ライフサイエンスコーパス: structural feature

1 eric state, thermal stability, and secondary structural features).

2 ching neutral loss peaks should contain that structural feature.

3 nal insight into the analysis of solid-state structural features.

4 ncover new natural products containing these structural features.

5 mechanical behavior to be linked to specific structural features.

6 tion with concurrent characterization of its structural features.

7 , with which they share many biochemical and structural features.

8 discrete biological control of these central structural features.

9 ructure that displays strong two-dimensional structural features.

10 does not imply the survival of solution-like structural features.

11 ns are determined in part by highly specific structural features.

12 d CoinDCA-NN that incorporate a large set of structural features.

13 ct on other DNA substrates that share common structural features.

14 y, which is attributed to their chemical and structural features.

15 We found that hIntL-1 and XEEL have similar structural features.

16 ding a platform for quantitative analysis of structural features.

17 y revealed that Hrq1 and RecQ4 share similar structural features.

18 mputational analyses to identify the optimal structural features.

19 ion patterns associated with their different structural features.

20 ter in pathogenic microorganisms with unique structural features.

21 g-target interactions using evolutionary and structural features.

22 Our study reveals some unique structural features: 1) the lack of an internal ligand b

23 photericin B, but it has several distinctive structural features: a noncationic 6-deoxymannose sugar

24 elical proteins designed with SEWING contain structural features absent from other de novo designed p

25 d their feeding interactions) share multiple structural features across ecosystems.

26 te correlations revealed the CAPT catalyst's structural features, affecting the production of this un

27 as then conducted to delineate its essential structural features, aiming to improve solubility and sa

28 ence specificities, thermosensitivities, and structural features, all orthologs share the unusually h

29 significant structural similarity; however, structural features alone are insufficient to explain th

30 od that has for the first time exploited the structural features along with the evolutionary features

31 id oxidases, it shows the following specific structural features: an additional novel alpha+beta subd

32 secretes a pore-forming VacA toxin that has structural features and activities substantially differe

33 ee genes encoding DNA ligases with conserved structural features and activities, but they also have n

34 degenerative diseases, exploiting the unique structural features and conformational changes identifie

35 The structural features and dynamics of biological macromole

36 ough the IL-1beta and IL-33 complexes shared structural features and engaged identical molecular surf

37 which can be rationalized from the different structural features and interactions with other nucleoti

38 Recent work that has uncovered structural features and new mechanisms for speeding the

39 The resulting silk nanofibrils, which retain structural features and physical properties of native si

40 nalytical comparisons are required to assess structural features and post-translational modifications

41 Many interesting structural features and reaction patterns have emerged,

42 To better understand the structural features and resulting electronic coupling th

43 -angle X-ray scattering is used to study the structural features and stability of the core-shell stru

44 s well as biochemical studies to address key structural features and surface residues involved in DNA

45 in disease pathology, provide an overview of structural features and the available modulators, includ

46 ults, we obtain the relation between network structural features and the collective fair behavior.

47 The associations between the structural features and the lithium storage mechanism ar

48 its structural counterparts is attributed to structural features and therefore offers insight into th

49 e we explore the use of a predictor based on structural features and which exploits random forest mac

50 apidly under mild conditions, can retain key structural features and yield otherwise inaccessible pha

51 s of 3-[iodo-Tyr(B26)]insulin to predict its structural features, and (ii) tested these predictions b

52 to medicinal chemistry rules, 2) distinctive structural features, and 3) enrichment in rod-like shape

53 We correlated this modification with aS structural features, and we suggest a possible functiona

54 Several structural features appeared to contribute to the anti-H

55 However, little is known about which structural features are dynamic.

56 Antibodies with similar structural features are elicited in multiple subjects, s

57 Such diversity animates the question "what structural features are essential for a chlorin to resem

58 le, low-density (semi-dilute) liquids, whose structural features are likely to strongly impact biolog

59 But these structural features are not completely understood.

60 with distinctively different absorption and structural features are reported.

61 lytic mechanism of AURKA, and identify a key structural feature as the target for a new class of dual

62 d dyn[4]arenes plays a crucial role on their structural features as well as their molecular recogniti

63 ctures have led to the identification of key structural features associated with kinase activation, t

64 lectron microscopy was adopted to reveal the structural features at an atomic level.

65 However, a clear description of the structural features at the basis of the R61T-ApoE4 mutan

66 epeat motif (IFIT) gene family members share structural features at the gene and protein levels.

67 In consideration of the different structural features between G4DNA and ssDNA, these bindi

68 Thus, our analysis identified major structural features can be exploited in the design of se

69 that integrating the additional RNA tertiary structural features can improve the model performance in

70 Other structural features can make contributions so an entire

71 complex structures that possess many of the structural features characteristic of the exosporium bas

72 Our results suggest that PrP(C) recognizes structural features common to both Abeta oligomers and f

73 According to this model, structural features common with warm-active trypsins wou

74 he effector site of LmFBPase shows different structural features compared with human FBPases, thereby

75 We have rationalized the structural features conducive to activities at the main

76 The only structural feature conserved across all groups was a seq

77 Ab repertoire is generated in the absence of structural features considered essential in mammalian Ig

78 We propose these newly revealed TRPV2 structural features contribute to diversity of TRPV chan

79 role for neutralizing antibodies in defining structural features critical to a pathogen's mechanism o

80 and thus its susceptibility to esterase, and structural features critical to the lactonization rate,

81 nucleic acids in vitro, but the sequence and structural features dictating their formation and functi

82 Additional structural features, docking simulations, and mutational

83 These structural features enable unprecedented performance for

84 Our approach is based on supervised structural feature extraction using deep learning, in co

85 dous research interest owing to their unique structural features, fascinating physicochemical propert

86 ce indicates that the conserved APH is a key structural feature for RTN13 function in vivo, and we pr

87 strate site of XPNPEP3 provide the necessary structural features for processing the mitochondrial sub

88 Calculated charges and structural features for reactants and transition states

89 Second, the binding data provided optimal structural features for the design of a tetraammonium io

90 rmations in vitro, all of which bear unusual structural features: Form 1 bears a V-shaped loop and a

91 rly the phenylethylamine, moiety is a common structural feature found embedded in many clinically app

92 The gem-dimethyl moiety is a structural feature frequently found in many natural prod

93 structure-processing pipeline that extracts structural features from DNA-protein complexes.

94 k can automatically extract effective hidden structural features from the encoded raw sequence and st

95 istry involved in constructing both of these structural features has been largely unexplored.

96 rivatives as QMPs was remarkably affected by structural features (i.e., conjugating arylethynyl moiet

97 reveals its activation mechanism as well as structural features important for its ligation activity.

98 e RBP targets by integrating their available structural features in all three dimensions is still a c

99 Many of the same secondary structural features in both enzymes are perturbed, sugge

100 as well as coding transcripts share similar structural features in different tetraploid species; yet

101 ded evidence that the unusual combination of structural features in gichigamins conferred on them an

102 fulcrum of these conformational changes, and structural features in its vicinity are consistent with

103 ol or JSmol session and returns DSSR-derived structural features in JSON format.

104 pyridinylimidazole scaffold varying several structural features in order to deduce crucial structure

105 hat these frictional domains derive not from structural features in the graphene but from self-assemb

106 The functional interpretation of any structural features in the model and its utilization for

107 Proteins with specific structural features including constricting rings, helica

108 ation, and allowed identification of precise structural features including the location of O-acetyl g

109 Bottromycins exhibit unique structural features, including a hallmark macrolactamidi

110 n patterns that allow elucidation of certain structural features, including acyl chain positions on t

111 he crystal structure of TacT and note unique structural features, including two positively charged su

112 Key structural features interacting with KHK were discovered

113 colloidal nanoparticles with pre-programmed structural features into targeted products have emerged

114 The PJTE origin of these structural features is confirmed also by estimates of th

115 Due to KuQs structural features, keto-enol tautomerization in soluti

116 Structural features, mainly the presence of a conserved

117 ucleotide content, implying that broader DNA structural features may define in planta binding.

118 Characterizing abnormal mitochondrial structural features may thus provide insight into the un

119 ned the historic changes in Env sequence and structural features (measured by integrity of epitopes o

120 Chemicals with structural features more varied than previously thought

121 study, chitins and chitosans with different structural features, namely deacetylation degree (5-91%)

122 f the phenylthiazoles revealed two important structural features necessary for antibacterial activity

123 These results define two distinct structural features necessary for PknB signal transducti

124 structures have strong predictive power for structural features not directly visible in the initial

125 The unique structural features observed for MtTOP1 may allow these

126 A unique structural feature of brigatinib is a phosphine oxide, a

127 e, we show that Fkh1 and Fkh2 share a unique structural feature of human FoxP proteins that enables F

128 The defining structural feature of inward-rectifier potassium (Kir) c

129 A common structural feature of natural communities is the non-ran

130 through tertiary interactions is a striking structural feature of the eukaryotic ribosome.

131 A subtle structural feature of the hERG selectivity filter might

132 inson's disease etiopathogenesis, and of the structural feature of the resulting amyloid fibrils may

133 The main structural feature of the wheat peptides responsible for

134 A unique structural feature of these clinically important enzymes

135 of prefibrillar species, indicating a unique structural feature of these intermediates.

136 A clear elucidation of structural feature of whole lignin in plant cell wall is

137 rylnitrile oxides possess the electronic and structural features of 1,3-dipolar cycloadditions.

138 Structural features of 3D-reconstructed eukaryotic cells

139 in mammalian cells essentially controls the structural features of a Golgi cisterna by regulating it

140 Herein, we describe structural features of a series of mu-opioid-receptor (M

141 We revealed the origin of the structural features of a series of tetrasilacyclobutadie

142 easy identification of molar mass and other structural features of aldehyde and ketone photoproducts

143 opy is a facile technique for characterizing structural features of alpha-synuclein fibrils.

144 This study also demonstrates how structural features of amorphous materials, traditionall

145 Low packing densities are key structural features of amphidynamic crystals built with

146 recipient cells, which demonstrates that the structural features of aSyn species determine their effe

147 ding pocket that can accommodate the diverse structural features of beta-glycoside ligands while stil

148 in-plane membrane anchor in IL-26, which are structural features of cationic amphipathic cell-penetra

149 tness and small-world effect are two crucial structural features of complex networks and have attract

150 Amount and structural features of CSR junctions reveal valuable inf

151 nide complexes have not been determined, the structural features of CYP2C8 active site support its bi

152 onides as CYP2C8 ligands and the active-site structural features of CYP2C8 that allow potential bindi

153 Compared to the core chromosomes, the structural features of DCs usually differ for gene densi

154 In this review, an analysis of the structural features of different beta-sheet peptide hydr

155 d segregation of the latent episome, but the structural features of EBNA1 that confer each of these f

156 Chemical composition and structural features of FG extracted at different tempera

157 These data indicate that the unique structural features of formoterol allow it to interact w

158 scape of prothrombin in solution and uncover structural features of functional significance that exte

159 rpesvirus pathogenesis and details important structural features of gK that are involved in gK-mediat

160 n drawing conclusions from investigations of structural features of HS and specificities of HS intera

161 antibody structures to evaluate sequence and structural features of human antibody repertoires at unp

162 taneously provides a direct insight into the structural features of lignin.

163 novel miRNAs usually involve the analysis of structural features of miRNA precursor hairpin sequences

164 vitro 2'O methylation, suggesting that other structural features of mRNAs may influence their sensiti

165 vent this limitation, we utilized the unique structural features of N-glycan molecules, the common co

166 ee of statistical regularity can capture key structural features of natural images.

167 Emerging evidence suggests that other structural features of nucleosomes also contribute to pr

168 behavioural assays we have characterized the structural features of Orb2 from the monomer to the amyl

169 Third, while the structural features of postsynaptic entities in mouse an

170 t stability in mice reproduces molecular and structural features of PTOA that would suggest potential

171 CO2 concentration, we hypothesized that the structural features of receptor protein tyrosine phospha

172 However, the structural features of spermidine required for B. subtil

173 he activities of Spt4/5 and interrogated the structural features of Spt5 required for it to interact

174 and cause hIAPP to take on the cytotoxic and structural features of that segment.

175 We show that Nop9 recognizes sequence and structural features of the 20S pre-rRNA near the cleavag

176 The structural features of the 26S proteasome observed in th

177 The data reveal structural features of the active site (Sa) critical for

178 We also propose that structural features of the anticodon-binding domain in M

179 The key structural features of the APN pharmacophore required fo

180 ee-dimensional collagen hydrogels that mimic structural features of the atherosclerotic fibrous cap,

181 The structural features of the Au-DNs and their interfacing

182 out the long-term consequences of AAS use on structural features of the brain.

183 Key structural features of the catalysts are analyzed, as is

184 llenging, partly due to the highly conserved structural features of the catalytic sites across the cl

185 s bound to the ribosome and reveal consensus structural features of the cisplatin-binding sites.

186 The morphological and structural features of the composite material were chara

187 support a model for native infection wherein structural features of the gag-pol mRNA actively compart

188 molecular simulation studies to explore the structural features of the geranyl group in the context

189 are unpredictable depending on the specific structural features of the included organic ligands, rea

190 Herein, key structural features of the interaction between TTR and t

191 This selectivity can be explained by unique structural features of the KIFC1 alpha4/alpha6 binding s

192 by accurate analyses of both the content and structural features of the molecules involved.

193 Structural features of the nucleus including shape, size

194 None of them affected the structural features of the protein at room temperature,

195 dular and places minimal requirements on the structural features of the protein building blocks, it c

196 tive necessitates the ability to control the structural features of the resultant assemblies through

197 Unique structural features of the Slo1 voltage sensor suggest t

198 bbit muscle GPb inhibitor complexes revealed structural features of the strong binding and offered an

199 deling can measure the tissue properties and structural features of the tracts that impact our abilit

200 While previous studies have outlined basic structural features of these invaginations, very little

201 utes to compound collections inspired by the structural features of these natural products is of part

202 t they play an active role in modulating the structural features of this CBP fragment.

203 We utilized the remarkable electronic and structural features of this product to achieve the first

204 d in seizures, but little is known about the structural features of this projection system in epilept

205 Cytochrome c recognizes the tertiary structural features of tRNA, particularly in the core re

206 ve site are interconnected and are intrinsic structural features of Uba1 and that the overall structu

207 Furthermore, TEM reveals important local structural features of ZIF-8 crystals that cannot be ide

208 lignments (e.g., genes, codon positions, and structural features) often favor hundreds if not thousan

209 et the virus shows a remarkable diversity in structural features, often with the same proteins adopti

210 insights described here suggest that unique structural features on CD1 regulate the molecular assemb

211 veloped an approach to identify and quantify structural features on the catalyst that determine selec

212 ined with confocal Raman microscopy to study structural features on the molecular scale, reveal a nan

213 h signal-to-noise ratio, can report multiple structural features per molecule, and allows both genome

214 el quality assessment method QAcon utilizing structural features, physicochemical properties, and res

215 The structural features present galactoglucan (30%) and gala

216 that the active site of the enzyme combines structural features previously only observed in either c

217 ation frequencies, but most have distinctive structural features probably causing elevated mutation r

218 These structural features provide the basis of human peroxidas

219 We will analyze and compare the structural features required for dual inhibition and com

220 ation, resulting in a detailed view into the structural features required for receptor activation, ac

221 To elucidate the structural features required for these sensory effects,

222 the platinum shell, which is known to be the structural feature responsible for the enhancement.

223 lso shed light on the reaction mechanism and structural features responsible for stabilizing the elus

224 nts that can cover this entire range and the structural features responsible for the extreme E degree

225 unds were prepared, and a description of the structural features responsible for the in vitro activit

226 ppGBP binds to monosaccharide, but the structural features revealed it to have an oligosacchari

227 o), a natively disordered protein possessing structural features similar to the flexible N-terminal t

228 e and interpret the kinetic data in terms of structural features specific for H-, K-, and N-Ras.

229 ith residues that are more loosely packed, a structural feature that facilitates motion of helices H5

230 H-bonding proton-delivery network is the key structural feature that transforms the reversible oxygen

231 cities for Ins(1,2,4,5,6)P5, have identified structural features that account for this difference, an

232 Here, we discuss the key structural features that all Artemis DNA substrates have

233 structures shows that the AF-Est2 has unique structural features that allow CoA binding.

234 To further explore the structural features that allow the clonally expressed TC

235 ammalian middle ear, thus illustrating novel structural features that are likely critical for middle

236 While adding the structural features that are more favored by on-target a

237 The OS, however, has several unique structural features that are not seen in primary cilia.

238 6-bound Abeta42 monomer exhibits alternative structural features that are strongly dependent on the h

239 missible and pathogenic in vivo To probe the structural features that confer transmissibility to prio

240 on, the opposite strategy of subtracting the structural features that contribute more to off-target a

241 by molecular guests, which suggests that the structural features that contribute to multistep switchi

242 ility maximums and minimums with interesting structural features that corroborate proposed mechanisms

243 We describe the structural features that determine Fe(2+) translocation

244 These results reveal key structural features that determine the force-transductio

245 xibility of the two wings revealed important structural features that dictate the potency and selecti

246 The structural features that distinguish Rb from other pocke

247 ATP-dependent mechanism, its biochemical and structural features that ensure efficient proteolysis an

248 Then, important structural features that exhibit considerable difference

249 strate that only Abeta(1-42) contains unique structural features that facilitate membrane insertion a

250 's catalytic properties requires identifying structural features that give rise to active surfaces.

251 Characterization of the structural features that govern functional erythrocyte b

252 emarkable, owing to the unique, multifaceted structural features that have been combined into one mol

253 Here, we present insights into specific structural features that increase the difficulty of find

254 y diverse subgroups and exhibit transitional structural features that may help explain reaction diver

255 unambiguous documentation of the diagnostic structural features that separate angiosperms from other

256 ycin B scaffold, as well as several chemical structural features that serve to enhance antimalarial s

257 We have defined structural features that underlie activation of the mult

258 e influence of preswelling conditions on the structural features, the SREL obtained through preswelli

259 Despite close structural features, the three molecules led to distinct

260 he spectra being compared differ by a single structural feature, these matching neutral loss peaks sh

261 Analysis of the active site emphasizes key structural features thought to be important in resistanc

262 he NBC model are then trained with intrinsic structural features through neural network learning for

263 approach that allows translation of observed structural features to a physically intuitive packing of

264 disproportionately large flippers with added structural features to aid in hydrodynamic performance [

265 r bioinformatics-derived restraints or novel structural features to be included, e.g. novel ligands,

266 Finally, we suggest structural features to be introduced or removed to impro

267 CALHM1, a transmembrane protein with shared structural features to connexins and pannexins, has been

268 Alternatively, we can modify essential NS2 structural features to marginally limit viral growth whi

269 ype I, Type II animal cryptochromes lack the structural features to securely bind the photoactive fla

270 a plausible correlation between the inherent structural features/topology of MOFs and the associated

271 As a characteristic structural feature, TRPC4/5 channels contain a C-termina

272 t in humans the Xi chromosome exhibits three structural features, two of which are not shared by othe

273 r interactions- can give rise to many of the structural features typically associated with amyloid se

274 Several clever structural features underlie this amazing phenomenon.

275 that do not form tripartite pumps, but share structural features underpinning mechanotransmission, in

276 We also describe structural features unique to HsIPMK.

277 has a combination of interrelated shape and structural features unique within Corvus, and possibly b

278 It also reveals how protein structural features used for reverse transcription evolv

279 This structural feature was proposed as the basis for initiat

280 The most active compound, bearing both the structural features, was able to inhibit tumor cell prol

281 = diethylamino), were synthesized, and their structural features were elucidated both in solution and

282 Their unique structural features were incorporated into design of a s

283 ption that food allergens must have specific structural features which causes their allergenicity.

284 Investigation of the structural features which could cause such an unusual oc

285 residues are very rare and rather startling structural features which play a variety of functional r

286 me is not sufficient, but that this specific structural feature, which entails higher connectivity de

287 unctional properties can be linked to unique structural features, which identify enzymes acting on bu

288 NBC posterior probability and the intrinsic structural features, which were found particularly impor

289 growth volume and with the identification of structural features with a 100 mum spatial resolution.

290 a-sheets mated by a dry interface that share structural features with and are similarly cytotoxic to

291 e with Sm proteins, and share biogenesis and structural features with cellular Sm-class small nuclear

292 HEV ORF3 shares several structural features with class I viroporins, and the fun

293 r diameter, mini microtubules share many key structural features with eukaryotic microtubules, such a

294 oside hydrolases (GH39s), and have conserved structural features with GH51s.

295 ructural organization and shares a number of structural features with mesoscale connectomes of mouse

296 The method utilizes a combination of structural features within the conformation of a protein

297 in the (99m)Tc concentration associated with structural features within the materials, such as macrop

298 Unique structural features within the S4-S5 linker permit uncou

299 The present results thus identify multiple structural features within the solvent-exposed SF region

300 as predictive biomarkers, but do not capture structural features within the tissue architecture.