ライフサイエンスコーパス: structural element

1 suggesting later evolution of this critical structural element.

2 AP25 surface, but Rabphilin-3A uses a unique structural element.

3 red phospholipids with systematically varied structural elements.

4 ishable from holo-CueO in terms of secondary structural elements.

5 its distinct preference for select viral RNA structural elements.

6 th significant differences in some secondary structural elements.

7 ell as subunit interfaces and some secondary structural elements.

8 sequence segments on the scale of secondary-structural elements.

9 (H1-SS-np) confirmed the preservation of key structural elements.

10 in domains lose a significant number of core structural elements.

11 InsP6 forms substantial contacts with both structural elements.

12 nd relative orientation of various secondary structural elements.

13 relating changes in function with removal of structural elements.

14 RNA folding from its secondary and tertiary structural elements.

15 uilding blocks using recognition modules and structural elements.

16 n's amino-acid sequence and/or its secondary structural elements.

17 detailed assessment of critical and tunable structural elements.

18 was reconstructed from the minimal number of structural elements.

19 rhamnogalacturonan, arabinan and galactan as structural elements.

20 n corresponding polymorphisms in key kinesin structural elements.

21 a folding intermediate of GB3 with nonnative structural elements.

22 eveal that NTMT1 contains two characteristic structural elements (a beta hairpin and an N-terminal ex

23 Two types of structural element, a stem-loop and a poly(G) motif, not

24 cture, particularly exceptionally stable RNA structural elements, act as gauges of protein co-transla

25 ted genes due to the coupled formation of 3'-structural elements acting as terminators.

26 er critical insights into how MazF secondary structural elements adapt to recognize diverse RNA subst

27 Here, we identify a structural element, alpha-helix-7, in human Argonaute2 (

28 Two structural elements, an alpha-helical pair and a rare, t

29 ted in a groove between the alphaB and betaB structural elements and a highly conserved carboxylate-b

30 ue for a hierarchical stability of secondary structural elements and demonstrate the existence of a c

31 ns to determine the relative contribution of structural elements and enhancers to the higher order st

32 assignment of (1)H signals belonging to key structural elements and functional groups.

33 show the conservation of the core secondary structural elements and the location of the N-terminal r

34 e the database's function by examining known structural elements and we explore example use cases in

35 ng their entire sequence, i.e. entirely lack structural elements, and IDRs as regions that are at lea

36 o enzymes released ferulic acid from various structural elements, and NMR spectroscopy indicated comp

37 ximities, relative orientations of secondary structural elements, and protein-cofactor interactions i

38 ght affect rates of folding of near-neighbor structural elements, and thus limit the ability to resol

39 sed on similarity in sequence, 2D, and/or 3D structural elements are available, our graph-based searc

40 ifferent conformations and crosstalk between structural elements are essential for the Mediator regul

41 y three-dimensional domain swapping, whereby structural elements are exchanged between adjacent subun

42 These new structural elements are important for growth and mRNA ex

43 conformers having at least some well-defined structural elements are stabilized as temperature is inc

44 kinase 1 (TBK1) and have generalized the key structural elements associated with degradation activiti

45 s of azetidinones enabled the recognition of structural elements associated with integrin selectivity

46 pectroscopic properties suggests that unique structural elements at H are critical for functionality.

47 minated novel and important contacts between structural elements at the C terminus of the noncatalyti

48 om the hierarchical arrangement of different structural elements at their relevant length scales.

49 A key structural element believed to regulate the degree of pr

50 tantially with reduced density because their structural elements bend under applied load.

51 These include additional secondary structural elements, beta0 and alpha6, and unique confor

52 umerous additions and deletions of secondary structural elements between related domains.

53 ork is unique in that it contains all of the structural elements both necessary and sufficient for re

54 Here, we describe structural elements called interface add-ons that fulfil

55 ion through protein-mediated binding of mRNA structural elements can govern cancer progression.

56 actor that binds the sRSE family and similar structural elements--collectively termed TARBP2-binding

57 The structural elements computed to contribute to the non-tw

58 h nucleus the embryonic volume arises from a structural element contained within the voxels identifie

59 Additional, non-TPR structural elements contribute to an RNA binding cleft.

60 Computations explain how these structural elements contribute to reversibility and the

61 s studies have investigated the DAT and SERT structural elements contributing to inhibitor and substr

62 We investigate the extent to which structural elements contributing to intermediate conform

63 cardiac glycoside variants, we assessed the structural elements critical for anti-CMV activity by bo

64 In this study, we report a structural element crucial for the biological function a

65 fied the amino-termini of Rad and Rem as the structural elements dictating the specific modes of inhi

66 To elucidate what structural elements differentiate TTLL glycylases from g

67 To pinpoint the structural elements discriminating collagen from non-col

68 c N-terminal helix of MscL acts as a crucial structural element during tension-induced gating, both s

69 Mutations within the 5'-UTR affecting RNA structural elements enabled restriction by or antagonism

70 ing cells as a cofactor for enzymes and as a structural element enabling the adequate folding of prot

71 ved in attachment and can furthermore act as structural elements, enabling bacteria to overcome unfav

72 ionships (SARs) were established to identify structural elements essential for efficiency and potency

73 These structural elements exhibit flexibility, which may hold

74 Since nothing is known of how mRNA structural elements factor in channel processing, we syn

75 -acetyl-muramic acid (NAM), serves as a core structural element for innate immune recognition of PG f

76 A key structural element for inter-head coordination is the ne

77 )A is within loop III of the GFD, a critical structural element for its binding with the beta-PDGF re

78 ecular motors and is emerging as a versatile structural element for protein and cellular engineering

79 ly designed molecule obtained by integrating structural elements for Abeta aggregation control, metal

80 fic requirement of secondary and/or tertiary structural elements for catalysis by Set7/9.

81 Detailed structural elements for differential binding of the gamm

82 ement for rearrangements of these peripheral structural elements for efficient gating to occur.

83 r TREX1 Arg-62 residues to provide necessary structural elements for full catalytic activity in the o

84 g that TcpC specifically engages these MyD88 structural elements for immune suppression.

85 acids (BAs) are building blocks or important structural elements for numerous primary and specialized

86 acids (BAs) are building blocks or important structural elements for numerous primary and specialized

87 the two enzymes use almost a similar set of structural elements for target recognition, the residues

88 d the presence of acetyl groups as important structural elements for the biological activity of the s

89 ied from filamentous fungi display conserved structural elements from both yeast and vertebrate TERs.

90 the kinetics of this interaction, we grafted structural elements from the slowest isoform, syt-7, ont

91 uch an assembly scenario, multiple secondary structural elements from within the RNA, termed "packagi

92 orrected for the presence of local secondary structural elements further validates our structural mod

93 protein biology is the understanding of how structural elements give rise to observed function.

94 Cis-acting RNA structural elements govern crucial aspects of viral gene

95 nd to computationally model the sequence and structural elements governing the specificity of TRUB1,

96 s how knowledge of various viral genetic and structural elements has begun to advance the development

97 The structural elements identified are: fibrous, helical, gr

98 mental evidence of a lateral gate in TamA: a structural element implicated in membrane protein assemb

99 The results provide insights into the structural elements important for aminoglycoside inhibit

100 solved to a resolution of 2.5 A to identify structural elements important for its invasion activity.

101 ld-effect-based devices are becoming a basic structural element in a new generation of microbiosensor

102 identify a coordinated Mg(2+) ion as the key structural element in closing the nucleotide site and st

103 -ray crystallography has revealed an unusual structural element in kinesin-5 motor proteins.

104 ese results identify the NTR as an important structural element in myosin force sensing and suggest a

105 Grain boundary triple junctions are a key structural element in polycrystalline materials.

106 phodiester bonds have emerged as a plausible structural element in prebiotic RNAs.

107 a catalytic cofactor in metalloenzymes and a structural element in proteins involved in general metab

108 Our work reported here shows that a helix structural element in the MuV nucleocapsid protein becom

109 Instead, a secondary structural element in the peripheral subdomain appears t

110 f tertiary folds combining several secondary structural elements in a single entity are rare.

111 The structure reveals extra structural elements in addition to the RNase H-like fold

112 special interest due to their role as major structural elements in all living systems, ranging from

113 (+)-binding reconfigures dynamically coupled structural elements in an allosteric interaction network

114 rived distance measurements between specific structural elements in Bak, here we clarify how the Bak

115 Eight structural elements in biological materials are identifi

116 findings demonstrate the importance of these structural elements in enzyme function and support the h

117 These results indicate that at least two structural elements in L4 are responsible for antiviral

118 bonds away from the C-N bond) are important structural elements in many pharmaceutical agents and na

119 Thus, structural elements in MRDI distal from the MTR-1-P cata

120 eric pseudonuclease core of TEFM with mobile structural elements in mtRNAP and the nucleic acid compo

121 al loads; however, little is known about the structural elements in myosin responsible for force sens

122 ing to an apparently new characterization of structural elements in prefusion synaptobrevin and provi

123 nduced-fit recognition mechanism adapt local structural elements in response to ligand binding on a r

124 Riboswitches are structural elements in the 5' untranslated regions of ma

125 priate polypeptide context or other adequate structural elements in the acceptor substrate could faci

126 igh resolution the orientation of individual structural elements in the catalytic domain while myosin

127 e identified multiple previously unannotated structural elements in the HIV-1 genome likely to functi

128 s difference was determined by non-conserved structural elements in the intracellular N terminus.

129 These findings indicate that PKR sequence or structural elements in the kinase domain, present in hPK

130 , both in vitro and in vivo, to sequence and structural elements in the SMN mRNA 3'-untranslated regi

131 ee to which they made contact with prominent structural elements in two folding domains of the RTA.

132 The identification of conserved structural elements in visual and acoustic communication

133 analysis confirms the importance of several structural elements, including a conserved cysteine resi

134 racterized and put into context discrete RNA structural elements, including the cis-acting Mta respon

135 in assembly in which rhodopsin uses distinct structural elements, including transmembrane helix 7 and

136 re new chemical transformations by embedding structural elements into the backbone designed to underg

137 To reveal key structural elements involved in alkali sensing, we devel

138 ies, but pertinent information regarding the structural elements involved in cation translocation and

139 rotein backbone, allowing us to identify the structural elements involved in gating and modulation of

140 re minimal and are largely restricted to the structural elements involved in metal coordination.

141 contributed to a better understanding of the structural elements involved in motor-substrate interact

142 heet, V3 loop, and beta19 strand) with gp120 structural elements involved in recognition of CD4 such

143 yses of 552 Type ISP enzymes showed that the structural elements involved in target recognition of Ll

144 aled unprecedented conformational changes in structural elements involved in the allosteric signal tr

145 e centriole distal end, confirming that this structural element is a target of importance for pathoge

146 ormations where the only conserved secondary structural element is one turn of helix that binds the c

147 r-transmembrane GlyR interface and that this structural element is vital for inhibitory GlyR function

148 processivity and the variation of peripheral structural elements is essential for their diverse funct

149 nknown sites residing within a MAPK-specific structural element known as the MAPK insert: T241 and S2

150 sive and persistent loss of bone mineral and structural elements leading to loss of bone strength and

151 studies have pointed toward highly conserved structural elements, like the motif-D active-site loop,

152 The latter structural elements make interdomain tertiary contacts (

153 Our findings indicate that non-coding RNA structural elements may be more broadly targeted by synt

154 nel structures, opening the door for mapping structural elements mediating activation by each stimulu

155 We also identify structural elements modulating viral stability, notably

156 l is supported by our identification of Kip3 structural elements necessary and sufficient for plus-en

157 ithout voltage-sensing machinery, it has the structural elements necessary for ion conduction, activa

158 for binding, as well as all of the essential structural elements necessary for the rational design of

159 our attention on the basic requirements and structural elements needed to fabricate MOF-based device

160 Compared to regular structural elements, non-periodic, non-repetitive confor

161 t 1.2-1.5 A resolution, which reveal several structural elements not detected in recent cryo-EM recon

162 affects mobility of the trigger loop (TL), a structural element of Rpb1 that moves in and out of the

163 The nuclear lamina is a key structural element of the metazoan nucleus.

164 ep corresponds to the folding of a secondary structural element of the native protein, termed a "fold

165 gh S1P and phospho-fingolimod share the same structural elements of a zwitterionic headgroup and lipo

166 regions of ACKR3 that elucidate fundamental structural elements of agonism in this atypical receptor

167 The main structural elements of biological smell systems are the

168 human A3B-CD1 variant and delineate several structural elements of CD1 involved in molecular assembl

169 Our study has uncovered the mechanism and structural elements of convallatoxin, which are importan

170 stablish conformational coupling between key structural elements of Galphas.

171 equence analysis and structure-based design, structural elements of glucagon were engineered into the

172 N- and O-linked glycans express structural elements of HMOs, and thus, the reported synt

173 veals how GTP, fMet-tRNA(fMet), and specific structural elements of IF2 drive and regulate this confo

174 undergoes a concerted reorganization of the structural elements of its central channel during intera

175 sed modeling to identify similarities in the structural elements of K(+) channel pore-forming regions

176 selectivity obtained by merging distinctive structural elements of known agonists and antagonists of

177 ophore hybridization strategy to combine key structural elements of merbarone and etoposide and gener

178 of the nanoparticles efficiently "glued" the structural elements of microfibrils together, producing

179 -13 amino acids is sufficient to build major structural elements of modern proteins.

180 Here, we hierarchically review the structural elements of RNA and how they contribute to RN

181 no concomitant denaturation of the secondary structural elements of Rsn-2 with the large-scale transf

182 e components that are dependent on different structural elements of RyR1.

183 c ion in the active site of HDAC and the key structural elements of statin for binding with both prot

184 ually mediated by direct interaction(s) with structural elements of the actin cytoskeleton.

185 Remarkably, Pep2-8 mimicked secondary structural elements of the EGF(A) domain that interact w

186 - to atomic-resolution structures reveal the structural elements of the enzyme involved in utilizatio

187 olecular simulations to show that individual structural elements of the group I ribozyme from the bac

188 t of GRK5 in a partially closed state, where structural elements of the kinase domain C-tail are alig

189 This vaccine candidate preserved structural elements of the native PvMSP119 and elicited

190 its dynamic interactions with tRNA and other structural elements of the ribosome.

191 tes, requiring communication between distant structural elements of the ribosome.

192 ne a digital rock model exemplifying the key structural elements of these carbonate grainstones.

193 ia and E. coli, with distinctively different structural elements of TopoI-CTD utilized for this prote

194 Caged (or bridged) bicyclic structural elements offer a variety of diverse features,

195 Several structural elements on both GV150013X and in CCK2R bindi

196 Of all predicted secondary structural elements, only a single 15-nt stem-loop showe

197 orly structured regions connecting secondary structural elements, or linkers that connect entire prot

198 We analyzed the secondary structural elements, or motifs, present in all human miR

199 Unique structural elements outside of the catalytic core called

200 The dynamic motions of protein structural elements, particularly flexible loops, are in

201 Paradoxically, neither structural element performs its implied function.

202 Additionally, the variation in structural elements peripheral to catalytic motor domain

203 hin the R2 surface region, whereas divergent structural elements pinpoint regions mediating virus-spe

204 RNA junctions are common secondary structural elements present in a wide range of RNA speci

205 Our goal was to determine the structural elements present in this peptide and evaluate

206 to changes of accessibility and dynamics of structural elements previously implicated in the transpo

207 hifts in the dynamic properties of adjoining structural elements rather than through a few discrete c

208 hroughs led to the identification of the key structural elements regulating gating, transport, select

209 metal binding, the functions of these unique structural elements remain unknown.

210 erties of variants were used to identify the structural elements required for catalysis and substrate

211 xisting immune effectors yet retain the core structural elements required for localization and functi

212 nstruct (mini-hSIRT1) containing the minimal structural elements required for lysine deacetylation an

213 ngaged, these precursors contain many of the structural elements required for neutralization, and can

214 Here, we define structural elements required for the Ndc80-Dam1 interact

215 t the C terminus of MSP3 may not be the only structural element responsible for oligomerization and t

216 with the anion of the achiral acid being the structural element responsible for the pi-facial discrim

217 ehydratases, wherein insertions of secondary structural elements result in the formation of a distinc

218 These structural elements should serve for functional/structur

219 tant receptors have proportions of secondary structural elements similar to wild-type receptors.

220 all covalent loop leads to a mechanism where structural elements slipknot to thread through the coval

221 rate throughput, could be used to screen for structural elements, small molecules, and host factors t

222 le topologies formed by up to five secondary structural elements (SSEs), searched for their occurrenc

223 ain a variety of conserved, nonproteinogenic structural elements such as d-amino acids and amide N-me

224 ble linker that harbors additional secondary structural elements, such as Stem III.

225 is a transportable domain that contains the structural elements sufficient for activation by noxious

226 lity of the AHR PAS-A and its loosely packed structural elements, suggest a dynamic structural hierar

227 revealed six residues that provide essential structural elements supporting the fold of the loop and

228 elements--collectively termed TARBP2-binding structural elements (TBSEs)--in transcripts.

229 Moreover, we identify a novel structural element, termed the homo-oligomer assembly (H

230 known to bind the kink-turn (K-turn), an RNA structural element that causes axial bending.

231 The alpha-helix is a ubiquitous secondary structural element that is almost exclusively observed i

232 that the overhang of a pre-miRNA is the key structural element that is recognized by TUT7 and its pa

233 he beta gate loop, a conserved and essential structural element that lies across the DNA channel from

234 The structure also reveals two structural elements that appear to mediate the coupling

235 esent study, we investigated the genetic and structural elements that are important for ampC inductio

236 AR) studies provided insights into conserved structural elements that are important for inhibition po

237 ns as well as loop diminutions affecting RNA structural elements that are otherwise conserved from ba

238 from E2 to lysine residues by: (1) harboring structural elements that block E2 Ub from adopting a '

239 107 analogs will allow us to define critical structural elements that can be mapped onto the receptor

240 The composite of secondary structural elements that comprise miRNAs could aid the d

241 To date, the residues and structural elements that comprise this epitope have not

242 ntibiotic pressure via evolution of specific structural elements that confer hydrolytic activity agai

243 In this work, we analyzed sequence and structural elements that contribute to efficient ligand-

244 genesis was also used to further dissect the structural elements that contribute to the interactions

245 these peptides in AgrC-III revealed two key structural elements that control AIP-III (and non-native

246 Determining the structural elements that define substrates and inhibitor

247 wever, little is known about the residues or structural elements that define this activity.

248 y is unique to the SARM1 TIR domain, yet the structural elements that enable this activity are unknow

249 gp120 binds to CD4, and concerted changes in structural elements that form at the CD4 interface durin

250 We propose that the native state contains structural elements that frustrate one another's folding

251 We explore the structural elements that govern Oct4 recognition by thes

252 rovide novel molecular information about the structural elements that govern the interaction between

253 teins, the in vivo biological chemistry, the structural elements that govern the selective S-nitrosyl

254 al importance and provide the first hints at structural elements that have important functions specif

255 mining region 3 (HCDR3) and possesses unique structural elements that interact with protein and glyca

256 Kink turns (k-turns) are widespread structural elements that introduce an axial bend into du

257 To examine the structural elements that lead to differences in force se

258 necessary step to unravel the electronic and structural elements that lead to ultrafast and near-unit

259 -associated hyperactivating mutations map to structural elements that maintain the inactive state, an

260 suggest that RAM contains sequence-specific structural elements that may be important for activation

261 e JEV at near-atomic resolution and identify structural elements that modulate stability and virulenc

262 identified a striking unique orientation of structural elements that position the motor's lever arm.

263 esence of a bulge between the G-quartets are structural elements that potentially can be targeted by

264 mbrane permeability by producing lipids with structural elements that putatively improve membrane int

265 of self-stress--tensions and compressions of structural elements that result in zero net forces--play

266 Microtubules are key structural elements that, among numerous biological func

267 Here we focus on one type of structural element, the alpha-helix, and measure triplet

268 es of the viral cycle, of a highly conserved structural element, the major homology region (MHR), wit

269 This pocket is formed by key structural elements thought to be pivotal for force gene

270 e virion architecture that lacks several key structural elements thought to stabilize a single-shelle

271 we propose that the fingerloop is the first structural element to detect signal sequence binding; th

272 Here, we use these structural elements to assess biophysical principles beh

273 ange of functional purposes and as important structural elements to facilitate protein folding and as

274 Large RNAs often utilize GNRA tetraloops as structural elements to stabilize the overall tertiary fo

275 is circuitry subserve that link these unique structural elements to their function?

276 by exploiting the ability of flavivirus RNA structural elements to trap XRN1 decay intermediates in

277 d2 fold in crystal and in solution, its core structural elements undergo discernible rigid-body movem

278 The actin cytoskeleton is a structural element underlying the proper morphology of d

279 Structural elements underlying the theft occurred early

280 uence element also turns into a well-defined structural element upon fibril formation.

281 d for measuring the rate of formation of two structural elements using a single triple-labeled mutant

282 at VWF A2 domain stability provided by its 2 structural elements (vicinal disulphide bond and CBS) is

283 o show that in some cases specific secondary structural elements, viz., extended coils or helices, ca

284 addition, the residue positions within these structural elements were under strong evolutionary const

285 ctions contain hot-spot regions on secondary structural elements, which contribute disproportionately

286 It shares core structural elements with clan CD cysteine peptidases but

287 PON-2 shares key structural elements with MEC-6, an endoplasmic reticulum

288 tric superfold protein composed of repeating structural elements with multivalent carbohydrate-bindin

289 iant CENP-A, hence, serving as a reinforcing structural element within the histone core.

290 nt genus, suggesting a conserved stabilizing structural element within the paramyxovirus family.

291 We also define a novel structural element within the second insertion that is h

292 cting initiation factors as well as sequence/structural elements within messenger RNAs and that non-A

293 us to identify and genetically validate key structural elements within TADs.

294 hosphorylation thus operates in concert with structural elements within the C-terminal tail of FFA4 t

295 ough a 'molecular corset' mechanism, whereby structural elements within the epithelium become circumf

296 highlights the presence of varyingly stable structural elements within the IDRs.

297 ting the physiological relevance of specific structural elements within the IRES for virus infection.

298 th long-range communication between specific structural elements within the ribosome.

299 en together, these results suggest that most structural elements within TRP channels and Kv channels

300 e in good agreement with the known secondary structural elements within ubiquitin.