ライフサイエンスコーパス: structural

1 tegy encompassing the expression of ZIKV non-structural-1 (NS1) protein from a clinically proven safe

2 ractivity disorder (ADHD) is associated with structural abnormalities in total gray matter, basal gan

3 One or more structural abnormalities were found in all 45 (100%) hem

4 Despite its importance, the structural alignment problem has not been formulated, mu

5 r the development of a host of high strength structural alloys, in particular, aluminium alloys for t

6 Our results show that m6A-dependent RNA structural alterations can promote direct binding of m6A

7 ansgene architecture, somatic mutations, and structural alterations.

8 erminal, moiety of MF6p/HDMs has a predicted structural analogy with cell-penetrating peptides and th

9 as further investigated through the multiple structural analyses including HPLC, IR and NMR.

10 re-based vaccine design depends on extensive structural analyses of antigen-antibody complexes.Single

11 Structural analysis and computational studies of MalA' i

12 thelium are very resistant to evidence-based structural analysis because of their inherent flexibilit

13 Structural analysis indicates that the 3 disease-associa

14 Structural analysis of a prototypical Vbeta8.1(+) TCR-H-

15 These findings, thus, uncover limitations of structural analysis of drug binding using X-ray structur

16 ith the Volta phase plate enabled a detailed structural analysis of TPPII despite its low abundance.

17 Protein structural analysis revealed that Phe10Leu mutation may

18 Structural and biochemical analyses revealed that UbVs s

19 Structural and bioinformatic analyses suggested that a c

20 ty to guide bone tissue regeneration through structural and biological cues.

21 nanocomposites, with exquisite control over structural and chemical parameters at multiple length sc

22 Combining the structural and dynamic investigations, rationales were d

23 Additional structural and dynamical aspects of the helical conforma

24 AF, and each factor has been shown to induce structural and electric remodeling of the atria.

25 We found that in healthy ageing, structural and functional alterations of muscle fibres o

26 We, therefore, recommend studying structural and functional aspects of ligand interactions

27 fabrication of composites exhibiting unique structural and functional capabilities.

28 rganized into an activity architecture whose structural and functional characteristics can be reveale

29 To investigate the structural and functional determinants of pattern separa

30 This work paves the way for overcoming the structural and functional limitations of thermal metamat

31 d with a reduced bread volume due to changed structural and functional properties of protein and star

32 covalent interactions can greatly expand the structural and functional space of supramolecular nanost

33 have small circular genomes with substantial structural and genetic similarity to bacteria.

34 Thus, the JDBM-2 stent with up to 6-month structural and mechanical integrity and excellent tissue

35 The structural and mineralization abnormality led to slight

36 s will require new tools for high-throughput structural and molecular profiling of the diverse popula

37 sing computational analysis, we describe the structural and photophysical properties of these unique

38 diac imaging in CHD, including assessment of structural and residual heart disease before and after s

39 pt interaction are based on a combination of structural and sequence components of the antisense lncR

40 oral orchestration of a series of metabolic, structural, and functional changes after aseptic trauma

41 mprehensive view of the genetic, biochemical structural, and serological bases of serotypes 35C and 4

42 iMet, a computational tool that facilitates structural annotation of metabolites not described in da

43 Structural annotation of metabolites relies mainly on ta

44 tubules using cell biological, in vitro, and structural approaches.

45 Structural assessment predicted that the five amino acid

46 differences in spectral data, the incorrect structural assignment of the natural product serratin wa

47 Structural attributes of the upper forest canopy were th

48 ctivation with small molecules and provide a structural basis for further development of Sirt6 activa

49 ate and the selectivity filter underlies the structural basis for gating in potassium ion channels.

50 This unique interaction provides a structural basis for grazoprevir's higher potency than s

51 Na(+)-selective AtTPC1 mutant elucidates the structural basis for Na(+) selectivity in mammalian TPCs

52 residues within Synaptotagmin that suggest a structural basis for several activities required for fus

53 The structural basis for substrate recognition and transloca

54 ges in the size of the D3-D4 cleft provide a structural basis for the conformational selectivity of t

55 s is the first study to provide the intimate structural basis for the normal and reverse prenylations

56 Modeled structural basis for the recognition of alpha2-3-sialyll

57 ne-containing collagen peptide and provide a structural basis for this stabilization with an atomic r

58 ed chemical shift predictions to explore the structural basis of allosteric product release.

59 Understanding the structural basis of immune recognition of capsular polys

60 The structural basis of the switch and many of the pathways

61 The structural basis underlying these distinctive transport

62 One goal of structural biology is to understand how a protein's 3-di

63 The PCDDB has found broad usage by the structural biology, bioinformatics, analytical and pharm

64 lectual disability of any degree, and (3) no structural brain abnormalities or metabolic conditions t

65 scuss the potential neurobiological basis of structural brain alterations in the disorder, highlighti

66 Structural brain differences have been associated with B

67 greater protein oligomerization from a minor structural change.

68 to investigate the association between these structural changes and the development of certain ocular

69 ion temperature at ambient pressure reverses structural changes and the initial glassy state is recov

70 he model can be used to quantify significant structural changes in boutons in long-term imaging exper

71 merase to the promoter whereas TFB2M induces structural changes in mtRNAP to enable promoter opening

72 the films, which has resulted in significant structural changes in the fully strained SFO films.

73 drive phloem transport only in concert with structural changes in the phloem that reduce transport r

74 Structural changes observed in the Raman spectra during

75 and electroretinography results; and retinal structural changes observed on clinical funduscopy as we

76 In exactly this region, structural changes occur in the ATP-induced opening of H

77 These distinct structural changes occurring in both Abeta(1-40) oligome

78 ding social inference is associated with the structural changes of specific social brain regions in l

79 To describe objectively the possible structural changes of the macula and optic nerve head in

80 2+) and ROS signaling through Ca(2+)-induced structural changes promoting dimerization of hSCGN.

81 is known about the dynamic compositional and structural changes that these systems undergo during pre

82 The key structural changes to 1 include bioisosteric replacement

83 ed-flow SAXS measurements, revealing dynamic structural changes upon iron binding and core formation,

84 Ceramide-rich membrane areas promote structural changes within the plasma membrane that segre

85 iated with bronchial inflammation and airway structural changes.

86 heless, the system still faces challenges in structural characteristics, incentives and policies, and

87 Structural characterization of one of these V2 Abs revea

88 However, significant challenges exist for structural characterization of the enzymes responsible f

89 Full structural characterization of the full-length oligomeri

90 nteractions, these limitations had precluded structural characterization of the PIC.

91 Despite their potential, structural characterization of these glycan epitopes rem

92 unds are presented, along with comprehensive structural characterizations (X-ray diffraction, electro

93 This study suggests that 12f is a new structural class of amphiphilic peptide with rapid fungi

94 tal of 158 individual HOCs from 32 different structural classes were detected in the blubber of 4 adu

95 A structural comparison of holo-ScNsrR with an apo-IscR-DN

96 Structural comparisons demonstrate that the initiation m

97 Their structural complexity is embodied in the densely functio

98 gical needs to detect food/predators and the structural complexity of the environments.

99 mRNAs tested, regardless of their degree of structural complexity.

100 dings, visual impairment, and association of structural complications of uveitis with visual impairme

101 Tg of carbon per year, and provide important structural components for life in coastal waters.

102 treating UTI, without notably disrupting the structural configuration of the gut microbiota.

103 in long flexible regions that adopt multiple structural conformations.

104 pathways, emerges primarily via monosynaptic structural connections.

105 ave been widely used to infer the underlying structural connectivity in neuronal networks.

106 nial magnetic stimulation were used to study structural connectivity, cerebral blood flow (CBF), and

107 Structural constraints also explain one-third of alloste

108 Structural constraints for the bound state are obtained

109 uently active compounds, indicating that the structural context in which PAINS occur modulates their

110 We apply the method in different structural contexts of G-quadruplexes and their complexe

111 of dynamic neurophysiological correlates of structural controllability.

112 rect correspondence between the atomic-level structural correlations and reported properties.

113 bility of SIFSIX-2-Cu-i in comparison to its structural counterparts is attributed to structural feat

114 The fibers presented different structural, crystallinity, and thermal properties, depen

115 NMR to bridge the gap between functional and structural data and models.

116 The surfeit of protein structural data enables development of computational met

117 ity complex (pMHC)-tetramer-sorted cells and structural data.

118 Structural defects observed in the postsynaptic compartm

119 via particle rearrangements localized around structural defects.

120 mono- and biactinide frameworks with minimal structural density.

121 algorithm of Decision Forest (DF) with Mold2 structural descriptors.

122 The structural design relied on the assumptions that the tau

123 Gross qualitative patterns and fine structural details of the data are inconsistent with the

124 However, inflammation and structural deterioration limit transplant durability.

125 e P-gp with a shortened linker to facilitate structural determination.

126 sequence conservation, there are significant structural differences between microtubules assembled in

127 ond-long atomistic simulations elucidate key structural differences between monomeric ApoE3 and ApoE4

128 s of Bcr-Abl p210, which constitute the only structural differences to p190.

129 , staple dissociation increases which causes structural disintegration.

130 e ApoE3 and ApoE4 sequences can give rise to structural dissimilarities between the two isoforms, whi

131 range for the same mass, suggesting a large structural diversity of these drugs.

132 In agreement with an absence of predicted structural domains, these were characterized as intrinsi

133 T) at 1.3 A resolution, and by exploring the structural dynamics of Aqy1 during freezing through mole

134 (HDX-MS) provides detailed insight into the structural dynamics of each subunit in a polymerization-

135 d are a critical element for unravelling the structural dynamics of matter.

136 otein Ribeye, very little is known about the structural dynamics of ribbons.

137 Here, we study the structural effect of three CMT-causing mutations in tyro

138 veals the different nature of the electronic structural effects of these two key principal amine comp

139 o examine in detail correlations between the structural, electronic and catalytic properties of ceria

140 h nucleus the embryonic volume arises from a structural element contained within the voxels identifie

141 phodiester bonds have emerged as a plausible structural element in prebiotic RNAs.

142 uence element also turns into a well-defined structural element upon fibril formation.

143 rate throughput, could be used to screen for structural elements, small molecules, and host factors t

144 ncing, and biochemical analyses coupled with structural elucidation of metabolites revealed that acyl

145 hrub seedling and mammal abundances, and use structural equation modelling to compare competing troph

146 We used structural equation modelling to test the importance of

147 light on the mechanisms of polyamorphism and structural evolution in metallic glasses under pressure.

148 The structural evolution of the Pt surface morphology strong

149 its structural counterparts is attributed to structural features and therefore offers insight into th

150 But these structural features are not completely understood.

151 Key structural features interacting with KHK were discovered

152 These data indicate that the unique structural features of formoterol allow it to interact w

153 Key structural features of the catalysts are analyzed, as is

154 bbit muscle GPb inhibitor complexes revealed structural features of the strong binding and offered an

155 cities for Ins(1,2,4,5,6)P5, have identified structural features that account for this difference, an

156 ATP-dependent mechanism, its biochemical and structural features that ensure efficient proteolysis an

157 Several clever structural features underlie this amazing phenomenon.

158 as predictive biomarkers, but do not capture structural features within the tissue architecture.

159 dous research interest owing to their unique structural features, fascinating physicochemical propert

160 ter in pathogenic microorganisms with unique structural features.

161 predominant form of iC3b that features high structural flexibility.

162 This study provides a structural framework for a mechanistic understanding of

163 Our data provide a structural framework for the enhanced activation of the

164 Plant Reactome employs the structural framework of a plant cell to show metabolic,

165 ods to systematically derive rules governing structural-functional relationships.

166 NA synthetases to be targeted in the Seattle Structural Genomics Center for Infectious Disease (SSGCI

167 r to other sea anemone peptides belonging to structural group 9a.

168 d clustering of structural proteins with non-structural HCV proteins, including core, E2, NS4B, and N

169 ICD) shocks in small series of patients with structural heart disease (SHD) and recurrent ventricular

170 VCs) most frequently occur in the context of structural heart disease.

171 lity and stiffness, without disrupting local structural heterogeneity.

172 The atlas is created from molecular and structural high-resolution neuroimaging data consisting

173 No structural homologs or high-resolution structure exists

174 By means of a formal structural hybridization of the antipsychotic drug aripi

175 R images, consisting of single-plane (axial) structural imaging (T2-weighted turbo spin-echo and diff

176 Those fluctuations do not only have structural impact, but additionally a dynamical one: The

177 This basic structural information could be relevant for providing l

178 eventually lead to wrong conclusions on the structural information derived from chemical cross-linki

179 Lack of structural information has precluded elucidation of the

180 urally relied extensively on available viral structural information.

181 -1 Fos/Jun transcription factors and provide structural insight for therapeutic interventions targeti

182 for simple and complex ligands augmented by structural insight into murine langerin.

183 Sirt2 inhibitors with a compact scaffold and structural insights for further inhibitor improvement.

184 The structural insights underscore the adaptability of fusic

185 ty sensing which is not adequate to evaluate structural integrity and natural cracks.

186 se data definitively establish that complete structural integrity is necessary to observe single-mole

187 known to affect the activity, stability, and structural integrity of proteins.

188 c operating conditions, without compromising structural integrity of the catalyst framework.

189 rom normal muscle use due to the compromised structural integrity of the dystrophin associated glycop

190 re embedded within cell walls, which provide structural integrity, but also spatially constrain cells

191 In-situ structural investigations were performed using confocal

192 own adsorbent, including para-functionalized structural isomers of the type M2(p-dobdc) (p-dobdc(4-)

193 pentafluorophenylbenzamides, providing a new structural lead for ligand design.

194 genes downstream of those encoding the T6SS structural machinery for effector delivery.

195 This process is aided by condensin, a structural maintenance of chromosomes (SMC) family membe

196 structures provide invaluable insight on the structural mechanism of the ion pumping process.

197 Based on the structural merits, this series hydrophilic multilayer gr

198 Here we use biochemical and structural methods to show that two molecules of Cas2/3

199 4G peptide and propose the first eIF4E-eIF4G structural model for plants.

200 Walther and co-workers have proposed a structural model for the TatA oligomer in which TatA mon

201 The combined structural model shows how Ragulator functions as a plat

202 describe opportunities and challenges in RNA structural modeling and design, as recently discussed du

203 Structural modeling and molecular simulations reveal uni

204 Structural modelling suggests that K265 interacts with D

205 In two structural models of the perfluoroarylated product, dist

206 rce microscopy to deliver, in atomic detail, structural models of three key PANS: the hexasome (H2A.H

207 This occurrence of slow structural modification with changes in trap state occup

208 -2,4,8-triene-7,10-diols, which form the key structural moieties of numerous natural biologically act

209 This structural motif is unusually consistent across all spec

210 self-assemblies describe not only the basic structural motif of G-quadruplexes formed by, e.g., telo

211 nadate compounds reveals the key role of VO4 structural motifs and electronic band-edge character in

212 We critically review the current state of structural neuroimaging in AN and discuss the potential

213 Structural OCT alone also had a sensitivity of 100%.

214 The specificity of structural OCT alone was 97.5% for grader A and 85% for

215 Structural optimization led to compound 28, which was 4-

216 hat the S531L mutation imparts subtle if any structural or functional impact on RNAP in the absence o

217 absorption spectroscopy to characterize the structural order of mercury in Hg(II)-DOM-sulfide system

218 lysis of vibrational spectra and appropriate structural order parameters as a function of temperature

219 However, synthetic control of the structural ordering in such a complex quaternary system

220 esses occurring within the assemblies to the structural organization of the pi-systems.

221 al quadrant model was built to represent the structural origins of regio- and enantioselectivity.

222 SV NS1 protein, which suggests that NS1 is a structural paralogue of hRSV matrix (M) protein.

223 ular mass distribution, and hydrodynamic and structural parameters of amylose (maize, sorghum, Hylon

224 ion emerges during early development and how structural patterning goes hand-in-hand with functional

225 calculations, the Gly1629Glu mutation causes structural perturbation in the A2 domain and thereby des

226 acids were used as probes, and thus possible structural perturbations were minimized.

227 This electrostatic-doping control of structural phase transition opens up new possibilities f

228 Tailoring structural phase transitions using alloying is a novel i

229 designing all 2D device architecture as the structural phases in 2D materials such as transition met

230 tribution to sensorimotor recovery, but this structural plasticity is also limited to the first few w

231 propose that signaling pathways involved in structural plasticity likely underlie this form of trans

232 ent, indicating preserved impact of Cav-1 on structural plasticity of hippocampal neurons with age.

233 reveal a role of Crem in regulating striatal structural plasticity.

234 Moreover, structural priming has now reached sufficient methodolog

235 e powerful combination of static and dynamic structural probes enabled us to derive direct correspond

236 In the modified houses, major structural problems such as leaking roofs were repaired,

237 Erosive wear undermines the structural properties of enamel resulting in irreversibl

238 ysical/observable-based approach to identify structural properties of quiescent glasses and relate th

239 To understand the relationship between structural properties of the beta2-adrenoceptor ligands

240 The structural properties of the resulting network depend on

241 e can drastically alter their electronic and structural properties.

242 nce depends on the interferon antagonist non-structural protein (NSs), which remains poorly character

243 ed to truncating mutations in the sarcomeric structural protein titin (TTNtv).

244 ng the potential risk of ADE associated with structural protein-based ZIKV vaccines.

245 that FLIm parameters linked to the amount of structural proteins (e.g. collagen, elastin) and lipids

246 ings underscore the importance of retroviral structural proteins for integration site selection and t

247 PH1 functions as a hub linking key motor and structural proteins that contain intrinsically disordere

248 ced viral assembly and induced clustering of structural proteins with non-structural HCV proteins, in

249 icity in disordered solids via a microscopic structural quantity, "softness," designed by machine lea

250 ree energy costs that may be associated with structural rearrangements between the oligomer and fiber

251 embly of ribosomal proteins and numerous RNA structural rearrangements.

252 lone or in recombinant RSVs demonstrate that structural regions unique to NS1 contribute to modulatio

253 lying antidepressant properties of ketamine, structural remodeling of prefrontal and hippocampal neur

254 e identify a signaling cascade that provokes structural remodeling of the RMS through recruitment of

255 h crystalline alloys, MGs have some specific structural responses to neutron irradiation.

256 Structural retinal imaging biomarkers are important for

257 These results define direct structural roles for yeast CAF-1 subunits and uncover a

258 teria on permeable membranes that serve as a structural scaffold.

259 Here, through a biochemical and structural screening paradigm, we have identified JNJ096

260 angiography (FA) and OCT was determined for structural SD-OCT alone, en face OCTA alone, and with en

261 This glycoprotein undergoes a major structural shift from the prefusion (pre-F) to the postf

262 didate 2), a Plasmodium berghei protein with structural similarities to subtilisin-like proteins.

263 and comparative analyses reveal sequence and structural similarities with the distant Acidobacteria L

264 tein surfaces are grouped by measuring their structural similarities.

265 Despite the high structural similarity between the two SH2 domains, we ob

266 these loops evolved independently, but their structural similarity suggests a common ancestor.

267 rapidly than Tim9 despite high sequence and structural similarity, and loss of Tim10 is accelerated

268 Our study emphasizes that maintaining structural stability is the key step towards high-voltag

269 the actin cytoskeleton, would compromise the structural stability of spines, leading to their loss.

270 aled that Phe10Leu mutation may decrease the structural stability of the TBL1XR1 protein.

271 rones perform these common functions, recent structural studies of many different histone chaperones

272 oprotein interactions have been derived from structural studies of oligomerized, RNA-encapsidating nu

273 Structural studies of the beta1AR define ligand-binding

274 The molecular and structural studies presented here thus reveal the mechan

275 sics for sample manipulation, functional and structural studies, detection and material processing.

276 ed a soluble IN fusion protein to facilitate structural studies, through which we present a high-reso

277 molecular docking was made to complement the structural study.

278 on shift in a subset of the original Abeta42 structural sub-populations, including a sevenfold enhanc

279 We propose that NDK5 dimer is an RS structural subunit with an additional mechanism that use

280 tions persist, however, about how individual structural subunits are assembled into a functional holo

281 Individual sites analysed structural T1-weighted MRI brain scans with harmonised p

282 The superconductivity is due to a structural transformation into another allotrope and acc

283 Their activity and structural underpinnings provide insights into biologica

284 cardiovascular homeostasis and therapy, our structural understanding of the MBS CC interaction with

285 The presence of the flavanol structural unit in the pyranoanthocyanins led to an incr

286 The centromere is the structural unit responsible for the faithful segregation

287 To understand the population genetics of structural variants and their effects on phenotypes, we

288 ns (MEIs) represent approximately 25% of all structural variants in human genomes.

289 We show that specific structural variants may be causative for quantitative tr

290 notypes, we developed an approach to mapping structural variants that segregate in a population seque

291 es indicated a stronger regulatory impact of structural variants, as they affect more transcription f

292 ycopeptides with different classes of glycan structural variants, including high mannose, sialylated,

293 iana genomes, we identified 6502 segregating structural variants.

294 ere we present SVScore, a tool for in silico structural variation (SV) impact prediction.

295 Structural variation (SV) influences genome organization

296 ivergent strategy that allows for systematic structural variation and the ability to conduct a carefu

297 oligomeric interfaces, 19% arise from family structural variation, and 27% are in repeat proteins lik

298 Large structural variations (SVs) within genomes are more chal

299 We found that small structural variations in the monomers dramatically affec

300 The promotional effects of structural water on the disordered vanadium oxide nanosh