ライフサイエンスコーパス: stromal interaction molecule 1

1 Many proteins, including stromal interaction molecule 1/2 (STIM1/2), Orai1/2/3, a

2 at the stimulation-induced redistribution of stromal interaction molecule-1, a critical event for the

3 I(SkCRAC) was reduced by siRNA knockdown of stromal interaction molecule 1 and expression of dominan

4 -activated Ca(2+) (CRAC) channels encoded by stromal interaction molecule 1 and Orai1 are a major rou

5 from control of the expression level of the stromal interaction molecule 1 and Orai1 proteins.

6 The endoplasmic reticulum calcium sensors stromal interaction molecules 1 and 2 (STIM1 and STIM2)

7 sion levels of some SOCE components, such as stromal interaction molecule 1, calcium release-activate

8 stores, and a second phase involving STIM 1 (stromal interaction molecule 1) clustering and CRAC (cal

9 To determine whether stromal interaction molecule 1-dependent (STIM1-dependen

10 or activated protein kinase C-1), and STIM1 (stromal interaction molecule 1) interact with Orai1 upon

11 STIM1 (stromal interaction molecule 1) regulates Ca(2+) signali

12 In T-lymphocytes, stromal interaction molecule 1 (STIM1) acts as the intra

13 ric, calcium-selective channels activated by stromal interaction molecule 1 (STIM1) after depletion o

14 3 enhances the signal-induced association of stromal interaction molecule 1 (STIM1) and Orai1 and is

15 Here, we report that stromal interaction molecule 1 (STIM1) and Orai1 channel

16 We overexpressed stromal interaction molecule 1 (STIM1) and Orai1, the co

17 xpress the two molecular components of SOCE--stromal interaction molecule 1 (Stim1) and Orai1--and ex

18 ed, whereas the expression of Ca(2+) -sensor stromal interaction molecule 1 (STIM1) and store-operate

19 ditions that induce contacts mediated by the stromal interaction molecule 1 (STIM1) and the Ca(2+) ch

20 the endoplasmic reticulum (ER) Ca(2+) sensor stromal interaction molecule 1 (STIM1) and the Ca(2+) re

21 lcium channel are the Ca(2+)-sensing protein stromal interaction molecule 1 (STIM1) and the channel p

22 ding the Ca2+ channel ORAI1 or its activator stromal interaction molecule 1 (STIM1) are immunodeficie

23 Stromal interaction molecule 1 (STIM1) deficiency is a r

24 Stromal interaction molecule 1 (Stim1) functions as a se

25 Stromal interaction molecule 1 (STIM1) has been identifi

26 Stromal interaction molecule 1 (STIM1) has recently been

27 We studied the role of stromal interaction molecule 1 (STIM1) in coupling store

28 Stromal interaction molecule 1 (STIM1) is a Ca(2+) senso

29 Stromal interaction molecule 1 (STIM1) is a dynamic calc

30 In non-excitable cells stromal interaction molecule 1 (STIM1) is a key element

31 Stromal interaction molecule 1 (STIM1) is an ER Ca(2+) s

32 Stromal Interaction Molecule 1 (STIM1) is an ER transmem

33 +) entry mechanism in most cancer cells, and stromal interaction molecule 1 (STIM1) is the endoplasmi

34 d Orai channels activated by their regulator stromal interaction molecule 1 (STIM1) on the ER.

35 e, we show that Ca(2+) signaling governed by stromal interaction molecule 1 (STIM1) plays a central r

36 Stromal interaction molecule 1 (STIM1) regulates store-o

37 protein ORAI1 or the Ca(2+) sensing protein stromal interaction molecule 1 (STIM1) result in severe

38 the endoplasmic reticulum (ER) Ca(2+) sensor stromal interaction molecule 1 (STIM1) to ER-plasma memb

39 ntration triggers its Ca(2+) ssensor protein stromal interaction molecule 1 (STIM1) to oligomerize an

40 re fully reconstituted via two proteins, the stromal interaction molecule 1 (STIM1), a Ca(2+) sensor

41 Here, we demonstrate that stromal interaction molecule 1 (STIM1), a sensor of Ca(2

42 amines this issue by focusing on the role of stromal interaction molecule 1 (STIM1), an endo/sarcopla

43 ular myocytes, the physiological function of stromal interaction molecule 1 (STIM1), an endo/sarcopla

44 rexpression of fluorescently tagged RyR2 and stromal interaction molecule 1 (STIM1), an ER Ca(2+) sen

45 n, TRPC1 interaction with the SOCE modulator stromal interaction molecule 1 (STIM1), and Ca(2)(+) ent

46 tion of store operated Ca(2+) entry involves stromal interaction molecule 1 (STIM1), localized to the

47 hannel gating by the CRAC channel activator, stromal interaction molecule 1 (STIM1), remains unknown.

48 vel truncating mutation in the gene encoding stromal interaction molecule 1 (STIM1), the endoplasmic

49 calcium stores results in the aggregation of stromal interaction molecule 1 (STIM1), the endoplasmic

50 We addressed the requirement for stromal interaction molecule 1 (STIM1), the endoplasmic

51 Oxidant stress triggers relocation of stromal interaction molecule 1 (STIM1), the endoplasmic

52 ticulum (ER) triggers the oligomerization of stromal interaction molecule 1 (STIM1), the ER Ca(2+) se

53 the redistribution of the ER Ca(2+) sensor, stromal interaction molecule 1 (STIM1), to peripheral si

54 of the transmembrane Ca(2+) sensor protein, stromal interaction molecule 1 (STIM1), to the junctions

55 An ER calcium sensor, stromal interaction molecule 1 (STIM1), translocates wit

56 depletion, which redistributes and clusters stromal interaction molecule 1 (STIM1), which then coclu

57 (CRAC)-mediated capacitive Ca(2+) entry, and stromal interaction molecule 1 (STIM1)- and Orai1-defici

58 Stromal interaction molecule 1 (STIM1)-mediated SOCE is

59 through activation of the ER calcium sensor stromal interaction molecule 1 (STIM1).

60 We observe that KSR2 deficiency affects stromal interaction molecule 1 (STIM1)/ORAI1 puncta form

61 ore-operated Ca(2+) entry pathway, involving stromal interaction molecule-1 (STIM1) and Orai1, but al

62 n the molecular machinery that mediate SOCE: stromal interaction molecule-1 (STIM1), which functions

63 Stromal-interaction molecule 1 (STIM1) is an endoplasmic

64 Stromal-interaction molecule 1 (STIM1), upon sensing the

65 We found that STIM1 (stromal interaction molecule 1), the main activator of s

66 rotein levels of Orai1, TRPC1, -C4, -C5, and stromal interaction molecule 1 through MR activation.

67 ce-site mutation in STIM1, the gene encoding stromal interaction molecule 1, which regulates store-op

68 and the endoplasmic reticulum Ca(2+) sensor stromal interaction molecule 1 with CD20 and CD95 into a