ライフサイエンスコーパス: structural model

1 n of exposure as binary or continuous in the structural model.

2 ng further support for the well-corroborated structural model.

3 of coimmunoprecipitation assays and protein structural models.

4 ure contact maps can assist the selection of structural models.

5 ght not be enough to propose high-resolution structural models.

6 rvival using time-dependent Cox and marginal structural models.

7 igating similarities and differences between structural models.

8 model clustering to rank and select protein structural models.

9 information to obtain these mixed-resolution structural models.

10 stic sampling of any set of models, not just structural models.

11 evere hypoxemia) at day 30, we used marginal structural models.

12 l lipid binding studies were consistent with structural modeling.

13 n mutant GABAA receptors were explored using structural modeling.

14 In the structural model, a resilience pathway showed less pover

15 cells, and >2,000 RosettaAntibody-predicted structural models across three healthy donors led to a n

16 Structural modeling along with other computational and e

17 Marginal structural model analyses largely confirmed the results

18 Protein and structural modeling analysis identified an amino acid si

19 toms on time to death using a joint marginal structural model and data from a cohort of HIV-infected

20 e support the functional significance of the structural model and indicate that the same interaction

21 Structural modeling and comparisons, catalytic-site chan

22 Sensitivity analyses, including marginal structural modeling and controlling for viral load and f

23 describe opportunities and challenges in RNA structural modeling and design, as recently discussed du

24 e to the NaV1.7 S241T mutation, predicted by structural modeling and functional analysis to be respon

25 ly unannotated PC dominated the dataset, but structural modeling and genomic context identified this

26 Structural modeling and in vitro experiments with recomb

27 tly solved crystal structure of Hv1, we used structural modeling and molecular dynamics simulations t

28 Using structural modeling and molecular dynamics simulations,

29 Structural modeling and molecular simulations reveal uni

30 Structural modeling and structure-based analysis indicat

31 We performed whole-genome sequencing, structural modelling and cytogenetic analyses of 17 diff

32 sk of cardiovascular event by using marginal structural models and Cox models extended to accommodate

33 ombinant allergens were correctly folded and structural models and patient reactivity profiles sugges

34 Sampling structural models and ranking them are the two major cha

35 s-linking and mass spectrometry, comparative structural modeling, and genetic and biochemical analyse

36 entry using molecular-dynamics simulations, structural modeling, and in vitro and in vivo functional

37 ality scores (i.e. GDT-TS scores) of protein structural models, and uses them to estimate its probabi

38 ool for assessing the adequacy of a proposed structural model as well as for future model development

39 Structural modeling, as supported by experimental probin

40 tructural optimizations do not give accurate structural models, as assessed by the experimental chemi

41 surements on the 3FD-IL nanosheets support a structural model based on a honeycomb lattice, in which

42 MG improves the GDT-TS score and TM-score of structural models by 2.96-6.37% and 2.42-5.19% on the th

43 unity and indicate that dynamics-inspired NM structural models can simultaneously agree with both Bra

44 The structural model chosen here, using continuous exposure,

45 This allows us to build a structural model combining the archaellum and its motor

46 on for arbitrary protein families leading to structural models complementary to often-difficult exper

47 Structural modeling, coupled with mutagenesis and bioche

48 d straightness of newly polymerized MTs, and structural modeling data suggest a conformational change

49 Prior structural models, derived from X-ray fiber diffraction

50 for such comparative studies have focused on structural models determined at atomic resolution, and m

51 we argue that primary sequence analysis and structural modelling do not readily explain why NasA, Na

52 Many structural models employ mean values of vessel microstru

53 Marginal structural models estimated the causal effect of statin

54 We used marginal structural models, estimated by inverse probability weig

55 Structural modeling followed by functional analyses furt

56 Rietveld refinement yielded a monoclinic structural model for a well-crystalline tridymite, consi

57 Our data provide a structural model for assembly of the active Tat transloc

58 The results include the first reliable structural model for beta-Bi2Sn2O7 (orthorhombic Aba2, a

59 These insights suggest a new structural model for cholesterol-mediated regulation of

60 Not only is the title complex thus the best structural model for CuZ* to date, but it also serves as

61 nce of this prediction and produces a mutant structural model for download.

62 We propose a structural model for EGFR multimerization through self-a

63 Murray et al. report an atomic-level structural model for FUS LCD fibrils that answers some q

64 The most probable structural model for hDAT dimer suggested by computation

65 These data allow us to present a structural model for how acidification during endocytic

66 We present here a structural model for how Set8 uses multivalent interacti

67 try assays and describe for the first time a structural model for human galectin-4.

68 electron microscopy enabled me to propose a structural model for its quaternary structure.

69 Candida colonization), and using a marginal structural model for longitudinal data, treatment was no

70 NSS homologue, LeuT, represents a principal structural model for Na(+)-coupled transport catalyzed b

71 4G peptide and propose the first eIF4E-eIF4G structural model for plants.

72 er, currently, there is a lack of a detailed structural model for the active state of the twister rib

73 f the complete transport process, offering a structural model for the alternating-access mechanism an

74 In addition to being a high fidelity structural model for the biological cofactor, the comple

75 raction within eIF2alpha; and (ii) the first structural model for the complex of eIF2B with its subst

76 resented in this work allows us to propose a structural model for the molecular interaction of the Sp

77 A structural model for the S0 state is proposed that is co

78 dynamics simulation procedures, we provide a structural model for the subdomain-mediated tetramer/tet

79 Walther and co-workers have proposed a structural model for the TatA oligomer in which TatA mon

80 aggregation, and we present an atomic-level structural model for the TDP-43 dimer based on NMR data.

81 Also, a comprehensive structural model for the tetrameric complex of vimentin

82 To generate a structural model for the TSHR we applied an integrated s

83 olecular modeling protocols, have provided a structural model for the TTR-Abeta interaction, as well

84 l dipolar couplings was employed to obtain a structural model for the ZZ domain-SUMO1 complex.

85 As a structural model for these intermediates, we characteriz

86 okaryotic NSS protein, constitutes a primary structural model for these transporters.

87 In a structural model for tubular CA assemblies based on cryo

88 Generating tertiary structural models for a target protein from the known st

89 riments, and existing NMR data, we developed structural models for all three states of the protein.

90 Detailed molecular structural models for certain fibrils and aggregation in

91 Paradoxically, structural models for collision suggest that the nucleas

92 function from multiple organisms and curated structural models for each variant from crystal structur

93 he server automatically provides a series of structural models for the complex, sorted by the pyDockS

94 tures providing chemical starting points and structural models for the development of potent and sele

95 o generate and functionally test data-driven structural models for three diverse HCV RNA genomes.

96 ll needs to be filled with a high-resolution structural modeling framework, which includes a minimall

97 mputational tools to generate and analyze 3D structural models from 3C data.

98 n channelrhodopsin crystal structure, and by structural model-guided redesign of channelrhodopsins fo

99 Additionally, the structural models have been expanded to include an extra

100 binding interface as indicated by HDX MS and structural modeling; however, HC Met257 oxidation was fu

101 The structural model illustrates the effects of using social

102 Our findings support recent structural models implicating the P-loop arginine in ATP

103 Based on these data, we propose a structural model in which contiguous CsPABPN1 RRM monome

104 These results enabled us to propose a structural model in which Ecm29 intrudes on the interact

105 talysis and substrate binding, and support a structural model in which rearrangement of a flexible lo

106 state-of-the-art in these various aspects of structural modeling in cellular biology, and the prospec

107 Functional-structural modeling in SimRoot indicates that, in common

108 These results and our structural modeling indicate that a more complex binding

109 The structural models indicate that BAF57 and/or BAF250 medi

110 NMR derived structural models indicate that MT1-MMP transiently asso

111 Structural modeling indicated that all substitutions aff

112 Structural models indicated that external Na(+) binding

113 RP3 PYD abrogate inflammasome activation and structural modeling indicates that phosphorylation of th

114 Structural modeling indicates that these two regions are

115 Fitting the p88 structural model into an electron microscopy map of hexa

116 We present also the first structural model involving an octahedral-type metallic c

117 e mechanism of the NMDA receptor activation, structural modeling is essential to provide presently mi

118 acy and coverage of three-dimensional genome structural models, it is important to integrate all avai

119 Thus, our revised structural models may provide a useful tool for interpre

120 croscopy, 3D reconstruction, and integrative structural modeling methods to determine the molecular a

121 Using conventional and marginal structural model (MSM) approaches, we estimated 54-g (95

122 stimation of causal parameters from marginal structural models (MSMs) requires a fundamental assumpti

123 rs measured at baseline, and fitted marginal structural models (MSMs) that more fully adjusted for co

124 Marginal structural models (MSMs) were used to estimate the contr

125 al activity on current asthma using marginal structural models (MSMs).

126 Based on structural models, NMR titrations, DNA-binding studies,

127 Our structural model not only offers an improved functional

128 Building on an atomic-level structural model of a low-light-adapted chromatophore ve

129 llographic and AFM data were used to build a structural model of a membrane landscape comprising 96 P

130 Finally, we generated a structural model of AMSH-STAM to show how the complex bi

131 A structural model of an anti-terminated glyQS T-box in co

132 r dynamics simulations, we have identified a structural model of an ApoE4 misfolded intermediate stat

133 We present what we believe to be the first structural model of an ApoE4 misfolded intermediate stat

134 ed and validated sites of modifications on a structural model of C9, as present in the MAC, hints at

135 Using a structural model of cooperating miRISCs, we identified a

136 We combine the Czapla-Swigon-Olson structural model of DNA with our extended Peyrard-Bishop

137 Using a structural model of DnaB complexed with the C-terminal d

138 An electron microscopy structural model of full-length ERdj3 shows that these t

139 ar coupling data, functional analysis, and a structural model of GCAP1 mutant (GCAP1(V77E)) in the Ca

140 OPG) is an important electrode material as a structural model of graphitic nanocarbons such as graphe

141 Here, we present a structural model of heterotetrameric ENaC alpha1betaalph

142 ng these sequence variations, we developed a structural model of Hsp21 based on homology modeling, cr

143 A homology-based structural model of human Insig-2, together with biochem

144 For the first time, the structural model of LnFe2O4.5 was fully understood by hi

145 immunity to B. cinerea Finally, we present a structural model of MOS7 and show that the mos7-1 mutati

146 The Co4O4 cubane is a representative structural model of oxidic cobalt oxygen-evolving cataly

147 ation system informs revision of the current structural model of rhamnogalacturonan-II and highlights

148 The structural model of SbCCoAOMT can serve as the basis for

149 On a structural model of SGLT1, based on the homology structu

150 We propose a structural model of SMN binding with the Gemin2 protein

151 tural, and biophysical methods, we present a structural model of the 400-kDa Cas14-Cas2-32 complex fr

152 h previous N. crassa CYT-18 structures and a structural model of the Aspergillus fumigatus mtTyrRS sh

153 This extensive data set informs the first structural model of the CAF and provides insights into h

154 Our structural model of the CaM-K-Ras4B HVR association prov

155 The NMR-based structural model of the complex between Hha/YmoA and the

156 f UP1 binding HIViSL3(ESS3) by determining a structural model of the complex scored by small-angle X-

157 A structural model of the complex was built via partial ho

158 utionary analysis and used them to compute a structural model of the complex.

159 structure prediction program to construct a structural model of the human (h) ZIP4 transporter.

160 Previously we have determined a complete structural model of the in vitro reconstituted COPI coat

161 Sequence analysis of the structural model of the L142 N-terminal domain indicated

162 Our data also provide a structural model of the LIMP-2/GC complex that will faci

163 To obtain the best possible structural model of the molecule at the best achievable

164 these data, we developed a three-dimensional structural model of the Nup82 complex that depicts how t

165 correspond well with the predictions of our structural model of the oligomers constructed from molec

166 and molecular modeling was used to provide a structural model of the TriA1-lipid II complex.

167 with the histone chaperone Asf1 and deduce a structural model of the Vps75-Asf1-H3-H4 (VAH) co-chaper

168 sed representations allowed us to generate a structural model of this major epitope and its antibody

169 A structural model of VAI was obtained from constraints de

170 We derived a structural model of WDR26 and note that missense variant

171 Here a NMR structural model of WhiB1 reveals that Wbl proteins are

172 Structural modeling of a cell complements computational

173 formed comparative evolutionary analysis and structural modeling of ABHD5 and ABHD4, a functionally d

174 Structural modeling of both complexes demonstrated that

175 Structural modeling of Cox15 suggests these two mutation

176 general strategy that may be employed in the structural modeling of equilibrium intermediate states o

177 Structural modeling of individual biomolecules and their

178 ew illustrates the developing shift from the structural modeling of individual molecules to that of c

179 xperimental data into simulations toward the structural modeling of metastable, multidomain aggregati

180 Structural modeling of missense variants suggests delete

181 s as well as the limits of knob-socket based structural modeling of protein contacts.

182 ss-linked residues can therefore assist with structural modeling of proteins.

183 Based on the structural modeling of RepC and on our experimental evid

184 Structural modeling of SpoIIIAG generated a 24-member ri

185 Structural modeling of SynDIG1 suggests that the membran

186 Structural modeling of the glycan chains suggests that t

187 Structural modeling of the HAP2/GCS1 protein family pred

188 Structural modeling of the human beta1-adrenoceptor sugg

189 utics would benefit from improved, in-silico structural modeling of the kinase's solution ensemble.

190 Finally, structural modeling of the PARP3-active site with differ

191 r identical laboratory protocols and permits structural modelling of experimental measurements, allow

192 brane region, we generated and validated new structural models of alpha7.

193 Accurate structural models of biological systems can be obtained

194 That confirms structural models of GO as a separate oxygenated hexagon

195 Here, we present three three-dimensional structural models of human MFSD2A derived by homology mo

196 he ability to discriminate between potential structural models of intermediate states.

197 From an earlier study, we had structural models of M.tb at a proteome scale from which

198 Here, we combine structural models of myosin from multiple stages of its

199 We built structural models of TARP-AMPA receptor complexes for TA

200 Structural models of the complex that regulates the dire

201 ilies proves sufficient to assemble accurate structural models of the diverse protein-oligomers.

202 We describe structural models of the Escherichia coli chromosome in

203 hen applied it to generate an ensemble of 3D structural models of the genome of human B-cells from a

204 Additional computations on structural models of the intermediate states along the c

205 In two structural models of the perfluoroarylated product, dist

206 ant biological evidence in support of recent structural models of the RSV immature virions and furthe

207 rce microscopy to deliver, in atomic detail, structural models of three key PANS: the hexasome (H2A.H

208 In observational analyses, dynamic marginal structural models on pooled randomized groups were used

209 Structural modeling placed ABHD5 R299/G328 and R303/G332

210 tiple length scales, but doing so requires a structural modeling platform.

211 Structural modelling points towards two plausible and di

212 First-principles calculations based on the structural model predicted a strong preference for a sin

213 Homology-based structural modeling predicted a cysteine residue (Cys-29

214 Three-dimensional structural modeling predicted that all five ABCB4 varian

215 Structural modeling predicted that HopAF1 is closely rel

216 Structural modeling predictions of decreased function an

217 ly, we discuss the features of a full-length structural model produced by small angle x-ray scatterin

218 Our novel structural model proposed for the DCT-CAV1 complex, in a

219 classification performance, and analysis of structural models provides physical insight into the str

220 Cox proportional hazards models and marginal structural models, respectively.

221 Whole-genome three-dimensional structural models reveal a radial architecture of chromo

222 NMR-based structural models reveal that these residues form a cont

223 Amino acid alignment and structural modeling revealed substitutions of several hi

224 Finally, structural modeling revealed that GPV-QH15 and the close

225 Sequence comparison and structural modeling revealed that TcdBNAP1 and TcdBNAP1V

226 Multistate structural modeling revealed that the R201 residue in Kv

227 Structural modeling revealed that two residues near the

228 Cellular and biochemical analyses as well as structural modelling revealed that two mutations disrupt

229 Mapping mutations onto existing structural models revealed the context of viral amino ac

230 Comparative structural modeling showed no distinct variations in fib

231 Protein structural modeling showed that the altered amino acids

232 Structural modeling showed that the stretch surrounding

233 The combined structural model shows how Ragulator functions as a plat

234 We used the functional-structural model SimRoot to evaluate the functional impl

235 e cerebral cortex: architectonic similarity (structural model), spatial proximity (distance model) an

236 Frataxin mutations were examined using structural modeling, stability analyses and systematic l

237 Although structural models (stoichiometry matrices) and pathway d

238 Bioinformatics and structural modelling studies indicate that the accumulat

239 The resulting structural models suggest two mechanisms for how these F

240 Structural modeling suggested that the missense mutation

241 Structural modeling suggested that this mutation may fac

242 Based on structural modeling suggesting that Pro-205 in green con

243 The structural model suggests that in addition to a possible

244 A structural model suggests that these three URAT1 residue

245 Structural modeling suggests that Ala1632 is a molecular

246 Structural modelling suggests that changes in filament p

247 Structural modelling suggests that K265 interacts with D

248 gous interaction site on tomosyn-1 and Lgl-1 structural models suggests a possible conserved Rab GTPa

249 ron scattering (SANS) were consistent with a structural model that involves formation of borate dimer

250 ommensurate superstructure and suggest a new structural model that is consistent with recent theoreti

251 by small- angle x-ray scattering suggests a structural model that places the receptor-binding site o

252 complementary approaches resulted in a novel structural model that rationalizes previous experimental

253 ill, we demonstrate specific deficiencies of structural modeling that must be addressed to enable tru

254 Ms often rely on untestable scenarios, or on structural models that are comparatively untested on rel

255 ollowed is based, for the first time, on two structural models that can be fitted simultaneously, and

256 niquely test the more than one dozen crystal structural models that have been proposed for vaterite.

257 otor ring assembly on DNA, supporting recent structural models that locate the P-loop at the interfac

258 anning up to 56 nucleotides in length yields structural models that recapitulate experimentally deter

259 We have used these data to construct structural models that suggest specific ways by which em

260 ur findings provide biochemical insights and structural models that will facilitate studying poxvirus

261 e with inverse probability-weighted marginal structural models, the structural transformation method,

262 or quality of the fit found for the original structural model-the NMR data can be largely accommodate

263 By structurally threading low-resolution structural models through the BioLiP library, the COFACT

264 Our coarse-grained structural model thus suggests that the high efficiency

265 oscopy, cross-linking mass spectrometry, and structural modeling to build a complete model of human R

266 peting risk survival regression and marginal structural modeling to estimate ICU mortality caused by

267 we apply cross-linking/mass spectrometry and structural modelling to determine the molecular architec

268 In the application of marginal structural models to compare time-varying treatments, it

269 We then used marginal structural models to decompose total effect of knee SxOA

270 multivariable linear regression and marginal structural models to estimate associations under 2 causa

271 s as causal mediators, we also used marginal structural models to estimate the controlled direct effe

272 es of the resulting fragment ions by fitting structural models to experimentally determined collision

273 significance is established, comprises both structural model uncertainty and natural climate variabi

274 ng of the identified mutations onto the SHMT structural model uncovered key residues for structural s

275 Structural modeling uncovered 2 novel binding surfaces w

276 of their treatment, by estimating a marginal structural model using data from the Australia and New Z

277 at the Na1 site were previously predicted by structural modeling using the x-ray structure of dicarbo

278 In this issue, Kadlecova et al. test structural models using quantitative microscopy in livin

279 seamlessly integrates sequence analysis and structural modelling (using the Rosetta protein modellin

280 hrough a validated connexin26 (Cx26) channel structural model, using molecular dynamics and associate

281 Here, using structural modeling, voltage-clamp, current-clamp, and m

282 The developed structural model was able to successfully describe also

283 Structural modeling was used to elucidate the mechanisti

284 Based on an evolutionary structural model, we propose a "sideways sliding" mechan

285 g genetic analysis, photo-cross-linking, and structural modeling, we show that DksA binds and acts up

286 Based on a combination of mutagenesis and structural modeling, we suggest that all benzothiazole/o

287 ording, immunoblotting, confocal imaging and structural modelling, we characterized the effects of th

288 Clear structure-activity relationships and a structural model were developed in the studies which pro

289 ed C4b2 and C2 and showed that the resulting structural models were independent of the glycans.

290 Marginal structural models were used to account for potential con

291 Marginal structural models were used to assess impacts of the pro

292 ceptors at the PSD and are consistent with a structural model where MAGUKs, corresponding to membrane

293 crimination capacity, the technique delivers structural models which can subsequently serve as an inp

294 t is the resilience pathway suggested by the structural model, which is highly amenable to interventi

295 lose was also explained on the basis of a 3D structural model, which was compared to the 3D structure

296 otein structures, we considered high-quality structural models, which increase genomic coverage from

297 omain-ligand interaction was explained by 3D structural models, which showed a hormone-regulated mech

298 The refined structural models will be essential for future investiga

299 d additionally facilitates comparison across structural models with different levels of details with

300 Marginal structural models with inverse probability weighting wer