ライフサイエンスコーパス: structural biology

1 X-ray lasers for advancing the frontiers of structural biology.

2 esolution EM maps should prove invaluable in structural biology.

3 ns in atomic detail is a major challenge for structural biology.

4 tance constraints is an important problem in structural biology.

5 r complexes are an important new approach to structural biology.

6 ir native environment is the ultimate aim of structural biology.

7 plant Striga hermonthica using chemical and structural biology.

8 of activity in computational biophysics and structural biology.

9 epresents a grand challenge in chemistry and structural biology.

10 s, which opens perspectives as a new tool in structural biology.

11 l tool in the advancement of high-resolution structural biology.

12 topology needed for biological activity and structural biology.

13 fficult to apply to them standard methods of structural biology.

14 recent advances in 7 transmembrane receptor structural biology.

15 implementation and application of MicroED in structural biology.

16 e benefit of multiple fields of cellular and structural biology.

17 ral cage, a structure that remains unique in structural biology.

18 ion, characteristics of great importance for structural biology.

19 have made important contributions to modern structural biology.

20 es to bridge knowledge gaps between cell and structural biology.

21 dard application of mainstream techniques of structural biology.

22 icroED', that may have wide applicability in structural biology.

23 to have an impact on challenging problems in structural biology.

24 f computational predictions, enzymology, and structural biology.

25 Protein crystallization is important for structural biology.

26 p to 40 kDa, and should be broadly useful in structural biology.

27 th residue mutations is a major challenge in structural biology.

28 istance constraints that are valuable in RNA structural biology.

29 aracterization beyond the reach of classical structural biology.

30 ons (CCS) providing "hard numbers" of use to structural biology.

31 multidomain proteins remains a challenge to structural biology.

32 has been one of the most elusive problems in structural biology.

33 es are the most intriguing targets of modern structural biology.

34 que for drug discovery, chemical biology and structural biology.

35 ction promises to accelerate the progress of structural biology.

36 advances in areas such as computational and structural biology.

37 view of what the future holds in TRP channel structural biology.

38 d fibrils is a challenging problem in modern structural biology.

39 domains is one of the central challenges in Structural Biology.

40 the most important problems in computational structural biology.

41 e employed in various fields of contemporary structural biology.

42 for the application of mass spectrometry to structural biology.

43 to describe with the established concepts of structural biology.

44 emistry, nanoscale physics, nanomedicine and structural biology.

45 eering research in molecular recognition and structural biology.

46 by advances in computational, molecular and structural biology.

47 res of proteins remains a major challenge in structural biology.

48 , which have resulted in amazing progress in structural biology.

49 is an outstanding challenge in the field of structural biology.

50 to characterize with existing techniques in structural biology.

51 o-EM structure determination is transforming structural biology.

52 ding an exceptionally challenging target for structural biology.

53 s to advances in biochemistry, genetics, and structural biology.

54 e field of G protein-coupled receptor (GPCR) structural biology.

55 me fashion, greatly enabling applications in structural biology.

56 s to be used to address problems relevant to structural biology.

57 osomes is still one of the key challenges in structural biology.

58 such as UCSF Chimera, are a standard tool in structural biology.

59 rane-spanning proteins is a key challenge in structural biology.

60 dvances in G protein-coupled receptor (GPCR) structural biology.

61 icability of MS/MS to analytical problems in structural biology, a better understanding of the interp

62 l exemplify the synergy of hybrid methods in structural biology, a powerful approach for exploring th

63 e twentieth anniversary of terpenoid cyclase structural biology: a trio of terpenoid cyclase structur

64 that employs methodologies transplanted from structural biology, adapted to giant supramolecular asse

65 use in all areas of cell research, including structural biology, advanced microscopy, and intracellul

66 A growing area of structural biology aims to characterize these dynamic st

67 Through structural biology and biochemical approaches we demonst

68 Using structural biology and biochemical approaches, we show t

69 try is providing invaluable contributions to structural biology and biochemistry.

70 eflect their varied backgrounds in genetics, structural biology and biochemistry.

71 reas such as protein design and engineering, structural biology and bioinformatics.

72 in recent years to become a powerful tool in structural biology and biophysics.

73 ion in materials and medicinal chemistry and structural biology and biotechnology.

74 A combination of structural biology and cell biology provided novel insig

75 d in the more general context of the role of structural biology and chemical biology in innovative dr

76 ques that have led to these advances in GPCR structural biology and discuss how they may influence th

77 ing application of gas-phase measurements in structural biology and drug discovery, the factors that

78 s advanced rapidly through genetic analysis, structural biology and electrophysiology.

79 ealth of data and many important lessons for structural biology and for future large-scale projects.

80 ities most active in their characterization: structural biology and functional genomics researchers.

81 As such, this work combines knowledge from structural biology and genomics, and suggests a new path

82 d through an analysis of variant proteins by structural biology and isothermal calorimetry.

83 can look forward to complementary data from structural biology and molecular simulations combining t

84 Studies using diverse methods, including structural biology and mutagenesis, have resulted in a d

85 pplying better stable mammalian homologs for structural biology and other biophysical characterizatio

86 an optimally stable MP that is suitable for structural biology and other biophysical studies.

87 discuss recent advances in the biochemistry, structural biology and physiology of CDI.

88 ary structures is a fundamental procedure in structural biology and protein bioinformatics.

89 on of biological, pharmacological, chemical, structural biology and protein network data, it provides

90 ocused on enabling a deeper understanding of structural biology and providing new structural views of

91 Here, we describe the use of both structural biology and somatic variation to develop opti

92 ntly used and integrated in several areas of structural biology and structural bioinformatics.

93 events calendar to present a broader view of structural biology and structural genomics.

94 strategy will help advance insights into the structural biology and systems biology of cell signaling

95 ew, we provide a brief introduction into RNA structural biology and then describe how RNA structures

96 s applications and are central to efforts in structural biology and therapeutic development.

97 structure was transplanted from the field of structural biology and will be applicable to other class

98 Here, by combining enzymology, structural biology, and activity-based metabolomics, we

99 Recent advances in disease modeling, structural biology, and an improved understanding of RAS

100 As an example of how genome data, structural biology, and biochemistry integrate into a re

101 Advances in genomic sciences, molecular and structural biology, and computational and medicinal chem

102 ing of the microbial physiology, enzymology, structural biology, and folding of the prokaryotic DAGK

103 ence of human monoclonal antibody isolation, structural biology, and high-throughput sequencing is pr

104 ommonly used in detection of DNA, in protein structural biology, and in protease assays but is less f

105 theories on the role of solvent molecules in structural biology, and should offer new opportunities i

106 Using a combination of mutagenesis, structural biology, and single molecule spectroscopy, we

107 dge of the evolutionary biology, immunology, structural biology, and virology of influenza virus is i

108 For structural biology applications that depend on side-chai

109 inant protein production quality control and structural biology applications.

110 aluable complementary method in the field of structural biology, applications concerning membrane pro

111 model for the TSHR we applied an integrated structural biology approach combining computational tech

112 Using a hybrid structural biology approach together with the ECD and 7T

113 Using a biochemical and structural biology approach, we demonstrate that the onl

114 Here we employ a 'systems structural biology' approach to functionally characteriz

115 Comprehensive biochemical and structural biology approaches permitted us to delineate

116 Thus, we employed biochemical and structural biology approaches to investigate the interac

117 Here, we combined biochemical and structural biology approaches with ensembles of RNA-prot

118 a formidable challenge and requires in situ structural biology approaches.

119 ral constraints in these ESs by conventional structural biology approaches.

120 ines requires multidimensional molecular and structural biology approaches.

121 Advances in structural biology are also shedding new insights into m

122 r, recent advances in molecular genetics and structural biology are helping to reveal the intricacies

123 ichroism (CD) spectroscopy is widely used in structural biology as a technique for examining the stru

124 parallel the development of biophysical and structural biology as well as our understanding of the m

125 e follows the broader, 50-year trajectory of structural biology, as I could rarely resist opportuniti

126 In this Review, we discuss the structural biology aspects and mechanisms of catalysis b

127 owing opportunities for integrative, dynamic structural biology at the atomic scale, contending there

128 es suggests that research will accelerate as structural biology becomes more closely entwined with th

129 ections, such as directed material assembly, structural biology, biocatalysis, DNA computing, nanorob

130 e used a combination of approaches including structural biology, biochemistry, and electrophysiology

131 The PCDDB has found broad usage by the structural biology, bioinformatics, analytical and pharm

132 l enable future applications in the areas of structural biology, biophysics, and biopharmaceutical ch

133 s fields in natural science, as for instance structural biology, biophysics, and molecular nanotechno

134 with possible application in fields such as structural biology, biophysics, synthetic biology and ph

135 has important applications in the fields of structural biology, biotechnology, and biopharmaceutics.

136 of workflows for applications in comparative structural biology, biotherapeutic analysis, and high th

137 perties not only in the traditional field of structural biology but also in the growing research area

138 lar couplings (RDCs) are important probes in structural biology, but their analysis is often complica

139 proteins of any size and will aid studies of structural biology by improving model quality and saving

140 scaffolds worthy of medicinal chemistry and structural biology campaigns to develop them into anti-t

141 the saccharide detergents widely employed in structural biology can cause unfolding of membrane prote

142 Thus, integrative structural biology can now benefit from the relative eas

143 and challenges of single molecule studies in structural biology, cell biology, and biotechnology.

144 rse research fields including, synthetic and structural biology, cellular reprogramming and functiona

145 s plant cell walls (CWs) poses a significant structural biology challenge.

146 The structural biology-chemistry interaction described in th

147 exibilities provide a unique resource to the structural biology community that can be computationally

148 unique opportunities to a rapidly developing structural biology community where there is increasing i

149 SAXS) has become much more accessible to the structural biology community.

150 is an iterative process, following cycles of structural biology, computer-aided design, synthetic che

151 As structural biology continues to provide increasingly hig

152 arative biology, experimental evolution, and structural biology, could thoroughly determine how viral

153 e (super)families, exploiting both available structural biology data and conformational similarities

154 n data publication and dissemination system, Structural Biology Data Grid (SBDG; data.sbgrid.org), to

155 Here, we integrate biophysical and structural biology data to reveal how these mutations le

156 espite recent advances in NMR approaches for structural biology, determination of membrane protein dy

157 cess in crystallization is useful in current Structural Biology efforts and in particular in high-thr

158 Structural biology efforts enabled the acquisition of th

159 s highly pure and is suitable for supporting structural biology efforts.

160 ecule toolkit for applications as diverse as structural biology, enzymology, nanotechnology and syste

161 rstanding of protein structures developed in structural biology, especially in the context of rapid d

162 DEM) has become a key experimental method in structural biology for a broad spectrum of biological sp

163 esis, experimental evaluation, modeling, and structural biology for a novel series of sulfonamide hyd

164 S) has evolved as an alternative strategy in structural biology for characterizing three-dimensional

165 The limitations of conventional methods of structural biology for fibril characterization have led

166 e X-ray crystallography has been a staple of structural biology for more than half a century and will

167 dge of medicine, biochemistry, genetics, and structural biology, formed the underpinnings for his con

168 Integrative structural biology has advanced our understanding of the

169 A long-sought goal in structural biology has been the imaging of membrane prot

170 Structural biology has benefited greatly from previously

171 ing use of mass spectrometry in the field of structural biology has catalyzed the development of many

172 approaches in characterizing these factors, structural biology has emerged during the past decade to

173 l such therapeutics target beta-tubulin, and structural biology has explained the basis of their acti

174 Membrane protein structural biology has greatly benefited from this seemi

175 Structural biology has played a key role in understandin

176 Structural biology has produced high-resolution images d

177 G protein-coupled receptor (GPCR) structural biology has progressed dramatically in the la

178 ified tens of thousands of interactions, and structural biology has provided detailed functional insi

179 Structural biology has recently documented the conformat

180 Over the past two decades, structural biology has shown how T-cell receptors engage

181 Structural biology has since precisely revealed those bi

182 Genetics, chemistry, and now structural biology have advanced this integrated biochem

183 f protein complexes that other techniques in structural biology have not been able to reveal.

184 ecent advances in G-protein-coupled receptor structural biology have provided only limited insight in

185 -MS) has evolved into a powerful adjunct for structural biology, helping to unravel the quaternary st

186 Despite advances in ribosome structural biology, identifying the protein and rRNA res

187 ariation patterns to complement experimental structural biology in elucidating the full spectrum of p

188 inal contributions to science in general and structural biology in particular.

189 mbly isomerism may represent a new regime of structural biology in which globally varying structures

190 Advances in molecular genetics and structural biology indicate strongly that modifications

191 Guided by structural-biology information, the binding-pocket depth

192 Our structural biology investigations reveal two notable obs

193 This correlation and its potential uses for structural biology is discussed.

194 Fundamental to the central goals of structural biology is knowledge of the energetics of mol

195 An unrealized goal in structural biology is the determination of structure and

196 One of the major open challenges in structural biology is to achieve effective descriptions

197 A major challenge in structural biology is to characterize structures of prot

198 A major challenge in structural biology is to determine the configuration of

199 The challenge for structural biology is to understand atomic-level macromo

200 One goal of structural biology is to understand how a protein's 3-di

201 nsured that only high-quality data enter the structural biology literature.

202 for in vitro investigation of biophysics and structural biology make use of purified macromolecules i

203 e is a long history of muscle biophysics and structural biology, many of the mechanistic details that

204 Until structural biology methods advance to the point of being

205 poses a significant challenge for classical structural biology methods.

206 apped and studied directly using traditional structural biology methods.

207 and therefore remain "unseen" by traditional structural biology methods.

208 therefore not easily amenable to traditional structural-biology methods.

209 Advances in synthetic chemistry, structural biology, molecular modelling and molecular cl

210 ess of CID and for applications to gas-phase structural biology more generally.

211 allenging unanswered questions regarding the structural biology of biomolecular machines such as the

212 Advances in understanding the structural biology of both the immature and the mature f

213 we describe the recent progress made in the structural biology of both the relaxosome and the T4SS.

214 New insights into the structural biology of disaggregation obtained from NMR s

215 ct monomeric and dimeric states on the known structural biology of ETS domains as well as potential E

216 ant achievement, a full understanding of the structural biology of facilitative glucose transport rem

217 Even with the remarkable progress in the structural biology of gamma(c) receptors and their cytok

218 blot analysis to elucidate the function and structural biology of glycoprotein E-selectin ligands ex

219 Utilizing recent advances in the structural biology of GPCRs, homology modeling has been

220 Despite recent progress in the structural biology of GPCRs, the molecular basis for ago

221 Therefore, a central question for the structural biology of IFs is whether individual subunits

222 le analysis has become an important tool for structural biology of large and flexible macro-molecular

223 Structural biology of membrane proteins has rapidly evol

224 arch were in the genetics, biochemistry, and structural biology of phospholipid and lipid A biosynthe

225 discuss both the biology and the underlying structural biology of RORc, and summarize the RORc modul

226 This review focuses on the structural biology of the Fab-like TCRalphabeta clonotyp

227 Many aspects of the structural biology of the Pap CU pathway have been eluci

228 Many aspects of the structural biology of the peptidoglycan pathway have bee

229 Recent advances in the biochemistry and structural biology of the SIR-chromatin system bring us

230 This Perspective looks at the structural biology of these important yet under-apprecia

231 The structural biology of these lncRNAs presents a brave new

232 Despite recent advances in the structural biology of this protein family, the mechanism

233 spectrometry, which is emerging as a tool in structural biology, offers opportunities to map antibody

234 We also illustrate the impact of structural biology on the design of PI3K inhibitors and

235 Despite spectacular advances in structural biology over the past half-century, only appr

236 s emerged as a critical and flexible tool in structural biology, particularly in the study of highly

237 We describe the synergistic role of structural biology, particularly in unmasking structure-

238 beta2m aggregates are challenging targets in structural biology, primarily due to their inherent tran

239 models and indispensable for development of structural biology processing methods.

240 ents available for diffusion measurements in structural biology projects involving molecular particle

241 pharmacological, drug and chemical data with structural biology, protein networks and druggability da

242 From the perspective of structural biology, protein-protein interactions have ma

243 in complexes with potential implications for structural biology, proteomics, biomarker detection and

244 opments in G protein-coupled receptor (GPCR) structural biology provide insights into GPCR-ligand bin

245 S) is a technology of growing importance for structural biology, providing complementary 3D structure

246 In structural biology, pulsed field gradient (PFG) NMR spec

247 Potential insights from the structural biology relevant to immunity and immunosuppre

248 dants have made significant contributions in structural biology research and pedagogy, recent technic

249 the growing utilization of CIU as a tool for structural biology, significant challenges have emerged

250 om multiple experimental systems biology and structural biology sources.

251 Modern structural biology still draws the vast majority of info

252 t protein structures play important roles in structural biology, structure prediction and functional

253 essons from Leloir (nucleotide-dependent) GT structural biology studies and recent applications of th

254 Previous structural biology studies have individually crystallize

255 itors have been identified, but only limited structural biology studies of IDO1 inhibitors are availa

256 cture-activity relationship, UV spectra, and structural biology studies of several analogues of 24 de

257 te plasticity seen here is expected to drive structural biology studies on CaADH, while the exception

258 R spectroscopy should have a major impact on structural biology studies using site-directed spin labe

259 roadens the pool of possible biochemical and structural biology studies, as well as greatly enhances

260 g may have a broad impact on the outcomes of structural biology studies.

261 zation of H atom positions is impractical in structural biology studies.

262 h will allow for high-throughput and dynamic structural biology studies.

263 the best of our knowledge, this is the first structural biology study to directly observe how changes

264 aches play an increasingly important role in structural biology, taking advantage of the complementar

265 lectron microscopy (cryo-EM) is an expanding structural biology technique that has recently undergone

266 Classical structural biology techniques have revealed detailed sna

267 years have seen much progress in the use of structural biology techniques to elucidate molecular mec

268 ar complexes that can be further examined by structural biology techniques to resolve the mechanism o

269 ld be difficult to obtain with more standard structural biology techniques.

270 ructure or assembly mechanism using standard structural biology techniques.

271 other biomolecular complexes using gas-phase structural biology techniques.

272 o selecting proteins or domains for study by structural biology techniques.

273 uperpositioning is an essential technique in structural biology that facilitates the comparison and a

274 cryo-microscopy (cryo-EM) is a technique in structural biology that is widely used to solve the thre

275 bining biochemistry, molecular genetics, and structural biology, that meningococcal type IV pili bind

276 can improve our fundamental understanding of structural biology, the molecular basis of diseases, and

277 rotein crystallography" began to morph into "structural biology." The course of the research recounte

278 to cloning and sequencing to biochemistry to structural biology to an understanding of how proteins e

279 me to divert greater effort and resources in structural biology to benefit the fight against parasiti

280 at multiple levels of resolution (e.g., from structural biology to cell biology).

281 y (MS) has evolved into an important tool in structural biology to decipher the composition of protei

282 Here, we used structural biology to determine how a group of PfEMP1 pr

283 importance for future PELDOR applications in structural biology to develop suitable approaches that c

284 e complementary approaches that combine with structural biology to explore the binding capabilities o

285 We used structural biology to identify hydrophobic patches on 10

286 ) adapted molecular visualization tools from structural biology to render and analyze complex cell su

287 to help extend this revolutionary advance in structural biology to the ultimate goal of recording mol

288 We used integrative structural biology to visualize the architecture of the

289 nance (DEER) spectroscopy is a very powerful structural biology tool in which the dipolar coupling be

290 ass spectrometry is an emergent and powerful structural biology tool, capable of simultaneously asses

291 However, mainstream structural biology tools are not applicable to many carb

292 pectrometry based techniques have emerged as structural biology tools for the characterization of mac

293 Few structural biology tools presently have the combined spa

294 Advances in structural biology unravel a rich repertoire of molecula

295 The ensuing effort in structural biology unveiled for the first time unique fe

296 lar assemblies remains a challenging task in structural biology when using integrative modeling appro

297 en difficult in the core subjects of current structural biology, which include multidomain and intrin

298 es is a difficult problem at the frontier of structural biology whose solution promises to further ou

299 t yet available, rapid progress in combining structural biology with other techniques is revealing th

300 les supply stable human protein homologs for structural biology; yet, eukaryotic thermophiles would p