ライフサイエンスコーパス: structural analog

1 TIR-199, a natural product-derived syrbactin structural analog.

2 re-activity investigation of suramin and its structural analogs.

3 n of binding in the presence of ChoP but not structural analogs.

4 rgeting inhibitor HG-9-91-01 and a series of structural analogs.

5 r total synthesis of RIF-1 stereoisomers and structural analogs.

6 ies systematically improves the detection of structural analogs.

7 ediately accommodating to the preparation of structural analogs.

8 azolylborate) cobalt(II) [Co(Tp)(2)] and two structural analogs.

9 t discriminators between remote homologs and structural analogs.

10 ies of 1 in neurons could be translated into structural analogs.

11 ntic hyaluronan oligosaccharides and related structural analogs.

12 ivity was seen with other anticonvulsants or structural analogs.

13 and successfully predicting the activity of structural analogs.

14 F]FDF revealed greater tumor uptake than did structural analog 1-[(18)F]FDF, whereas 1-[(18)F]FDAM wi

15 tigate the ability of luteolin and its novel structural analog 3',4',5,7-tetramethoxyluteolin (methlu

16 -d]pyrimidine (PP2), but not by the inactive structural analog 4-amino-7-phenylpyrazol[3,4-d]pyrimidi

17 tivity was structurally specific in that the structural analogs 4,5-dihydro-C6-ceramide and dioctanoy

18 Uptake of 5-FTHF was inhibited by the structural analogs 5-methyltetrahydrofolate, methotrexat

19 The binding modes of ACC and the structural analog alanine specifically labeled with 15N

20 SMZ is a structural analog and competitive antagonist to p-aminob

21 (apparent Km of 1.4 microM), 4) inhibited by structural analogs and anion transport inhibitors, and 5

22 bits specific and selective recognition over structural analogs and non-related carboxyl-containing m

23 construction of other members of the family, structural analogs and provide a practical synthetic rou

24 lective synthesis, we created a series of PB structural analogs and the structurally related compound

25 sents the first database containing pairs of structural analogs and their alignments.

26 the interaction of p17 with heparin, a HSPG structural analog, and CXCR1.

27 the results presented here indicate that LPS structural analog antagonists Rhodobacter sphaeroides di

28 (S/N=3) and a very high selectivity towards structural analogs (aspirin, BPA, and piperazine) even i

29 specifically, they provide a means by which structural analogs, based upon these first-generation My

30 letion of the catabolism of ferulate and its structural analogs, caffeate and coumarate, through prot

31 t potent compound discovered by screening of structural analogs, CFTR(inh)-172, reversibly inhibited

32 re we demonstrate that mithramycin A and its structural analog chromomycin A3 are potent inhibitors o

33 nh)-02, which was identified by screening 35 structural analogs, competitively inhibited V(2)R-induce

34 ence of four disulfide bridges, but no close structural analogs could be identified.

35 c for heme; protoporphyrin IX and other heme structural analogs did not activate bhu gene expression.

36 /ALK activity, cabozantinib (XL-184) and its structural analog foretinib (XL-880) demonstrate a strik

37 leukotriene receptor antagonists-leukotriene structural analogs, FPL 55712 analogs, and random screen

38 Good specificity toward fumonisin B1 and its structural analog, fumonisin B2, was observed, together

39 ibited excellent selectivity for SY over its structural analogs, good stability, and adequate reprodu

40 easured by amperometry, whereas the inactive structural analog had no stimulatory effect on secretion

41 rlie violent behavior specifically and their structural analogs, however, remain poorly understood.

42 ch EF hand in one pair by a duplicate of its structural analog in the other.

43 Quercetin or fisetin (a structural analog) inhibited the O-methylation of 2- and

44 MP265, an A22 structural analog, is less toxic than A22 for growth yet

45 and U266 with thalidomide (100 muM) and its structural analog lenalidomide (10 muM) results in stabi

46 nomodulatory drug (IMiD) thalidomide and its structural analogs lenalidomide and pomalidomide are hig

47 ST and its structural analog, linaclotide, an FDA-approved oral sec

48 he uptake process is inhibited by unlabelled structural analogs (lumiflavin, lumichrome) but not by s

49 e results suggest that mithramycin A and its structural analogs may be effective agents for the treat

50 )-dependent block of TRPM7, waixenicin A, or structural analogs may have cancer-specific therapeutic

51 diated down-regulation of IP3Rs, whereas the structural analog N-acetyl-Leu-Leu-methioninal was witho

52 The classical cannabinoid agonist HU210, a structural analog of (-)-Delta(9)-tetrahydrocannabinol,

53 In addition, a PPARgamma agonist that is a structural analog of 15d-PGJ2, and lacks the electrophil

54 peridine hydrogen chloride (AC-42), a potent structural analog of AC-42 called 4-[3-(4-butylpiperidin

55 xin pathways; (2) CMA does not function as a structural analog of ACC; (3) COR has a broader range of

56 ML-3H2 is a structural analog of amebicidal drugs, which have porphy

57 A structural analog of celecoxib, SC-236, completely preve

58 A novel structural analog of ceramide was synthesized by N-acyla

59 A structural analog of choline, 3,3-dimethyl-1-butanol (DM

60 Compound 2, a close structural analog of compound 1, was also found to be we

61 yl-cyclopropapyrroloindole (MCPI) residue, a structural analog of cyclopropapyrroloindole (CPI), the

62 ely expressed oleyl-acetyl-glycerol (OAG) (a structural analog of DAG) -sensitive TRPCs, when activat

63 t is noteworthy that trans-stilbene, a close structural analog of DES that lacks hydroxyl and ethyl g

64 ak inhibition was observed with cemadotin, a structural analog of dolastatin 15, and with the depsipe

65 SDX-101 is another structural analog of etodolac that is already used in cl

66 V also catalyzes the amidation of FDM M-3, a structural analog of FDM C, to afford amide FDM M-6 in v

67 Gabapentin is a structural analog of GABA that has anticonvulsant proper

68 Here, we studied S-sulfocysteine (SSC), a structural analog of glutamate that accumulates in the p

69 We constructed a stable structural analog of H-DNA that cannot flip into B-DNA,

70 s, only the MM-derived ones bind heparin - a structural analog of heparan sulfate proteoglycans known

71 The tracer (18)F-AFETP is a structural analog of histidine and is a lead compound fo

72 A structural analog of HS38, with inhibitory activity towa

73 This study examined whether zileuton (ZL), a structural analog of hydroxyurea, possessed Hb F-inducin

74 id IVa and paclitaxel, which, although not a structural analog of LPS, activates cells expressing mTL

75 to be a potent inhibitor of PI3K activity, a structural analog of LY2, LY303511 (LY3), which did not

76 A structural analog of norepinephrine, (-)-[11C]phenylephr

77 UC-514321, a structural analog of NSC-370284, exhibited a more potent

78 s-4alphaH-fluoren-++ +4alpha-amine (NEFA), a structural analog of phencyclidine (PCP).

79 t to the phytotoxic amino acid m-tyrosine, a structural analog of phenylalanine.

80 An inactive structural analog of PMA, 4alpha-PMA, had no effect on b

81 5-deazariboflavin derivative that is a close structural analog of riboflavin.

82 ble reduction in the selectivity of RY-24 (a structural analog of RY-80) for alpha(5)beta(3)gamma(2)

83 N-linolenoyl-l-glutamine is a structural analog of several other elicitors including v

84 hthalenetrisulfonic acid hexasodium salt), a structural analog of suramin, has an increased affinity

85 Pomalidomide is a potent structural analog of thalidomide and member of a new cla

86 Escherichia coli Dps, a structural analog of the 12-subunit Listeria innocua fer

87 Heparin is a functional and structural analog of the Chlamydia trachomatis heparan s

88 SC-58125, a structural analog of the Cox-2-selective inhibitor Celeb

89 Parenterally administered domoic acid, a structural analog of the excitatory amino acids glutamic

90 A recent study showed that SKF92374, a structural analog of the histamine H2 receptor antagonis

91 L-767,827, an inactive structural analog of the insulin mimetic, had no effect

92 We focused on a novel and more potent structural analog of the nonsteroidal anti-inflammatory

93 he-gauche-trans conformer, which serves as a structural analog of the nucleic acid phosphodiester gro

94 Gemcitabine (dFdC), a structural analog of the nucleoside deoxycytidine (dC),

95 by ATP in the crystal and represents a close structural analog of the previously proposed CEA-adenyla

96 at an N(2)-furfuryl-dG (N(2)-f-dG) lesion, a structural analog of the principal lesion generated by N

97 2,5-Dimethyl-celecoxib (DMC) is a close structural analog of the selective cyclooxygenase-2 (COX

98 contrast, 50 or 100 microM rosiglitazone, a structural analog of TRO, did not cause apoptosis in the

99 A structural analog of XA, kynurenic acid (C10H6NO3), also

100 We have synthesized structural analogs of a natural RNA editing substrate an

101 osteric compounds like carbachol, another by structural analogs of AC-42, and a third by structural a

102 Plant oxylipins are structural analogs of animal prostaglandins which are de

103 Finally, we identify structural analogs of APLF in lower eukaryotes with the

104 e similarity to other proteins, a search for structural analogs of BRCT2 returned the second BRCT dom

105 The structural analogs of clozapine, loxapine and amoxapine,

106 Brown algal phlorotannins are structural analogs of condensed tannins in terrestrial p

107 intake suppression and ALDH-2 inhibition by structural analogs of daidzin established a link between

108 vities, we have tested a series of synthetic structural analogs of daidzin.

109 We also observed that structural analogs of DENSPM which differentially induce

110 Further studies with three structural analogs of ditekiren revealed that one analog

111 These effects were mimicked by structural analogs of GABA with relative specificity at

112 f these polymerases to replicate through the structural analogs of gamma-HOPdG that are permanently e

113 by tetradecanol or 2,6 diterbutylphenol, two structural analogs of general anesthetics that are hydro

114 Stable inhibitory structural analogs of hepoxilin A(3) are capable of impe

115 We demonstrate here that structural analogs of individual TMs of GPCRs can serve

116 study mechanism of iNKT cell activation for structural analogs of KRN7000, and our study can aid in

117 We hypothesized that these structural analogs of malondialdehyde would react with D

118 Structural analogs of MDPD did not affect AtFAAH activit

119 structural analogs of AC-42, and a third by structural analogs of N-desmethylclozapine.

120 erences including the 6-biopterin and pterin structural analogs of neopterin as well as glucose and c

121 Two structural analogs of OAC1 also activated Oct4 and Nanog

122 Flavone and flavanone, two closely related structural analogs of PD98059, inhibited AHR transformat

123 olyl)succinimide, which are chemically inert structural analogs of PDM.

124 or this hypothesis was obtained by examining structural analogs of PM in which its known bidentate me

125 For structural analogs of RH-4032 and various N-phenylcarbam

126 n were explored by studies of the effects of structural analogs of taurine on the activity of Cx26-co

127 Photoproducts can also react to produce structural analogs of TBA metabolites.

128 K inhibitors achieved by covalent linking of structural analogs of the ATP-competitive PI3K inhibitor

129 The structural analogs of the BBB are occlusive (pleated-she

130 rther investigated by solution studies using structural analogs of the drugs and the T306A CYP46A1 mu

131 and S1.ADP.AlF(4)(-), i.e., the established structural analogs of the myosin weakly bound states.

132 we establish that the biological activity of structural analogs of the natural inducer displays a mar

133 ationally designed and assembled a series of structural analogs of the natural product, including a f

134 Functional assessment of structural analogs of the prototype CCK-2R antagonist, L

135 A series of structural analogs of the Pseudomonas aeruginosa autoind

136 l transferases that can recognize and couple structural analogs of their natural substrates and the i

137 the resting state channel, we have employed structural analogs of TID.

138 Further screening of >1000 structural analogs revealed tetrahydrobenzothiophenes th

139 RKI-18, but not the inactive closely related structural analog RKI-11 is effective at suppressing mal

140 selected a pair of RKIs, the closely related structural analogs RKI-18 (potent; IC50 values of 397 nM

141 Kinetic studies using cysteine structural analogs show that most are inhibitors and tha

142 We found that C-5 alkylcytosines and related structural analogs specifically enhance the reactivity o

143 NO synthesis, in that a number of "inactive" structural analogs still bind to iNOS and affect its hem

144 Analysis of structural analogs suggested that the molecular interact

145 als 15 steps and is immediately amenable for structural analog synthesis.

146 However, unlike its herbicide structural analogs, the mode of action of cyperin is not

147 As evidenced by the binding of structural analogs, the primary arylamine group is indis

148 replacing choline in the growth medium with structural analogs, the quantity of capsular polysacchar

149 Using structural analogs to 1, 25-(OH)2D3, we found that analo

150 1, 25-dihydroxyvitamin D3 (1,25(OH)2D3) and structural analogs to modulate expression of voltage-sen

151 he binding of chemically diverse PGF(2alpha) structural analogs to the FP receptor and compared these

152 de (Pca) and hydralazine (Hyd) with those of structural analogs, to determine if the degree of LFA-1

153 B was leucine-specific because isoleucine, a structural analog, was ineffective in these regards.

154 Thirty-three structural analogs were examined to develop a stronger S

155 and A77636), as well as six less efficacious structural analogs, were obtained from D1 dopamine radio

156 oyl-2-arachidonyl-PC, and four corresponding structural analogs with CD36 binding activity were ident

157 a promising starting point for the design of structural analogs with improved activity.

158 nal will facilitate the preparation of novel structural analogs with potential biological activity.

159 e introduce "promiscuity cliffs" as pairs of structural analogs with single-site substitutions that l

160 odels, TM-align can almost always find close structural analogs, with an average root mean square dev

161 entration-dependent manner but not by B17, a structural analog without effects on Golgi function.