ライフサイエンスコーパス: structural similarity

1 arbapenemases given the high degree of their structural similarity.

2 the above three criteria despite their high structural similarity.

3 o align glycan structures and quantify their structural similarity.

4 cal relationships masked by apparent lack of structural similarity.

5 -1 and HIV-2 proteases share a great deal of structural similarity.

6 Y transcription factors revealed significant structural similarity.

7 in each ED3, despite their high sequence and structural similarity.

8 on exposure potential, carcinogenicity, and structural similarity.

9 ansporters that share extensive sequence and structural similarity.

10 glycoproteins do not show significant global structural similarity.

11 face charge distributions without underlying structural similarity.

12 tein surfaces are clustered into groups with structural similarity.

13 ntrons, with which they show mechanistic and structural similarity.

14 tein surfaces are grouped by measuring their structural similarities.

15 age constructions when these have sufficient structural similarities.

16 ey are evolutionarily related and share many structural similarities.

17 Languages of the world display many structural similarities.

18 ast and mammalian proteins may in fact share structural similarities.

19 function that combines both global and local structural similarities.

20 n of a steroid is challenging owing to their structural similarities.

21 d new language constructions with sufficient structural similarities.

22 and hydrophobic/water surfaces exhibit great structural similarities, a small stabilization of the OH

23 The ability to accurately measure structural similarities among small molecules is importa

24 e same for all six cases studied, suggesting structural similarities among the three channels.

25 romatin-modifying enzymes in epigenetics and structural similarity among many PMTs, we envision that

26 for particular inhibitors; such instances of structural similarity among phylogenetically diverse kin

27 Despite the high structural similarity among them, only homotypic interac

28 Protein Data Bank, also implies large scale structural similarity analyses to retrieve and classify

29 Structural similarities and a core set of genes support

30 also highlight what is known regarding their structural similarities and common mechanisms of regulat

31 hted network of binding sites based on their structural similarities and detecting communities of str

32 , the EID fragmentation patterns reflect the structural similarities and differences among apo-, Zn-,

33 Structural similarities and differences between Abeta(1-

34 icant challenges that range from identifying structural similarities and differences between models t

35 e Ca(2+)-bound structure of A3, which reveal structural similarities and differences with gelsolin.

36 Despite structural similarities and shared binding partners, inc

37 ee double bonds is a great challenge, due to structural similarities and similar polarities.

38 It combines structural similarity and accounts for evolutionary cons

39 such different evolutionary origins achieved structural similarity and adapted to control by the same

40 The observed structural similarity and common oligomerization pathway

41 and function despite their high sequence and structural similarity and common origin from a single an

42 We show here that, despite the strong structural similarity and functional redundancy of these

43 PrISEC, combines local structural similarity and general structural similarity

44 This process maintains structural similarity and is further supported by this s

45 onists SB269,652 (1) and SB277011A (2) whose structural similarity and pharmacological disparity prov

46 However, because of the structural similarity and the multiple isomeric forms of

47 On the basis of the high structural similarity and tissue coexpression, we here i

48 eceptors share a high degree of sequence and structural similarities, and excessive activity of these

49 Identified compounds were classified by structural similarity, and 15 were selected for secondar

50 he hydrophobins, BslA shares no sequence nor structural similarity, and here we show that the mechani

51 rapidly than Tim9 despite high sequence and structural similarity, and loss of Tim10 is accelerated

52 chemical interaction, the information of the structural similarity, and the information of the finger

53 esistance rapidly to multiple Bt toxins when structural similarities are present among toxins, and ra

54 ne families (DGF-1 and PSA) with no apparent structural similarity are independent derivations of a c

55 Results were discussed by correlating structural similarities, as well as the membrane effects

56 Despite their structural similarity, as ascertained by electronic abso

57 e.cs.iastate.edu/ CONCLUSIONS: Local surface structural similarity based methods offer a simple, effi

58 ologs, we introduce PrISE, a family of local structural similarity-based computational methods for pr

59 The unprecedented structural similarities between an F420-dependent enzyme

60 We compared the molecular and structural similarities between Bla g 5 and WbGST by in

61 critical role in neurodegeneration; however, structural similarities between caspase-6 and other casp

62 f that goal (the reconfiguration principle), structural similarities between conscious and unconsciou

63 Within each TF family we observed structural similarities between DNA-binding motifs of di

64 The structural similarities between dopamine D3 receptor (D3

65 The observed structural similarities between Hsp33's own metastable l

66 Although structural similarities between human and prokaryotic Ar

67 Importantly, despite the structural similarities between human bGP and the two ot

68 Despite the high level of tegument structural similarities between KSHV and alphaherpesviru

69 Structural similarities between RC-DNA and cellular topo

70 Structural similarities between SgK269 and SgK223 includ

71 od of the inhibited enzymes, and result from structural similarities between substrate and inhibitors

72 In addition, the structural similarities between the compounds within a d

73 Finally, we observed structural similarities between the PEAK1 SHED region an

74 Despite the structural similarities between the two classes of compo

75 The notable structural similarities between the two lobes of comet 6

76 However, high structural similarities between the wild-type and mutant

77 Structural similarities between TOP2 isoforms challenge

78 from human, fly and worm, and we demonstrate structural similarities between transcription start site

79 We found remarkable sequence and structural similarities between TssA1 and gp6 C-termini,

80 nk between AD and T2D might originate from a structural similarity between aggregates of Abeta and hI

81 These data suggest a strong structural similarity between bacterial and eukaryotic v

82 Despite the structural similarity between C4a and well-described ana

83 , we develop a cluster analysis based on the structural similarity between configurations and use it

84 emble for quantifying population overlap and structural similarity between ensembles.

85 Because of the structural similarity between ibogaine and serotonin, it

86 Furthermore, structural similarity between Juno and the cholesterol-b

87 es is especially challenging given the close structural similarity between oxoG and its normal progen

88 The structural similarity between p63 and p73 rationalizes p

89 Thus, while close structural similarity between PET ligands and drug leads

90 is particularly significant in light of the structural similarity between SAc and the reduced form o

91 Here, we provide evidence for the structural similarity between TDP-43 peptides and other

92 We report important structural similarity between the active sites of Bud23

93 Hence, despite the structural similarity between the compounds, differences

94 Despite strong structural similarity between the cores of SAM-I and SAM

95 that it successfully captures the underlying structural similarity between the datasets.

96 its size, and 4) whether there is sufficient structural similarity between the two model samples in e

97 Despite the high structural similarity between the two SH2 domains, we ob

98 We observed a high degree of structural similarity between their backbone atoms (0.96

99 In line with this structural similarity, biochemical characterization of t

100 r two cationic alpha-helical AMPs that share structural similarities but have a ten-fold difference i

101 nosine A2AR and A2BR share many sequence and structural similarities but highly differ in their respo

102 arch revealed that SpoVAD shares significant structural similarity but not sequence homology to a gro

103 l cycle fingerprint analysis and 3D chemical structural similarity clustering identified unexpected F

104 ompounds, and (iv) the capability to harness structural similarities common in many biologically rela

105 Although sharing many sequence and structural similarities, CUL4B plays distinct roles in s

106 -like tetramers and exhibit a high degree of structural similarity despite classification into differ

107 ing the first three skip residues share high structural similarity despite their low sequence homolog

108 ed by different proteins/peptides share many structural similarities, despite sometimes large amino a

109 Despite the structural similarity, differences were observed in thei

110 /beta-hydrolase core, they showed unexpected structural similarities even in the cap region.

111 (La, Pr for high and Ce for low) affirm the structural similarities extend beyond the unit cell para

112 ierarchical clustering protocol based on DRP structural similarity, followed by two post-processing s

113 erences and clusters them according to their structural similarities for easy analysis.

114 nd murine DC subsets has emerged, underlying structural similarities for the DC lineages between thes

115 , supporting the hypothesis that some of the structural similarities found in natural languages are s

116 Sequence and structural similarity further allowed us to ascertain th

117 Despite high structural similarity, however, contrasting binding mode

118 Protein kinases share significant structural similarity; however, structural features alon

119 Structural similarities in the arrangement of hosts and

120 "pocket profile method", we use sequence and structural similarities in the binding pockets of human

121 Despite the structural similarities in the mode of dabigatran bindin

122 ablishment, and reactivation in vivo Despite structural similarities in their DNA-binding domains (DB

123 nt than that of torsion angles or of overall structural similarities in virus host tropisms.

124 Thus, subtle structural similarities independent of sequence homology

125 ays to assess transmitted image quality: the structural similarity index (SSIM), a perceptual distort

126 ee aspects: peak signal-to-noise ratio, mean structural similarity index, and visual information fide

127 onstructed image quality, quantified using a structural similarity index.

128 However, their structural similarities is an amazing example of converg

129 We prove that this structural similarity is a consequence of the asymptotic

130 However, when sequence-based structural similarity is added, the accuracy of SSpro ri

131 ource, the ability to search the database by structural similarity is essential.

132 This structural similarity is supported by sequence compariso

133 es enzymatic transformations with metabolite structural similarity, mass spectral similarity and empi

134 an in complex with the antidote reveals many structural similarities of dabigatran recognition compar

135 NA self-assembly because of the chemical and structural similarities of DNA and RNA.

136 X-ray scattering (SAXS) studies confirm the structural similarities of TAPBPR with tapasin.

137 The brevity of the route and the structural similarity of a key intermediate to many pote

138 Herein, starting from the structural similarity of a potent G4 ligand previously d

139 Regardless of the structural similarity of both the organosulfur compounds

140 The striking structural similarity of CblD to CblC, believed to be co

141 ction between FGF2 and CD44 and based on the structural similarity of CD44 and LYVE-1, we investigate

142 Predicted overall structural similarity of Herp to the ubiquitin-proteasom

143 On the basis of the structural similarity of isoprostanoid moieties that are

144 Moreover, due to the structural similarity of KuQuinones with camptothecin (C

145 On the basis of the structural similarity of our previous 5-HT2C agonists wi

146 Considering close structural similarity of sphingosine and FTY720 we inves

147 Due to the structural similarity of the DHBTs to known antagonists

148 exes, determined to 1.6 A, reveal remarkable structural similarity of the dimer interface with 3CL(pr

149 electrically driven CE is determined by the structural similarity of the sulfur sublattices between

150 ecretory processes in different tissues, the structural similarity of the three isoforms makes this d

151 but the cause has remained elusive given the structural similarity of the two tandem domains.

152 otential parent compounds and TPs, while the structural similarity of these pairs hypothesized by MS/

153 plasma membranes remain ill-defined, but the structural similarity of water and NH3 has pointed to th

154 VAST service, which summarizes and presents structural similarity on the level of biological assembl

155 Despite their structural similarities, only Xlf(-/-) cells, but not Pa

156 grammatical inferences overwhelmingly favor structural similarity over preservation of superficial o

157 ity 4 (Ctf4) based on phylogenetic analysis, structural similarities, physical interaction with the C

158 as a measure of a random network's internal structural similarity, ranking networks on a continuous

159 dicated that both processes were governed by structural similarity rules.

160 Therefore, despite the high degree of structural similarity, RUNX1B and RUNX1C isoforms have d

161 alignment is then determined by the maximum structural similarity score, GS-score, which is size-ind

162 a crystal structure of PCNA and a subsequent structural similarity search of the ZINC chemical databa

163 Based on this structural similarity several conserved amino acid resid

164 identify more HPIs than sequence or complete structural similarity since it appears more common than

165 Despite this structural similarity, substantial differences in the di

166 Structural similarities suggest this pathway follows a b

167 these loops evolved independently, but their structural similarity suggests a common ancestor.

168 of a family of three related proteins whose structural similarity suggests functional redundancy.

169 This structural similarity suggests that the putative PirAB(v

170 Based on a structural similarity survey of other inhibitors with th

171 However, despite close structural similarity, the roles of CBP and p300 differ

172 Despite relevant sequence and structural similarity, the structures revealed two uniqu

173 Notably, despite their structural similarities they exert diverse modulation on

174 = 1,4-dicarboxylbenzene-2,3-dithiolate) with structural similarities to [FeFe]-hydrogenase active sit

175 erodimeric proteins on its surface that have structural similarities to a protein crucial for invasio

176 Despite ticagrelor's structural similarities to adenosine, the Fab is highly

177 s placed on designing polymers which have no structural similarities to antifreeze proteins but repro

178 that, despite low sequence identity, M11 has structural similarities to Bcl-xL, Bcl-2, and Bcl-w.

179 nce of double bonds, the [n]cumulenes, share structural similarities to both of their conjugated rela

180 biosynthesis of ergothioneine in EgtB shows structural similarities to cysteine dioxygenase which tr

181 y, multiple dynein arm assembly factors show structural similarities to either Tah1 or Pih1, the othe

182 single to double strand boundaries that have structural similarities to hairpins and fixed 5' and 3'

183 In contrast, HdeB, which has high structural similarities to HdeA, shows negligible chaper

184 ChtA and ChtC share structural similarities to HtaA; however, a function for

185 Taken together, despite structural similarities to MDMA, exposure to methylone o

186 tein (LDSP) with unique primary sequence but structural similarities to other LD proteins.

187 wn functions do not have global sequence and structural similarities to proteins of known function.

188 didate 2), a Plasmodium berghei protein with structural similarities to subtilisin-like proteins.

189 contain highly ordered water molecules with structural similarities to the "ice channels" observed i

190 omplex with PilM, a cytoplasmic protein with structural similarities to the cytoskeletal protein MreB

191 -to-noise ratio of 31 +/- 9 and demonstrated structural similarities to the gray matter distribution

192 spike structure is unique, with only distant structural similarities to the human astrovirus capsid s

193 nstituent of these illicit products, and its structural similarities to the more well-known drugs of

194 ycoprotein with heparin-binding activity and structural similarities to thrombospondin-1.

195 ferent regions of Izumo1 display significant structural similarities to two proteins expressed by the

196 We observe that specific domains of HTT have structural similarities to yeast Atg proteins that funct

197 ructure of human Thg1 revealed a fascinating structural similarity to 5' --> 3' polymerases, indicati

198 crystal structure of CT263 displays striking structural similarity to 5'-methylthioadenosine nucleosi

199 reveals the effector shares highest overall structural similarity to a glycoside hydrolase family as

200 an accessory N-terminal domain that has high structural similarity to a recently discovered motif pre

201 In spite of its structural similarity to acetylcholine, there are no oth

202 Cr-UVR8 shares sequence and structural similarity to Arabidopsis thaliana UVR8, has

203 e deiodinase 3 (Dio3), which reveals a close structural similarity to atypical 2-Cys peroxiredoxin(s)

204 main in the BF1687 protein, show significant structural similarity to bacterial pore-forming toxins.

205 d by NMR spectroscopy and revealed excellent structural similarity to BBI and SFTI-1.

206 The new materials bear close structural similarity to BODIPYs but differ significantl

207 Structural similarity to cadherins suggested calcium-dep

208 This ligand shares structural similarity to cariprazine (2), a drug awaitin

209 domains (CARDs), MALT1 is a paracaspase with structural similarity to caspases.

210 The C domain of ParB harbors structural similarity to CenpA, which dictates eukaryoti

211 a pure blocker or releaser rather than their structural similarity to cocaine.

212 res with fivefold symmetry, which bear great structural similarity to colloidal gels.

213 The unexpected structural similarity to components of cellular multisub

214 Based on Tk-AMP-X2 structural similarity to cone snail and scorpion potassi

215 rget the thyroid system, likely due to their structural similarity to endogenous thyroid hormones.

216 make a variety of related diterpenes, whose structural similarity to ent-kaurene makes them potentia

217 ely present in bacteria that has significant structural similarity to eukaryotic cadherins.

218 of a two-layered (4 + 3) beta-sandwich with structural similarity to fibronectin type 3 domains.

219 While individual MUB domains showed structural similarity to fimbrial proteins from Gram-pos

220 nd bioinformatics predictions that suggested structural similarity to folliculin, the Birt-Hogg-Dube

221 Despite structural similarity to Gbeta-like subunits, Cpc2p appe

222 Because of its structural similarity to glucose, genetic studies of 1,5

223 Despite apparent structural similarity to group I introns, the LC ribozym

224 ound to the host receptor CD4, which reveals structural similarity to HIV-1 gp120 despite divergence

225 ically screen for new lipids sharing distant structural similarity to known lipid classes and have de

226 eptide (named GrCLE1-1Hyp4,7g) with striking structural similarity to mature plant CLE peptides.

227 a unique class 27 myosin, TgMyoF, which has structural similarity to myosin V, the prototypical carg

228 lethanolamide and cardanolethanolamide, with structural similarity to NAEs and characterized their ef

229 hetype human IgG, and those that do approach structural similarity to native antibodies are often cha

230 nd that Pseudomonas FliD exhibits unexpected structural similarity to other flagellar proteins at the

231 The structural similarity to other ZZ domains suggests that

232 sin, which is a nonapeptide with substantial structural similarity to oxytocin, did not alter ethanol

233 photolysis yields photoproducts with strong structural similarity to parent steroids, and these phot

234 is a globular beta-sandwich protein showing structural similarity to Phl p 2 and the Phl p 1-C-termi

235 ines local structural similarity and general structural similarity to predict interface residues.

236 eals that this N-terminal extension shows no structural similarity to previously characterized protea

237 natural products being published today bear structural similarity to previously published compounds,

238 is indicated that CT009 shares high level of structural similarity to RodZ, revealing the conserved o

239 The protein shows structural similarity to ROK (repressors, open reading f

240 ven protein segments, each of which has high structural similarity to segments in other species, thou

241 sinosteroids (BRs), a group of steroids with structural similarity to steroid hormones of mammals.

242 structure determined, shows a high degree of structural similarity to that of human ADS lyase.

243 Although MraZ has structural similarity to the AbrB transition state regul

244 , a not unexpected outcome given their close structural similarity to the antiandrogenic drug nilutam

245 ology of the enzyme reveals that it shares a structural similarity to the AsnC/Lrp family of transcri

246 ulmonary antimicrobial response based on its structural similarity to the bactericidal/permeability-i

247 ated region (UTR) of M mRNA with significant structural similarity to the cellular GAIT (gamma-activa

248 er, one compound (1), a rhodanine with close structural similarity to the commercial diabetes drug ep

249 sion of this mitochondrial protease that has structural similarity to the cytoplasmic proteosome is i

250 Notably, the pyridine synthases show structural similarity to the elimination domain of lanth

251 lly synthesized peptidomimetics that bear no structural similarity to the established TLR4 ligand, li

252 Despite high sequence (48% identity) and structural similarity to the GRE-type glycerol dehydrata

253 dues, and a portion of the active site shows structural similarity to the GTP-binding site of MoaA, s

254 d consists of a four-alpha-helix bundle with structural similarity to the high mobility group box, a

255 This enzyme shows a strong structural similarity to the human phosphatases of regen

256 conserved region (region IX) with predicted structural similarity to the human topoisomerase I core

257 ology modeling suggested that ORF16 shares a structural similarity to the N-terminal half of CLF.

258 DPUP has close structural similarity to the severe acute respiratory sy

259 ReMAX/RLP1 is a typical RLP with structural similarity to the tomato (Solanum lycopersicu

260 information on the domain of applicability (structural similarity to the training set) and estimates

261 2 reveals that the protein shares intriguing structural similarity to ToxA from the wheat pathogen Py

262 Domain A, which exhibits structural similarity to tRNA, appears to be an essentia

263 lar that the C-terminal domain of HTT shares structural similarity to yeast Atg11, an autophagic scaf

264 E3 ubiquitin ligase that shows sequence and structural similarity to yeast Degradation of alpha fact

265 nking functional information to sequence and structural similarities using protein similarity network

266 In contrast to their structural similarity, wCp149 demonstrates enhanced asse

267 Despite structural similarities, we demonstrate that the electro

268 They share significant sequence and structural similarities, which results in cross-recognit

269 el, and the additional use of sequence-based structural similarity, which uses similarity to sequence

270 conformational changes, PspA may then share structural similarities with a bEBP regulatory domain.

271 domains through a disulfide bond, revealing structural similarities with ADP regulation in the human

272 s further study, ORF52 shares functional and structural similarities with alphaherpesvirus VP22, unde

273 ubcomplexes, composed of subunits that share structural similarities with bacteriophage tail and base

274 d-open Sav1866 structures show that McjD has structural similarities with both states without the int

275 ld-containing (BPIF) protein family, sharing structural similarities with BPI-like proteins.

276 fold-containing protein family, which shares structural similarities with BPI-like proteins.

277 ares functional and quaternary and secondary structural similarities with connexins and evolutionaril

278 Amphomycin and MX-2401 share structural similarities with daptomycin, but unlike dapt

279 The fusion protein shares structural similarities with its regulated parent protei

280 Due to widespread human exposure, and structural similarities with known endocrine disruptors,

281 th microtubule (MT)-stabilizing activity and structural similarities with known NSAIDs, we conducted

282 a nanoparticles by thermolysis, due to their structural similarities with silica materials.

283 Together, WarA and WarB have structural similarities with the bifunctional Escherichi

284 on to the ammonia transporter, AmtB, reveals structural similarities with the bound water network in

285 and comparative analyses reveal sequence and structural similarities with the distant Acidobacteria L

286 Despite the high structural similarity with 64.3% sequence identity, thei

287 MppR shares a high degree of structural similarity with acetoacetate decarboxylase, t

288 pporting this, the N terminus of UL37 shares structural similarity with cellular multisubunit tetheri

289 PAXX is the newest NHEJ factor, which shares structural similarity with known NHEJ factors-XRCC4 and

290 Although PA1343 lacks obvious primary structural similarity with known PagP enzymes, the beta-

291 rich alpha1-helix in endostatin-which shares structural similarity with noncanonical nuclear receptor

292 cop and czc operons showed a high degree of structural similarity with other known proteins involved

293 IPK1 shares structural similarity with protein kinases and is suspec

294 t into SAGA function in gene regulation, its structural similarity with TFIID, and functional interac

295 ns with high allergenic activity and exhibit structural similarity with the C-terminal portion of maj

296 ions of GM-CSF and IL-2, without sharing any structural similarity with the cytokine receptors.

297 he VosA velvet domain revealed an unforeseen structural similarity with the Rel homology domain (RHD)

298 component reaction, would possess sufficient structural similarity with TLR7/8-agonistic imidazoquino

299 a-RalGAPbeta heterodimer shares sequence and structural similarity with Tsc1-Tsc2.

300 ajor Arctic conformers has surprisingly high structural similarity with wild-type Abeta42.