ライフサイエンスコーパス: structural change

1 ier associated with an initial amyloidogenic structural change.

2 se processes and how disease mutations cause structural change.

3 ate and bicarbonate (both chaotropic) caused structural changes.

4 otential windows depending on the underlying structural changes.

5 with protein synthesis-dependent presynaptic structural changes.

6 2), CH(3) bend and C-O-C stretch represented structural changes.

7 ifetimes, and exquisite sensitivity to local structural changes.

8 omaticity in boron clusters survives radical structural changes.

9 ue eosinophilia and increases in IL-5 but no structural changes.

10 clear layer (ONL) thickness, and tomographic structural changes.

11 tes, and thus characterised the locations of structural changes.

12 oth models instigated post-ischemic vascular structural changes.

13 icrobleeds, and brain atrophy reflecting key structural changes.

14 y balanced and can be shifted by single-atom structural changes.

15 s in BM and lung tissue but failed to affect structural changes.

16 er, but rather a dynamic segment adapted for structural changes accompanying fusion.

17 gets due to their role in human disease, but structural changes accompanying receptor activation rema

18 pe and also the regulatory mechanisms of RNA structural changes across subcellular compartments.

19 t decreased permeability as a result of soil structural changes acts as a barrier creating a zone wit

20 fornix, and ventral prefrontal tract, showed structural changes after completing training in the visu

21 flammation that does not resolve, leading to structural changes and an overall environment primed for

22 The observed structural changes and energetic cost of bringing the pr

23 Depending on their structural changes and expression patterns, some of the

24 diator of allosteric signaling that dictates structural changes and motions that relieve SERCA inhibi

25 ow time-resolved characterization of dynamic structural changes and pave the road to study the molecu

26 ardly predictable and often results in major structural changes and polydisperse mixtures.

27 1)H-(15)N residual dipolar couplings suggest structural changes and rapid motions in the region respo

28 ty, (th)G appears ideal for monitoring local structural changes and single nucleotide polymorphism.

29 has already been applied to monitor protein structural changes and small molecule interactions at el

30 ersion, the counterion promotes considerable structural changes and weakens the NH...pai interactions

31 3 days after ligation before any detectable structural changes, and intensified with the progression

32 e severity of ABCA4 variants, precedes other structural changes, and may remain without clinically re

33 notonic evolution is probably due to protein structural changes, and shows that this content should b

34 These structural changes are brought about by lipid binding.

35 These structural changes are driven by changes in actin filame

36 This project investigated whether structural changes are present in the subthalamic nucleu

37 ntical experimental conditions, allowing the structural changes arising from the spin-transition to b

38 residues, which is buried during the initial structural change, as a way to probe the kinetics of thi

39 studies by the ENIGMA Consortium identified structural changes associated with attention-deficit/hyp

40 ortem tissue analyses can only imply dynamic structural changes associated with injury-induced pain.

41 h free fatty acid-enriched media resulted in structural changes associated with nonalcoholic fatty li

42 ange, as a way to probe the kinetics of this structural change at different temperatures and under di

43 iber layer (pRNFL), or both mGCIPL and pRNFL structural change at enrollment, and then evaluated for

44 sence of folinic acid, which induces a local structural change at the level of the loop-receptor.

45 Decreased Is activity did not induce structural changes at its own synapses, but the coinnerv

46 stological examinations did not reveal major structural changes at proximal sciatic nerve branches or

47 eted reagents with high specificity, probing structural changes at selected sites.

48 e and demonstrate that this region undergoes structural changes at similar temperatures that lead to

49 f high-resolution instruments that can probe structural changes at the atomic and molecular levels in

50 live perfusion through microcapillaries and structural changes at the level of single photoreceptors

51 enefit in the ColQ-/- mouse and to long-term structural changes at the neuromuscular junction.

52 model parameter (Parameter A) for the tissue structural changes between the two sample groups (p = 0.

53 have highlighted the role of charge in such structural changes, but the mechanism is not completely

54 nding metal center reactivity, as even small structural changes can dramatically alter the metal acti

55 moisture exposure, important molecular-level structural changes can still occur during water adsorpti

56 ture, such as a double helix, although small structural changes can yield single stacks as well.

57 conditions and show that the most remarkable structural changes coincide with periods of intense morp

58 c inhibitor MK2206 drives distinct PH domain structural changes compared to baseline autoinhibited Ak

59 yosin may be instructive for determining the structural changes desired for other potential myosin-ta

60 Understanding how the surface structural changes determine the performance degradation

61 ttering reveals asymmetric rates of lamellar structural change during doping and dedoping that do not

62 s well as operando characterization of their structural changes during catalytic reactions are still

63 esent the first real-time observation of the structural changes during doping and dedoping of a conju

64 ns showed different mechanical behaviour and structural changes during nanoindentation and micro-tens

65 ular-level insights into the factors driving structural changes during OCP-mediated photoprotection i

66 testis undergoes dramatic developmental and structural changes during puberty, including proliferati

67 Structural changes during severe drought stress greatly

68 and c(a) signals was partially confounded by structural changes during stand development.

69 We noted that the overall structural changes during the disulfide cascade expose t

70 er, little is known about the progression of structural changes during the process of decline in visu

71 trate that BCX in solution undergoes minimal structural changes during turnover.

72 hanistic insight into beta2m's amyloidogenic structural change, especially the role of Pro32 isomeriz

73 Subtle structural changes exerted significant influence, partic

74 The extent of structural changes experienced by genomes of eukaryotic

75 related to cognition; however, whether these structural changes facilitate the development of cogniti

76 the Is terminal failed to show functional or structural changes following loss of the coinnervating I

77 this approach were translated into striking structural changes for parent and affinity-matured antib

78 n is not sufficient to promote the necessary structural changes for tRNA selection to proceed.

79 artefacts in the reconstruction; 2) a small structural change, for example, a tumor, may not be capt

80 erface is counteracted by the ligand-induced structural changes from a different sensor domain.

81 ing-like domain and allow us to describe how structural changes from the ligand-binding site can be t

82 able differences in the CTD, indicating that structural changes from the mutation were confined to th

83 arison with known structures, we deconvolute structural changes governing the mammalian 'deactive tra

84 We demonstrate that these structural changes have a considerable effect on epidemi

85 Together, the results demonstrate that small structural changes have significant effects on hCT fibri

86 tion of analogues of jogyamycin to study how structural changes impact the selectivity in binding to

87 lament - and that mutations in KBTBD13 cause structural changes impairing muscle-relaxation kinetics.

88 ansition must have occurred but, remarkably, structural change in the circulatory or respiratory syst

89 egatively stained exocyst complexes reveal a structural change in the mutant exocyst that exposes a b

90 did not escalate into higher-level systemic structural change in the wider agricultural ecosystem.

91 Not much is known about brain structural change in younger populations and minorities.

92 Outward-facing structural changes in a bound small molecule can thus re

93 non-linear model parameters to discriminate structural changes in a damaged cornea.

94 we explore whether ubiquitination can induce structural changes in alpha-synuclein aggregates in vitr

95 ated behavior for anxiety, and recapitulated structural changes in BLA neurons seen in OTCs, while a

96 Furthermore, anomalous blood clotting and structural changes in blood components are presented.

97 nt disorder, is characterised by progressive structural changes in both the cartilage and the underly

98 Structural changes in both the peripapillary and macular

99 AXS) techniques, determining nanometer scale structural changes in breast tissue has been demonstrate

100 resonance energy transfer (TR-FRET) to study structural changes in CaM that may play a role in the re

101 Here, we investigated structural changes in cannabinoid-receptor 1 (CB(1))-med

102 the alpha-helical/beta-sheet protein ratio, structural changes in carbohydrates (observed via change

103 existing self-molecules after stress-induced structural changes in CD1d-expressing cells.

104 the past, the underlying secondary/tertiary structural changes in DNA remain poorly understood.

105 HIV-1 envelope (Env) and inhibit CD4-induced structural changes in Env trimers.

106 coupled with force measurements to study the structural changes in FVB mouse skeletal muscle sarcomer

107 used electron microscopy to assess potential structural changes in GABAergic and glutamatergic microc

108 and DTI captured functional, metabolic, and structural changes in key regions of the learning and se

109 ster analysis to simultaneously identify the structural changes in meat trade networks and the factor

110 with and without sous vide cooking, promotes structural changes in meat, and thus may have the potent

111 clear whether these reductions caused deeper structural changes in mobility networks and how such cha

112 The introduction of a bioisostere leads to structural changes in molecular size, shape, electronic

113 ommon and precipitate adverse functional and structural changes in multiple organs which contribute t

114 n with tetanus toxin light chain resulted in structural changes in muscle innervation.

115 tle is known about the resultant dynamics of structural changes in myosin heads during relaxation.

116 powerstroke myosin suggest that dATP induces structural changes in myosin heads that increase the sur

117 powerstroke myosin suggest that dATP induces structural changes in myosin that increase the surface a

118 psoriasis is associated with biochemical and structural changes in non-lesional skin that can be asse

119 However, the structural changes in NOTCH3 involved in CADASIL etiolog

120 dsRNA binding induces allosteric structural changes in OAS1 that reorganize its catalytic

121 RF, or vice versa, inhibited or reversed all structural changes in OTCs.

122 k with optical coherence tomography, showing structural changes in outer retinal mitochondrial signal

123 The bridging induces structural changes in PARP2 that signal the recognition

124 ation, differences in water composition, and structural changes in participants with type 2 diabetes

125 ich could be a new parameter to detect early structural changes in PPG.

126 Structural changes in pre and postsynaptic neurons that

127 hat RTX induces neuroplasticity, rather than structural changes in primary afferents, that are respon

128 ion mechanism, and at high flow rates-due to structural changes in protein molecules in large ESI dro

129 or studying these problems, revealing subtle structural changes in proteins not accessible by other m

130 Slower, structural changes in random connectivity, consistent wi

131 nsfer, although this is not coupled to large structural changes in Rev1 like those observed with othe

132 ported by a theoretical model to account for structural changes in scattering properties of surface-t

133 n phenotypes, the mutants did not show major structural changes in silico, and they maintained their

134 ommon cause of mitochondrial dysfunction and structural changes in skeletal muscle tissue remains to

135 ting techniques to directly measure relevant structural changes in solution at room temperature remai

136 he active site to examine how myosin couples structural changes in the actin- and nucleotide-binding

137 f the inflammatory cascade that led to wider structural changes in the associated neurocircuitry.

138 Small structural changes in the axial coordinating linkers res

139 ion governed by Shh signaling that generates structural changes in the developing mammalian brain.

140 iants (SNVs), mobile element insertions, and structural changes in the DNA, is a common phenomenon in

141 The compounds are not fluorescent due to structural changes in the excited state, as revealed by

142 n brain undergoes significant functional and structural changes in the first decades of life, as the

143 d a FRET approach to examine the kinetics of structural changes in the force-generating lever arm in

144 res of the frontal lobe, which suggests that structural changes in the frontal lobe may have an indir

145 derable uncertainty as to how the impacts of structural changes in the global electric power system w

146 As structural changes in the heart are a defining feature o

147 The novel backbone chemistry induces structural changes in the ionomer, restricting ionomer d

148 In this study, we examine the structural changes in the lamellar arrangements of semic

149 Structural changes in the mAb can lead to unwanted immun

150 Structural changes in the macula are associated with man

151 glymphatic fluid transport and in provoking structural changes in the meninges and cerebral cortex o

152 measures caused substantial and long-lasting structural changes in the mobility network.

153 This imaging technique therefore relates the structural changes in the photoreceptor to the underlyin

154 e-electron laser(2) to observe light-induced structural changes in the photosynthetic reaction centre

155 To determine whether the structural changes in the plasma membrane of Saccharomyc

156 lso determined that the response of water to structural changes in the protein is localized to the sp

157 While structural changes in the retinal nerve fiber layer and

158 nd vascular insufficiency, due to detectable structural changes in the retinoid re-supply route from

159 tion kinetics in NEM6 patients are caused by structural changes in the thin filament, a sarcomeric mi

160 y-driven TCR allostery, and for pMHC-induced structural changes in the transmembrane and cytoplasmic

161 ose and/or TCBZ metabolite led to measurable structural changes in the treated F. hepatica tegument.

162 easily modified without invoking chemical or structural changes in the underlying system.

163 We determined that phosphorylation-induced structural changes in TOMM34 are further augmented by bi

164 ilaments to Ca(2+) and slows the kinetics of structural changes in troponin induced by Ca(2+) dissoci

165 es and a native control sample, any regional structural changes in unknown samples can be detected.

166 It offers the possibility to analyze structural changes, in a controlled molecular environmen

167 Brain neuroimaging may demonstrate structural changes including, but not limited to, focal

168 ystal structure of ERK2 E-K reveals profound structural changes, including disorder in the CD site an

169 d with metastasis and had associated genomic structural changes, including globally enhanced entropy.

170 iated with a wide range of subclinical brain structural changes, including MRI markers of cerebral sm

171 We observe that the structural changes induced by twist were reversible, ind

172 Structural changes induced by various types of enrichmen

173 n abundance have been shown to correspond to structural changes induced upon some perturbation.

174 te during withdrawal to maintain the plastic structural changes initially established by cocaine self

175 ing brought on-resonance by the chemical and structural changes introduced by the bis-Dtp framework.

176 e simulations reveal the sequence of coupled structural changes involved in driving conformational ch

177 The degree of these localized structural changes is associated with 5'UTR length, mean

178 nding partners in facilitating the requisite structural changes is not well understood.

179 hesions, yet how this occurs or what induces structural changes is unknown.

180 with a catalytically impaired state through structural changes; it also causes SII motions to anti-c

181 se mechanism entails one of the most drastic structural changes known.

182 nge early in glaucoma, as well as to measure structural change late in the disease.

183 rong electrostatic interactions, and undergo structural changes leading to exposing normally buried s

184 t upon KU-32 binding, Hsp90 undergoes global structural changes leading to the formation of a "partia

185 These structural changes mirror those inferred by comparing X-

186 ovel insights on the role of D3 receptors in structural changes observed following APD administration

187 However, the actual structural changes observed in each pH range differed co

188 A discontinuous structural change occurred in which low-density liquid d

189 al laser scanning microscopy (CLSM), and the structural changes occurring during enzyme-mediated deco

190 r structures, hindering the understanding of structural changes occurring during the oligomerization

191 AS OCT provides an assessment of structural changes occurring in PUK, useful for its diag

192 (alpha-syn) pathology and the functional and structural changes occurring in the brain is not well un

193 ved at 20 GPa, we find no evidence for major structural changes occurring in the silicate melts studi

194 Herein, the structural change of cytochrome c (Cyt c) upon encapsula

195 AMP2 SNARE motif in mammalian cells, and the structural change of VAMP2 upon the change of intracellu

196 ass spectrometry was used to probe gas-phase structural changes of alcohol dehydrogenase (ADH, 4mer)

197 It revealed both morphological and structural changes of all corneal layers but the endothe

198 Data characterizing structural changes of arrhythmogenic right ventricular (

199 oes not induce any significant effect on the structural changes of BLG due to pressure.

200 correlation of electrochemical behavior with structural changes of crystalline active materials.

201 N9 binding sites and revealed CSN9-dependent structural changes of CSN.

202 commonly involve protein synthesis-dependent structural changes of dendritic spines.

203 Heat-induced structural changes of high molar mass complexes influenc

204 This work opens the way to studying chemical-structural changes of individual molecules for a wide ra

205 rgy transfer (FRET) experiments to determine structural changes of PLB-bound SERCA in response to bin

206 EC and the electrode were used in a study of structural changes of Prussian blue according to differe

207 The structural changes of RdRp VP1 and associated capsid she

208 The metabolic changes occurred prior to structural changes of RPE and retinal degeneration.

209 nd ONH in advanced glaucoma, suggesting that structural changes of the 2 regions have different time

210 photodissociation (UVPD) were attributed to structural changes of the ADH 4mer.

211 the structure also provides an insight into structural changes of the aptamer and PSMA upon complex

212 e potential to recombine all V genes entails structural changes of the entire genome in pro-B cells.

213 ped to explain this phenomenon, the detailed structural changes of the enzymes upon encapsulation wit

214 lomerular injury with edema, proteinuria and structural changes of the glomerular filtration barrier.

215 of the outstanding catalytic activities and structural changes of the materials are not clear, in pa

216 ractions between spliceosomal components and structural changes of the spliceosome between steps, but

217 Evidence for structural changes of these domains compared to controls

218 ural evolution and oxidation state and local structural changes of V(2)O(5).

219 tion is detected objectively on mfERG before structural change on spectral domain optical coherence t

220 th C(60), which in turn also induces a large structural change on the other face (second potential bi

221 ings only, illustrating the impact of subtle structural changes on spin-density distribution.

222 Retinal vascular and structural changes, particularly outside of the central

223 tic collisions with background gas can cause structural changes ranging from unfolding to subunit dis

224 There is evidence that such structural changes reflect underlying cerebral SVD.

225 RM repairs and evaluate long-term visual and structural changes related to ILM peeling.

226 t is particularly challenging to disentangle structural changes related to normal brain ageing from t

227 All three of these structural changes result in a switch from intercalation

228 Instead, A277V-induced structural changes result in local and delocalized incre

229 Structural changes resulting from the adsorption of prot

230 This structural change results in induction of programmed cel

231 mall-angle inelastic scattering, and nuclear structural changes (ring puckering) were monitored by la

232 In particular, whether structural changes shape adaptation by suppressing recom

233 These structural changes slightly reduce proton conductivity w

234 Structural changes suggest mechanisms for producing an i

235 ir its calcium-binding and calcium-dependent structural changes, suggesting a key role of the EF-hand

236 ever measure of the activation barrier for a structural change that initiates the amyloid formation p

237 The kinetics of the structural change that initiates the amyloid pathway, ho

238 during antibiotic recognition and suggested structural changes that accompany the substrate-evoked d

239 Inspired by the hypothesis that structural changes that are associated with events initi

240 ons of mechanosensitive proteins by inducing structural changes that are determinant for force-depend

241 A-bound Mfd, which reveals large DNA-induced structural changes that are linked to the active site vi

242 is associated with molecular, cellular, and structural changes that are robust on the group level, y

243 denaturation of collagen causes predictable structural changes that can be viewed through TEM.

244 es in the Fe-oxido unit correlate with small structural changes that could be difficult to measure, e

245 Abnormal histological and structural changes that could lead to cardiac conduction

246 hed pair analysis was completed to determine structural changes that impacted off-target activities.

247 Cerebrovascular structural changes that occur as a result of chronically

248 ls induces unique patterns of functional and structural changes that occur at different temporal stag

249 ly preventing the curved-to-straight tubulin structural changes that occur during microtubule assembl

250 , what are the reversible, loading-dependent structural changes that occur during water adsorption.

251 ensity functional theory was used to predict structural changes that occur upon spin transition that

252 Crystallographic analysis revealed structural changes that reshaped the TMSiPhe-specific am

253 transport, and localization imposes distinct structural changes that result in the assembly of fibril

254 otein synthesis and ubiquitination to elicit structural changes that underlie long-term reduction of

255 As PLGA microparticles went through structural changes, the surface showed raisin-like wrink

256 ith other heteroatoms results in significant structural changes, thus suggesting more rigorous select

257 perties may provide a mechanism to propagate structural changes to a bound client protein.

258 The combined platform enables local structural changes to be probed by monitoring changes in

259 ine incorporation into SH3 causes only minor structural changes to both the free and bound states usi

260 any that are JA-associated), and distinctive structural changes to chloroplasts.

261 ent orofacial pain as well as functional and structural changes to its bone, cartilage, and ligaments

262 tains cell shape, but it remains unclear how structural changes to MreB affect its organization in vi

263 sex hormone production and undergoes monthly structural changes to release mature oocytes.

264 Modest structural changes to the C-3, C-4, and C-5 position sub

265 en TADs and gene expression by investigating structural changes to the paternal X chromosome before a

266 as not been possible to directly explore the structural changes triggered by Rac1 activation at the m

267 Among the observed structural changes, ubiquitin mediates the destabilizati

268 mulus and are unable to achieve programmable structural changes under different stimuli.

269 he DNA sequence is crucial for understanding structural changes under mechanical stress.

270 Identifying agonist-induced structural changes underlying nAChR activation is fundam

271 n on the adult brain and the extent to which structural changes underpin these effects are currently

272 the substrate needs to only undergo minimal structural changes upon activation to its TS.

273 ation and NMR spectroscopy, we observe large structural changes upon dimerization of TDP-43.

274 three-fold symmetry and undergoes localized structural changes upon ligand binding.

275 g by a charge-compensation mechanism, and by structural changes upon substrate release.

276 ionally flexible and can undergo substantial structural changes upon two-electron oxidation to the P(

277 different times at pH 5.0 and directly image structural changes using single-particle cryo-electron m

278 These structural changes vanish during further RNA transcript

279 thresholds of species in response to forest structural change, we identify areas of degraded forest

280 Microscale structural changes were correlated with macroscale visco

281 Structural changes were investigated using electron micr

282 the full temperature range investigated, all structural changes were reversible and reproducible by a

283 anic frameworks (MOFs), are known to undergo structural changes when subjected to applied hydrostatic

284 involve varying stress fields, resulting in structural changes, whether intentional or undesirable.

285 photoactivation involves a unique series of structural changes which terminate with an opening of th

286 tis B virus capsid protein undergoes similar structural changes, which has implications for drug desi

287 des and ketolides, resulting from even small structural changes, which makes it important to consider

288 rystals or PIX) which could undergo dramatic structural changes while maintaining crystalline periodi

289 These structural changes with enlarged A cations result in sig

290 with ICI allows for a direct correlation of structural changes with not only electrochemical propert

291 They demonstrate dynamic and structural changes within and across networks linked to

292 edly, upon m4-1BB binding, m4-1BBL undergoes structural changes within each protomer; moreover, the i

293 Structural changes within intercalated discs were reveal

294 o-frontal cortex with caudate nucleus and to structural changes within limbic areas.

295 we used simulations of each mutant to probe structural changes within NS3 caused by each mutation.

296 y an adsorbed interfacial layer, significant structural changes within the calcite surface, and incre

297 Here we demonstrate how structural changes within the Escherichia coli replisome

298 Large structural changes within the nucleotide-binding and tra

299 s of circuit level abnormalities demonstrate structural changes within the prefrontal cortex (PFC) an

300 ation is conferred by temperature-responsive structural changes within the RNA thermometer that direc