180 ween the upregulation of the chemoattractant stromal cell-derived factor-1 (SDF-1)/CXCL12 in the inju

181 Stromal cell-derived factor-1 (SDF-1)/CXCL12 is a potent

182 Costimulation by the chemokine, stromal cell-derived factor-1 (SDF-1)/CXCL12, has been s

183 between the chemokine receptor 4 (CXCR4) and stromal cell-derived factor-1 (SDF-1, also known as CXCL

184 Disruption of stromal cell-derived factor-1 (SDF-1/CXCL12 [CXC chemoki

185 Because the CXCR4 receptor for the stromal cell-derived factor-1 (SDF-1/CXCL12) chemokine i

186 sforming growth factor-beta1 (TGF-beta1) and stromal cell-derived factor-1 (SDF-1/CXCL12).

187 onment, constitutively secrete the chemokine stromal cell-derived factor-1 (SDF-1/CXCL12).

188 (CXCR4) is a G protein-coupled receptor for stromal cell-derived factor-1 (SDF-1/CXCL12).

189 CXCR4 is a chemokine receptor that binds stromal cell-derived factor-1 (SDF-1; also known as CXCL

190 chemokine receptor 4 (CXCR4) and its ligand, stromal cell-derived factor-1 (SDF-1alpha or CXC chemoki

191 Events mediating stromal cell-derived factor-1 (SDF-1alpha/CXCL12) chemot

192 beta 1-integrin ligand fibronectin regulated stromal-cell derived factor-1 (SDF-1) activation of ERK.

193 ent evidence demonstrates that the chemokine stromal-cell derived factor-1 (SDF-1, also known as CXCL

194 molecule E-selectin and the chemoattractant stromal-cell-derived factor 1 (SDF-1) in discrete, disco

195 selective activation of chemokines, such as stromal-cell-derived factor 1 (SDF-1), macrophage inflam

196 Stromal-cell-derived factor 1 (SDF-1), required for stem

197 Exogenously added stromal cell-derived factor-1 ((SDF-1)/CXC chemokine lig

198 C chemokine ligand 12 (CXCL12, also known as stromal cell-derived factor 1 [SDF-1]), a chemokine prev

199 We show here that stromal cell-derived factor-1 [SDF-1, also known as chem

200 R7 by their shared cognate chemokine ligand (stromal cell-derived factor-1 [SDF-1]) in Stx-mediated p

201 The chemokine stromal cell-derived factor 1, SDF-1, is an important re

202 onstitutively expressed in the CNS (known as stromal cell-derived factor 1; SDF-1), regulates cleavag

203 afish has shown that the interaction between stromal cell-derived factor 1 (SDF1) and its G-protein-c

204 Angiogenic myeloid cells home through the stromal cell-derived factor 1 (SDF1) receptor CXCR4.

205 1-deficient MKs in response to a gradient of stromal cell-derived factor 1 (SDF1), a major chemokine

206 nly in muscles atrophying because of cancer: stromal cell-derived factor 1 (SDF1), adenylate cyclase

207 human intercrine reduced in hepatomas (hIRH)/stromal cell-derived factor 1 (SDF1-alpha)/pre-B-cell gr

208 The chemokine stromal cell-derived factor-1 (SDF1) is expressed within

209 Stromal cell-derived factor-1 (SDF1) regulates homing of

210 The chemokine, stromal cell-derived factor-1 (SDF1), is produced in the

211 CM-CXCR4 expression and are mediated by MSC stromal cell-derived factor-1 secretion.

212 e of adhesion molecules, CXC receptor 4, and stromal cell-derived factor-1 signaling pathway in the r

213 Recent progress has implicated CXCR4-SDF1 (stromal cell-derived factor 1) signaling in regulating n

214 While SDF1 (stromal cell-derived factor-1) signaling is necessary fo

215 <em>CXCL12</em>, which encodes a chemokine, stromal cell-derived factor 1, that is expressed in card

216 and increased renal expression of its ligand stromal cell-derived factor 1, thus favoring mobilizatio

217 ein 7, macrophage colony-stimulating factor, stromal cell-derived factor-1, tissue inhibitor of metal

218 r adhesion molecule 1; interleukin 6 [IL-6]; stromal cell-derived factor 1; tissue inhibitor of metal

219 , dose-dependent inhibitor of the binding of stromal cell-derived factor 1 to its receptor, CXCR4.

220 tor-alpha; chemokine (C-X-C motif) ligand 1; stromal cell-derived factor 1; transforming growth facto

221 ediated by E-selectin and can be enhanced by stromal cell-derived factor-1 under different wall shear

222 ue repair and suggest that overexpression of stromal cell-derived factor-1 via gene therapy is a stra

223 Stromal cell-derived factor-1 was present at low levels

224 In particular, the release of stromal cell-derived factor-1 was synergistically augmen

225 actors, transforming growth factor alpha and stromal cell-derived factor 1, was not affected by 100 p

226 CXCR4, a receptor for the chemokine stromal-cell derived factor-1, was also identified as a

227 roblast growth factor, stem cell factor, and stromal cell-derived factor-1, whereas SVPs release high

228 In contrast to stromal cell-derived factor-1, which attracts multiple t

229 For example, stromal-cell-derived factor 1, which is synthesized cons

230 n-1 receptor 2, programmed cell death-1, and stromal cell-derived factor-1) with consequent myocardia