ライフサイエンスコーパス: structural change

1 is for allostery in the absence of canonical structural change.

2 ons have indicated protein vibrations enable structural change.

3 irming that 7SK undergoes a P-TEFb-dependent structural change.

4 greater protein oligomerization from a minor structural change.

5 r than exponential, intermittency and abrupt structural changes.

6 the network organization and coordination of structural changes.

7 sible key analogues that contain deep-seated structural changes.

8 differentiation occurs in the absence of 3D structural changes.

9 lthood, sensitive to environmentally induced structural changes.

10 ing processes is unavoidably associated with structural changes.

11 tained and the procedure induced macroscopic structural changes.

12 wn in preclinical studies may underlie these structural changes.

13 ndria (tau congruent with 10 ms), indicating structural changes.

14 usly reported cancer treatment-related brain structural changes.

15 rther optimized through a number of rational structural changes.

16 ed as a functional readout of the epigenomic structural changes.

17 iated with bronchial inflammation and airway structural changes.

18 matter gains or losses induced the observed structural changes.

19 d for type 1 ROP (2 eyes, 15.4%); concerning structural changes (9 eyes, 69.2%), including tangential

20 y of both nucleobase surrogates to the small structural changes accompanying base flipping.

21 ic bond lengths and angles shed light on the structural changes accompanying oxidation and reduction.

22 in which the response is mediated by protein structural changes after photon absorption.

23 rly identical, ruling out both a large-scale structural change and a local steric constriction of the

24 main interface may be responsible for global structural changes and a population shift in the DnaK ch

25 phiphile exhibits strong fluorescence due to structural changes and aggregation induced by host-guest

26 In this study, we investigated the impact of structural changes and an alternative splicing event in

27 To explore the structural changes and functional impact induced by phos

28 wn that the aged kidney undergoes a range of structural changes and has altered transcriptomic, hemod

29 w changes in temperature are transduced into structural changes and hence the functional outcome.

30 However, the relationship between structural changes and magnitude of neuropathic pain (NP

31 cral and mucosal melanomas were dominated by structural changes and mutation signatures of unknown ae

32 Here, we report on structural changes and phase transformations of Ti-Nb al

33 zide by a 10-fs UV pulse at 8 eV drives fast structural changes and strong nonadiabatic coupling that

34 This work reveals the range of G structural changes and suggests that G monomers can re-a

35 ity of stability-activity relations to minor structural changes and the crucial role that these relat

36 to investigate the association between these structural changes and the development of certain ocular

37 ion temperature at ambient pressure reverses structural changes and the initial glassy state is recov

38 applied to characterize the nature of these structural changes and the modified amino acids in model

39 e association between connectivity measures, structural changes, and the principal outcome was explor

40 tric silicon oxide drives surprisingly large structural changes, apparent as density variations, oxyg

41 Such structural changes are also likely to occur in vivo, whe

42 occurrence of these epitopes is important as structural changes are associated with several human dis

43 These results suggest that pectin structural changes are connected with increases in pecti

44 The molecular origins of these structural changes are likely associated with at least t

45 synthesis of pi-conjugated polymers in which structural changes are necessary for fine-tuning of elec

46 is now substantial evidence that progressive structural changes are of direct clinical relevance, wit

47 d than by the TNBS method after heat-induced structural changes, arising from disulfide or sulfhydryl

48 Arteries also undergo structural changes as they age.

49 Although extensively studied, structural changes associated with allosteric activation

50 ze the putative binding pathway, and observe structural changes associated with channel function.

51 ith carboxylate and phenolate formation, but structural changes associated with enolate formation fro

52 red Fourier transform spectroscopy (DRIFTS), structural changes associated with the gold nanoparticle

53 The structural changes associated with the phase transition

54 chniques are available for quantification of structural changes at high resolution in response to for

55 unds (1-16) obtained by introducing specific structural changes at key points of our lead compound SG

56 copic nature of field-induced electronic and structural changes at low temperatures remains unclear.

57 solved spectroscopic studies of chemical and structural changes at redox sites within a variety of pr

58 on-gated cation channels is likely caused by structural changes at the channel's PD similar to those

59 Together, these results suggest that structural changes at the heme-proximal side, the globin

60 ntify the impact of root development on soil structural change, at scales relevant to individual micr

61 the two subunits tend to undergo cooperative structural changes, both on local (extracellular gate op

62 s in activity between compounds having minor structural changes, but antiproliferative and ERalpha-do

63 derate, and severe glaucoma, suggesting that structural changes can be detected in severe glaucoma.

64 ts imply a feed-forward regulation, although structural changes cannot be ruled out.

65 d adjacent transmembrane domains emulate the structural changes caused by cytokinin binding, resultin

66 It is hypothesized that the structural changes caused by these mutations in the sens

67 to modification in thiol content and related structural changes causing destruction and/or masking of

68 D516V mutant does not exhibit any such gross structural changes, certainly the electrostatic surface

69 nase-inhibition activity (activity test) and structural changes (circular dichroism) of tyrosinase wi

70 The observed structural changes confirmed hypothesis about partial de

71 cule concentrations in parallel with in situ structural changes determined using fluorescent probes o

72 lses that, although directly associated with structural changes, do not match the expectations of the

73 Nonetheless these structural changes dramatically decreased endoplasmic re

74 rom room temperature structures and avoiding structural changes due to cooling.

75 In particular, the structural changes due to Cu-binding and a point mutatio

76 icability of the HDX-MS technique to monitor structural changes due to methionine oxidation at sensit

77 cient, D, sets the timescale for microscopic structural changes during folding transitions in biomole

78 isulfide linkages can significantly restrict structural changes during hydration and dehydration, and

79 ited from graphene oxide, displaying minimal structural changes during lithiation/delithiation proces

80 property makes it challenging to probe their structural changes during the electrochemical reaction.

81 These structural changes (elongation/dynamic behavior) are rat

82 The latter structural change enables the substrate to bind leading

83 iquely identify electronic contributions and structural changes, even in isotropic samples when well-

84 nsitive measures of the molecular and subtle structural changes following mTBI.

85 xamined and lead to similar pressure-induced structural changes for any composition.

86 Our results show that the structural changes found for pressurized starches were m

87 ssipation of shock wave energy through large structural changes (free volume collapse and endothermic

88 r basis of vancomycin resistance, peripheral structural changes have been explored to improve antimic

89 in bone strength, and their relationship to structural changes, have not been described.

90 Structural changes identified with fluid-attenuated inve

91 rychnine have contributed to visualizing the structural changes implicated in the transition between

92 that a single amino acid mutation induces a structural change in a loop that is responsible for anti

93 Chi recognition elicits a structural change in AddAB that maps to a region of AddB

94 irreversible and probably the most relevant structural change in cystic fibrosis) peribronchial thic

95 inding to fragment D of fibrinogen induced a structural change in the C-terminal region of the fibrin

96 Computational investigations reveal a structural change in the phosphonium moiety induced by t

97 t opening of the intracellular gate causes a structural change in the selectivity filter, which leads

98 n the actin-containing thin filaments, and a structural change in the thin filaments that allows myos

99 These structural changes in a group of middle-aged and older i

100 ] is required to allow large agonist-induced structural changes in A2AR, and that patterns of sidecha

101 sted almonds), hypothesized to be related to structural changes in almond proteins during roasting.

102 pecial synapse subtypes in coordination with structural changes in astrocytes, a glial cell that infl

103 methodology for detection and measurement of structural changes in axonal boutons imaged with time-la

104 Accurate mechanistic description of structural changes in biomolecules is an increasingly im

105 he model can be used to quantify significant structural changes in boutons in long-term imaging exper

106 evelopment, yet it is unclear to what extent structural changes in chromatin underlie tissue regenera

107 of scleraxis in mice leads to geometric and structural changes in cortical bone, as well as asymmetr

108 It is also unclear whether RD leads to structural changes in DACs, impairing functional regulat

109 Although cocaine-induced and stress-induced structural changes in dendritic spines have been well do

110 ypothesized that in cases with AD pathology, structural changes in dendritic spines would distinguish

111 However, the precise mechanisms by which structural changes in ECM proteins contribute to angioge

112 g of G/H/HN to a host cell receptor triggers structural changes in G/H/HN that in turn trigger F to u

113 results reveal distinct age/gender-dependent structural changes in joint cartilage and subchondral bo

114 hat the binding of c-di-GMP induces dramatic structural changes in MapZ that are crucial for CheR1 bi

115 Electron microscopy was used to characterize structural changes in mitochondria and sarcoplasmic reti

116 tic genes, mitochondrial function, and ultra-structural changes in MitoQ- and SS31-treated mutant Htt

117 structure, arguing for a role of DNA-induced structural changes in modulating GR activity.

118 merase to the promoter whereas TFB2M induces structural changes in mtRNAP to enable promoter opening

119 ptic excitation mediates a broad spectrum of structural changes in neural circuits across the brain.

120 The ability to measure minute structural changes in neural circuits is essential for l

121 This study addresses the importance of the structural changes in P10 during infection and how they

122 establish the sequence of nucleotide-driven structural changes in p97 at atomic resolution.

123 These results suggest that structural changes in PACG occur earlier than the reduct

124 tron microscopic examination revealed severe structural changes in patients with TCM.

125 rocess in which Tpz1 binding to Poz1 elicits structural changes in Poz1, allosterically promoting Rap

126 on on protein oligomerization and to observe structural changes in protein oligomers upon drug, subst

127 ulations of the DNA-bound RelA:p50 predicted structural changes in RelA caused by R30 methylation or

128 The motor cortex exhibits structural changes in response to learning, and substant

129 sues can undergo a variety of biological and structural changes in response to mechanical forces.

130 amond anvil cells enabled the measurement of structural changes in silica glass with total X-ray diff

131 The ability to characterize structural changes in single nanocrystals and extract la

132 wever, there is limited evidence linking the structural changes in social brain to development of soc

133 ncrease their surface expression and elicits structural changes in spines, including increased growth

134 r to the most consistently reported cerebral structural changes in SZ (e.g., hippocampus volume and f

135 ntramolecular agonist isomerizes and induces structural changes in the 7-transmembrane helix domain,

136 Together, HGF induces both structural changes in the actin-bound junctional protein

137 he allosteric regulators induce intermediate structural changes in the active site as compared to tho

138 istinct HS-LS phases is the result of subtle structural changes in the alkyl chains and produces a se

139 er, and greater lens thickness were the main structural changes in the anterior segment components of

140 Cigarette smoking is associated with structural changes in the brain and CYP2A6 mediates thes

141 The loss of function correlates with structural changes in the C-terminal alpha-helix and an

142 mplex leads to large quaternary and tertiary structural changes in the complex that are likely necess

143 teraction: there is a nuanced combination of structural changes in the dense coacervate phase and a 1

144 We expected that structural changes in the dry treatments would occur in

145 modulation when bound to Mn(II) is based on structural changes in the enzyme.

146 e-nucleotide polymorphism causes significant structural changes in the extracellular loop of p22(phox

147 cross-linking to examine nucleotide-induced structural changes in the Fe protein and their effects o

148 cal shift, is extremely sensitive to minimal structural changes in the first coordination sphere of L

149 record the overall sequence of photoinduced structural changes in the foldamer, starting from the in

150 the films, which has resulted in significant structural changes in the fully strained SFO films.

151 The m(6)A-induced structural changes in the MALAT1 hairpin can serve as a

152 real time how a membrane protein responds to structural changes in the membrane.

153 Our results provide insights into structural changes in the myosin motor domain that are t

154 n-containing thin filaments but modulated by structural changes in the myosin-containing thick filame

155 and DiI labeling, we examined functional and structural changes in the nucleus accumbens (NAc) and pr

156 centration of a variable tend to be blind to structural changes in the pattern of occurrence of rare

157 Elevated intracranial pressure leads to structural changes in the peripapillary retina.

158 drive phloem transport only in concert with structural changes in the phloem that reduce transport r

159 he two domains, which results in significant structural changes in the phosphatase domain.

160 ion on pre-mRNA splicing that is mediated by structural changes in the pre-mRNA.

161 ibition mature after puberty, in tandem with structural changes in the prefrontal cortex.

162 ough SND is accompanied by atrial myocardial structural changes in the right atrium, atrial fibrillat

163 Below-level NP-associated structural changes in the spinal cord and brain can be d

164 meric calsequestrin network and catastrophic structural changes in the SR.

165 esults show that coordinated and cooperative structural changes in the thick and thin filaments are f

166 diac contractility is also regulated through structural changes in the thick filaments, although the

167 The time-dependent structural changes in this model photocatalyst, as well

168 mpairments are accompanied by functional and structural changes including oxidative stress, neuroinfl

169 However, what determines these structural changes, including their ATP requirement, is

170 information on oxygen evolution activity and structural changes, increasingly positive potentials fro

171 Using estimations of the degree of structural change induced by known recessive- and domina

172 The implication is that the IL structural change induced by the polymer interface can p

173 o open Env conformations, recapitulating the structural changes induced by CD4 binding.

174 Understanding the structural changes induced by early odorant experience c

175 Structural changes induced by radiation damage in X-ray

176 g it difficult to understand and predict how structural changes influence NP activity.

177 how that MinE-membrane interactions induce a structural change into a state resembling the open confo

178 Understanding the natural evolution and structural changes involved in broadly neutralizing anti

179 s insight into the detailed mechanism of the structural changes involved.

180 This structural change is accompanied by reduced membrane flu

181 ge density of states and the fact that small structural changes lead to large changes in electronic c

182 These structural changes may affect the interfacial properties

183 These structural changes may correspond to the early neurodege

184 These pectin structural changes may lessen the ability of the cell wa

185 bilization efforts implemented and completed structural change objectives to address local barriers t

186 Structural changes observed in the Raman spectra during

187 and electroretinography results; and retinal structural changes observed on clinical funduscopy as we

188 In exactly this region, structural changes occur in the ATP-induced opening of H

189 HDX-MS reveals that while the dominant structural changes occur proximal to the cofactor-bindin

190 nd allocation of water, metabolic events and structural changes occurring during germination.

191 These distinct structural changes occurring in both Abeta(1-40) oligome

192 experimental data, an unrealistically large structural change of the channel is required.

193 ional changes of mushroom PPO, the secondary structural change of the enzyme during thermosonication

194 ggested that nucleic acid binding promotes a structural change of the spring helix at the transition

195 ce resonance energy transfer measurements of structural changes of ACRs with the molecules in a demon

196 y the association between the functional and structural changes of default mode network (DMN) underly

197 This could indicate that CD74 NTF-induced structural changes of endosomes are not directly involve

198 o use 3D photogrammetry to assess fine-scale structural changes of entire individual colonies in situ

199 t hysteresis is attributed to the reversible structural changes of kerogens.

200 Importantly, both behavioral defects and structural changes of L5 PNs are prevented by selective

201 treatment creates a time-window of profound structural changes of liver sinusoidal vasculatures, exh

202 Structural changes of nisin induced by complexation with

203 Light-induced structural changes of photoswitches are of special high

204 tation and side-chain modification suggested structural changes of R5 epitopes in C-hordein.

205 e results give experimental insight into the structural changes of silicate glasses as analogue mater

206 ding social inference is associated with the structural changes of specific social brain regions in l

207 ic ligands are sensitive reporter groups for structural changes of the cofactor.

208 To describe objectively the possible structural changes of the macula and optic nerve head in

209 We have assessed the structural changes of the Nav voltage sensor domain usin

210 ationship between functional vision loss and structural changes of the optic nerve head and retinal g

211 The distinct structural changes of troponin C in the thin filaments a

212 nes, transgene insertion was associated with structural changes of variable complexity, illustrating

213 R, we describe here a variety of anticipated structural changes often involving reintegration of the

214 To investigate the effect of Mn oxide structural changes on BPA oxidation rate, 12 sequential

215 l findings of SANS have been correlated with structural changes on intraorbital and intracranial magn

216 However, the influence of Al-induced structural changes on the mechanical properties at atomi

217 ts reveal zeolite amorphization and distinct structural changes on the particle exterior as the drivi

218 aboration across scientific fields and their structural changes over time are hardly known.

219 ver, response is not accompanied by specific structural changes over time detectable with this method

220 this mechanism requires the ability to study structural changes over time.

221 es in RNFL preceding conversion suggest that structural changes precede clinically significant vision

222 2+) and ROS signaling through Ca(2+)-induced structural changes promoting dimerization of hSCGN.

223 These structural changes reflect amino acid differences that a

224 e bound toxins, and reveal voltage-dependent structural changes related to channel gating.

225 Are structural changes relevant to the patient?

226 nistic basis for allostery in the absence of structural change remains unclear.

227 This specific structural change required the C-terminal 36 amino acids

228 We show that these ion-specific structural changes result in binding affinity shifts of

229 The structural changes resulting from functionally biasing m

230 substitutions likely control specific capsid structural changes resulting from TfR binding required f

231 entify conformational transition states from structural changes, revealing common switching mechanism

232 s suggest that vascular dysfunction precedes structural changes seen in glaucoma, longitudinal studie

233 d a fluorescence-based method, which reports structural changes separately in the thick and thin fila

234 e effects can be ascribed solely to membrane structural changes since in silico cooling of the membra

235 sical approaches, we show that AgnB2 evolved structural changes so as to resist the antibiotic by eli

236 Structural changes span from synaptic plasticity to adul

237 Although cardiac structural changes, steatosis, and energetics were simil

238 Nearly all protein functions require structural change, such as enzymes clamping onto substra

239 the underlying topology, but induces subtle structural changes, such as ligand rotation, and mediate

240 The structural changes suggest that FeMo-cofactor belt sulfu

241 sensitivity of isometric force and filament structural changes suggest that the co-operativity of ca

242 forms of the kinase domains show no apparent structural change that could explain how phosphorylation

243 teration in the enzyme induces a significant structural change that reduces ALKBH7's ability to bind

244 rs on the tripodal ligand, which undergoes a structural change that results in the formation of a new

245 a high-affinity TCR (B4.2.3) to examine the structural changes that accompany binding to its p/MHC l

246 gnificantly contribute to the functional and structural changes that affect the irradiated brain and

247 to the EF-hands of hSCGN induces significant structural changes that affect the solvent exposure of N

248 ivers and volcanoes can produce irreversible structural changes that are detectable in geophysical da

249 has been interpreted in terms of propagated structural changes that are induced by effector binding.

250 rved as a powerful system for dissecting the structural changes that are related to four major functi

251 This program could provide tangible structural changes that can be implemented in other heal

252 he mitochondrial outer membrane (MOM) induce structural changes that commit cells to apoptosis.

253 microscopy measurements, which elucidate the structural changes that lead to catalyst deactivation.

254 eating the sea buckthorn extract resulted in structural changes that led to red- or blue-shifts in ma

255 coprotein (Env) undergoes receptor-triggered structural changes that mediate viral entry through memb

256 e fusion inhibitors could interfere with the structural changes that occur between the prefusion and

257 odelling is the term used to describe tissue structural changes that occur in a disease setting and r

258 a lipid bilayer have allowed us to probe the structural changes that occur upon channel activation an

259 oarse-grained protein structure by following structural changes that occur upon ligand binding, pH ch

260 d X-ray scattering to visualize the solution structural changes that occur when the light-sensitive m

261 FT-Raman analysis highlighted the structural changes that occurred during the formation of

262 SP12 Fingers domain and induces a cascade of structural changes that reach a critical ubiquitin-conta

263 is known about the dynamic compositional and structural changes that these systems undergo during pre

264 defects, induced by irradiation, are primary structural changes, the accumulation of which will lead

265 that undergo time- and temperature-dependent structural changes, the polymer nanodiscs experience neg

266 It occurs concurrently with major structural changes: The second coordination shell around

267 The chemical, structural changes; the extractability of protein, carbo

268 uence coverage of DXPS allowed us to monitor structural changes throughout the entire enzyme, includi

269 The key structural changes to 1 include bioisosteric replacement

270 We find that Spy1 confers structural changes to Cdk2 that obviate the requirement

271 direct structural-functional correlation of structural changes to loss of rod function.

272 re found with small, but rationally designed structural changes to P4.

273 ffects of CD4 (CD4Ms) also induce reversible structural changes to states that exhibit isolate-specif

274 Production of DDGS results in structural changes to the AX.

275 selective ANG-ALS variants we correlated the structural changes to the effects on neuronal survival a

276 cular dynamics (MD) methods to elucidate the structural changes to the kinase's activation loop that

277 sion, and sets the stage for later permanent structural changes to the microcirculation.

278 nt caging of reactants and products; and (v) structural changes to the solvation shells in response t

279 This coincides with hemodynamic and structural changes typical of HFpEF.

280 the catalyst did not undergo any significant structural changes under NTP conditions.

281 sus cis-activity) respond non-uniformly to a structural change underscores the power of combining syn

282 -porous crystalline materials that undergo a structural change upon exposure to an external stimulus-

283 ed-flow SAXS measurements, revealing dynamic structural changes upon iron binding and core formation,

284 Our XANES measurements reveal that the structural changes upon photoexcitation occur mainly in

285 der various comminution conditions and their structural changes were investigated using Fourier trans

286 n of LR and NR significant morphological and structural changes were observed as evident from pin-hol

287 No structural changes were observed in MeA bipolar neurons,

288 o change their structure spontaneously; such structural changes were suppressed in the crystallograph

289 Dendritic and mitochondrial structural changes were tracked longitudinally using tra

290 phosphorylated myosin heads reported similar structural changes when neighboring heads were phosphory

291 of the allene buildup are controlled by the structural changes, whereas the decay is limited by the

292 logy, we have a complete kinetic pathway for structural change which is common to both ageing and cry

293 ke and binding correlate with Mn(II)-induced structural changes, which are more substantial at pH 4 t

294 on on the RRE that is correlated with an RNA structural change within the RRE that persists even afte

295 esonance energy transfer, directly detecting structural changes within the bound actomyosin complex d

296 up-regulation to co-occur with the chromatin structural changes within the genomic cluster of carcino

297 Ceramide-rich membrane areas promote structural changes within the plasma membrane that segre

298 In this work we explore the effects of structural changes within the secondary ligand sphere af

299 ng to cell-derived microvesicles undergoes a structural change without disrupting the pentameric symm

300 Such structural changes would modulate the probability of myo