ライフサイエンスコーパス: structural requirement

1 imposing any specific sequence or secondary structural requirement.

2 7-position does not appear to be a critical structural requirement.

3 l length requirement, and versatility in the structural requirement.

4 ion of P/rds with Rom-1 has a more stringent structural requirement.

5 m such as binding or phosphorylation and its structural requirements.

6 was also demonstrated and exhibited the same structural requirements.

7 Each of these catenanes has specific structural requirements, allowing control of their forma

8 d molecular dynamics simulations uncover the structural requirement and sequential steps during TRF2-

9 ne tethering assay we have now dissected the structural requirements and concentration ranges for Ca(

10 However, the structural requirements and mechanism of action for NEAT

11 y provides the modeler with insight into the structural requirements and performance capabilities of

12 The present studies addressed the structural requirements and the mechanism for PA regulat

13 y structures of enriched RNAs, their minimal structural requirements and their stabilities in RT-apta

14 of HOX/TALE superclass interactions, protein structural requirements, and sites of in vivo cooperativ

15 etically separable and suggest that the YidC structural requirements are different for the Sec-indepe

16 We demonstrate that these structural requirements are distinct for each interactio

17 The structural data provide insight into the structural requirements at the catalytic site of RNase H

18 ycin unit C beta-alanine residue, but strict structural requirements at the phenyl group position of

19 p53 modulators were prepared to explore new structural requirements at the thiazolidine domain for t

20 o acid mutagenesis to determine the specific structural requirements at these sites.

21 In order to investigate the structural requirements behind iGb3 triggered iNKT cell

22 ced by copper or CDDP, suggesting a distinct structural requirement between metal transport and oligo

23 Here we studied the detailed C4S structural requirements by assessing the ability of chem

24 the genetic polymorphisms and determined the structural requirements controlling antibody recognition

25 nsitive to aminosulfonates, the well defined structural requirements described here argue strongly fo

26 uted tryptamines was prepared to explore the structural requirements determining TRPM8 modulation.

27 hich initial DNA binding is based on minimal structural requirements followed by a rate-limiting conf

28 ificity results, it appears that the minimal structural requirement for a good pPAF-AH substrate is t

29 zation, which is consistent with a stringent structural requirement for ion channel modulation by the

30 demonstrate for the first time that the C4S structural requirement for IRBC adherence is parasite st

31 In this study, we defined the structural requirement for its activity to stimulate cas

32 We identify the tile nick position as a structural requirement for lattice formation.

33 ty to form the apoB "lipid pocket" without a structural requirement for microsomal triglyceride trans

34 etent to complete the lipid pocket without a structural requirement for MTP; (ii) a portion, or perha

35 domain of claudin-4 reconstituted the basic structural requirement for optimal binding activity to C

36 Thus, our study reveals an additional structural requirement for pri-miRNA processing and emph

37 tains two types of sterol binding sites; the structural requirement for the ACAT activator site is mo

38 The minimal structural requirement for the activating effect corresp

39 Although a structural requirement for the band 3-ankyrin bridge is

40 ses from Golgi to lysosomes, but the precise structural requirement for the M6P ligand-receptor recog

41 revention activity of VCP and identified the structural requirement for this activity.

42 The permissive structural requirement for this to occur is an extremely

43 LR4)-MD-2 dependent and to elucidate the LOS structural requirement for TLR4 activation.

44 Swi1 function and to define the sequence and structural requirements for [SWI(+)] formation and propa

45 ltracentrifugation, which is consistent with structural requirements for a honeycomb.

46 To better understand structural requirements for a mu ligand of the trans-3,4

47 ansion led to the establishment of the basic structural requirements for activity and to the identifi

48 Structural requirements for activity are discussed.

49 Progress was also made in understanding the structural requirements for activity by synthesizing a f

50 These models offer insight into the structural requirements for activity of thalidomide anal

51 Critical structural requirements for activity were determined, an

52 subfamilies of the RDR enzyme with distinct structural requirements for activity.

53 We established the structural requirements for activity: the presence of an

54 ther, our results show that PARP13 lacks the structural requirements for ADP-ribosyltransferase activ

55 and biochemical analyses to investigate the structural requirements for ADP-ribosyltransferase activ

56 In this study, the structural requirements for anionic phospholipid-selecti

57 We define the structural requirements for ankyrin-B/obscurin interacti

58 In this study, the structural requirements for APL-selective binding of nSM

59 ay crystallography), we have established the structural requirements for artificial inhibitors of the

60 We have examined the structural requirements for ASAP1-dependent formation of

61 Acanthamoeba myosin-II tail to delineate the structural requirements for assembly of bipolar mini-fil

62 Here we have investigated the structural requirements for BARD1 in this process by com

63 ni, each of which can be varied to probe the structural requirements for beta-sheet self-assembly pro

64 Structural requirements for binding and isomerization of

65 We investigated the structural requirements for binding of naturally elicite

66 Here we describe the RNA structural requirements for binding to the coat protein

67 We studied the motif and structural requirements for both types of activity using

68 Here, the structural requirements for carbohydrate recognition by

69 hese results contribute to understanding the structural requirements for cargo transport, autoinhibit

70 cluster surfaces to probe the mechanism and structural requirements for CO oxidation catalysis at co

71 To investigate the structural requirements for collagenolysis, varying numb

72 To examine the structural requirements for complement activation, we ha

73 hatases are intrinsically modular and define structural requirements for coupling of enzymatic activi

74 We examined the structural requirements for COX-mediated, AEA oxygenatio

75 urther insight into pancratistatin's minimum structural requirements for cytotoxicity, particularly t

76 In this report we further define the structural requirements for decay-accelerating activity

77 se Delta variants has delineated a number of structural requirements for Delta trafficking, receptor

78 imers within HIV host cells and identify the structural requirements for dimerization in vivo.

79 strates, we have systematically investigated structural requirements for DNA unwinding by DinG.

80 nel internalization partially overlap in the structural requirements for drug binding.

81 The structural requirements for dual emission were explored

82 the hit, it provided a detailed insight into structural requirements for EAAT1 activity of this scaff

83 Nor do we understand the protein structural requirements for each individual function of

84 oid receptor subtypes helps to differentiate structural requirements for each subtype and serves as a

85 The results provided insight into the structural requirements for effective visualization of e

86 athic peptides was designed to elucidate the structural requirements for efficient and nontoxic deliv

87 ions, there do not appear to be any specific structural requirements for either chain collapse or cha

88 LR4ECD should allow better definition of the structural requirements for endotoxin-induced TLR4 activ

89 vels of constraints on BER, dependent on the structural requirements for enzyme activity.

90 location of a DNA lesion is dependent on the structural requirements for enzyme catalysis.

91 ghlight the unknown complexity of telomerase structural requirements for expression and function in v

92 se findings shed light on the functional and structural requirements for filamentous phage assembly,

93 To probe structural requirements for folate receptor targeting wi

94 gating human centromere organization and the structural requirements for formation of HAC vectors tha

95 of B. subtilis levansucrase (SacB) acceptor structural requirements for fructosylation.

96 ants should provide important information on structural requirements for function of Kitl and other h

97 Structural requirements for function of the Rho GEF (gua

98 To define structural requirements for functional interactions of g

99 ghtly hydrophobic motif to identify possible structural requirements for fusion activity.

100 Here we have analyzed the structural requirements for fusion of domains extracted

101 To determine the structural requirements for gammaKA-PE activity, we test

102 Altogether, these data elucidate crucial structural requirements for glucan hydrolysis on surface

103 To investigate the structural requirements for gp80 independence of vIL-6,

104 We defined interactions and structural requirements for heparin/HS interactions with

105 2.4 nM), allowing us to identify the minimal structural requirements for hERG blocking liability.

106 s of this ion channel have shed light on the structural requirements for hERG interaction but most im

107 action and provide useful information on the structural requirements for high affinity binding of org

108 acyclic nitriles and esters reveals the key structural requirements for high selectivity while provi

109 These results suggest that the structural requirements for high-affinity binding are fu

110 Less is known regarding the structural requirements for highly specific reversible M

111 We can conclude that structural requirements for HSV entry, PRV and BHV-1 ent

112 tablish a new resolution of insight into hTR structural requirements for hTR-TERT interaction and for

113 ound thus far only in fungi, we asked if the structural requirements for in vivo function were simila

114 and revealed a remarkably restrictive set of structural requirements for inducing rosette development

115 and 4-keto group of the C-ring were the main structural requirements for inhibition of adhesion molec

116 While examining the structural requirements for inhibition of PGHS, we disco

117 nd, using mutants, provide evidence that the structural requirements for inhibition of the AP are con

118 nalling provided succinct information on the structural requirements for inhibition, and demonstrated

119 To dissect the structural requirements for inhibition, RT-catalyzed DNA

120 es with alanine substitution to evaluate the structural requirements for interactions with the APJ re

121 These results elucidate some of the structural requirements for isoform-selective inhibition

122 bacteria, its activation mechanism, and the structural requirements for its function as a molecular

123 To analyze structural requirements for ligand binding we made a mut

124 n efficiency in vitro, provided that optimal structural requirements for ligation were met by both li

125 bed here can be useful for understanding the structural requirements for LPC recognition by G2A and t

126 rbazole natural product (+)K-252a identified structural requirements for MLK activity and a novel ser

127 These data suggest separable structural requirements for modulation of TRPA1 by coval

128 Here we investigate the structural requirements for mono- and poly-ubiquitinatio

129 The strict structural requirements for mPGES-1 and 5-LO inhibition

130 studies might help to understand the general structural requirements for natural endogenous ligands r

131 ylic acid have been synthesized to probe the structural requirements for NR2C/NR2D selectivity.

132 sigma(1) receptors were performed to examine structural requirements for optimal binding at these two

133 and the acceptor sides of FDDNP to learn the structural requirements for optimal binding to Abeta agg

134 Opposing stereoselectivity and divergent structural requirements for optimal DAT binding suggest

135 Here we examined the minimal DNA structural requirements for optimal hRad54 ATPase and br

136 nstrated different trends in substituent and structural requirements for optimal photochromism.

137 s neuroprotective agents and (ii) define the structural requirements for p53 inactivation.

138 The structural requirements for peptide binding to each mole

139 d there is relatively little known about the structural requirements for phosphorylating internal 2'O

140 Structural requirements for potency were systematically

141 ogy, and computational chemistry merging the structural requirements for potency with the requirement

142 In this work, we investigate the structural requirements for potent HDAC inhibition by ma

143 We explored the structural requirements for potentiation of glutamate-in

144 Here, we have examined the structural requirements for pre-microRNA binding by Exp5

145 ectionality and to explore poorly understood structural requirements for processive stepping.

146 emical natures are known to possess specific structural requirements for producing functional effects

147 ing to MART-1.HLA-A2, probably due to either structural requirements for proper Valpha/Vbeta associat

148 ogenesis in vitro and were used to probe the structural requirements for PSTPIP2 suppression of osteo

149 In this study, we set out to test the structural requirements for PTEN complex assembly and id

150 s were synthesized to gain insights into the structural requirements for quorum sensing inhibition in

151 The DNA structural requirements for reaction with alpha,beta-uns

152 pt the C-terminal region, indicated separate structural requirements for receptor binding and activat

153 in the context of this T cell response, the structural requirements for recognition at CDR1alpha are

154 Further insights into the structural requirements for retinoid isomerization by RP

155 le Michael acceptors have been reported, the structural requirements for reversibility are poorly und

156 ding that significant latitude exists in the structural requirements for ring closure may facilitate

157 The structural requirements for RNAP interaction and promote

158 ed in order to further ascertain the optimal structural requirements for S-adenosylmethionine decarbo

159 The structural requirements for scission are even more strin

160 (Sfh1), which seemingly conserves all of the structural requirements for Sec14 function.

161 this study provides valuable clues about the structural requirements for selective A-site recognition

162 s on the study of the three-dimensional (3D) structural requirements for selective antagonist activit

163 re synthesized in an effort to delineate the structural requirements for selectively inhibiting human

164 We define here the structural requirements for small peptides to competitiv

165 idea that single domains do not possess the structural requirements for specific CSA binding.

166 re, we established Sre2 as a model to define structural requirements for SREBP cleavage.

167 sults yield an improved understanding of the structural requirements for stabilizing the DFG-out form

168 ion of the STAT signaling pathway and on the structural requirements for STAT activation.

169 The descriptors reflect the structural requirements for strong inhibition: good ster

170 studies provide additional insight into the structural requirements for substrate metabolism and ina

171 The structural requirements for such an effector mechanism,

172 yields (42-77%) with a Z geometry due to the structural requirements for syn-beta-hydride elimination

173 We then examined the structural requirements for synaptobrevin to function in

174 Recent studies have highlighted the structural requirements for T cell costimulation and hav

175 inactive against HIV-2 virus, suggesting the structural requirements for targeting these two retrovir

176 this study also suggests differences in the structural requirements for the activation of homomeric

177 To investigate the structural requirements for the assembly of rNV VLPs, we

178 Prp22 highlights common as well as distinct structural requirements for the ATP-dependent steps in p

179 The structural requirements for the binding of AMDA at 5-HT(

180 ticle, I suggest an explanation based on the structural requirements for the binding of transcription

181 To investigate the structural requirements for the cellular cholesterol eff

182 The structural requirements for the chemokines CXCL8 and CCL

183 We determined structural requirements for the dumbbell templates used

184 To understand the structural requirements for the electrogenicity of NBCe1

185 To evaluate the structural requirements for the formation and allosteric

186 these data define in vitro the sequence and structural requirements for the function of bacterial N-

187 Here, we explored the structural requirements for the functional interaction b

188 of compound 1 has provided insight into the structural requirements for the inhibition of Tdp1.

189 tants and UCNII fragments, we determined the structural requirements for the interaction between the

190 Structural requirements for the interaction of these age

191 suit of a more detailed understanding of the structural requirements for the key side chain cannabino

192 To understand the structural requirements for the kinase-CPD domain, we pe

193 tional analysis of p300 reveals differential structural requirements for the N-terminal p300 module b

194 tion with careful analysis of electronic and structural requirements for the PDE2a enzyme.

195 he results from the NaChBac channel point to structural requirements for the S3-S4 loop to generate a

196 SAR studies in the CCK region examined the structural requirements for the side chain groups at pos

197 To better understand the structural requirements for the switch to nanomolar cyto

198 These results demonstrated the structural requirements for the transformation of daidze

199 s (GABA(A)Rs), but little is known about the structural requirements for their actions.

200 e analogues within AChE and BChE and defined structural requirements for their differential inhibitio

201 ngiogenic activities to probe more fully the structural requirements for these anticancer properties.

202 Here, we studied the structural requirements for these penetrating ODNs to el

203 To further investigate structural requirements for this divergent binding mode,

204 To investigate the structural requirements for this function of SV2, we use

205 The structural requirements for this inhibition were explore

206 bacterial membranes and the possible peptide structural requirements for this phenomenon.

207 To understand the structural requirements for this transformation and obta

208 To unveil the structural requirements for TLR4.MD-2-specific ligands,

209 Therefore, the template structural requirements for transcription in vivo by RNA

210 Because the structural requirements for transport activity are not k

211 em, and the results provide insight into the structural requirements for transport by AtSUC2.

212 duced a series of mutations to determine the structural requirements for tropomyosin binding (using n

213 To delineate the structural requirements for VWF-mediated conformational

214 led to a number of conclusions regarding the structural requirements for woody odor, including absolu

215 These results may give new insights into the structural requirements for zinc finger and polyamide bi

216 ither the function of these clusters nor the structural requirements governing their persistence have

217 The essential active-site structural requirements have been identified for the pos

218 though its precise biochemical activities or structural requirements have not been elucidated.

219 f siRNA, meeting different compositional and structural requirements, have been reported to trigger I

220 To determine the structural requirements in HIV-1 Vif HCCH motif for Cul5

221 N-linked carbohydrate chain suggesting that structural requirements in this region favored O-glycosy

222 In an effort to understand the structural requirements necessary for auxotroph rescue,

223 We also discuss the structural requirements necessary for the formation of a

224 protein-protein interactions, establish the structural requirements needed for efficient CD40-CD40L

225 operties of this molecule to investigate the structural requirements needed to elicit a protective im

226 pted to distinguish between a functional and structural requirement of cytochrome c in COX assembly.

227 lts provide additional indications about the structural requirement of pharmacophores for further inc

228 ividual ion channels, is constrained by this structural requirement of sustaining several functional

229 In this study the structural requirement of transmembrane segment 1 (TM1)

230 herein can be utilized to further elucidate structural requirements of alpha-syn fibril growth and t

231 Together, these studies have defined structural requirements of an anchor residue within the

232 The elucidation of structural requirements of apelin-13 in its interaction

233 ode of action of bistramide A and identifies structural requirements of bistramide-based compounds th

234 We also deduced the structural requirements of BPA analogues that activate h

235 ceramide containing beta-galactose, and the structural requirements of ceramides for apoptosis induc

236 The structural requirements of flavaglines for cardio- and n

237 The identification of the structural requirements of Gli1/DNA interaction highligh

238 was undertaken to resolve the mechanism and structural requirements of heparin inhibition of human n

239 We assessed the structural requirements of HP activity and excluded that

240 and primary SMG epithelia to investigate the structural requirements of HS for FGF10-mediated epithel

241 the G2-G3-C1 regions underlies the different structural requirements of IF2 during the initiation pro

242 Here, we reveal key structural requirements of indole-2-carboxamides for all

243 A better understanding of the structural requirements of inhibitors for these transpor

244 rts have been made to further understand the structural requirements of its mechanism of action throu

245 ses lead to an improved understanding of the structural requirements of kinase binding that will be u

246 trix biosynthesis, little is known about the structural requirements of LOXL2 that enable collagen IV

247 A better understanding of the structural requirements of modulators of P-gp function w

248 Here, we examined the structural requirements of NBD1 for sterol transport.

249 Here we examined the structural requirements of NS3.4A and the therapeutic po

250 To define the relative and unified structural requirements of nucleoside analogs for intera

251 ses lead to an improved understanding of the structural requirements of PDE binding that will be usef

252 To establish the structural requirements of PGN recognition and the enzym

253 sults contribute to our understanding of the structural requirements of potent AHR antagonists and th

254 ghts the importance of specific sequence and structural requirements of pre-miRNA for editing along w

255 Here we dissected the minimal structural requirements of PTIP and its different protei

256 icity k(cat)/K(m) provided insights into the structural requirements of quinone substrates.

257 Here, we have dissected the structural requirements of RCA proteins that are crucial

258 cell receptor (TCR) signaling; however, the structural requirements of SLP-76 for mediating thymopoi

259 To test the structural requirements of SLP-76 in mast cell signaling

260 To better understand the structural requirements of specific residues for convers

261 To determine the sequence and structural requirements of the 5'-proximal stem-loop RNA

262 modifications enabled an exploration of the structural requirements of the anticodon for aminoacylat

263 We examined the structural requirements of the AT1 receptor for transact

264 These analogues were designed to study the structural requirements of the corresponding GABAA recep

265 To understand the molecular and structural requirements of the enzymes that favor the bi

266 Here, we test the minimal structural requirements of the Escherichia coli DinJ ant

267 , each defined by antibody specificities and structural requirements of the HIV envelope monomer.

268 thus define more precisely the sequence and structural requirements of the HRV-14 cre and provide ad

269 the CR7 domain, identified the sequence and structural requirements of the hTR processing and CB loc

270 m to further analyze the Ca2+ dependence and structural requirements of the IP3R proteasomal degradat

271 In this study, sequence and structural requirements of the M1H were further assayed

272 Here we have defined 1) the structural requirements of the N terminus of tropomyosin

273 To identify the structural requirements of the NTP, we determined the ef

274 Here, we clarify the structural requirements of the pathway effector Gli1 for

275 Here, we have investigated structural requirements of the PT alpha/beta-subunit pre

276 Exploration of the structural requirements of the substituents by probing t

277 To study the structural requirements of the substrate for this cataly

278 ave used Xenopus oocytes to characterize the structural requirements of the U3 snoRNA 3'-hinge intera

279 ese derivatives have been used to define the structural requirements of the VMAT substrate and inhibi

280 data provide the first insight into the RNA structural requirements of the yeast translational machi

281 , this study is the first to demonstrate the structural requirements of these thiosemicarbazones nece

282 recombinant human NK(2) receptor support the structural requirements of this new designed molecular t

283 We define the minimal structural requirements on ankyrin-B for direct Na/Ca ex

284 We define the structural requirements on ankyrin-G for Na(v)1.5 intera

285 egrees vertex) in a 3:2 ratio to explore the structural requirements on the building blocks for the s

286 the latter cells was characterized by strict structural requirements, PTX sensitivity, and dependence

287 The structural requirements rendering certain AQPs permeable

288 4 have hampered investigation of the precise structural requirements rendering inhibition by this dru

289 The key structural requirement responsible for optimal V(1b) sel

290 To determine the minimal structural requirement(s) for C3 cleavage in the single-

291 We discover the unanticipated structural requirement that TFP motors need to have a mi

292 The structural requirements that appear necessary to provide

293 erging mephedrone analogs, and give clues to structural requirements that govern drug selectivity at

294 standing of carbohydrate specificity and the structural requirements that lead to high-affinity inter

295 etails of the consequential significance and structural requirements to form the dimerization interfa

296 each of which have different minimum ligand structural requirements to induce structural changes.

297 ite of the kynurenine pathway that meets the structural requirements to interact with glutamate recep

298 with the aim of revealing the most relevant structural requirements underlying the binding affinity

299 ncover the reason for these isoform-specific structural requirements, we analyzed a series of Orai mu

300 The structural requirements within E3/19K necessary to seque