ライフサイエンスコーパス: structural modification

1 ctivity and sensitivity could be improved by structural modification.

2 x2 that are responsible for Pin1 binding and structural modification.

3 zole framework can be achieved with a simple structural modification.

4 vity can only be achieved by chemical and/or structural modification.

5 arly differing profiles of CarC tolerance to structural modification.

6 n route in acquisition of resistance via LPS structural modification.

7 and biologic impact for postbiosynthetic LPS structural modification.

8 itization properties of Coumarin 343 through structural modification.

9 n to be associated with the pressure-induced structural modification.

10 rational design of switching properties via structural modification.

11 to understand thermoelectric performance by structural modifications.

12 ammalian ceramides distinguished by specific structural modifications.

13 ce, have largely been unexplored for in vivo structural modifications.

14 gated as 5-HT(2C) agonists through iterative structural modifications.

15 kers that have blockade kinetics tunable via structural modifications.

16 induced due to relatively small and limited structural modifications.

17 owed some limitations in elucidating certain structural modifications.

18 atically addressed and eliminated by concise structural modifications.

19 s with XIAP BIR2 suggested potency-enhancing structural modifications.

20 strate coupling of this redox behaviour with structural modifications.

21 iciency (LipE) was optimized through two key structural modifications: (1) identification of the pyrr

22 With three distinct sites for structural modification, A affords access to a structura

23 Driven by virus-mediated structural modifications, aberrant immunological respons

24 a function of applied voltage bias indicate structural modifications across multiple length scales v

25 make HA an excellent model of the way subtle structural modifications affect a protein's stability an

26 Structural modifications affecting the efficacy of analo

27 ionality to evaluate the contribution of new structural modification against the A3AR.

28 BLG structural modification and LA binding properties were m

29 and delamination are the primary methods for structural modification and pore tailoring.

30 in view of the atomic level understanding of structural modification and the development of high dens

31 The approach often employs a simple structural modification and utilizes ubiquitous endogeno

32 31A variant displayed substantial N-terminal structural modifications and a dramatic decrease in acti

33 ity in two cell lines revealed tolerance for structural modifications and agreement in activity trend

34 cles but also induce particle-size-dependent structural modifications and are likely to promote inter

35 Emphasis is placed on structural modifications and corresponding variations in

36 Focused structural modifications and docking simulations enabled

37 Numerous structural modifications and formulations have been intr

38 KII is necessary for learning and associated structural modifications and learning triggers an FMRP-d

39 ds were designed and synthesized for further structural modifications and led to the identification o

40 ory activity toward TDO and was subjected to structural modifications and molecular docking studies.

41 Using analogous structural modifications and oxidation that results from

42 Structural modifications and the nature and amount of nu

43 building-block component change, an overall structural modification, and a functional evolution of a

44 ish that release profiles can be modified by structural modifications, and compare COS/H2S release ra

45 ybin could be significantly enhanced through structural modifications, and identify strong anti-cance

46 es often involve large-amplitude strains and structural modifications, and thus require an understand

47 its, although targeted for initial chromatin structural modifications, are insufficient to activate g

48 Slight structural modifications around the proximal pyrimidine

49 the development of agents to limit chromatin structural modification as a chemotherapeutic approach i

50 Analogues 13h and 13i, with structural modifications at each site, were shown to pos

51 ation of isothiazoloquinolones (ITQs) having structural modifications at the 6-, 7-, and 8-positions.

52 The impact of structural modifications at the C-terminus of 1 upon cyt

53 tely activate integrin signaling and trigger structural modifications at the Drosophila neuromuscular

54 Structural modifications at the indole 3-position of 1-m

55 To determine how structural modifications at the steroid C-6 and C-7 posi

56 efficiency (LE) of 0.47, included additional structural modifications binding in the S1 and S3 pocket

57 ptoglobin (Hp), the complex protects Hb from structural modification by preventing alpha-globin cross

58 Our analysis implies that transient structural modification can be an effective tool for man

59 Moreover, the WTW structural modification can be considered as concluded i

60 ids has demonstrated that certain peripheral structural modifications can alter binding affinity and

61 ructurally related compounds show that minor structural modifications can alter the function of minoc

62 Structural modifications can be foreseen to improve the

63 ractions have held the promise that directed structural modifications can have predictable functional

64 Structural modifications could be used to alter the HOMO

65 Structural modifications designed to address the ADME is

66 the resistant bacteria to cope with diverse structural modifications despite the observation that se

67 Structural modifications detailed herein, including core

68 alities and that a broad selection of ligand structural modifications directed to this area can be in

69 sp27 chaperone function, suggesting that the structural modification dissected the dual targeting eff

70 ations, an unusual phenomenon of interfacial structural modifications, due to the interface chemistry

71 The effect of various structural modifications (e.g., chirality, side chain st

72 This indicates that our structural modifications either constrain the ring syste

73 The high precision structural modifications enabled by unnatural amino acid

74 Collectively, our findings suggest that the structural modification enhances efficacy and selectivit

75 core and shell undergo distinct patterns of structural modifications following ethanol exposure and

76 catalytic activity provides new insight into structural modifications for controlling charge separati

77 This method involves a purely structural modification free of chemical additives leadi

78 32-Asn oxidase upon introduction of a second structural modification further inside the pathway (Asn-

79 but one which is easily amendable to further structural modifications given the modular nature of thi

80 Two types of structural modification have been performed, an introduc

81 ria of free host and guest binding, selected structural modifications have been performed over a fami

82 The noted structural modifications imparted molecular rigidity and

83 I), which contains a deep-seated fundamental structural modification in the CC-1065 and duocarmycin a

84 The low E(m) is believed to be caused by a structural modification in the head domain of cytochrome

85 ed cells showed morphological changes due to structural modifications in actin microfilaments (MFs) a

86 The MD simulations also suggested structural modifications in AQP4 in response to changes

87 Alkali- or acid-induced structural modifications in beta-chitin from squid (Dosi

88 eomics effort to characterize the breadth of structural modifications in individual proteins in the g

89 ction method enables accurate measurement of structural modifications in near-surface layers, which m

90 al conditions such as temperature, pressure, structural modifications in proteins, or presence of che

91 is of 63 new thiazole derivatives by further structural modifications in search of more potent fascin

92 Structural modifications in the 5- and 3'-position have

93 harmacological properties were fine-tuned by structural modifications in the arylacetamide and amine

94 Structural modifications in the beta-enamino diketone sy

95 rces extrinsic to the membrane as well as by structural modifications in the bilayer or at the bilaye

96 In addition, we detect structural modifications in the Eg5 motor domain during

97 rat and mouse TAAR1 (rTAAR1 and mTAAR1) for structural modifications in the ethylamine portion of 1.

98 , we used this model to examine how specific structural modifications in the occludin protein affect

99 behavior in adulthood via long-term cellular structural modifications in the oPFC.

100 The tailoring of structures via subtle structural modifications in the presented molecular seri

101 as a lead molecule, we were able to engineer structural modifications in the solvent-exposed region o

102 lass of neurosteroid analogues which possess structural modifications in the steroid D-ring region.

103 The structural modifications in these variants reduced, pres

104 Pressure induced structural modifications in vitreous GexSe100-x (where 1

105 Several structural modifications including bringing conformation

106 purine gives several insights into how small structural modifications, including amino substitution a

107 zed a number of derivatives of 4 with subtle structural modifications, including incorporation of car

108 in many diseases, in the absence of evident structural modifications, indicating a high sensitivity

109 Finally, the structural modifications induced by oxidation are associ

110 Structural modifications induced by singlet-oxygen produ

111 Thus, AMP activity can be modulated through structural modifications induced by the nature and the p

112 We analyzed the structural modifications induced on human DJ-1 by DAQs i

113 unit are of particular significance as their structural modification inhibits activation by GABA.

114 Introducing structural modifications into biomolecules represents a

115 Activity-induced synaptic structural modification is crucial for neural developmen

116 onspecific degradation, suggesting that this structural modification is relevant to physiological str

117 reasing application in the clinic, extensive structural modification is typically required to prevent

118 timization of peptidic catalysts by rational structural modifications is difficult.

119 th the aid of DFT calculations, finding that structural modifications lead to changes in the frequenc

120 These structural modifications lead to polymers with different

121 This structural modification leads to enhanced electrophilici

122 Structural modifications led to hybrid molecules which i

123 Extensive structural modifications led to the discovery of a numbe

124 Structural modifications led to the identification of se

125 Vascular occlusions are common structural modifications made by many plant species in r

126 Such structural modifications may account for our observation

127 Both structural modifications may have facilitated the transm

128 bly due to a conformational change, and such structural modifications may participate in the developm

129 These structural modifications not only demonstrate the possib

130 virus particle, which demonstrated that most structural modification occurred in the putative A prote

131 We evaluated the structural modification occurring in the fractionated mi

132 consisted of a six-step linkup involving the structural modification of 22 so as to generate ent-30b.

133 Structural modification of a virtual screening hit led t

134 does not maintain the antiviral potency, the structural modification of alkenyldiarylmethanes with a

135 nstrated by the successful prediction that a structural modification of an aryl group within the cata

136 ty might be predictable-arising via adaptive structural modification of analogous labile regulatory l

137 his methodology has been demonstrated in the structural modification of androsterone.

138 Structural modification of carboxylate-containing lead R

139 g of the biochemical process leading to this structural modification of carotenoids in plants.

140 The structural modification of dendritic spines plays a crit

141 ility to engineer homochiral footedness by a structural modification of enantiopure (S)-proline, whic

142 Additionally, minor structural modification of J-113,397 can dramatically sh

143 Structural modification of lobeline affords the defuncti

144 To set the stage for structural modification of meridamycin by genetic engine

145 cycles can be improved significantly through structural modification of Mo catalysts.

146 Here we implement a structural modification of multi-walled CNTs (MWCNTs) to

147 The structural modification of nanomaterials at the atomic l

148 Structural modification of peptidoglycan (PG) is one of

149 The Pin1-mediated structural modification of Runx2 is an indispensable ste

150 Structural modification of salvinorin A, the active comp

151 benzoic acids were extensively explored, and structural modification of the alcoholic and benzoic moi

152 Both approaches require structural modification of the arene, limiting their gen

153 We investigated the structural modification of the bacterial cell wall by Ol

154 ingle-handed helical wrapping and electronic structural modification of the conjugated polymer motif

155 tein Data Bank) and to assess the effects of structural modification of the derivatives.

156 These data demonstrate that structural modification of the HIV-1 envelope immunogen

157 Structural modification of the indolecarbazole natural p

158 potentially and differentially sensitive to structural modification of the ligand.

159 Structural modification of the piperidine leads 1 and 2

160 nhibitors (NRIs) for multiple indications by structural modification of the previous 3-(arylamino)-3-

161 Structural modification of the submicromolar hit compoun

162 In this article, we describe the structural modification of the tert-butyl phenoxy portio

163 ty and selectivity can be controlled through structural modification of the thiourea substituents.

164 ove these physical properties, the effect of structural modification of the urea pharmacophore on the

165 ine microorganisms adapt to their habitat by structural modification of their membrane lipids.

166 g debris size, which could be related to the structural modification of this plastic as a consequence

167 Structural modifications of 12a generally weakened bindi

168 This indicates that additional structural modifications of 1a may lead to analogues wit

169 /3 receptors, we have explored the effect of structural modifications of 1S,2S,5R,6S-2-aminobicyclo[3

170 Small structural modifications of active compounds were found

171 id-state NMR spectroscopy to investigate the structural modifications of amyloid beta(1-42) (Abeta42)

172 a rare event that can be overcome by subtle structural modifications of an AMP.

173 The emitter presented here contains structural modifications of an existing setup, which inh

174 Structural modifications of BSA were investigated by 2D

175 ral topics of carbohydrate chemistry embrace structural modifications of carbohydrates and oligosacch

176 In addition, structural modifications of compound 2 were identified t

177 maintenance of LTP as well as LTP-dependent structural modifications of dendritic spines.

178 Our results demonstrate that structural modifications of Env that aim to mimic the CD

179 dulator scaffold has been discovered through structural modifications of hydantoin antiandrogens.

180 Raman measurements, provides information on structural modifications of hydrogen as a function of de

181 Structural modifications of identified hit VA240 in synt

182 likely, it occurs in the following sequence: Structural modifications of individual nucleobases (G >

183 Structural modifications of isoquinolinone lead 1 afford

184 Thus, a new strategy for structural modifications of kanamycin class aminoglycosi

185 properties on immunogenicity in relation to structural modifications of MPER/liposome vaccines.

186 Recent studies have shown that fine structural modifications of Mycobacterium tuberculosis c

187 c gamma receptors, but it is unclear how the structural modifications of N-glycan termini, which are

188 curs during the first 3-4 weeks, but further structural modifications of newborn neurons take place f

189 Structural modifications of nonsteroidal anti-inflammato

190 ur program to explore the influence of small structural modifications of our drug candidate 3beta-(hy

191 is work focuses on elucidating dynamical and structural modifications of porcine aortic elastin expos

192 Structural modifications of psymberin uncoupled inhibiti

193 e organization of actin filaments leading to structural modifications of synapses.

194 Sequential structural modifications of the aryloxypropanamine templ

195 stry, and chemical analyses, we propose that structural modifications of the cell wall matrix in the

196 se behavioral deficits possibly occur due to structural modifications of the cerebral cortex secondar

197 the kinetic product could be achieved by key structural modifications of the different reaction partn

198 e concentrations can be realized with simple structural modifications of the familiar kinetic proofre

199 ty arising from the flexibility and possible structural modifications of the host material.

200 How the chromatin structural modifications of the inner centromere are int

201 Structural modifications of the known autotaxin inhibito

202 en discovered and synthesized as a result of structural modifications of the lead compound 2-arylthia

203 asing k(ET) and/or decreasing k(CdS) through structural modifications of the nanocrystals.

204 increase in sensitivity is achieved through structural modifications of the peptide and the expressi

205 objective of investigating the influence of structural modifications of the polyketide chain of the

206 Structural modifications of the pyridine moiety, side ch

207 cardioprotection, high levels of ROS induce structural modifications of the sarcomere that impact on

208 Structural modifications of the scaffold led to compound

209 ent of intersystem crossing) responds to the structural modifications of the series as a whole.

210 We also reveal unexpected structural modifications of the spindle pole bodies (SPB

211 Based on structural modifications of the switching unit the photo

212 iaminals has been developed using late-stage structural modifications of the tert-leucinol-derived ch

213 Structural modifications of these molecules can regulate

214 Herein, we explored three structural modifications of these prodrugs in an attempt

215 R-ablative agents could be developed through structural modifications of troglitazone.

216 In the present study, a series of structural modifications of UA was achieved, which resul

217 A subtle structural modification on the diene (replacement of an

218 examine directly the influence of nanoscale structural modifications on electronic carrier dynamics,

219 Further structural modifications on myricetin might improve its

220 ure to drugs of abuse can result in profound structural modifications on neurons in circuits involved

221 To test the effect of such structural modifications on the hormonal activities of t

222 The structural modifications optimized polymers' spectral co

223 Leaves have undergone structural modifications over evolutionary time, and pre

224 Despite their versatility and ease of structural modification, peptidomimetic oligomers have n

225 Structural modification performed on a 4-methyl-4-(4-hyd

226 In general, all structural modifications performed on HOCPCA led to redu

227 ity profile was found to be dependent on the structural modifications performed on the dietary antiox

228 Further structural modification, perhaps to generate a less lipo

229 Structural modifications, pre-organisation and different

230 This molecule is known to undergo structural modification (primarily alterations in the A-

231 istered at moderate doses, but fairly simple structural modifications profoundly impact its pharmacol

232 The combination of these two structural modifications provides for cross-linking of a

233 Finally, several structural modifications reduced lipophilicities while r

234 The structural modifications result in significant shifts of

235 arrangements combined with a knowledge-based structural modification resulted in a protein unable to

236 Our structural modifications resulted in analogues with incr

237 The following structural modifications resulted in only modest changes

238 sed to create polyladderane allowed specific structural modification, resulting in the formation of t

239 This structural modification serves to introduce flexibility

240 perature induce transitions between numerous structural modifications, several of which are highly co

241 Structural modifications showed that both the carboxylic

242 terations in behavior are thought to involve structural modifications, specifically alterations in pa

243 bitor (K(i) = 21 muM) more than 200-fold via structural modifications targeting two binding hot spots

244 -metal regions are highly sensitive to local structural modifications, thanks to (17)O wide chemical

245 Here we describe a simple structural modification that improves the brightness and

246 pping of the DENV RNA genome is an essential structural modification that protects the RNA from degra

247 However, structural modifications that affected MPER membrane ori

248 An improved understanding of specific structural modifications that are likely to alter the fu

249 nhancing the affinity of lead molecules with structural modifications that displace water molecules f

250 MDR1-MDCKII cells, we were able to identify structural modifications that markedly reduce recognitio

251 ter bioavailability properties together with structural modifications that may result in gains in act

252 and was found to be amenable to predictable structural modifications that modulate intrinsic reactiv

253 shed in this study have demonstrated diverse structural modifications that result in potent rotamase

254 Herein, we report selected structural modifications that resulted in the identifica

255 is of 80 piperlongumine analogs has revealed structural modifications that retain, enhance, and ablat

256 s 3b and 3c were used as vehicles to explore structural modifications that retained antiviral potency

257 With increasing height, the xylem structural modifications that satisfied hydraulic requir

258 onamide 1 as a starting point, we engineered structural modifications that significantly improved hum

259 In addition to identifying structural modifications that were critical to the emerg

260 nability of unnatural polyketides to further structural modifications, the chemical probes constitute

261 as deleterious may not result in significant structural modifications, they can plausibly modify the

262 Structural modification to affect clearance, and to a le

263 r potent antitubercular properties was their structural modification to evade the Rv1258c efflux pump

264 selectivity with metabolic stability through structural modification to the metabolized site on the q

265 ology model of the GR ligand binding domain, structural modifications to 2 were carried out that were

266 The agonist, THI0019, was generated via two structural modifications to a previously identified alph

267 Hypothesis driven structural modifications to endogenous FFAs, focused on

268 ing natural draft (ND) stoves, which feature structural modifications to enhance air flow, and forced

269 inhibitors with the active site that suggest structural modifications to further enhance potency.

270 Neither structural modifications to GM volume nor modifications

271 There are many reported examples of small structural modifications to GPCR-targeted ligands leadin

272 hilicity), applied to the 32 series suggests structural modifications to improve potency.

273 ity), applied to the anilide series suggests structural modifications to improve potency.

274 In the first study, described herein, structural modifications to one aryl ring were evaluated

275 n renal clearance and can aid the chemist in structural modifications to optimize drug disposition.

276 ent evaluation of AG treatment paradigms and structural modifications to reduce hair cell damage.

277 ily accessible precursors and is amenable to structural modifications to tailor color and lifetime of

278 ive Hsp90 inhibitor was accomplished through structural modifications to the amide side chain, coumar

279 nblastine analogues that contain deep-seated structural modifications to the core ring system of the

280 biased agonism can be finely tuned by minor structural modifications to the head group containing th

281 Herein, structural modifications to the N, 4, 5, and 4' position

282 ompounds have the potential, with additional structural modifications, to yield clinical agents that

283 re, the great versatility of NHC ligands for structural modifications, together with the use of other

284 ecular hybridization approach is an emerging structural modification tool to design new molecules wit

285 ly grown gold nanowires undergo irremediable structural modification under external stimuli.

286 e important insight about the lesion-induced structural modifications upon dehydration in the cancer

287 a new insight into the atomic-scale surface structural modification using ALD and post-treatment, wh

288 mportant insights into the interplay between structural modifications, water exchange rate, and kinet

289 xicity-required improvement for translation, structural modifications were made by introducing nitrog

290 ivo with positron emission tomography (PET), structural modifications were made to the high-affinity

291 Herein, more impactful structural modifications were performed via alteration o

292 The only permissible structural modifications were removal of the isoprene me

293 ortance of understanding the consequences of structural modifications when designing metal-peptide co

294 ulk rutile structure, but as an orthorhombic structural modification, which previously has only been

295 hat the Fe4S4-to-Fe2S2 change requires large structural modifications, which are most likely responsi

296 This occurrence of slow structural modification with changes in trap state occup

297 Thus, N-cadherin couples persistent spine structural modifications with long-lasting synaptic func

298 ructure-activity relationships indicate that structural modification within the pyrrolidine series re

299 in of the molecule can tolerate considerable structural modifications without losing biological actio

300 energetics was sought in cases where similar structural modifications yield qualitatively different o