ライフサイエンスコーパス: structural genomics

1 ng reduces cost and material requirements in structural genomics.

2 or structure determination in the context of structural genomics.

3 (a)s or electrostatic strain is relevant for structural genomics.

4 terest for automated resonance assignment in structural genomics.

5 mportant implications for bioinformatics and structural genomics.

6 and sensitivity remains a major challenge in structural genomics.

7 of function to structures in the context of structural genomics.

8 s each of which may be a suitable target for structural genomics.

9 e number of structures that will evolve from structural genomics.

10 ose in PDB, and discuss the implications for structural genomics.

11 nd protein complexes in the growing field of structural genomics.

12 hods play in the growing worldwide effort in structural genomics.

13 Data Bank, and discuss the implications for structural genomics.

14 ture are of growing importance in the age of structural genomics.

15 iscrete space has important implications for structural genomics.

16 r discovering new motifs, a basic premise of structural genomics.

17 AGE database is a collaborative resource for structural genomics.

18 ated by the New York SGX Research Center for Structural Genomics.

19 mportant task in comparative, functional and structural genomics.

20 rotein modelling coverage, in the context of structural genomics.

21 ent a broader view of structural biology and structural genomics.

22 n structures, particularly in the context of structural genomics.

23 protein structures is a central challenge in structural genomics.

24 assignment to sequences, as in computational structural genomics, a fast yet sensitive sequence searc

25 A worldwide initiative in structural genomics aims to capitalize on the recent suc

26 Structural Genomics aims to elucidate protein structures

27 nd proteome technologies-in combination with structural genomics and combinatorial chemistry-the floo

28 ealth of data being generated by large-scale structural genomics and disease association studies.

29 ombinant proteins are a major issue for both structural genomics and enzymology research.

30 These are necessary criteria for structural genomics and proteomics applications.

31 With the use of structural genomics and systems biology, we generated a

32 bundance of protein structures emerging from structural genomics and the Protein Structure Initiative

33 ed for future expression array construction, structural genomics, and analyses of the mechanism and r

34 ns in related fields such as bioinformatics, structural genomics, and proteomics, in which one's abil

35 Consortium in establishing its pipeline for structural genomics, and some of the experimental and bi

36 Current interests in structural genomics, and the associated need for high th

37 ture of unknown function, such as those from structural genomics, and with no prior knowledge of its

38 e- and metabolome-wide experimental studies; structural genomics; and atomistic simulations of cellul

39 Enzyme/non-enzyme homologues, "structural genomics" annotated proteins and catalytic/no

40 e difficulty of assigning function through a structural genomics approach for some folds.

41 in various types of cancers, as well as the structural genomics approach to develop new therapeutic

42 These discoveries highlight the value of structural genomics approaches in identifying ligands wi

43 f the multitude of structures available from structural genomics approaches.

44 ion and improve the efficiency and output of structural genomics, as well as general structural biolo

45 ures offers an assessment of the progress of structural genomics based on the functional coverage of

46 NA synthetases to be targeted in the Seattle Structural Genomics Center for Infectious Disease (SSGCI

47 context of structures recently deposited by structural genomics centers (i.e., NudCL and mouse NudCL

48 at includes protein target data from the NIH structural genomics centers and a number of internationa

49 the exchange and deposition of data with the structural genomics centers and creating software tools

50 The progress of the structural genomics centers in the U.S. and around the w

51 A structural genomics comparison of purine nucleoside phos

52 t of our target selection for the North-East Structural Genomics Consortium (NESG).

53 escribe the methods used in the Tuberculosis Structural Genomics Consortium (TBSGC), ranging from pro

54 -scale experimental results of the Northeast Structural Genomics Consortium and experimental folding

55 ight NMR protein structures of the Northeast Structural Genomics Consortium pipeline.

56 gh-quality structure of the 14 kDa Northeast Structural Genomics consortium target protein, YqfB (PDB

57 serves as the central hub for the Northeast Structural Genomics Consortium, allowing collaborative s

58 ystal structures determined by the Northeast Structural Genomics Consortium, for proteins ranging in

59 which were recently solved by the Northeast Structural Genomics Consortium.

60 structures have recently been reported by a structural genomics consortium.

61 tabase and analysis system for the Northeast Structural Genomics Consortium.

62 n was conducted in parallel by the Northeast Structural Genomics Consortium.

63 r rapidly determining RNA conformations in a structural genomics context, and may increase the size l

64 plexes) by integrating chemical genomics and structural genomics data and by introducing a functional

65 from structure would add tremendous value to structural genomics data.

66 on many targets in the system-wide scale of structural genomics depends critically on three paramete

67 hilus influenzae was undertaken as part of a structural genomics effort in order to assist with the f

68 been created to turn the products of the PSI structural genomics effort into knowledge that can be us

69 ase in structure determinations arising from structural genomics efforts and advances in mass spectro

70 Although the PSI and other structural genomics efforts around the world have led to

71 Structural genomics efforts contribute new protein struc

72 Structural genomics efforts contributed approximately 50

73 n Structure Initiative and related worldwide structural genomics efforts facilitate functional annota

74 erties onto the numerous folds determined in structural genomics efforts is an area of intense intere

75 Structural genomics efforts previously yielded a crystal

76 tein production pipeline is a bottleneck for structural genomics efforts, as most methods require pur

77 ill be achieved within 15 y, whereas without structural genomics efforts, realizing this goal will ta

78 ein crystallization that may prove useful in structural genomics efforts.

79 lications ranging from therapeutic trials to structural genomics efforts.

80 ring and annotating structures determined by structural genomics efforts.

81 Retrospective benchmarks in 605 Structural Genomics enzymes showed that multiple templat

82 iable basis for the application of TASSER to structural genomics, especially to proteins of low seque

83 Structural genomics eventually aims at determining struc

84 2 protein was chosen by the Joint Center for Structural Genomics for crystal structure determination

85 data from GWAS, high-throughput sequencing, structural genomics, functional genomics, and chemical g

86 this group and others for genome annotation, structural genomics, gene prediction and domain-based ge

87 tructures originally determined by the RIKEN structural genomics group.

88 Structural genomics has as its goal the provision of str

89 Structural genomics has become a powerful tool for study

90 The developing science called structural genomics has focused to date mainly on high-t

91 The advent of functional and structural genomics has greatly accelerated our understa

92 Structural genomics has the ambitious goal of delivering

93 sion from sequence to structure (genomics to structural genomics), has been widely known as the struc

94 How many proteins will structural genomics have to target?

95 Protein crystals play a pivotal part in structural genomics, hence there is an urgent requiremen

96 Similarly, advances in structural genomics in conjunction with in vitro and in

97 Substantial new investments in structural genomics in the past 2 years indicate the hig

98 is is particularly important in the field of structural genomics, in which the fast screening approac

99 faecalis, determined as a part of an ongoing structural genomics initiative (www.mcsg.anl.gov), revea

100 One of the primary aims of the structural genomics initiative is the determination of r

101 One of the principal goals of the structural genomics initiative is to identify the total

102 This is critical for the structural genomics initiative where protein expression

103 verage of protein fold space afforded by the structural genomics initiative, can be used to further t

104 We present the rationale for creation of a structural genomics initiative, recount the efforts of o

105 n structures, including 20 determined by the structural genomics initiative, to show that this overla

106 should prove valuable in the context of the Structural Genomics Initiative.

107 f recently solved enzyme structures from the structural genomics initiative.

108 mining structures, for example as part of a 'structural genomics' initiative, will make a major contr

109 are currently three components to this site: Structural Genomics Initiatives contains information and

110 target information related to the worldwide structural genomics initiatives from its portal at http:

111 ing more and more important as the worldwide structural genomics initiatives gather pace and continue

112 verage of genome sequences, we show that the structural genomics initiatives should aim to provide st

113 tructural homologues being determined by the structural genomics initiatives, more sensitive methods

114 ing number of structures being solved by the structural genomics initiatives, the GRATH server also p

115 determined protein structures, stimulated by structural genomics initiatives, there will be an increa

116 We also discuss the impact of worldwide Structural Genomics initiatives, which are producing new

117 makes the resource of particular interest to structural genomics initiatives.

118 ng the flood of structures soon to flow from structural genomics initiatives.

119 efforts and in particular in high-throughput Structural Genomics initiatives.

120 Structural genomics is emerging as a principal approach

121 P revealed the significant contribution that structural genomics is making to the coverage of superfa

122 erspective of this analysis, it appears that structural genomics is on track to be a success, and it

123 An often stated goal of structural genomics is the high-throughput structural ch

124 A major goal of structural genomics is the provision of a structural tem

125 An important goal after structural genomics is to build up the structures of hig

126 in the future, especially with the advent of structural genomics, is to survey and re-survey the fini

127 The Protein Structure Initiative Structural Genomics Knowledgebase (PSI SGKB) has been cr

128 as a bioreactor is especially well suited to structural genomics, large-scale protein expressions, an

129 regions that are not globular, we found that structural genomics may have to target about 48% of all

130 f function to new proteins in functional and structural genomics may require an understanding of the

131 As part of the Midwest Center for Structural Genomics (MCSG) we have developed a fully aut

132 n from the central registration database for structural genomics, namely, TargetDB.

133 esult is the ETAscape plugin, which builds a structural genomics network based on local structural an

134 ined by the New York SGX Research Center for Structural Genomics (NYSGXRC).

135 primary purpose of reporting progress of the Structural Genomics of Caenorhabditis elegans project at

136 The structural genomics of histone tail recognition web serv

137 These results open the door for structural genomics of RNA in living cells and reveal ke

138 In the Joint Center for Structural Genomics, one-dimensional (1D) 1H NMR spectro

139 l-organized bioinformatics communities (e.g. structural genomics, ontologies, next-generation sequenc

140 tic membrane proteins in either an academic, structural genomics or commercial environment.

141 nd generalized method that can be applied to structural genomics or other targets in a high-throughpu

142 esulted in the formation of an International Structural Genomics Organization to formulate policy and

143 predicted NTPase was determined as part of a structural genomics pilot project.

144 s initiative, recount the efforts of ongoing structural genomics pilot studies, and detail the lofty

145 osynthesis pathway have been determined in a structural genomics pilot study.

146 sign and implementation of a high-throughput structural genomics pipeline and its application to the

147 s and its progress through each stage of the structural genomics pipeline, from cloning, expression,

148 iction into our PSI:Biology membrane protein structural genomics pipeline.

149 Structural genomics presents an enormous challenge with

150 tential bottlenecks in various stages of the structural genomics process through specialized "pipelin

151 Genomic sequencing and structural genomics produced a vast amount of sequence a

152 Current structural genomics programs aim systematically to deter

153 The advent of high-throughput structural genomics programs and advances in cloning and

154 Structural genomics programs are only now moving into th

155 otein is being studied or in high-throughput structural genomics programs.

156 ests that NMR will play an important role in structural genomics programs.

157 rge number of orphan protein structures from structural genomics project are now solved without their

158 As part of a structural genomics project, we have determined the 2.0

159 a protein whose structure was solved by the structural genomics project.

160 make predictions for target proteins from a structural genomics project.

161 A 'structural genomics' project has been initiated aimed at

162 Structural genomics projects aim to provide a sharp incr

163 Structural genomics projects aim to solve the experiment

164 Structural genomics projects are beginning to produce pr

165 tional diversity within supefamilies for the structural genomics projects are discussed.

166 Worldwide structural genomics projects are increasing structure co

167 Structural genomics projects are producing many three-di

168 Current structural genomics projects are yielding structures for

169 Structural genomics projects as well as ab initio protei

170 mation in the Protein Data Bank generated by structural genomics projects but not described in the li

171 Worldwide structural genomics projects continue to release new pro

172 The advent of sequencing and structural genomics projects has provided a dramatic boo

173 protein structural data and the emergence of structural genomics projects have increased the need for

174 As the global Structural Genomics projects have picked up pace, the nu

175 otential cost savings of millions of US$ for structural genomics projects involving high-throughput c

176 The progress of individual targets or entire structural genomics projects may be tracked over time, a

177 Structural genomics projects represent major undertaking

178 Structural genomics projects such as the Protein Structu

179 highlights the utility of enlarging current structural genomics projects that exhaustively sample fo

180 This work is complementary to other structural genomics projects whose primary aim is to det

181 ongoing success of the genome sequencing and structural genomics projects, the increase in both seque

182 ved in various aspects of the informatics of structural genomics projects--developing and maintaining

183 known supra-domains as potential targets for structural genomics projects.

184 ber of experimental structures expected from structural genomics projects.

185 ficult to crystallise and largely ignored in structural genomics projects.

186 iochemical functions of orphan proteins from structural genomics projects.

187 pid determination of protein structures from structural-genomics projects will make it increasingly d

188 locking the secrets in both the sequence and structural-genomics projects.

189 A structural genomics protein from Mycobacterium avium (PD

190 For the structural genomics protein PY01515 (PDB ID 2aqw) from P

191 y and speed, for large scale applications in structural genomics, protein structure prediction and pr

192 yme functional site predictions are made for structural genomics proteins, suggesting that a substant

193 d structure will, inter alia, be valuable in structural genomics/proteomics since disordered regions

194 As the science of structural genomics ramps up adding more and more inform

195 d structure-based annotation by the New York Structural Genomics Research Consortium, models for pred

196 hroughput structural studies by the New York Structural Genomics Research Consortium.

197 d structure-based annotation by the New York Structural Genomics Research Consortium; e.g. the 53 new

198 ling technology that may change the way that structural genomics research is done.

199 Since the advent of investigations into structural genomics, research has focused on correctly i

200 e is intended to enhance communication among structural genomics researchers and aid dissemination of

201 unction based on our interpretation of prior structural genomics results and on its sequence homology

202 structural information may be combined on a Structural Genomics scale to create motifs of mixed cata

203 In the last 3 years, structures solved by structural genomics (SG) initiatives, especially the Uni

204 ructure determination inspired the launch of structural genomics (SG) initiatives.

205 Structural genomics (SG) projects aim to expand our stru

206 By design, structural genomics (SG) solves many structures that can

207 s, and reflects a major focus on classifying structural genomics (SG) structures and transmembrane pr

208 When focusing on structural genomics (SG) structures, we observe that the

209 tives contains information and links on each structural genomics site, including progress reports, ta

210 spects for prediction of functional sites in structural genomics structures of unknown function, and

211 The method can be applied in structural genomics studies where protein binding sites

212 l protease site such as are being created in structural genomics studies worldwide.

213 ly-specific studies, genomic annotation, and structural genomics target suggestion and assessment.

214 erage of the human genome by PDB structures, structural genomics targets and homology models.

215 y, we apply the method to approximately 1700 structural genomics targets and predict that 37 targets

216 MTH538 is one of numerous structural genomics targets selected in a genome-wide su

217 Application of this method to 2235 structural genomics targets uncovered 37 as DNA binding

218 On the remaining members of the family (two structural genomics targets, and a protein involved in t

219 ant regions in such crude models, as well as structural genomics targets, remains an extremely import

220 further predicts 25 targets as RBPs in 2076 structural genomics targets: 20 of 25 predicted ones (80

221 and annotates sub-cellular localization for structural genomics targets; LOCnet is one of the method

222 gy development has played a critical role in structural genomics, the difficulties at each step of de

223 A decade of structural genomics, the large-scale determination of pr

224 As a case study in structural genomics, this work illustrates that comparat

225 These results emphasize the potential of structural genomics to reveal new unexpected connections

226 Here we bridge structural genomics to structural biology with a procedu

227 e hydropathy sequence analysis, an important structural genomics tool.

228 ield, which encompasses functional genomics, structural genomics, transcriptomics, pharmacogenomics,

229 Plant structural genomics was pioneered on a genome-scale in A

230 Taking advantage of the recent advances in structural genomics, we have compiled a relatively large

231 ins of unknown function, as might arise from structural genomics, we tested it on 618 proteins of div

232 Caution is appropriate in structural genomics when using sequence similarity for a

233 The server is likely to be of most use in structural genomics where a large proportion of the prot

234 is of great importance as we enter an era of structural genomics where there is a likelihood of an in

235 BioEditor is relevant in the era of structural genomics, where annotation and publication co

236 Many of the targets of structural genomics will be proteins with little or no s