ライフサイエンスコーパス: stromal interaction molecule

1 In T-lymphocytes, stromal interaction molecule 1 (STIM1) acts as the intra

2 ric, calcium-selective channels activated by stromal interaction molecule 1 (STIM1) after depletion o

3 3 enhances the signal-induced association of stromal interaction molecule 1 (STIM1) and Orai1 and is

4 Here, we report that stromal interaction molecule 1 (STIM1) and Orai1 channel

5 We overexpressed stromal interaction molecule 1 (STIM1) and Orai1, the co

6 xpress the two molecular components of SOCE--stromal interaction molecule 1 (Stim1) and Orai1--and ex

7 ed, whereas the expression of Ca(2+) -sensor stromal interaction molecule 1 (STIM1) and store-operate

8 ditions that induce contacts mediated by the stromal interaction molecule 1 (STIM1) and the Ca(2+) ch

9 the endoplasmic reticulum (ER) Ca(2+) sensor stromal interaction molecule 1 (STIM1) and the Ca(2+) re

10 lcium channel are the Ca(2+)-sensing protein stromal interaction molecule 1 (STIM1) and the channel p

11 ding the Ca2+ channel ORAI1 or its activator stromal interaction molecule 1 (STIM1) are immunodeficie

12 Stromal interaction molecule 1 (STIM1) deficiency is a r

13 Stromal interaction molecule 1 (Stim1) functions as a se

14 Stromal interaction molecule 1 (STIM1) has been identifi

15 Stromal interaction molecule 1 (STIM1) has recently been

16 We studied the role of stromal interaction molecule 1 (STIM1) in coupling store

17 Stromal interaction molecule 1 (STIM1) is a Ca(2+) senso

18 Stromal interaction molecule 1 (STIM1) is a dynamic calc

19 In non-excitable cells stromal interaction molecule 1 (STIM1) is a key element

20 Stromal interaction molecule 1 (STIM1) is an ER Ca(2+) s

21 Stromal Interaction Molecule 1 (STIM1) is an ER transmem

22 +) entry mechanism in most cancer cells, and stromal interaction molecule 1 (STIM1) is the endoplasmi

23 d Orai channels activated by their regulator stromal interaction molecule 1 (STIM1) on the ER.

24 e, we show that Ca(2+) signaling governed by stromal interaction molecule 1 (STIM1) plays a central r

25 Stromal interaction molecule 1 (STIM1) regulates store-o

26 protein ORAI1 or the Ca(2+) sensing protein stromal interaction molecule 1 (STIM1) result in severe

27 the endoplasmic reticulum (ER) Ca(2+) sensor stromal interaction molecule 1 (STIM1) to ER-plasma memb

28 ntration triggers its Ca(2+) ssensor protein stromal interaction molecule 1 (STIM1) to oligomerize an

29 re fully reconstituted via two proteins, the stromal interaction molecule 1 (STIM1), a Ca(2+) sensor

30 Here, we demonstrate that stromal interaction molecule 1 (STIM1), a sensor of Ca(2

31 amines this issue by focusing on the role of stromal interaction molecule 1 (STIM1), an endo/sarcopla

32 ular myocytes, the physiological function of stromal interaction molecule 1 (STIM1), an endo/sarcopla

33 rexpression of fluorescently tagged RyR2 and stromal interaction molecule 1 (STIM1), an ER Ca(2+) sen

34 n, TRPC1 interaction with the SOCE modulator stromal interaction molecule 1 (STIM1), and Ca(2)(+) ent

35 tion of store operated Ca(2+) entry involves stromal interaction molecule 1 (STIM1), localized to the

36 hannel gating by the CRAC channel activator, stromal interaction molecule 1 (STIM1), remains unknown.

37 vel truncating mutation in the gene encoding stromal interaction molecule 1 (STIM1), the endoplasmic

38 calcium stores results in the aggregation of stromal interaction molecule 1 (STIM1), the endoplasmic

39 We addressed the requirement for stromal interaction molecule 1 (STIM1), the endoplasmic

40 Oxidant stress triggers relocation of stromal interaction molecule 1 (STIM1), the endoplasmic

41 ticulum (ER) triggers the oligomerization of stromal interaction molecule 1 (STIM1), the ER Ca(2+) se

42 the redistribution of the ER Ca(2+) sensor, stromal interaction molecule 1 (STIM1), to peripheral si

43 of the transmembrane Ca(2+) sensor protein, stromal interaction molecule 1 (STIM1), to the junctions

44 An ER calcium sensor, stromal interaction molecule 1 (STIM1), translocates wit

45 depletion, which redistributes and clusters stromal interaction molecule 1 (STIM1), which then coclu

46 (CRAC)-mediated capacitive Ca(2+) entry, and stromal interaction molecule 1 (STIM1)- and Orai1-defici

47 Stromal interaction molecule 1 (STIM1)-mediated SOCE is

48 through activation of the ER calcium sensor stromal interaction molecule 1 (STIM1).

49 We observe that KSR2 deficiency affects stromal interaction molecule 1 (STIM1)/ORAI1 puncta form

50 I(SkCRAC) was reduced by siRNA knockdown of stromal interaction molecule 1 and expression of dominan

51 -activated Ca(2+) (CRAC) channels encoded by stromal interaction molecule 1 and Orai1 are a major rou

52 from control of the expression level of the stromal interaction molecule 1 and Orai1 proteins.

53 rotein levels of Orai1, TRPC1, -C4, -C5, and stromal interaction molecule 1 through MR activation.

54 and the endoplasmic reticulum Ca(2+) sensor stromal interaction molecule 1 with CD20 and CD95 into a

55 stores, and a second phase involving STIM 1 (stromal interaction molecule 1) clustering and CRAC (cal

56 or activated protein kinase C-1), and STIM1 (stromal interaction molecule 1) interact with Orai1 upon

57 STIM1 (stromal interaction molecule 1) regulates Ca(2+) signali

58 We found that STIM1 (stromal interaction molecule 1), the main activator of s

59 sion levels of some SOCE components, such as stromal interaction molecule 1, calcium release-activate

60 ce-site mutation in STIM1, the gene encoding stromal interaction molecule 1, which regulates store-op

61 To determine whether stromal interaction molecule 1-dependent (STIM1-dependen

62 Many proteins, including stromal interaction molecule 1/2 (STIM1/2), Orai1/2/3, a

63 The endoplasmic reticulum calcium sensors stromal interaction molecules 1 and 2 (STIM1 and STIM2)

64 Stromal-interaction molecule 1 (STIM1) is an endoplasmic

65 Stromal-interaction molecule 1 (STIM1), upon sensing the

66 ore-operated Ca(2+) entry pathway, involving stromal interaction molecule-1 (STIM1) and Orai1, but al

67 n the molecular machinery that mediate SOCE: stromal interaction molecule-1 (STIM1), which functions

68 at the stimulation-induced redistribution of stromal interaction molecule-1, a critical event for the

69 , including the transmembrane proteins Stim (stromal interaction molecule) and Orai.

70 t that mice with T-cell-targeted deletion of Stromal Interaction Molecule (STIM) 1 and STIM2 [double-

71 , ORAI2, and ORAI3 proteins and activated by stromal interaction molecule (STIM) 1 and STIM2.

72 Ca(2+) (CRAC) channels that are activated by stromal interaction molecule (STIM) 1 and STIM2.

73 In line with these observations, the stromal interaction molecule (STIM) 1 and the calcium re

74 dered upon binding, the EF-SAM domain in the stromal interaction molecule (STIM) 1 is distinct in tha

75 a(2+) channel ORAI1 and the ER Ca(2+) sensor stromal interaction molecule (STIM) 1.

76 d by the endoplasmic reticulum Ca(2+) sensor stromal interaction molecule (STIM) 1.

77 Stromal interaction molecule (STIM) 2, but not STIM1, wa

78 AC channel function is the identification of stromal interaction molecule (STIM) and ORAI, two essent

79 The Ca(2+)-sensing stromal interaction molecule (STIM) proteins are crucial

80 has revealed that a calcium-binding protein, stromal interaction molecule (STIM), plays an essential

81 of the store-operated Ca(2+) influx mediator stromal interaction molecule (STIM), the plasma membrane

82 The stromal interaction molecule (STIM)-ORAI calcium release

83 eins in the plasma membrane and activated by stromal interaction molecule (STIM)1 and STIM2 in the en

84 Orai1 and stromal interaction molecule (STIM)1 are critical compon

85 They are activated by stromal interaction molecules (STIM) 1 and 2 in response

86 ontroversy concerning externalization of the stromal interaction molecule STIM1 upon depletion of Ca(

87 Stromal interaction molecules (STIM1 and STIM2) are sing

88 Orai channels and the endoplasmic reticulum stromal interaction molecules (STIMs), is a major Ca(2+)