ライフサイエンスコーパス: structurally

1 These differences can be rationalized structurally.

2 nce, get their nourishment from newly formed structurally abnormal vessels which present wide and irr

3 However, enamel secreted thereafter was structurally abnormal; presumably due to the UPR modulat

4 ffectively solved to enhance the assembly of structurally altered regions in human genomes.

5 )} n , extending many mum in length that are structurally analogous to natural DNA.

6 polymerases has only recently been explored structurally and all three DNA polymerases studied to da

7 To do so, we have structurally and biophysically characterized the interac

8 The structurally and dynamically perturbed hydration shells

9 thesized oligonucleotides containing several structurally and electronically varied artificial linkag

10 ase/loxP system in mice with optogenetics to structurally and functionally characterize angiotensin t

11 Here, we structurally and functionally characterized one of these

12 gets because they control cell death and are structurally and functionally different from normal cell

13 ith blood by specialized vasculature that is structurally and functionally distinct from that of the

14 henotype values and plasticity measures form structurally and functionally distinct groups.

15 Cyanobacteria produce structurally and functionally diverse polyketides, nonri

16 teins with conserved rare codon clusters are structurally and functionally diverse, they are enriched

17 strate that the avian auditory thalamus is a structurally and functionally heterogeneous structure, i

18 Of note, Thr(264) is in close vicinity to a structurally and functionally important TRPV3 region com

19 The orange carotenoid protein (OCP) is a structurally and functionally modular photoactive protei

20 It is structurally and functionally modular, comprised of a C-

21 The OCP is structurally and functionally modular, consisting of a s

22 s cell-surface cargoes from endosomes and is structurally and functionally related to the well-charac

23 into the mechanism based on comparison with structurally and functionally similar enzymes, and the a

24 Here, we identify a large set of structurally and functionally unrelated mitochondrial pr

25 defines LigM as a distinct demethylase, both structurally and functionally, and provides insight into

26 d disrupts socially relevant neural circuits structurally and functionally.

27 oach for restoring dystrophic cardiomyopathy structurally and functionally.

28 DNA polymerases has been extensively studied structurally and kinetically, but several key steps foll

29 smegmatis that confer resistance to several structurally and mechanistically unrelated classes of an

30 nes and subsequent aldol addition was probed structurally and mechanistically using a combination of

31 d in the same experimental conditions in two structurally and sequentially distinct protein scaffolds

32 0RhoGAP, characterize them biochemically and structurally and show that they influence RhoGAP activit

33 These were characterized biochemically and structurally, and the one partially sharing some of the

34 ed metabolomics approaches, the inability to structurally annotate relevant features and map them to

35 ingle-stranded segment, which we rationalize structurally as a key recognition determinant that may f

36 riles, the prototype TAML activator gave the structurally authenticated reactive iron(V)oxo units (Fe

37 d example (outside of matrix isolation) of a structurally authenticated transition-metal terminal par

38 that a potential trimerization interface is structurally blocked by the HECT domain alpha1-helix, wh

39 al therapeutic interest and functionally and structurally characterize the antagonist SPA70 and the s

40 ization of MOF modularity also allowed us to structurally characterize the first example of bimetalli

41 In total, we structurally characterized 101 Mass2Motifs with biochemi

42 The structurally characterized alpha3Y model protein has all

43 DEP and CER-based protein extracts were structurally characterized by peptide mass mapping.

44 enz)]MgH allows access to a variety of other structurally characterized carbatrane derivatives, inclu

45 les NO(g) at RT in methanol (MeOH), giving a structurally characterized hyponitrito-dicopper(II) addu

46 s the first anionic dithiolene radical to be structurally characterized in the solid state.

47 phenylalanine, into various positions of the structurally characterized isozyme histone deacetylase 8

48 a diameter of 4.5 nm, making it the largest, structurally characterized M2nLn complex described to da

49 Protonation of Os-N2(-) affords a structurally characterized Os=NNH2(+) hydrazido species

50 Here, we structurally characterized the stable equilibrium urea u

51 Although BamB has been biochemically and structurally characterized, its mechanism still remains

52 NC(Me)]2 ) was synthesized in high yield and structurally characterized.

53 y, this compound can be readily isolated and structurally characterized.

54 has been prepared and spectroscopically and structurally characterized.

55 illuminate the distinct mechanisms by which structurally, chemically, and functionally diverse ligan

56 he structure-function studies performed with structurally close analogs explain the FD44 specificity

57 (IL)-15 is a pleiotropic cytokine, which is structurally close to IL-2 and shares with it the IL-2 b

58 Structurally colored materials are often used for their

59 rption in a thin layer within a transparent, structurally colored multilayer material, an optical Jan

60 odes, and rather close to the highest levels structurally compatible with the networks' reputation la

61 electron-rich, electron-deficient as well as structurally complex (hetero)arylmetals.

62 The sponges are often large and structurally complex and represent numerous different li

63 noid as a platform for the synthesis of more structurally complex congeners may be a general approach

64 frican swine fever virus (ASFV), is a highly structurally complex double stranded DNA virus.

65 biochemical and functional properties of the structurally complex ejaculates of Pieris rapae butterfl

66 provide insight into how global declines in structurally complex estuarine habitats may have reduced

67 m Bacteroides thetaiotaomicron uses the most structurally complex glycan known: the plant pectic poly

68 Forskolin is a unique structurally complex labdane-type diterpenoid used in th

69 ognized in the biosynthetic pathways of many structurally complex natural products.

70 econd couplings, the third coupling used the structurally complex nucleophile.

71 allowed for estimation of Kd values for more structurally complex organic cations to homoionic montmo

72 Notably, structurally complex pharmaceutical agents could be func

73 lf-assembly of reactive building blocks into structurally complex yet robust materials, such as coval

74 Male ejaculates are often structurally complex, and this complexity is likely to i

75 This experimentally simple protocol provides structurally complex, biologically relevant heterocycles

76 ae are protein-dense plasma membrane domains structurally composed of caveolin-1 or -3 along with oth

77 ters into aquifers can occur from unlined or structurally compromised mine tailings storage facilitie

78 otropy values of the CC subregion III, which structurally connects the bilateral motor cortices.

79 Coat components are structurally conserved between COPI and clathrin/adaptor

80 te docking sites for bromodomains, which are structurally conserved modules present in transcription-

81 Type III Secretion Systems (T3SSs) are structurally conserved nanomachines that span the inner

82 wn that this pathogen expresses a variety of structurally conserved protective antigens that include

83 HTNV Gn is structurally conserved with the Gn of a genetically and

84 ormed by helix II of the DnaJ J-domain and a structurally contiguous region of DnaK, involving lobe I

85 d electronic circuits are much more strongly structurally controllable (SSC) than other types of real

86 hallenging due to the difficulty in creating structurally controlled macromolecules.

87 This state is structurally created in the tetrameric channel by a tran

88 and biochemical process necessary to restore structurally damaged tissue.

89 how that familial PD-associated variants are structurally defective in membrane binding and alter the

90 Those with a structurally defective or severely defective LES improve

91 Consequently, to structurally define this critical interaction, we have r

92 Fortunately, structurally defined oligosaccharides can be used as mod

93 iates in this process have been isolated and structurally defined.

94 Nucleoli were isolated to homogeneity and structurally defined.

95 vity through physical-transformation into 3D structurally deformed nanostructures.

96 citing class of porous materials that can be structurally designed by choosing particular components

97 On the other hand, the four ZFs in the structurally destabilized Miz1-4(A86K) mutant bound to t

98 ge and chemical crosslinking showed that Rca structurally destabilizes elements of the Rubisco active

99 nown ligands even if they do not appear in a structurally determined complex, although this will requ

100 such as DMF, no "mixed" products possessing structurally different amide fragments are detected eith

101 , the connections between the components are structurally different and their divergent character sug

102 ecular copolymerization between two slightly structurally different benzene-1,3,5-tricarboxamide (BTA

103 ronic excitation, and compare the results of structurally different BODIPY chromophores.

104 Corneocytes from AD skin are structurally different from corneocytes from normal heal

105 stinct strategies that each address multiple structurally different members of the isocyanoterpenes,

106 Here we show that two structurally different phycobiliproteins refold and reas

107 rgic to one kind of PPI could tolerate other structurally different PPI without cross-hypersensitivit

108 f external causes in vitro, the interplay of structurally differently conserved elements in this prot

109 es energy from ATP hydrolysis to export many structurally dissimilar hydrophobic and amphipathic comp

110 ures, whereas the somatic diversification of structurally distinct antigen receptor genes evolved ind

111 each cell type to construct functionally and structurally distinct cells.

112 istribution function, the coexistence of two structurally distinct domains is observed at T = 125 K.

113 a conceptual advancement in integrating two structurally distinct drugs of different action mechanis

114 Phages 80alpha and phiNM1 encode structurally distinct dUTPases, Dut80alpha (type 1) and

115 also generate blunt-ended products, and to a structurally distinct enzyme (the HNH endonuclease PacI)

116 MAbs 5B4 and 6H4 recognize structurally distinct epitopes present in the vast major

117 tors, respectively; these photoreceptors are structurally distinct from each other.

118 isms by a cofactor-independent mutase (iPGM) structurally distinct from the mammalian cofactor-depend

119 Petunia spp. synthesize acylsugars that are structurally distinct from those of tomato.

120 Glo1 or pharmacological inhibition using two structurally distinct GLO1 inhibitors (S-bromobenzylglut

121 Structurally distinct Keap1-Nrf2 PPI inhibitors promote

122 e, validation with knockout animal models or structurally distinct ligands with affinity for the same

123 ta provide evidence that compositionally and structurally distinct lower airway microbiomes are assoc

124 by the overlay of bound structures of three structurally distinct NS5B palm site allosteric inhibito

125 oscopy, the phase transition between the two structurally distinct phases (i.e., brownmillerite and p

126 Thus, the two OmpA proteins bind related but structurally distinct receptors.

127 nd teleosts, resulting in the formation of a structurally distinct replacement.

128 , as well as specific recognition of its two structurally distinct ribosomal RNA targets.

129 omerize to form perakine, an alkaloid with a structurally distinct scaffold.

130 lling being responsible but found that three structurally distinct T-type - but not L-type - CC block

131 s. wurtzite polymorphs by cation exchange of structurally distinct templates.

132 adjacent ORFs on the same mRNA molecule are structurally distinct.

133 milies and identified a phylogenetically and structurally distinctive monophyly in Archaeplastida.

134 ncated ComGC revealing a highly flexible and structurally divergent type IV pilin.

135 tones but feature an open-chain unit linking structurally diverse A-ring moieties to the butenolide D

136 y of the process and its ability to generate structurally diverse and valued aryl, heteroaryl, and al

137 oited as a biotechnological tool to generate structurally diverse arrays of macrocycles, including th

138 that is based on computational ecologies of structurally diverse artificial neural networks, and on

139 irect primary amination and hydroxylation of structurally diverse aryl- and heteroarylmetals.

140 on Michael addition-elimination reaction of structurally diverse beta-ketoenols with amines, and use

141 These structurally diverse biopolymers are omnipresent constit

142 It was shown to biodegrade structurally diverse compounds.

143 feature that enhances the misreplication of structurally diverse DNA lesions.

144 ses and aminomutases are mechanistically and structurally diverse enzymes which catalyze the deaminat

145 ss a range of hydroamination reactions using structurally diverse phosphine ligands, revealing the cr

146 We report herein a collection of structurally diverse polycyclic fused and spiro-4-aminop

147 It is unclear whether or how these structurally diverse proteins or pathways mediate any of

148 atalysis and facilitates the activation of a structurally diverse range of therapeutics in cancer cel

149 en sought for the production of libraries of structurally diverse scaffolds via combinatorial gene as

150 , have been employed for the construction of structurally diverse scaffolds, ranging from simple bicy

151 The structurally dynamic B-repeat domain of M1 was critical

152 The colloidosomes can be structurally elaborated post assembly by in situ epitaxi

153 solated from the tuber ethanolic extract and structurally elucidated by Nuclear Magnetic Resonance (N

154 nto potential reactive intermediates of this structurally elusive catalyst.

155 ed an approach to obtain the molarity of any structurally enriched semiconducting single-walled carbo

156 Mucosal IgA or secretory IgA (SIgA) are structurally equipped to resist chemical degradation in

157 potentially to increase the stability of the structurally essential tryptophan ladder or to provide a

158 Then, using dark-field imaging, we structurally examine the reaction intermediates with 1 n

159 It is demonstrated that the structurally flexible building units of the amorphous GS

160 antibodies against HIV-1 is to stabilize the structurally flexible HIV-1 envelope (Env) trimer in a c

161 CD23 variants were purified as monomeric and structurally folded proteins, as demonstrated by gel fil

162 The pyrazolopyrimidine-based core differs structurally from that of aminopyrimidine-based third-ge

163 Additionally, we show the human CTD is also structurally heterogeneous and able to substitute for th

164 forces in soft, three-dimensional (3D), and structurally heterogeneous ECM environments such as occu

165 rrays must tackle the challenge of capturing structurally highly dynamic strands onto defined substra

166 his question using a set of domains that are structurally homologous but evolved with widely varying

167 circuits supporting model-based behavior are structurally homologous to and overlapping with those th

168 out the function of Teb2 and Teb3, which are structurally homologous to the RPA middle and small subu

169 The clusters are structurally identical in the two charge states, with ne

170 s, several parameters that are theoretically structurally identifiable, are, in practice, unidentifia

171 nd questions our long-standing beliefs about structurally important factors.

172 entifying a wider range of antigenically and structurally improved soluble trimers based on multiple

173 we evaluated the (-)-JQ1 enantiomer that is structurally incapable of inhibiting BET bromodomains, w

174 However, this pentameric model is structurally incompatible with the monomeric 'initiation

175 Silicate is structurally incorporated within this layer and inhibits

176 r of the film and those near the surface are structurally indistinguishable despite exhibiting very d

177 ative polarity He-CTD provided a full set of structurally informative fragments, which permitted the

178 Our results indicate that structurally integrated primary cilia are required for d

179 knowing the relative contributions of these structurally integrated systems to cell mechanics is cri

180 identified regulatory category that we call structurally interacting RNA or sxRNA for convenience.

181 Here, we structurally investigated two neutralizing antibodies th

182 Chromatin is structurally involved in the transcriptional regulation

183 rial has limited its clinical indications to structurally less demanding applications, such as orthod

184 Structurally, Lmods and Tmods display crucial difference

185 laxation of purifying selection, in residues structurally mapped after sequence and X-ray structural

186 bilities of iBu2 AlTMP and Ga(CH2 SiMe3 )3 , structurally mapping their TMT reactions and probing rel

187 y 170-residue-long N-terminal extension that structurally mimics a dimer-dimer interface of these enz

188 ns, we expect forests to become increasingly structurally mismatched to water availability and thus o

189 ion with the cylindrical inclusion bodies at structurally modified PDs in cells coexpressing 6K2, CI,

190 Pressures up to 200MPa resulted in a structurally molten globule-like state where PepX mainta

191 Therefore, inhibition is functionally and structurally more robust and diverse in ACC than in LPFC

192 Our EILV platform represents the first structurally native application of an insect-specific vi

193 3DPyM-pDTC, which is structurally nearly planar with a very small DeltaEST, s

194 We sought to determine whether slight, structurally nonrelevant modifications of the prototypic

195 iNICD mice have structurally normal atria and preserved sinus node archi

196 mode, Enamp.S55I heterozygous mice secreted structurally normal enamel.

197 gement of VT that occurs in the setting of a structurally normal heart and the role of catheter ablat

198 ventricular contractions in the setting of a structurally normal heart carries a low risk for sudden

199 ycardia (VT) that occurs in the setting of a structurally normal heart, VT that occurs in patients wi

200 cal lesions affect the communication between structurally normal regions of the brain, and that these

201 nctional tricuspid regurgitation (TR) with a structurally normal tricuspid valve (TV) may occur secon

202 ble, dual antagonist of XIAP and cIAP1 and a structurally novel chemical probe for IAP biology.

203 es have led to the identification of several structurally novel fragments that bind to diverse Cyp is

204 vitro model of a blood clot mechanically and structurally on both microscopic and macroscopic scales.

205 t does not apply to full-length PKCdelta) in structurally organizing diverse elements within the enzy

206 ily accessible (minimal synthetic steps) and structurally planar selenophene-based building block, 1,

207 Structurally, PON1 is a six-bladed beta-propeller with a

208 We demonstrate that although no structurally privileged folding level exists, TADs emerg

209 Although structurally quite similar to the transitional-turbulent

210 Overall, we structurally rationalize phosphorylation of Ins(1,4,5)P3

211 ing to understand how these compartments are structurally registered and functionally integrated with

212 not bind tubulin, which was observed for the structurally related 4 (BKM120, buparlisib).

213 -VL-2098 as a VL preclinical candidate, this structurally related 7-substituted 2-nitro-5,6-dihydroim

214 ly characterize the antagonist SPA70 and the structurally related agonist SJB7.

215 zed by quite broad cross-reactivity to other structurally related amphetamine-type stimulants.

216 sis and a unique nanoscale platform to study structurally related biological electron transfer.

217 selectivity issues (particularly against the structurally related BRD4 protein).

218 rily functions as a catalytic subunit in two structurally related but functionally distinct multi-com

219 med reverse-transcription and utilization of structurally related capsids.

220 rbiturate anions were compared with those of structurally related carbanions, e.g., Meldrum's acid an

221 ty to inhibit DYRK1A, DYRK1B, DYRK2, and the structurally related CLK1.

222 tability (90 degrees C, 5h) of six isolated, structurally related cyanidin-3-O-glycosides from black

223 mediated transport of cytarabine and various structurally related cytidine analogues, such as 2'deoxy

224 IL-4 drives production of these structurally related defense collagens, SP-A and C1q, an

225 ips for analogs of 3 with exploration of the structurally related dioxoisoindoline class.

226 Protein kinases comprise a large family of structurally related enzymes.

227 g systems to generate these large classes of structurally related families is oligomerization, wherei

228 tic investigation of the smell properties of structurally related guaiacol derivatives.

229 age recognition properties over a variety of structurally related guests, together with the kinetic s

230 Inhibition by (-)-fenchone and six structurally related inhibitors of Agam/Or15 receptors c

231 anes, the hierarchical phase outperforms the structurally related microporous HKUST-1 as well as sili

232 tric oxide (NO) is synthesized in animals by structurally related NO synthases (NOSs), which contain

233 Structurally related pentacyclic triterpenoids methyl 2-

234 ibutions, small sequence differences between structurally related RNAs can alter their ligand selecti

235 , the Scl proteins signify a large family of structurally related surface proteins, which contribute

236 HCV inhibitor (EC50 = 9440 nM), a series of structurally related thiazole derivatives has been ident

237 d, including that vertebrate biogenic amines structurally related to octopamine acted as superagonist

238 A series of congeners structurally related to pritelivir, N-[5-(aminosulfonyl)

239 pendent, acidic cyclolipopeptide antibiotics structurally related to the clinically approved daptomyc

240 tion of recombinant albumin that displays 17 structurally relevant disulfides.

241 lowing neo-microvessels, which after 14 days structurally resembled that of uninjured muscle.

242 low leaching indicate that our material is a structurally resilient single-site heterogeneous catalys

243 ly and accurately evaluating the dynamics of structurally resolved systems, from individual molecules

244 (-)3TC-TP) and emtricitabine ((-)FTC-TP), we structurally reveal the correct sequence of post-chemist

245 As a case study, we analyze smFRET data of structurally rigid, double-stranded DNA-oligonucleotides

246 iated coupling between alkynes to generate a structurally rigid, linear 1,3-diyne linkage has been kn

247 We compare these structures to two structurally similar 'PD-D/ExK' restriction endonuclease

248 tides self-associate into highly ordered and structurally similar amyloid cross-beta aggregates.

249 , RGB cones (red, green, and blue cones) are structurally similar and unite into mirror-symmetric pen

250 s in the accurate discrimination between two structurally similar base pairs: A:oxoG and A:T.

251 al similarities and detecting communities of structurally similar binding sites based on the minimum

252 Structurally similar binding sites in the same community

253 A molecular weight fractions are shown to be structurally similar by Fourier-transform ion cyclotron

254 their low concentrations and large number of structurally similar components, mass spectrometric scre

255 Comparing structurally similar cortical regions revealed significa

256 Remarkably, structurally similar drugs display both common and diffe

257 ting the glycosylated asparagine residues to structurally similar glutamines or alanines.

258 However, coexisting structurally similar isomers often render an unambiguous

259 re cytoplasmic pheromone receptors sharing a structurally similar pheromone-binding domain that funct

260 The cross-reactivity to structurally similar PPI was also observed in LAT assay.

261 ss-hypersensitivity reactions to alternative structurally similar PPI.

262 The proteolytic P-ring and the structurally similar R-ring form the core complex that c

263 S confirms that the immobilized cluster 2 is structurally similar to 1.

264 lymphocyte-derived membrane conduits (LMCs) structurally similar to membrane nanotubes with unknown

265 Justicidin B is structurally similar to more potent vacuolar-type H(+)-A

266 ulation by Tolypothrix FRP, which we show is structurally similar to the dimeric form of Synechocysti

267 metabolites in a reference database that are structurally similar to the unknown metabolite.

268 novel colorimetric and ratiometric probe is structurally simple and offers detection within 20 min.

269 Two structurally simplified nucleobase analogues (1 and 4) l

270 ides, proteins, enzymes, and DNA, and can be structurally stabilized by sodium alginate or gelatin-ba

271 ent of toxin-secreting killer yeasts, K28 is structurally stable and biologically active as a disulfi

272 Specifically, structurally stable mutants show low aggregation propens

273 Structurally, this represents the current end-point of a

274 By structurally threading low-resolution structural models

275 ssion profiles delineated brain regions into structurally tiered spatial groups and we observed strik

276 bout how DISC1 interacts with other proteins structurally to impact human brain development.

277 networks with cohesive subgroups are able to structurally trap infections within a few subgroups and

278 ember of the ErbB family possesses a unique, structurally uncharacterized C-terminal tail that plays

279 llowing phosphodiester bond formation remain structurally uncharacterized due to utilization of natur

280 overy, limited success has been achieved for structurally unconstrained GFP chromophore analogues (uG

281 ns and may represent a large fraction of the structurally unidentified metabolome.

282 ally-derived precursor oligosaccharides into structurally uniform human-type N-glycans.

283 CARTs are structurally unique and operate through an unprecedented

284 to spur growth in the lipidomics field, more structurally unique lipid species are detected and annot

285 The structurally unique polyazole antibiotic goadsporin cont

286 We consider whether or not parasites play structurally unique roles in ecological networks; that i

287 ccurate and unambiguous 3-D structure of the structurally unknown guest molecule from only micro- or

288 A functional role of this Phe is structurally unpredictable.

289 In the present work, 79 structurally unrelated analytes were taken into account

290 We now report a structurally unrelated compound, Photoregulin3 (PR3) tha

291 Only a few structurally unrelated compounds interfering with ELAV p

292 Hapten inhibition and the use of structurally unrelated hapten-BSA adducts confirmed anti

293 Kir7.1-T153C mutation enhances block by the structurally unrelated inhibitor VU714 but not by a high

294 Our results rationalize how a multitude of structurally unrelated molecular patterns can activate C

295 analogues were synthesized and characterized structurally using NMR spectroscopy.

296 and potential functions of these complex and structurally variant telomere-adjacent DNA regions.

297 diarylcyclobutanes by photocycloaddition of structurally varied 2'-hydroxychalcones with a range of

298 r cystine knot domains separated by a short, structurally well-defined linker.

299 These structurally well-defined, asymmetric membranes facilita

300 Yet, the synthesis of structurally well-defined, core-fucosylated glycoprotein