ライフサイエンスコーパス: structural alteration

1 ngle-nucleotide mutations in the vicinity of structural alteration.

2 ycosylation site likely responsible for this structural alteration.

3 le ground for studying the mechanism of this structural alteration.

4 ent parts of the cage can be changed without structural alteration.

5 t the observed kinetic diversity arises from structural alteration.

6 ansgene architecture, somatic mutations, and structural alterations.

7 he collapsed state without substantial local structural alterations.

8 from the proton release group and resulting structural alterations.

9 re helping to uncover potentially associated structural alterations.

10 glomeruli did not have any major sequence or structural alterations.

11 tral role of protein phosphorylation for the structural alterations.

12 extreme stability and rare examples of their structural alterations.

13 otide changes occur frequently near sites of structural alterations.

14 t position 20 (P20L), resulting in secondary structural alterations.

15 , acetylation is known to produce nucleosome structural alterations.

16 ar earlier and more predominantly than other structural alterations.

17 h the disappearance of CSR- and SHM-mediated structural alterations.

18 ed packaging of bacteriophage phi29 DNA with structural alterations.

19 through the cumulative effect of many small structural alterations.

20 ) after global cerebral ischemia on synaptic structural alterations.

21 feature of cancer that involves large-scale structural alterations.

22 Recovery sleep normalizes these structural alterations.

23 in biological activity in response to minor structural alterations.

24 this activity could be abolished by multiple structural alterations.

25 gesting the first evidence in vivo of NOTCH3 structural alterations.

26 and inflammation and were protected against structural alterations.

27 ction evolve independently and are caused by structural alterations affecting the S-haplotype.

28 Similarly, ultrastructural analysis revealed structural alteration among hair cells within 15 minutes

29 de substitution rate is higher near sites of structural alteration and decreases with increasing dist

30 at Val-1(beta) gives rise to less pronounced structural alteration and different functional change.

31 that protein can change, either because of a structural alteration and/or a direct modification of an

32 uggests an association between the predicted structural alteration and/or damage to retinoschisin and

33 tutions and small insertion/deletions, large structural alterations and copy number events.

34 mitochondrial leak of OPA1 leads to cristae structural alterations and exposure of previously seques

35 and a 3-fold increase in platelet size with structural alterations and functional impairments in act

36 lexes bind to promoters to control chromatin structural alterations and gene activation in a cell con

37 pressure (MAP) and was associated with renal structural alterations and proteinuria characteristic of

38 ecular dynamic simulations confirm the local structural alterations and the Raman sensitive band iden

39 However, characterization of complex structural alterations and their underlying mechanisms r

40 reduces atrial sympathetic nerve sprouting, structural alterations, and AF complexity in goats with

41 est that learning-induced freezing behavior, structural alterations, and enhanced neural sensory repr

42 These structural alterations are attributed to a change in pre

43 Associated with these structural alterations are compensatory changes in the p

44 n transcripts have been reported, additional structural alterations are largely uncharacterized.

45 Thus, in the mutational landscape, structural alterations are linked to single-nucleotide c

46 l damage, whereas in minimal change disease, structural alterations are mostly transient.

47 The identified structural alterations are, for the most part, not consi

48 rom these features, there are no significant structural alterations as a result of either substitutio

49 icated that the mutations caused undesirable structural alterations as evidenced by significant chang

50 iron-sulfur centers, rather than from global structural alterations as has been suggested previously.

51 novel EPHB4 mutations that lead to putative structural alterations as well as increased cellular pro

52 ar smooth muscle cells (vSMCs) can result in structural alterations associated with aneurysms and vas

53 Histologic studies revealed that structural alterations associated with thymic involution

54 ature that has implicated direct or indirect structural alterations at dendritic spines in the pathog

55 ens from cryptogenic patients not presenting structural alterations at imaging.

56 ular and animal model studies that implicate structural alterations at spiny synapses in the pathogen

57 vestigated by 205Tl+ NMR to monitor possible structural alterations at the active site by Thr-298 mut

58 formation in the nucleus, as well as virion structural alterations at the cell surface and in the cy

59 Fourth, the profound structural alterations at the EPs likely contribute impo

60 Our results show that m6A-dependent RNA structural alterations can promote direct binding of m6A

61 and binding assays, we offer evidence that a structural alteration caused by phosphorylation partiall

62 ancy of the photoreceptor but is caused by a structural alteration close to the ATP-binding site.

63 CR)-peptide-MHC complexes reveal substantial structural alterations compared to antimicrobial TCRs.

64 s introduced in apoE4-mut2 result in smaller structural alterations compared with those observed in a

65 nally, the SAXS data indicate a pH-dependent structural alteration consistent with either a pH-induce

66 These structural alterations correlate with protein degradatio

67 Our findings raise the possibility that structural alterations could be a general mechanism unde

68 synthesized, demonstrating that a number of structural alterations could be made while maintaining g

69 As these structural alterations did not impair functional express

70 chizophrenia phenotype, brain functional and structural alterations differentiate schizophrenic patie

71 atures of natural B-form DNA, but with a few structural alterations due to its increased helical diam

72 ubunit F of V-ATPases is proposed to undergo structural alterations during catalysis and reversible d

73 ate that b-type cytochromes may also undergo structural alterations during mitochondrial swelling and

74 Here we investigate the relationship between structural alterations (e.g., insertions and deletions)

75 g processes, resulting in macromolecular and structural alterations - features similar to those seen

76 nally greater gray matter and persistence of structural alterations following long-term recovery.

77 Although the sensitivity of detecting structural alterations from exomes is considerably lower

78 Although a number of structural alterations have been associated with the pat

79 Either modified ANP plasma levels or peptide structural alterations have been involved in development

80 This suggests that some structural alterations have to take place on the pathway

81 We conclude that agonist ligands initiate structural alteration in AhR that is Arnt-dependent and

82 At the species level, genes with structural alteration in nearby regions show increased s

83 Extensive structural alteration in omega6 makes it more rigid, the

84 This suggests a structural alteration in P(M) that is centered on the Hi

85 The double mutants show only slight structural alteration in the beta-heme pockets.

86 n, changes at selected sites induce a global structural alteration in the direction of an outward-ope

87 of amino acid side-chains without wholesale structural alteration in the polypeptide appears to occu

88 To clarify if structural alteration in these brain areas can be verifi

89 here that the BLIMP1 gene is inactivated by structural alterations in 24% (8 out of 34) activated B

90 sease (AD) is associated with functional and structural alterations in a distributed network of brain

91 st that p53 is able to bind DNA with certain structural alterations in a sequence-independent manner

92 These structural alterations in aging mitochondria correlate w

93 The findings indicate that subtle structural alterations in apoA-I may alter the stability

94 are now underway to understand the impact of structural alterations in autoimmune TCR-pMHC complexes

95 This was also evident from structural alterations in BAT morphology, including mito

96 Although pre-RC deficiency induces chromatin structural alterations in both nontransformed and cancer

97 f arrestin binding, we directly observed the structural alterations in both reaction partners.

98 We aimed to characterize functional and structural alterations in cerebral microvasculature befo

99 s in CC density correlate with photoreceptor structural alterations in choroideremia.

100 Although recent studies suggest that structural alterations in chromatin are critical for tri

101 poisomerase-induced DNA breaks and chromatin structural alterations in conjunction with AIRE-dependen

102 f our analyses provide initial evidence that structural alterations in corticocerebellar circuitry su

103 Structural alterations in DNA can serve as natural imped

104 tration to pregnant rabbits causes permanent structural alterations in dopamine-rich cerebral cortica

105 es of intratumoral androgen synthesis and AR structural alterations in driving AR activity in CRPC, m

106 We propose that structural alterations in eIF2gamma subtly alter the con

107 The resultant structural alterations in hippocampal neurons in vivo ar

108 hanges in their expression patterns and gene structural alterations in human tumors.

109 Structural alterations in individual posterior lobules,

110 In addition, evidence for structural alterations in key oxytocinergic regions emer

111 nderstanding of the extent and nature of the structural alterations in limb muscles in patients with

112 Using fluorescence spectroscopy to probe structural alterations in lyophilized proteins has been

113 as a key factor mediating Lkb1 loss-induced structural alterations in mammary epithelium and BM frag

114 epressive Disorder Working Group on cortical structural alterations in MDD.

115 d properties of Ac-6-FP were attributable to structural alterations in MR1 that subsequently affected

116 S.V(+) and SJL-beta2M(-/-) mice did not have structural alterations in Myc or T(12;15) translocations

117 commissure, an increase in the frequency of structural alterations in myelin sheaths, and an increas

118 rative conditions that correlate to specific structural alterations in neurons that are believed to b

119 eizures can induce more subtle functional or structural alterations in neurons.

120 t a different extent while they both induced structural alterations in nucleic acids.

121 um in rate, attributed to the onset of local structural alterations in or near the binding site, occu

122 ociated with cognitive dysfunction and brain structural alterations in otherwise healthy adults.

123 ctric field (PEF) treatments caused cellular/structural alterations in Oxalis tuberosa (oca) tubers a

124 , the findings provide new insights into the structural alterations in patients with dilated cardiomy

125 tered cocaine or food self-administration on structural alterations in PL neurons.

126 This is paralleled by structural alterations in plaque composition, which may

127 ltreatment results in similar functional and structural alterations in previously maltreated but heal

128 orts that a decrease in pH below 6.0 induces structural alterations in profilin, favoring dissociatio

129 Neuroimaging studies have shown structural alterations in several brain regions in child

130 vide evidence for a functional effect of the structural alterations in Sle1c Crry and suggest that th

131 ovel cellular and extracellular matrix-level structural alterations in term and preterm human fetal a

132 guishable from wild-type beta, implying that structural alterations in the AB domain do not necessari

133 This appears to give rise to substantial structural alterations in the amino-terminal globular do

134 Together, these data demonstrate that structural alterations in the AR gene are linked to stab

135 atial distribution of fibrillation waves and structural alterations in the atrial free walls in a goa

136 90 mm Hg and with evidence for functional or structural alterations in the cardiovascular system.

137 ules VI and VII are underdeveloped, while no structural alterations in the cerebral cortex are observ

138 nstrate that sialylation induces significant structural alterations in the Cgamma2 domain and propose

139 in the Xaa positions does not lead to large structural alterations in the collagen triple helix.

140 gnal relay from SRII to HtrII involves early structural alterations in the deeply membrane-embedded d

141 ted oligosaccharides of HS that portray fine structural alterations in the diabetic rats indicative o

142 ry by binding to the coreceptor and inducing structural alterations in the extracellular loops.

143 ormalities in aspects of face processing and structural alterations in the fusiform gyrus, part of th

144 nucleotide polymorphism genotyping to detect structural alterations in the genomic DNA of patients wi

145 Structural alterations in the hippocampus and other medi

146 Most epileptic rats had no apparent structural alterations in the hippocampus detectable usi

147 e brains of Df(16)A(+/-) mice and results in structural alterations in the hippocampus.

148 ment in glandular tissues is associated with structural alterations in the hollow ducts and spherical

149 of Pseudomonas aeruginosa ClpV1 and observed structural alterations in the hydrophobic groove.

150 ycemic db/db mouse suppresses functional and structural alterations in the kidney, in the absence of

151 CF-5/20 are not related to the induction of structural alterations in the LPS or cell permeability.

152 is associated with persistent functional and structural alterations in the medial prefrontal cortex (

153 ested whether chronic social defeat produces structural alterations in the mPFC in mice.

154 To elucidate the structural alterations in the mutant enzyme that might l

155 PEL cells, in contrast, lack structural alterations in the MYC gene, but have deregul

156 Structural alterations in the platelet internal membrane

157 Chronic stress leads to neurochemical and structural alterations in the prefrontal cortex (PFC) th

158 The above structural alterations in the recently activated CTLs ar

159 precede the ability to detect functional and structural alterations in the retina, ONH, and visual co

160 tron microscopy further revealed PCD-related structural alterations in the TAB-meristem of BE-treated

161 The differences in intrinsic KIEs reflect structural alterations in the transition states.

162 The structural alterations in the trimolecular complex are d

163 At the earliest point, MMP-2 leads to structural alterations in the tubular basement membrane,

164 lpha-helix and the C-terminal helix, showing structural alterations in the two ScDF structures.

165 nd irrelevant stimuli, and is accompanied by structural alterations in the white matter of the fronta

166 ich cells of the human body normally acquire structural alterations in their DNA post-zygotically.

167 in schizophrenia reflects molecular and not structural alterations in these cells and their axon ter

168 copy tools, which fail to reveal any notable structural alterations in these regions at a submicrosco

169 thodology was applied to investigate whether structural alterations in this oligosaccharide pool, enr

170 We highlight important structural alterations in two loops flanking the dimer i

171 ) exhibited basal bradycardia but no cardiac structural alterations; in contrast, no homozygotes were

172 fuse large B-cell lymphoma--harbour frequent structural alterations inactivating CREBBP and, more rar

173 ucleotide variations and somatic large-scale structural alterations, including amplifications and del

174 channel inactivation is sufficient to drive structural alterations, including atrial and ventricular

175 aged mice revealed a variety of age-related structural alterations, including axonal swellings, spro

176 The resulting structural alterations indicate that LTA4 entrance into

177 Microfractures are structural alterations indicative of areas of tissue rem

178 We have found that the structural alterations induced by sialylation can be mim

179 demonstrate that Fc variants that mimic the structural alterations induced by sialylation, such as F

180 The structural alterations induced by the refolding procedur

181 We present evidence that structural alteration induces single-nucleotide changes

182 The observed structural alteration involves a substantial proportion

183 sc2 tumor suppressor gene, in the absence of structural alterations involving the HMGA2 locus.

184 This structural alteration is associated with agonist-indepen

185 The degree of structural alteration is however very significant, mimic

186 The role of distant enhancers in these structural alterations is not well understood.

187 This structural alteration leads to an expansion of the AR bi

188 Structural alterations led to altered mechanical propert

189 ergo numerous physiological, biochemical and structural alterations, making them more attractive to s

190 This structural alteration may increase helix-helix interacti

191 Similarly, mutations leading to structural alterations may induce constitutive inactivat

192 These structural alterations may provide DS with an additional

193 ulted in a detectable secondary and tertiary structural alteration measured by circular dichroism.

194 ther, our data establish that the Pro32Pro33 structural alteration modifies the function of integrin

195 Despite this severe structural alteration, mur3 plants were phenotypically n

196 for productive coenzyme binding, whereas the structural alterations near the active site are consiste

197 Therefore, the structural alterations observed for drug-resistant mutat

198 profilin-actin complex, corresponds with the structural alterations observed in the partially unfolde

199 hanisms, showing complex relationships among structural alterations observed with conventional neuroi

200 of a novel hybrid series of compounds where structural alteration of aromatic hydrophobic moieties c

201 st time that chronic alcohol exposure causes structural alteration of dendrites and their spines in t

202 plex 16p11.2 rearrangement involving de novo structural alteration of KCTD13.

203 nt with a mechanism involving a mAb-mediated structural alteration of P1 on the cell surface, immuniz

204 demonstrate that centrosome amplification, a structural alteration of the cytoskeleton, can promote f

205 The consequences of the structural alteration of the DNA-bound A35T mutant vnd/N

206 ated by both DNA sequence information and by structural alteration of the duplex.

207 Inactivation results from structural alteration of the heme a(3)-Cu(B) active site

208 contributes to tRNA binding and suggesting a structural alteration of the substrate-binding pocket oc

209 P-43, FUS, and hnRNPA2B1, bind to and induce structural alteration of UGGAAexp.

210 triggered allergic lungs with functional and structural alterations of airways.

211 idespread transport deficits, which preceded structural alterations of axons, cargos, or microtubules

212 ime to our knowledge, an association between structural alterations of bronchi and PH in COPD.

213 Widespread structural alterations of cancer genomes are increasingl

214 istone H3S10 phosphorylation are a result of structural alterations of chromatin.

215 ablation of the Kera gene resulted in subtle structural alterations of collagenous matrix and did not

216 impaired alcohol seeking was associated with structural alterations of dendritic spines in the CeA an

217 n in keratinocytes of transgenic mice causes structural alterations of epidermal desmosomes.

218 le aspects of asthma pathogenesis, including structural alterations of epithelial cells and smooth mu

219 rometry was used to characterize dynamic and structural alterations of human PAI-1 (hPAI-1) in relati

220 Aging was associated with profound structural alterations of murine uterine arteries, inclu

221 ffects of alcohol exposure and withdrawal on structural alterations of NAc MSNs.

222 The structural alterations of neuronal processes in mice wer

223 VP37-tubule generation also induced structural alterations of PD as well as modifications to

224 as a sensitive indicator for monitoring the structural alterations of proteins that are often associ

225 that these mutations may result in critical structural alterations of RPE65 protein, disrupt its mem

226 id changes provided preliminary evidence for structural alterations of the A-, B- and/or C-helices wi

227 Systematic structural alterations of the C(gamma)(35)-substituent g

228 a is the only strain identified to date with structural alterations of the capsule polysaccharide Gal

229 We compared the extent of structural alterations of the CC, retinal pigment epithe

230 s reflected in a local unfolding or in other structural alterations of the collagen triple helix is u

231 oteins was associated with pronounced (ultra)structural alterations of the elastic fiber network in t

232 ngle-nucleotide substitutions to large-scale structural alterations of the genome.

233 retardation syndrome that is associated with structural alterations of the GLP/EHMT1 gene.

234 nnel, a functional coupling exists such that structural alterations of the kinase domain alter the se

235 ulmonary artery banding, not associated with structural alterations of the lung circulation) was comp

236 wever, these are jeopardized by chemical and structural alterations of the NCs induced by the environ

237 nuclear envelope (NE) that is accompanied by structural alterations of the NE.

238 recociously in an MU-specific manner, before structural alterations of the NMJ.

239 Fe-O bond (relative to Fe-S), but only minor structural alterations of the overall tertiary structure

240 s, however, unknown whether it is related to structural alterations of the retina.

241 Together, these data suggest that structural alterations of the retinal dopaminergic netwo

242 In this study, we explore the properties and structural alterations of the S512R mutation in GlyT2.

243 e a change in illumination did not result in structural alterations of the synaptic ribbon.

244 odulate the size of conduit arteries through structural alterations of the vessel wall that are depen

245 , this mutation induces major functional and structural alterations of the whole trimeric langerin ex

246 Due to their slow photocycle, structural alterations of these proteins can be studied

247 Structural alterations on medium spiny neurons (MSNs) of

248 Further structural alterations on these two alleles begin to rev

249 The majority showed extensive structural alterations (one had an ultramutated profile)

250 d proteolysis studies suggested little or no structural alteration outside of the C-terminal region.

251 The structural alterations parallel those observed in models

252 morphology in wild-type macrophages, similar structural alterations persist in CCT alpha-deficient ce

253 The role that these structural alterations play in overall catalysis and pot

254 Even minute structural alterations preclude it from assisting in rib

255 s seen in patients with tumors carrying CDH1 structural alterations, preferentially those belonging t

256 ole-genome paired-end sequencing to identify structural alterations present in a primary PCa patient

257 xtent of strain background polymorphisms and structural alterations present in the host strain, which

258 een cisplatin administration and chromosomal structural alterations, providing mechanistic informatio

259 Structural alterations ranged from precipitate-like alte

260 These structural alterations render the enzyme inactive.

261 The structural alterations suggest functional changes in end

262 EGFR compared with WT, rather than from any structural alteration that impairs the donor role of the

263 , 9p24.1 amplification is a disease-specific structural alteration that increases both the gene dosag

264 ious types of human cancer to IDH1(R132H), a structural alteration that leads to catalysis of alpha-k

265 pocket to facilitate linker dynamics and the structural alterations that accompany drug binding of th

266 al uncertainties associated with significant structural alterations that accompany the HF(aq) treatme

267 t aberrant DNA transposase activity promotes structural alterations that are clonally selected to dri

268 n alleles are among the largest possible RNA structural alterations that can be induced by a single n

269 Computational analysis suggested structural alterations that could provide additional int

270 riments demonstrate that SAM binding induces structural alterations that indirectly stabilize the apt

271 ms that electrophile-protein adducts produce structural alterations that influence biological functio

272 the structure-function of the MuV NC and the structural alterations that occur through its interactio

273 herin mutations and calcium depletion induce structural alterations that propagate from the N terminu

274 ling the hydrolysis of one ATP molecule into structural alterations that result in movement of approx

275 eptic and pancreatic digestion attributed to structural alterations that resulted in much lower antig

276 a limiting factor, and the morphological and structural alterations that the nucleus encounters can p

277 demonstrated prevention of podocyte loss and structural alterations, the absence of vascular congesti

278 Despite these structural alterations, they exhibited similar respirati

279 This labeling method causes minimal structural alteration to peptidyl phosphates and allows

280 ociated with auditory-cognitive deficits and structural alterations to auditory thalamocortical syste

281 he fluorine atom can be used to make defined structural alterations to biologically important molecul

282 Mitochondria undergo dynamic structural alterations to meet changing needs and to mai

283 s to prevent corpus cavernosal smooth muscle structural alterations to not only maximize the chances

284 As permanent structural alterations to the cornea after laser-assiste

285 nction through distinct mechanisms involving structural alterations to the nucleosome.

286 e residue is predicted to induce substantial structural alterations to the protein complex.

287 in-domain dimer does not undergo significant structural alteration upon interaction either with class

288 u(II) and Co(II) sites experience only small structural alterations upon loop contraction with the la

289 1.8-2.2 A for the various mutants to compare structural alterations vis a vis the wild type protein.

290 Using tumor-specific structural alterations, we developed an approach to iden

291 acterized by numerous non-random chromosomal structural alterations, we sought to delimit regions of

292 Analogous molecular and structural alterations were also found in human Rasmusse

293 At the cellular level, however, subtle structural alterations were evident.

294 Finally, these structural alterations were noted to persist following a

295 y viewed, these 3D structures reveal complex structural alterations whereby photoisomerization of the

296 iferation defects but did result in arterial structural alterations, which frequently led to aortic r

297 The K41P mutation produced only local structural alterations, while the A51P mutation resulted

298 expense of lignin content and induced lignin structural alterations, with an unexpected increase of l

299 gate the biologic links between cellular and structural alterations within facet joint components and

300 Both structural alterations within pre-existing collagen matr