ライフサイエンスコーパス: structural motif

1 of photochromic molecules based on the imine structural motif.

2 dem repeating a simple helix-loop-helix-loop structural motif.

3 trix with triple helix as the characteristic structural motif.

4 cting single stereoisomers of this important structural motif.

5 al signature of the [U(mu-O)2U] diamond core structural motif.

6 or the generality of the role played by this structural motif.

7 ns similar to those in the four-helix bundle structural motif.

8 olecular HER catalysts based on a MoO(S2)2L2 structural motif.

9 Lite is computationally feasible on any beta-structural motif.

10 s show that the core extends with a repeated structural motif.

11 large number of proteins that lack a common structural motif.

12 p-economical enantioselective access to this structural motif.

13 e to the long-range commensurately modulated structural motif.

14 emical modifications available for the enone structural motif.

15 cages in EMFs by just counting three simple structural motifs.

16 and found evidence for the existence of new structural motifs.

17 ors of these kinases usually carry analogous structural motifs.

18 te localization of proteins via a variety of structural motifs.

19 rials combining nanoscale and supramolecular structural motifs.

20 econdary metabolites that possess intriguing structural motifs.

21 ions/clusters, yielding myriads of possible structural motifs.

22 timigration activities than those with other structural motifs.

23 easy access to a variety of 3-arylpiperidine structural motifs.

24 ve been typically based on a small number of structural motifs.

25 uidance outcomes through the use of distinct structural motifs.

26 incorporated cations that applies to diverse structural motifs.

27 tary pairing, duplex formation, and specific structural motifs.

28 e largely increased current knowledge of RNA structural motifs.

29 entry proteins suggests the conservation of structural motifs.

30 eported crystal structures featuring unusual structural motifs.

31 size and sequence discrimination within RNA structural motifs.

32 lored in several classes of biomolecules and structural motifs.

33 oader match with metastable, non-crystalline structural motifs.

34 ting a wide variety of biologically relevant structural motifs.

35 eld low-valent group 14 compounds with novel structural motifs.

36 ding of the folding properties of individual structural motifs.

37 ploration beyond conventional strategies and structural motifs.

38 asso Bundle (PLB) and the knot-like threaded structural motif a Pierced Lasso (PL).

39 We show that this structural motif, a minimal Pro(314)-Trp(316) turn, is e

40 ce includes algorithms and tools to discover structural motifs, a heatmap visualization to compare mu

41 lso expands our understanding of the diverse structural motifs achievable with modified nucleic acid

42 ensional atomic-scale "molecular squares," a structural motif adapted from supramolecular chemistry.

43 This new structural motif allows the construction of fluorescent

44 form of the protein in which an Asp-Phe-Gly structural motif along the activation loop adopts a so-c

45 els, encircling larger octagonal channels, a structural motif also found in some zeolites.

46 body BLV1H12 folds into a novel "stalk-knob" structural motif and has been exploited to generate nove

47 of functionalized alpha-tetralones-a common structural motif and versatile building block in organic

48 he coiled-coil dimer is a widespread protein structural motif and, due to its designability, represen

49 The effects of structural motifs and cluster-cage interactions on forma

50 he cation is therefore critical in directing structural motifs and dictating the resulting hydrogen a

51 nadate compounds reveals the key role of VO4 structural motifs and electronic band-edge character in

52 cules--natural and designed--of all types of structural motifs and for all intents and purposes.

53 sferases that share homologous sequences and structural motifs and have many connections to cancer.

54 Oxetanes offer exciting potential as structural motifs and intermediates in drug discovery an

55 and reconcile crystallographically observed structural motifs and non-covalent interaction acceptor-

56 However, piRNAs lack conserved structural motifs and show relatively low sequence simil

57 es of enzymes and the correlation of protein structural motifs and translational pausing.

58 ular but complex energetic properties of RNA structural motifs and will aid in the eventual quantitat

59 into nanosheets that inherited the hole/edge structural motifs and, under certain conditions, possess

60 The current findings make it clear that new structural motifs and/or substitution patterns need to b

61 SpoIIIAH folds into the ring-building structural motif, and modeling shows that the structure

62 their sequence diversity, ultra-stable core structural motif, and range of bioactivities, cyclotides

63 The Specifier Loop domain contains a loop E structural motif, and the single-strand Specifier nucleo

64 rmine whether SpoIIIAH adopts a ring-forming structural motif, and whether interaction of SpoIIIAH wi

65 lore sHsps, expand our understanding of sHsp structural motifs, and provide a testable Hsp21 structur

66 lar intermetallics exhibit a wide variety of structural motifs, and this hexagonal-diamond-like gold

67 The two structural motifs are connected through an acetylene lin

68 RNA structural motifs are the building blocks of the complex

69 l space, providing the possibility for novel structural motifs as well as useful quantities of less a

70 ences have been derived for cappings but the structural motifs associated to them are still unclassif

71 Structural motifs at the cleavage sites of starch, beta-

72 e investigate the potential of an artificial structural motif, azobenzene, in the preparation of enzy

73 tion between pi systems is a well-recognized structural motif, but stacking between sigma systems was

74 he dimerization interface of a transmembrane structural motif called GASright, which is characterized

75 thod relies on a database of super secondary structural motifs called smotifs.

76 in guanine-rich DNA, here we show that this structural motif can be exploited to guide the self-asse

77 d conventional tools as well as a search for structural motifs characteristic of scorpion venom compo

78 in a model peptide that forms beta sheets, a structural motif common in protein misfolding diseases.

79 The X-ray structure of ClbM shows a structural motif common to the recently described MATE f

80 ently be converted into molecules displaying structural motifs commonly found in medicinal agents.

81 otochromic properties, and how the different structural motifs compare under identical conditions.

82 erestingly, both PrV gH and EBV gH contain a structural motif composed of a DB and supporting amino a

83 over because the addition of new topological structural motifs consistent with cubic ice leads to the

84 The beta-ketoester structural motif continues to intrigue chemists with its

85 However, no known structural motifs could be identified from its sequence,

86 Reverse genetics analyses suggest that the structural motifs critical for the IFITM proteins' enhan

87 acids and we show that this patch defines a structural motif crucial for MapZ function.

88 We use a set of NTP binding sub-structural motifs derived from a previous study and scan

89 rug scaffold and late-stage cleavage of this structural motif during product export.

90 The pivotal structural motif enabling this transition was the second

91 s demonstrates the broad design space of DNA structural motifs, enriching the toolbox of DNA tile-bas

92 TGF-beta monomer, lacking the heel helix, a structural motif essential for binding the TGF-beta type

93 Numerous variations on structural motifs exist within pharmaceutical compounds

94 More importantly, several novel structural motif families have been revealed by our clus

95 hexagonal vacancy as a new and more flexible structural motif for borophene.

96 This study reveals a never before observed structural motif for ordered protein aggregates and sugg

97 of proMPO-processing proconvertase, (ii) the structural motif for subsequent cleavage to the heavy an

98 T@Gan) endohedral Ga-clusters as a favorable structural motif for superconductivity and develop empir

99 est that azobenezene is a useful non-natural structural motif for the preparation of enzyme responsiv

100 mental method to determine the importance of structural motifs for biological function.

101 clopropyl ketones were recognized as crucial structural motifs for C-C bond formation.

102 sphatase CheZ but appears to utilize similar structural motifs for CheY dephosphorylation in close an

103 lifies the need of empirical analysis of RNA structural motifs for facilitating the rational design a

104 Coiled coils are important structural motifs formed by two or more amphipathic alph

105 Naturally occurring G-quadruplex structural motifs, formed by guanine-rich nucleic acids,

106 htly packed radical pi-stacks, including the structural motif found for 3a.MeCN in which radicals in

107 beta-Lactones are a privileged structural motif found in both therapeutic agents and ch

108 t nuclear import of ankyrin repeats (ARs), a structural motif found in over 250 human proteins with d

109 We employed the enhanced aromatic sequon, a structural motif found in the reverse turns of some N-gl

110 Pyridine rings are common structural motifs found in a number of biologically acti

111 A variety of structural motifs found in biological composites have be

112 and gamma-lactams, both of which are common structural motifs found in drug molecules and bioactive

113 Cyclobutanes and cyclobutenes are important structural motifs found in numerous biologically signifi

114 cyl-piperidine is a widespread and important structural motif, found in approximately 500 currently a

115 t X-rays can be applied to unveil nano-scale structural motifs from functional nanomaterials or biolo

116 fficient and selective construction of these structural motifs from simple building blocks is desirab

117 uggest that the alpha2beta2 heterotetrameric structural motif has evolved to enable catalysis of dehy

118 The reactivity and diversity of these structural motifs has captured the interest of synthetic

119 systems of design principles underlying such structural motifs has enabled the fabrication of lightwe

120 elective compounds with strikingly different structural motifs have been identified.

121 G-quadruplex (G4) structural motifs have been linked to transcription, rep

122 resent a clustering approach for de novo RNA structural motif identification.

123 Mutagenesis of this shared structural motif identified Tyr126, which is part of the

124 ide structures, which are based on different structural motifs, if an appropriate choice of cations i

125 Vicinal diamines are a common structural motif in bioactive natural products, therapeu

126 ligation is a common and well-characterized structural motif in bioinorganic synthesis.

127 HLA-E and HLA-Cw1 alleles revealed a shared structural motif in both HLA class molecules, which coul

128 tly well-conserved staggered cross-heme wire structural motif in functionally related outer membrane

129 The carbamate group is a key structural motif in many approved drugs and prodrugs.

130 The k-junction is a structural motif in RNA comprising a three-way helical j

131 Here, we identify a short structural motif in the disordered NS5A-D2 and report it

132 pirooxetane moiety was identified as a novel structural motif in the field of anti-HCV nucleosides.

133 A dominant structural motif in the rRNAs is an RNA helix capped wit

134 al, similar to the recently discovered MB6 M structural motif in the Ti7 Rh4 Ir2 B8 solid compound.9.

135 The BRC repeat is a structural motif in the tumor suppressor BRCA2 (breast c

136 ssive antibody based on a novel "stalk-knob" structural motif in the ultralong complementary-determin

137 2,4-Oxazole is an important structural motif in various natural products.

138 results shed new light on the nature of the structural motifs in ACKR2 that are responsible for liga

139 arallels between the in vitro assemblies and structural motifs in developing enamel.

140 ive as potential electrolyte additives or as structural motifs in drug synthesis, with the latter bei

141 sheets that, on a basic level, mimic protein structural motifs in fully synthetic systems.

142 twisted assemblies of filaments are crucial structural motifs in macroscopic materials (cables, rope

143 te described gives access to these important structural motifs in moderate to high levels of enantios

144 uted 5,6-dihydrophenanthridines as important structural motifs in natural products and bioactive mole

145 Nucleic acid junctions are ubiquitous structural motifs in nature and in designed materials.

146 lycyclic aromatic hydrocarbons are important structural motifs in organic chemistry, pharmaceutical c

147 2-pyridyl)-N'-ethylpiperazines are important structural motifs in several medicinally relevant compou

148 bsence of S15 revealed specific sequence and structural motifs in the central junction that are impor

149 agation of the allosteric signal through key structural motifs in the cyclic nucleotide-binding domai

150 ich we show is linked to the location of the structural motifs in the dimer interface, thereby establ

151 The mutations tested included truncations of structural motifs in the gp41 CT and two point mutations

152 Particular attention is paid to the overall structural motifs in the three-periodic cyanometallates,

153 derived from knot-free and bifurcation-free structural motifs in the underlying family.

154 either by H(+) or Na(+), reflecting distinct structural motifs in their membrane domains, and distinc

155 ed 1,1,2-triarylethyl products that occur as structural motifs in various natural products.

156 dinary stability is associated with distinct structural motifs, in particular the abundance of regula

157 P12 conformation characterized by a circular structural motif including the C-terminal disulfide is s

158 broad range of geminal diazides with various structural motifs including sterically demanding substit

159 isordered in isolation, p27 adopts secondary structural motifs, including an alpha-helical structure,

160 hat contains several predicted coiled-coils, structural motifs involved in protein-protein interactio

161 ordering in PCDTBT, and postulate that this structural motif is a direct consequence of the polymer'

162 lipid vesicles have shown that a key peptide structural motif is a prominent "GG kink," centered at t

163 e same, reinforcing the conclusion that this structural motif is completely general.

164 The basic structural motif is composed of 2D acetato-benzimidazola

165 inct registers accommodated by a twist: this structural motif is exploited by vFLIP, allowing it to b

166 a spectral evolution suggests that a common structural motif is formed as early as the tetramer.

167 This structural motif is not possible for the native opiorphi

168 This structural motif is responsible for the pronounced stabi

169 This structural motif is unusually consistent across all spec

170 Identification of non-coding RNA structural motifs is a critical step towards understandi

171 nstead, the formation of core and peripheral structural motifs is cooperatively linked in near-native

172 products bearing non-native and rigidifying structural motifs, isotopic labels, and a variety of bio

173 remarkable carbon allotrope with highly rare structural motifs, it also reveals a fascinating hierarc

174 NAs are built from a common set of recurring structural motifs, leading to the perspective that a gen

175 ucture shows specific interactions between a structural motif located at the end of the Rnt1p dsRNA-b

176 These data suggest structural motifs located in the two adjacent Ig-like do

177 frared spectroscopy (FTIR) and tested if the structural motif matches previous data on the organic ma

178 fluorescent property of coumarin, these new structural motifs may find potential application in mate

179 The synergy between two structural motifs--nanoscale brick-and-mortar stacking o

180 module for nano-construction, is a recurrent structural motif of 13 nucleotides that establishes a 90

181 self-assemblies describe not only the basic structural motif of G-quadruplexes formed by, e.g., telo

182 te leading to the formation of an aniline, a structural motif of prospective safety concern.

183 h human breast tumors that occur in a common structural motif of RAD51.

184 subclass of aza-heterocyles as they are the structural motif of relevant cationic alkaloids, and the

185 new class of compounds that incorporated the structural motif of the 1-(3',4',5'-trimethoxtbenzoyl)-3

186 reoselectively the cyclopentenone alkylidene structural motif of the molecule.

187 We further elucidate structural motifs of both HKa and ferritin that are requ

188 f the backbone dihedral angles and secondary structural motifs of the glutamine residues.

189 sing Ag concentration (0, 2, 5 at.%) but the structural motifs of the medium-range ordered clusters b

190 g previously identified domains and critical structural motifs of the membrane-spanning portions of K

191 lly stable FeSb2 products also contain local structural motifs of the metastable phase, despite their

192 se crystal structures shed light on specific structural motifs of the S. aureus ribosome and the bind

193 cursors are determined and compared with the structural motifs of their crystalline products.

194 Our results describe important structural motifs of this channel family and lay the gro

195 roteins composed of tandem arrays of a short structural motif often mediate protein-protein interacti

196 Analyses of structural motifs only apparent after systematic structu

197 Thus, different structural motifs or conformations of MsRecO are respons

198 inding model for SEFIR domain, with distinct structural motifs participating in either homotypic or h

199 pentanal (4-OPA), which has a 1,4-dicarbonyl structural motif present in many limonene SOA compounds.

200 The Mn(IV)3CaO4 cubane is a structural motif present in the oxygen-evolving complex

201 The reactions offer potential entry to key structural motifs present in bioactive natural products.

202 addition, our work highlights how very small structural motifs present in intrinsically disordered pr

203 In this study, we focused on structural motifs present in the core of the key immunog

204 Lipid-binding and lipid transfer structural motifs range from multi-beta-strand barrels,

205 provement in area under curve (AUC) for beta-structural motif recognition as compared with HMMER (a w

206 stituted aromatic piperazines are privileged structural motifs recognized by aminergic G protein-coup

207 support the presence of two kink-turns, the structural motifs recognized by L7Ae, in distinct functi

208 that BP position scales systematically with structural motifs, reflecting local rigidity: disordered

209 ique class of mammalian transporters and the structural motif required to discriminate between Zn(2+)

210 binding proteins A, G, and L that retain the structural motifs required for antibody binding.

211 ions is essentially governed by a few simple structural motifs, requiring only the connectivity infor

212 n a tetratricopeptide repeat (TPR) domain, a structural motif responsible for mediating protein-prote

213 Thus, this study identified the structural motif responsible for the unique autophosphor

214 The structural motifs responsible for activation and regulat

215 tive phase, the presence of the rutile phase structural motif results in a faster structural collapse

216 omputational methods, we establish that this structural motif results in near optimal adsorption ener

217 Identification of structural motifs shared by vertebrates and HIV-1 provid

218 most sulfur atoms in the structure exhibit a structural motif similar to that observed at MoS2 edges.

219 re increasingly turning to an unconventional structural motif: small, strained ring systems.

220 drug binding sites and have revealed unique structural motifs specific for this pathogenic strain, w

221 Racemic indolines including a variety of structural motifs such as C-2 and C-3 substitutions (alk

222 NA, but none focus specifically on secondary structural motifs such as internal, bulge and hairpin lo

223 of new recombinant selenoproteins containing structural motifs such as selenyl-sulfhydryl and diselen

224 eic acid recognition, binuclear zinc-binding structural motifs, such as LIM (Lin-11, Isl-1, Mec-3), R

225 persistent molecular nanoparticles and other structural motifs, such as polymers, and can be viewed a

226 been that proteins with curvature-promoting structural motifs, such as wedge-like amphipathic helice

227 ules may rely on the movement of a conserved structural motif, switch II.

228 ns, we found that amino acid residues in two structural motifs termed "loop 1" and "loop 2," are impo

229 to its basic elements, which we dub tertiary structural motifs (TERMs).

230 long linear fatty acyl component, an unusual structural motif that has not been reported before in ot

231 Triazabutadienes are an understudied structural motif that have remarkable reactivity once re

232 The k-turn is a commonly occurring structural motif that introduces a tight kink into duple

233 we highlight the concept of tessellation, a structural motif that involves periodic soft and hard el

234 n of pyrroloindolines, an important alkaloid structural motif that is commonly found among biological

235 and suggests that granulopoiesis requires a structural motif that is conserved between the mouse Ren

236 The G-quadruplex is an alternative DNA structural motif that is considered to be functionally i

237 of RNA polymerase II (Pol II) is a conserved structural motif that is crucial for Pol II catalytic ac

238 t for the establishment of an AdoMet radical structural motif that is likely common to ~6,400 unchara

239 loop-receptor interaction represents a novel structural motif that is present in multiple structured

240 report a complex with a rare Cu(II)-O-Cu(II) structural motif that is stable at room temperature, whi

241 arrangement of the protein on the surface, a structural motif that likely drives the formation of ret

242 iting sites and discovery of a conserved RNA structural motif that may be functionally relevant to ed

243 The peptide alpha-helix represents a common structural motif that mediates communication between sig

244 ory calculations (DFT), we have identified a structural motif that more effectively delocalizes elect

245 d to fold into an amphipathic alpha-helix, a structural motif that targets a protein to the cytoplasm

246 led/Egl/pleckstrin (DEP) domain, a conserved structural motif that, although missing from the active

247 of the electronic structure, we identify key structural motifs that are associated with high water sp

248 sed this assay to examine the roles of three structural motifs that are conserved among MRFs: an alan

249 The structural motifs that are necessary for improved autoph

250 assembly of angularly substituted decalins--structural motifs that are ubiquitous in natural product

251 at the MAPK insert and C-terminal extension, structural motifs that are unique to MAPKs, play a criti

252 n architectures to create highly specialized structural motifs that can greatly enhance the rates of

253 To identify structural motifs that cause animal toxicity, we synthes

254 port the conclusion that Rb evolved specific structural motifs that confer its unique capacity to bin

255 Here, we identify two structural motifs that determine the time course of AMPA

256 ved alpha-helical core, made up of ancestral structural motifs that have acted as a skeleton, might h

257 et revealed that of the various sequence and structural motifs that have been proposed to specify FMR

258 aryne intermediates for the introduction of structural motifs that have conventionally been viewed a

259 n biomedical applications and sheds light on structural motifs that make this possible.

260 entified some unique internal and peripheral structural motifs that may be potential candidates for i

261 In the present model, we identify remarkable structural motifs that may explain fundamental electroph

262 of lipids for CD1d presentation and identify structural motifs that may prove useful for therapeutic

263 In this study, we investigated the structural motifs that mediate Cx43 GJ endocytosis.

264 opeptide repeat (TPR) domains are ubiquitous structural motifs that mediate protein-protein interacti

265 synthetic RNAs with particular sequence and structural motifs that permit subsequent experimental de

266 stituting, with purified proteins, the basic structural motifs that recur in diverse cytoskeletal arr

267 ptide repeats (TPR) are well studied protein structural motifs that support intermolecular protein-pr

268 es of a set of variants of a common tertiary structural motif, the tetraloop/tetraloop-receptor (TL/T

269 e receptor binding sites that share a common structural motif, thus suggesting a potential interactio

270 (QD), we apply the thick-shell or "giant" QD structural motif to this notoriously environmentally sen

271 n evasion mechanism by which viruses use RNA structural motifs to avoid immune restriction.

272 trofragments allowed the group efficiency of structural motifs to be assessed, the identification of

273 RNA nanotechnology uses RNA structural motifs to build nanosized architectures that

274 crystals holds promise for the design of new structural motifs to create programmable 3D DNA lattices

275 mbrane-water interface may provide excellent structural motifs to develop new antimicrobials that can

276 ative Poisson's ratio by using stability and structural motifs to predict new instances of homogenous

277 coarse-grained model with a set of secondary structural motifs to predict the equilibrium solution st

278 ributions of codon bias, AA bias and protein structural motifs to the three-base periodicity of codin

279 le, M = Co(II) or Zn(II)) which have similar structural motifs to ZIFs.

280 atives of this sort are considered promising structural motifs toward the construction of molecular s

281 d their narrow hydrophobic inner pores mimic structural motifs typical of biological channels.

282 of triazole-containing dipeptides having the structural motives typical of turn inducers.

283 rminal domain consists of a concatenation of structural motifs typically found in trimeric viral prot

284 D NMR and X-ray crystallography, revealing a structural motif unique among human CBX proteins.

285 The attachment of the aziridine structural motif was achieved by application of the Ess-

286 The desired structural motif was formed in moderate to good yields (

287 Compounds with these structural motifs were found to be metabolically stable

288 mical connectivity patterns, as described by structural motifs, were different within and across func

289 ta Bank led to identification of a recurring structural motif where lysine NH3(+) group interacts wit

290 dentified a (S,S)-cyclopropylcarboxylic acid structural motif which gave selectivity against GPR40.

291 tion between critical residues and important structural motifs which undergo reorganization during ma

292 t the coordination number of network-forming structural motifs, which play a key role in defining the

293 1,3-Dihydro-1,3-azaborine is a stable structural motif with considerable aromatic character as

294 alation region is a new type of DNA tertiary structural motif with similarities to the i-motif.

295 phasizes the robustness of parallel-stranded structural motifs with a 1 nt loop.

296 ffolds allow the positioning of user-defined structural motifs with an accuracy that is similar to th

297 The structural motifs within CRH-R1 that mediate G protein a

298 rare codon clusters separate smaller protein structural motifs within structural domains.

299 w that pathogenic alphaviruses use secondary structural motifs within the 5' untranslated region (UTR

300 ing signal sequences that may form compacted structural motifs within the ribosome tunnel and lure th