ライフサイエンスコーパス: structural basis

1 f the chemical diversity of StreptomeDB on a structural basis.

2 h previous results, these findings provide a structural basis and a general model for product specifi

3 tively, our studies provide insight into the structural basis and evolution of multiple binding partn

4 biophysical and cellular studies define the structural basis and functional importance of a form of

5 The structural basis and functional mode of recruitment of S

6 context of our improved understanding of the structural basis and mechanism of P-gp-mediated MDR.

7 the most challenging scenario, although the structural basis and physiological implications of this

8 The structural basis and role of the fast component of gatin

9 To find the structural basis and the molecular mechanisms underlying

10 e, we report on the biological activity, the structural basis, and therapeutic effects of the family

11 These experiments demonstrate the structural basis for "dominance" by one protein domain o

12 To elucidate the structural basis for 5G6 binding to GPIbalpha, we determ

13 These structures reveal the structural basis for a GSH-mediated allosteric mode of a

14 ed the domain structure of the STATs and the structural basis for activation through tyrosine phospho

15 ctural features of Uba1 and that the overall structural basis for adenylation and thioester bond form

16 ification patterns tolerated in siRNAs and a structural basis for advancing therapeutic siRNA design.

17 these concepts have been used to reveal the structural basis for allostery in several proteins and p

18 Our data shed light on the structural basis for antigen binding affinity and sugges

19 ve ATP-binding configuration may provide the structural basis for antimicrobial design against these

20 fork but also will lead in the long run to a structural basis for antiviral drug design.

21 mportantly, these findings may provide a new structural basis for antiviral drug development.

22 Here we investigate the thermodynamic and structural basis for Arabidopsis thaliana ARF7 PB1 domai

23 een developed as AT(1)R blockers (ARBs), the structural basis for AT(1)R ligand-binding and regulatio

24 However, the structural basis for binding and recognition of alpha2-3

25 Our results define the structural basis for binding of dihydropyridines and phe

26 Here, we uncover the structural basis for both chain selection and stagger fo

27 The structural basis for branch-specific cleavage by ERManI

28 identify critical residues, and provide the structural basis for catalysis by this new family of enz

29 Understanding the structural basis for catalysis with non-ribosomal peptid

30 ransmembrane helix 8, which likely forms the structural basis for CFTR's channel function.

31 for specific tRNA binding is known, but the structural basis for charge sensing and the role of othe

32 hitecture of the 30S*RNAP complex provides a structural basis for co-localization of the transcriptio

33 del for the autoinhibitory mechanism and the structural basis for cooperative DNA binding.

34 Here, we examine the structural basis for cross-reactive antibody binding to

35 To reveal a structural basis for dCTP incorporation opposite dG(1,8)

36 We also reveal the structural basis for defects in patients with xeroderma

37 These data may provide a structural basis for designing drugs to counter the noxi

38 ght as long-lived radicals, and provides the structural basis for designing photocatalysts with long-

39 The resulting complex suggested the structural basis for dienoate formation and provided the

40 arm of the neighboring protomer, providing a structural basis for dimerization as a prerequisite for

41 variants that also provide insight into the structural basis for Env antigenicity.

42 n of the ptRNase superfamily, and presents a structural basis for evolutionary tuning of function in

43 By providing a higher resolution view of the structural basis for fluorogenicity, these results provi

44 Our results uncover the structural basis for foreign DNA capture and the mechani

45 Here the authors present the structural basis for formation of the 100S complexes in

46 Interfaces provide the structural basis for function as, for example, encounter

47 tinct grey matter areas and may serve as the structural basis for function specialisation within brai

48 To provide a structural basis for function, the crystal structure was

49 ctivation with small molecules and provide a structural basis for further development of Sirt6 activa

50 structure within the membrane and provide a structural basis for further investigation of conformati

51 Our studies establish a structural basis for further mechanistic studies and the

52 Our work provides a structural basis for future studies of bactofilin biolog

53 polarized epithelial layers that provide the structural basis for gastrulation or subsequent developm

54 ate and the selectivity filter underlies the structural basis for gating in potassium ion channels.

55 Our results establish a structural basis for GRAS-GRAS and GRAS-BIRD interaction

56 This unique interaction provides a structural basis for grazoprevir's higher potency than s

57 Taken together, our studies demonstrate the structural basis for HIV-1 genomic RNA to recruit benefi

58 Here, we present the structural basis for how a mouse-derived neutralizing an

59 symmetrical upon binding to DNA, providing a structural basis for how substrate DNA bound to one acti

60 urring human mAbs to site II; therefore, the structural basis for human antibody recognition of this

61 To provide a further structural basis for immunochemically based glycoform di

62 We go on to determine the biochemical and structural basis for increased resistance to daptomycin

63 r mechanism revealed in this work provides a structural basis for interpreting experimental studies o

64 tagonists and a lack of understanding of the structural basis for ion channel subconductance states f

65 itive S. aureus lacks an RMF homolog and the structural basis for its 100S formation was not known.

66 m spinach chloroplasts (cATPase) providing a structural basis for its function as a nanomotor.

67 tal structure of 31 with BRD4 BD2 provides a structural basis for its high binding affinity to BET pr

68 provide the first structures of MoeN5 and a structural basis for its mechanism of action, results th

69 hout relinquishing DNA binding, suggesting a structural basis for its processivity.

70 tal structures of BAR, and further delineate structural basis for its substrate selectivity and catal

71 ture of the LytA/PG complex provides a novel structural basis for ligand restriction by the pneumococ

72 However, the structural basis for ligand-induced NLR activation has s

73 Our study uncovers the structural basis for LPS recognition, delineates the con

74 Our data provide a structural basis for Ly49.MHC-Ib recognition and demonst

75 signal for protein degradation; however, the structural basis for Lys 48 selectivity remains largely

76 To shed light on the structural basis for muOR activation, here we report a 2

77 Na(+)-selective AtTPC1 mutant elucidates the structural basis for Na(+) selectivity in mammalian TPCs

78 Our studies thus revealed important role and structural basis for NS4B protein in supporting YFV repl

79 ogous repeat sequences within TcdA suggest a structural basis for observed differences in actoxumab b

80 lateral than contralateral ORNs, providing a structural basis for odor lateralization behavior.

81 we identified its lipid-binding site and the structural basis for phosphatidyl-based substrate bindin

82 . luminescens lectin PllA have disclosed the structural basis for PllA's high specificity for alpha-g

83 entically to the substrate dCTP, providing a structural basis for Pol gamma-mediated drug toxicity.

84 The structural basis for positive selection has long been de

85 DNA polymerase beta (hPolbeta) and provide a structural basis for PPi release.

86 Our results provide a structural basis for pre-existing data describing the ex

87 These data provide a structural basis for previously unidentified insights in

88 has potential for new understandings of the structural basis for protein function.

89 We determined the structural basis for receptor inhibition by obtaining th

90 binding properties of LIN54 and describe the structural basis for recognition of a CHR sequence.

91 ution of CENP-N and CENP-A and establish the structural basis for recognition of the CENP-A nucleosom

92 with reduced protein stability, suggesting a structural basis for reduced cetuximab efficacy.

93 domain using solution NMR spectroscopy, the structural basis for regulating the DNA-binding activity

94 Z1 and PDZ3 bound to beta-PIX, we define the structural basis for Scribble's ability to specifically

95 residues within Synaptotagmin that suggest a structural basis for several activities required for fus

96 Poz1-Rap1(467-496) complex that provides the structural basis for shelterin bridge assembly.

97 Our study provides the structural basis for SMPDL3A substrate specificity and s

98 Here, we present the structural basis for specific binding of Smad3 and Smad4

99 However, the structural basis for specific G-quadruplex recognition b

100 The structural basis for specific tRNA binding is known, but

101 Ras WT and K-Ras G12D offer insight into the structural basis for specificity, highlighting differenc

102 Furthermore, we provide the first structural basis for stabilization of triple helical col

103 ted sodium channel and give insight into the structural basis for state-dependent binding of sodium c

104 Together, our results provide the structural basis for studying the functional diversity o

105 These results provide a structural basis for studying translation in Mtb as well

106 The structural basis for substrate recognition and transloca

107 These results provide a structural basis for the ability of AS PKCdelta to effic

108 Observations here provide a structural basis for the alterations in cerebral white m

109 Moreover, since the structural basis for the anti-silencing activity of UCOE

110 - and C-terminal domains of p58 provides the structural basis for the bulk of enzyme's conformational

111 opose a model with a regular dodecahedron as structural basis for the caveolae architecture.

112 at 1.4 A resolution, which provides a solid structural basis for the compound's high binding affinit

113 rylation site to PTEN autoinhibition and the structural basis for the conformational closure is still

114 ges in the size of the D3-D4 cleft provide a structural basis for the conformational selectivity of t

115 These experiments delineate the structural basis for the crosstalk of the TF-FVIIa compl

116 Computational modeling provided a structural basis for the D2R selectivity of 1, illustrat

117 uence influence C99 processing and provide a structural basis for the development of small molecule m

118 Collectively, these findings provide a structural basis for the development of this occupationa

119 To understand the structural basis for the differences between apoE3 and E

120 The structural basis for the different binding, action, and

121 This work for the first time provides the structural basis for the different remote prior glycosyl

122 This study provides a structural basis for the DNA cleavage activity of 1, wil

123 Here, we reveal the structural basis for the exquisite selectivity of CENP-N

124 This study unveils a hitherto not recognized structural basis for the features endowing diversity to

125 We also discuss the structural basis for the fluorescence and photophysical

126 ter connectivity was investigated to provide structural basis for the functional dissociation observe

127 The structural basis for the functions of A3G-CD1 remains el

128 nd catalytic mechanism of Tps2 and provide a structural basis for the future design of novel antifung

129 examination of this docking model suggests a structural basis for the high substrate and nucleotide s

130 Our results not only provide the structural basis for the inhibition mechanism but also s

131 to its therapeutic potential, and suggests a structural basis for the initial interactions that under

132 In this review, we assess the structural basis for the interaction between these NK re

133 Our results suggest a structural basis for the intron specificity of different

134 interactions and allosteric changes form the structural basis for the kinetic and mechanical tuning o

135 D160 cross-compete for binding HVEM, but the structural basis for the ligand selectivity by UL144 and

136 unlike many protein-ligand interactions, the structural basis for the long-range communication that u

137 ther with the X-ray crystal data, provides a structural basis for the mechanism of PCNA inhibition by

138 or two Mg2+ were bound forming probably the structural basis for the modified GCAP1 function.

139 e obtain with 8 MyD88 molecules provides the structural basis for the MyD88-templated myddosome helic

140 s is the first study to provide the intimate structural basis for the normal and reverse prenylations

141 are connected upon dimerization, providing a structural basis for the observed Mg(2+)-dependent stero

142 al models provides physical insight into the structural basis for the observed specificities.

143 of SpPaaI in the presence of CoA provides a structural basis for the observed substrate specificity,

144 P-1 as a BMP-2/-4 antagonist and presented a structural basis for the physical interaction between TS

145 actions between HgII and nucleobases and the structural basis for the rational design of C-HgII-T or

146 Modeled structural basis for the recognition of alpha2-3-sialyll

147 nformation of the bound acyl chain provide a structural basis for the regioselectivity and stereospec

148 The structural basis for the similarities between avian and

149 Using molecular simulations we provide a structural basis for the switch in the pathways and dram

150 re often key virulence determinants, yet the structural basis for their activity remains elusive.

151 pies against trypanosomiases and provide the structural basis for their development.

152 mic thermoregulatory mechanisms, providing a structural basis for their frequently being coordinated

153 res of 16 and 18 complexed with WDR5 provide structural basis for their high affinity binding to WDR5

154 none (SCT) herbicide families, revealing the structural basis for their inhibitory activity.

155 tential as anticancer agents, but a detailed structural basis for their mechanism of action is still

156 eptor 3 (CR3) have been widely sought, but a structural basis for their mode of action is not availab

157 fication of TrkA-specific inhibitors and the structural basis for their selectivity over other Trk fa

158 To address the structural basis for these differences, reciprocal swaps

159 ith both compounds 1 and 2 to understand the structural basis for these findings.

160 ight be relevant to these functions, but the structural basis for this activity is poorly understood.

161 To understand the structural basis for this binding profile and activity,

162 The underlying structural basis for this difference has not been establ

163 key interaction interfaces that reveals the structural basis for this difference in functional conse

164 To understand the structural basis for this effect we compared the structu

165 However, the structural basis for this increase is unknown.

166 However, the structural basis for this interaction remains to be defi

167 The structural basis for this key preference is unclear, tho

168 fferent oligomerization states; however, the structural basis for this observation is not understood.

169 henylacetyl-CoA substrates, and we provide a structural basis for this specificity, highlighting a no

170 ne-containing collagen peptide and provide a structural basis for this stabilization with an atomic r

171 The structural basis for tight gold(I) complex/G-quadruplex

172 Our study provides a structural basis for understanding how activators activa

173 These studies offer a structural basis for understanding LC domain self-assemb

174 Our results provide a structural basis for understanding microbial phosphonate

175 Our results provide a structural basis for understanding nucleotide sugar reco

176 Collectively, our results provide the structural basis for understanding peptide repertoire se

177 al system of a Drosophila larva, providing a structural basis for understanding the neural circuitry

178 These observations provide the structural basis for understanding the PAM-dependent dir

179 Overall, our results provide a solid structural basis for understanding the structure and fun

180 n has been extensively studied, the detailed structural basis for voltage-dependent gating mechanisms

181 ng of DNA substrates have been reported, the structural basis for XPA's DNA-binding activity remains

182 Our work reveals the structural basis for, and the potent signaling effects o

183 in extracellular matrix homeostasis, but its structural basis has long been shrouded in mystery.

184 familial Parkinson's disease to describe the structural basis of a molecular mechanism enabling alpha

185 Uncovering the structural basis of allergenicity would allow improved d

186 articles in this issue of Neuron explore the structural basis of allosteric inhibition in ionotropic

187 ed chemical shift predictions to explore the structural basis of allosteric product release.

188 The structural basis of allosteric signaling in G protein-co

189 ed cryo-electron microscopy to elucidate the structural basis of AMPAR regulation by one of these aux

190 We report here the structural basis of Ang1-induced Tie2 dimerization in ci

191 Our study thus reveals the structural basis of anion conduction in a TMEM16 channel

192 Here we elucidate the structural basis of autonomous activation of CLL B cells

193 The structural basis of autoregulation, and whether it affec

194 Molecular modeling was used to elucidate the structural basis of binding and antagonism of selected v

195 phospho-Mob1-Lats1 complexes, revealing the structural basis of both phosphorylation-dependent bindi

196 ter understand the prevalence, function, and structural basis of catalytic activity in antibodies.

197 To further understand the structural basis of CD-I control of Kir channel gating,

198 Here, we used cryo-EM to elucidate structural basis of channel assembly and gating.

199 in multiple functional states revealing the structural basis of channel gating and ligand-dependent

200 eat shock protein oligomers, elucidating the structural basis of chaperone action and oligomerization

201 is generally applicable for elucidating the structural basis of cholesterol's effects on membrane pr

202 expression data to provide insights into the structural basis of CNAs as well as the impact of SVs on

203 tic core, completes our understanding of the structural basis of cofactor recycling in the metaboloso

204 Here, we elucidate the structural basis of coincidence detection that relies on

205 Our structure explains the structural basis of cristae formation in mitochondria, a

206 The structural basis of CSN binding to CRL4A(DDB2) and the p

207 However, the structural basis of Delta remains unknown.

208 sh Wee1 and Wee2 from Myt1 and establish the structural basis of differential inhibition by the widel

209 These results highlight the structural basis of distributed neural activity and sugg

210 recent studies have started to elucidate the structural basis of duplex DNA unwinding.

211 To understand the biochemical and structural basis of electron transfer from FMN-hydroquin

212 inal coactivator-binding site, revealing the structural basis of endocrine resistance.

213 ructures provide the first insights into the structural basis of enzyme dysfunction in PGM1 deficienc

214 course studies of glycan cleavage probed the structural basis of enzyme specificity.

215 The structural basis of filament instability, which plays a

216 odeling chromatin dynamics and assessing the structural basis of genome-wide observations.

217 To understand the structural basis of grid cell activity, we compare media

218 To better understand the structural basis of HLA-DQ2.5's unusual CLIP association

219 However, the structural basis of homo-oligomerization and the fractio

220 The molecular/structural basis of how circadian protein complexes func

221 The structural basis of how Vta1NTD binds to Did2176-204 is

222 Here we review progress in understanding the structural basis of human and Tetrahymena telomerase act

223 rovide novel insights into the molecular and structural basis of Huntingtin Exon1 aggregation and tox

224 Understanding the structural basis of immune recognition of capsular polys

225 nal evolution of ABHD family members and the structural basis of lipase regulation.

226 e LPATs provides tools for understanding the structural basis of LPAT substrate specificity and for g

227 te mitochondrial fusion, in part because the structural basis of mitofusin function is not completely

228 c" conditions, including a discussion of the structural basis of mutations that cause distinctive cha

229 s has provided fundamental insights into the structural basis of neuronal signalling; however, the na

230 spite more than three decades of effort, the structural basis of nucleosome recognition by linker his

231 Understanding the structural basis of P-gp, substrate polyspecificity has

232 To investigate the structural basis of partial agonism, we performed compar

233 iary proteins is additive, and therefore the structural basis of polyamine permeation and unblock is

234 (HPV) L1 virus-like particles (VLPs) is the structural basis of prophylactic vaccines.

235 sed in two main directions, the sequence and structural basis of protein thermostability and the mech

236 e used to make testable hypotheses about the structural basis of receptor function and about the mole

237 Our results help illuminate the structural basis of resistance to apoptosis, immune evas

238 tness of the mutant enzymes and strains, the structural basis of resistance, and the compensatory rel

239 y tumour virus provides new insight into the structural basis of retroviral DNA integration.

240 ics and FRET-based approaches to dissect the structural basis of selective G protein interactions.

241 )-G protein pairing is well established, the structural basis of selective interactions remains unkno

242 cal, and computational analyses revealed the structural basis of selectivity, showing a small motif w

243 with at least four states and illustrate the structural basis of signal transmission.

244 Here we reveal the structural basis of SSB detection and how multi-domain f

245 However, the structural basis of stress-induced p53 activation remain

246 We have characterized the structural basis of substrate binding by the EcfS subuni

247 f low sequence identities, understanding the structural basis of substrate recognition by SBPs has re

248 ificity for PKCalpha, it does not inform the structural basis of substrate-binding and kinase activit

249 ico docking, which provide insights into the structural basis of the activity of the two series of co

250 otifs and provide valuable insights into the structural basis of the affinity changes that occur upon

251 The structural basis of the alterations in the receptor bind

252 However, the structural basis of the altered aggregation propensities

253 The structural basis of the Az1-mediated regulation of polya

254 way in which these domains interact and the structural basis of the BCAA dependence of this interact

255 protein folding studies is to understand the structural basis of the coupling between stabilizing int

256 To better understand the structural basis of the CpAM mechanism, we determined th

257 Our results thus provide insights into the structural basis of the distinct functions of the angiot

258 The structural basis of the evolved affinity was improved sh

259 The structural basis of the fibril formation and stabilizati

260 platform to study shell permeability and the structural basis of the function of intact BMC shells bo

261 Here we elucidate the structural basis of the interaction of AR with ELK1.

262 he human Dicer-TRBP interface, revealing the structural basis of the interaction.

263 However, the structural basis of the mechanism underlying fusion inhi

264 er IGF1, can be enhanced, and we examine the structural basis of the mechanistic and functional conse

265 Although the structural basis of the MIF-CXCR2 interaction has been w

266 Here, we review the structural basis of the principal nuclear import pathway

267 conformation of kinesins, which provides the structural basis of the stable 2HB state and offers a te

268 The structural basis of the switch and many of the pathways

269 bound to HTLV-1 PR were determined, and the structural basis of their affinity is discussed.

270 To understand better the structural basis of these characteristics of SCD functio

271 The structural basis of these key but poorly understood prot

272 e their capsid with the genome; however, the structural basis of this co-assembly is poorly understoo

273 The structural basis of this coupling has only been well cha

274 ial flagella-to drive cell motility, but the structural basis of this function is unknown.

275 ule (NCAM) has been studied in vivo, but the structural basis of this functional interaction is still

276 Knowledge of the structural basis of this interaction could facilitate th

277 However, the structural basis of this interaction remains unknown.

278 A complete understanding of the structural basis of this mechanism requires the ability

279 To determine the structural basis of this selectivity, we determined crys

280 cular dynamics simulations have revealed the structural basis of this specificity for two Affimer pro

281 ge-activated (LVA) calcium channels, and the structural basis of toxin sensitivity remains incomplete

282 We examined the structural basis of TRIP8b-mediated HCN-channel traffick

283 To further understand the structural basis of TRPV channel function, we determined

284 erally, our results provide insight into the structural basis of two-component signal transduction, w

285 We further investigated the structural basis of UP1 binding HIViSL3(ESS3) by determi

286 formal discussions from the symposium on the structural basis of voltage-gated K(+) channel function,

287 structures, providing new insights into the structural basis of VS activation and H(+) transfer mech

288 Currently, nothing is known regarding the structural basis or molecular mechanisms underlying CXCL

289 gnaling but is likely to involve a different structural basis than previously suggested by the MLA10

290 ctance by ACRs has a fundamentally different structural basis than the relatively well studied conduc

291 ible Ebolavirus glycoprotein landscape and a structural basis to evaluate patient and vaccine antibod

292 This work provides a structural basis to explain biochemical and genetic data

293 This study provides a structural basis to further investigate the starch degra

294 e important for coronavirus entry, provide a structural basis to support a model of membrane fusion m

295 However, very little is known regarding the structural basis underlying hCXCL1-GAG interactions.

296 However, the molecular and structural basis underlying the increased toxicity of ag

297 Our data shed new light on the structural basis underlying the interaction between PRL

298 The structural basis underlying the natural substrate bindin

299 However, structural basis underlying these base pairs remains poo

300 The structural basis underlying these distinctive transport