ライフサイエンスコーパス: structural analogue

1 strongly than carboxypropylpyrrole, a close structural analogue.

2 antipsychotics, chemical chaperones, or VPA structural analogues.

3 ling the incorporation of a broad variety of structural analogues.

4 that allows it to discriminate choline over structural analogues.

5 selectively recognised GA in presence of its structural analogues.

6 S(2))](2+), in correlation to their peroxide structural analogues.

7 he M1G-2BD duplex was similar to that of the structural analogue 1,N(2)-propanodeoxyguanosine (PdG) i

8 is 10-80-fold more cytotoxic than the close structural analogue 1031U89, which is an equipotent inhi

9 nalysis of HOMePAESe in human urine, using a structural analogue, 4-fluorophenyl 2-aminoethyl selenid

10 5R-5,6-dihydro-5-hydroxythymidine (5R-3) and structural analogue 5,6-dihydro-5-methylthymidine (9) at

11 er exploration of the most potent hit (1), a structural analogue (6) was identified demonstrating 10-

12 is study, the toxic effects of two groups of structural analogues (alcohols and anilines) with predef

13 y of three dichloroacetamide safeners and 12 structural analogues [all neutral compounds of the form

14 Compound 24 and its two structural analogues also inhibited atRA metabolism in H

15 s showed that diacylglycerol and some of its structural analogues also were important, positive effec

16 o-component gelation systems that are direct structural analogues and draws conclusions about the mol

17 egligible cross reactivity with other tested structural analogues, and the recovery from spiked urine

18 Structural analogues are assumed to elicit toxicity via

19 stins A, B, C, and D as well as a variety of structural analogues are reported.

20 eospecifically by phosphatidylserine and its structural analogues, but not by other anionic phospholi

21 have determined the binding mode of a close structural analogue by X-ray crystallography.

22 be syntheses of trioxacarcin A, DC-45-A1 and structural analogues by late-stage stereoselective glyco

23 Prodigiosin and its structural analogue (compound R) induced the expression

24 In contrast, the close structural analogue CP-236,492 inhibited neither process

25 trazepines BN 50727 and BN 50730 and the PAF structural analogues CV 3988 and CV 6209 competitively i

26 sition inhibitor, cyclosporin A, but not the structural analogue, cyclosporin H.

27 t key oxygen atoms of ring C of COL or C' of structural analogues establish with the protein.

28 indicate that the E2 aptamers bind E2 and a structural analogue, estrone (E1), equally well and are

29 The natural product and its structural analogues exhibited antitumor activities agai

30 uded from the cell/bead interface, whereas a structural analogue, fast DiI, which differs from DiIC16

31 Direct evidence for H-bonding is seen in a structural analogue, [Fe(II)(Cl)(N3Py(amide)SR)](BF4)2 (

32 (2)-Propanodeoxyguanosine (PdG) is a stable structural analogue for the 3-(2'-deoxy-beta- d- erythro

33 h library contained between 10000 and 750000 structural analogues for a total of >6 million compounds

34 The results show that the affinity of the structural analogues for the NIP is controlled mostly by

35 The complexes represent structural analogues for the proposed organonickel inter

36 omain adopts a novel alpha/beta fold with no structural analogues found in the Protein Data Bank (PDB

37 An inactive structural analogue, GRGESP, did not alter shear stress-

38 c and electrochemical studies on a series of structural analogues have established that the accelerat

39 Butyrate and its structural analogues have recently entered clinical tria

40 ein structures in the Protein Data Bank have structural analogues in the compact model set.

41 had good selectivity for fluorene over close structural analogues including naphthalene, fluoranthene

42 the synthesis of dibenzodiazepines and their structural analogues is reported.

43 y, has been explored by the synthesis of its structural analogues, leading to 2-(1-((2-methoxyphenyl)

44 Analysis of a set of structural analogues led us to identify a lead compound

45 4) trans-stimulated by unlabelled RF and its structural analogue lumiflavine, (5) cis-inhibited by th

46 gue lumiflavine, (5) cis-inhibited by the RF structural analogues lumiflavine and lumichrome but not

47 well-known PI3K inhibitor LY294002, and its structural analogue LY303511, which does not inhibit PI3

48 hese results, we propose that ShK-Dap22 or a structural analogue may have use as an immunosuppressant

49 relationship studies, MPC-6827 and its close structural analogue, MPI-0441138, were discovered as pro

50 the industrial substrate gamma-lactam or its structural analogue, norcamphor, result in the displacem

51 spermidine-deficient B. subtilis mutant, the structural analogue norspermidine, but not homospermidin

52 /cm(3) (35 bar and 298 K)) compared with its structural analogue, NOTT-103.

53 A route is developed to a structural analogue of [5]HELOL, a previously reported h

54 r perifusion conditions, whereas an inactive structural analogue of AFC failed to inhibit insulin rel

55 r this binding affinity of darbufelone but a structural analogue of darbufelone competes directly for

56 thyl-4-isoxazole propionic acid), kainate (a structural analogue of glutamate) or NMDA (N-methyl-D-as

57 NMDA (N-methyl-D-aspartate), and kainate, a structural analogue of glutamate.

58 Co(III)bleomycin has often been studied as a structural analogue of HOO-Fe(III)bleomycin, and hence,

59 nhibited by treatment with aminoguanidine, a structural analogue of L-arginine.

60 city of azetidine-2-carboxylic acid (A2C), a structural analogue of L-proline, results from its incor

61 , herein, we report the first synthesis of a structural analogue of lucidin [N(2)-methyl-(1,3-dimetho

62 We found that caffeine is a structural analogue of strychnine and a competitive anta

63 The complex is the first structural analogue of the active sites in fully oxidize

64 new palladium macrocycles were discovered: a structural analogue of the existing {Pd84 }(Ac) wheel wi

65 Compound 9 is a structural analogue of the lumazine synthase substrate 5

66 A close structural analogue of the metal-free cytochrome c oxida

67 Similarly, a close structural analogue of the most active inhibitors contai

68 H-benzimidazole-2-selone, H(sebenzim(Me)), a structural analogue of the selenoamino acid, selenoneine

69 support the hypothesis that tunicamycin is a structural analogue of the UDP-D-HexNAc substrate and is

70 s thus quite different from staurosporine, a structural analogue of UCN-01, which arrests normal cell

71 Interestingly, alpha-humulene, a structural analogue of zerumbone lacking the carbonyl gr

72 100 microM), and a series of closely related structural analogues of (+)-avrainvillamide, the latter

73 -specific responses of several Diabrotica to structural analogues of (E)-cinnamaldehyde, the major at

74 More than 200 structural analogues of 3D-cliff compounds were identifi

75 Novel structural analogues of a HDAC inhibitor FK228 have been

76 The use of two structural analogues of ABA, known to have biological ac

77 in vivo immune response of mice to a set of structural analogues of alpha-GalCer.

78 e a series of 9,10-diaryl compounds that are structural analogues of anthracene derivatives used in t

79 igated using steady-state kinetics employing structural analogues of arginine as both alternative sub

80 available for study by this technique, seven structural analogues of arginine were prepared and used

81 nditions, e.g., in rice paddy soils, and are structural analogues of arsenate.

82 When various synthetic structural analogues of CAPE were examined, it was found

83 The effects of structural analogues of ceramide on rat brain mitochondr

84 Experiments using structural analogues of cholesterol have revealed that s

85 ibitions of tubulin self-assembly by several structural analogues of colchicine (COL) was investigate

86 acterization of a series of morphinans 3a-c, structural analogues of cyclorphan [(-)-3-hydroxy-N-cycl

87 In this study, binding of 31 structural analogues of D-galactose was examined by site

88 aluate this possibility, we synthesized more structural analogues of daidzin and tested and compared

89 bition of 5-HIAA (or DOPAC) formation by six structural analogues of daidzin suggested a potential li

90 e synthesis of a number of diastereomers and structural analogues of discodermolide, which should ser

91 (DMA), and with three commercially available structural analogues of DMA: EDTA, TmDTA, and CyDTA.

92 Studies with structural analogues of EGCG suggest the importance of D

93 Structural analogues of FPA provide insight on chemical

94 resents the synthesis of various fluorinated structural analogues of FTY720, their in vitro and in vi

95 Structural analogues of homocitrate prevent the acetylen

96 A series of bis(phenylalkyl)amines, structural analogues of ifenprodil and nylidrin, were sy

97 ntial to greatly simplify access to epimeric structural analogues of important steroid scaffolds for

98 S-mimetic activities are blocked by inactive structural analogues of LPS, indicating that despite the

99 lly simple inorganic materials can behave as structural analogues of otherwise inaccessible 'toy' spi

100 ribution of individual hydroxyls, binding of structural analogues of p-nitrophenyl alpha-D-galactopyr

101 eactivity and in failing to react with other structural analogues of quinine.

102 Two structural analogues of SB, epiSB and SBimide, were also

103 The quinobenzoxazines, a group of structural analogues of the antibacterial fluoroquinolon

104 xtra A-lattice seams in GMPCPP microtubules, structural analogues of the GTP caps of dynamic microtub

105 gand binding activity of CqsS is probed with structural analogues of the natural signal.

106 p to 4 mol of nitric oxide (NO) and that are structural analogues of the NO prodrug and anticancer le

107 basic molecules in a biomimetic approach to structural analogues of the oxidized sites in the xanthi

108 ical characterization and provides access to structural analogues of the siderophore.

109 In this work, a series of structural analogues of the substrate SRH and a 2-ketone

110 er nonimprinted (NIP), of compounds that are structural analogues of the template were acquired by fr

111 has been then applied to the preparation of structural analogues of the trisaccharide repeating unit

112 analysis shows that the nucleodyes are sound structural analogues of their native nucleoside counterp

113 First, close structural analogues of thiazolidenediones, whereas devo

114 activity relationship study with a series of structural analogues of thioxolone yielded similar estim

115 Effects of daidzin and its structural analogues on the activities of monoamine oxid

116 e can be used to prioritize the synthesis of structural analogues on the basis of their potentials of

117 ecision, and is free from interferences from structural analogues, qualifies as a candidate reference

118 Several BTEA structural analogues reversibly inhibited Na,K-pump curr

119 170 samples in order to identify a series of structural analogues suitable for future optimization to

120 e MIP affinity toward the enantiomers of the structural analogues that have a stereochemistry differe

121 s of the MIP toward the enantiomers of these structural analogues that have the same stereochemistry

122 Close structural analogues that showed only weak binding to th

123 ined full selectivity for SAH over its close structural analogue, the highly abundant methylation cof

124 ells may respond to endogenous PGs and their structural analogues through interaction with these rece

125 %) of dichloronitrolysine, a halonitroalkane structural analogue to chloropicrin.

126 ,6-trifluorophenol, acts as a highly soluble structural analogue to the native substrate 2,4,6-tribro

127 rmidine, and spermine) and a series of their structural analogues to stabilize DNA.RNA and RNA.RNA du

128 rmidine, and spermine, and a series of their structural analogues to stabilize RNA-DNA hybrids using

129 eceptor protein; stimulation with CRF, or it structural analogue urocortin (Ucn) showed that the rece

130 tide and two amino acids with deuterated and structural analogues used as internal standards.

131 Notably, the accuracy of exact deuterated structural analogues was found to vary based upon the nu

132 es of overlapping H2B synthetic peptides and structural analogues, we have mapped the different epito

133 targeting activity and cytotoxicity of these structural analogues were assessed in RPMI8402 and P388

134 Values of K(i) for 1 and a series of 31 structural analogues were determined from radioligand bi

135 Ansamycin natural products and selected structural analogues were evaluated in a competitive bin

136 Using a flexible synthesis, families of TLM structural analogues were obtained that possess selectiv

137 -12-ol ring (designated ring C), a series of structural analogues were prepared and evaluated using a

138 n addition, calphostins A, B, D, and several structural analogues were prepared to evaluate biologica

139 The substituted triazolopyrimidine and its structural analogues were produced by an inexpensive thr

140 r 100 naturally occurring small molecules or structural analogues were screened for ligand binding us

141 zoic acid, as lead compound, five classes of structural analogues were synthesized and evaluated for

142 ese initial analogues proved to be excellent structural analogues with good cross-linking capability,