ライフサイエンスコーパス: subcellular target

1 d in more precise reconstructions of complex subcellular targets.

2 stem are directed onto specific cellular and subcellular targets.

3 is tightly regulated in both activity and in subcellular targeting.

4 y, the type I activation loop is also key in subcellular targeting.

5 the biological consequence of this specific subcellular targeting.

6 east was improved by manipulation of protein subcellular targeting.

7 , is up-regulated 2.5-fold without change in subcellular targeting.

8 and common DISC1 amino acid substitutions on subcellular targeting.

9 r cellular complement, expression level, and subcellular targeting.

10 ol of mRNA translation rates, stability, and subcellular targeting.

11 h a concomitant isoform switch and change of subcellular targeting.

12 tions, such as interactions with proteins or subcellular targeting.

13 domain located at its N terminus involved in subcellular targeting.

14 or pRTL2 plasmids, and used to study protein subcellular targeting.

15 Subcellular targeting analysis by fluorescence microscop

16 The subcellular target and cellular uptake mechanism of the

17 modulated by a combination of stage-specific subcellular targeting and assembly dynamics.

18 apoptotic effect of PAK-2p34 is regulated by subcellular targeting and degradation by the proteasome.

19 extent alternative splicing might influence subcellular targeting and function of ClC-3.

20 ac2 crystal structure, is important for Epac subcellular targeting and in vivo functions.

21 rget for protein kinases and be required for subcellular targeting and membrane clustering of the rec

22 f beta4, a subunit predicted to regulate the subcellular targeting and modulation of both P/Q- and N-

23 y seems to be controlled by IKK interaction, subcellular targeting and oxidative stress conditions.

24 These in vivo and in vitro subcellular targeting and recombinant expression experim

25 a1 variants and explored their roles in Duox subcellular targeting and reconstitution.

26 C15 or C20 isoprenoid moieties) may mediate subcellular targeting and regulation of activity; and se

27 protein function largely depends on specific subcellular targeting and specific interactions with cel

28 Subcellular targeting and the activity of facilitative g

29 protein targeting sequences, mutant signals, subcellular targets and source organisms.

30 Multiple mechanisms regulate the properties, subcellular targeting, and cell-surface expression of Kv

31 r, these results suggest that actin binding, subcellular targeting, and dimerization are associated i

32 ly crucial for endoplasmic reticulum export, subcellular targeting, and fibril formation by Pmel17 an

33 R/K-V/I-X-F) in a family of proteins mediate subcellular targeting, and the amino acids that form the

34 Our subcellular targeting approach can be transferred to oth

35 th identity of the linker and control of its subcellular targeting are highly modular.

36 ailed overview of the recent developments in subcellular targeting as a novel platform for next-gener

37 how this functional diversity affects their subcellular targeting behaviors, we measured the binding

38 in complexes that are likely involved in the subcellular targeting, cytoskeletal anchoring, and local

39 ic endosomes, but its pH sensitivity and its subcellular targeting differed from transferrin.

40 This domain is responsible for the subcellular targeting differences between gamma and delt

41 We have determined the subcellular targeting domain of delta(E) CaMK-II, an iso

42 ficially localized to the cell edge with the subcellular targeting domain of Rap1a, it increases cell

43 ers is a challenge because the dimensions of subcellular targets (e.g., the cell nucleus) are of the

44 Examination of coding sequences and subcellular targeting elements indicated that the comple

45 ional simulations indicate that the observed subcellular targeting enables control over the nonlinear

46 nction in heterologous cells is regulated by subcellular targeting, endocytosis, and intracellular tr

47 d (4) the neuromuscular synapse is a primary subcellular target for muscle ERK1/2 function in vivo.

48 Here we show, using subcellular-targeted, genetically encoded hemoprotein pe

49 they are targeted to, and we monitored their subcellular targeting in living cells.

50 ome and into pRTL2 plasmids to study protein subcellular targeting in the presence and absence of vir

51 ug is sequestered away from the nucleus, its subcellular target, in vesicles expressing each of the t

52 ophagy has been shown to selectively degrade subcellular targets, including proteins, organelles, and

53 ases share 73% identity, provide no apparent subcellular targeting information, and predict inclusion

54 amilies contain distinct regulatory domains, subcellular targeting information, and substrate specifi

55 These findings indicate that subcellular targeting is a critical determinant of eNOS

56 llipodia and membrane ruffles, and that Fgd1 subcellular targeting is dynamic.

57 Efficient delivery of therapeutic agents to subcellular targets is a major challenge in pharmacology

58 a large Stokes shift, and displays intrinsic subcellular targeting, its compatibility with super-reso

59 However, the subcellular targeting mechanism of these proteins is unk

60 other in a tRNA-binding area and the 5'-end subcellular targeting motif area.

61 studies therefore identify mitochondria as a subcellular target of reperfusion damage and a site of a

62 e purpose of this study was to determine the subcellular target of the group IIA PLA(2) and its role

63 Thus, subcellular targeting of a chemoattractant can direct ou

64 Thus, both structural features and subcellular targeting of Ags can have strong effects on

65 The subcellular targeting of alpha2 to the transverse tubule

66 However, notable differences exist in the subcellular targeting of alternatively configured comple

67 differences in both the synaptic density and subcellular targeting of BLA inputs.

68 We therefore hypothesized that subcellular targeting of CaMKII can direct its substrate

69 investigated the effect of estradiol on the subcellular targeting of endothelial nitric oxide syntha

70 Both the post-translational processing and subcellular targeting of eNOS appear to be modified by c

71 onal modifications essential for the correct subcellular targeting of eNOS have not been described pr

72 These data suggest that the subcellular targeting of eNOS to caveolae can restrict N

73 th acylations are required for the efficient subcellular targeting of eNOS to plasmalemmal caveolae.

74 Disruption of the DEP-dependent subcellular targeting of Epac abolished cAMP-Epac-mediat

75 ctivation of PKB by Epac requires the proper subcellular targeting of Epac.

76 he I3 domain alone are sufficient for proper subcellular targeting of exogenous hDlg.

77 rosmotic conditions results from inefficient subcellular targeting of F-actin.

78 revealed that the mutation prevented proper subcellular targeting of FGF12 to the axon initial segme

79 Regulated membrane trafficking and subcellular targeting of GABA(A) receptors is important

80 el constructs unravel a presenilin-dependent subcellular targeting of gamma-secretase complexes.

81 The subcellular targeting of hNMT was also examined by immun

82 density-93 (PSD-93), a protein involved the subcellular targeting of ion channels and glutamate rece

83 Subcellular targeting of kinases controls their activati

84 Subcellular targeting of LpdA required a C-terminal moti

85 We trace this variance to the divergence in subcellular targeting of Mid1 and show that duplication

86 te that AMPK couples local energy demands to subcellular targeting of mitochondria during cell migrat

87 eby TGB protein interactions function in the subcellular targeting of movement protein complexes and

88 Since then, it has become clear that subcellular targeting of mRNAs is prevalent, and there i

89 The subcellular targeting of neurotransmitter receptors is v

90 We investigated the pathways underlying the subcellular targeting of NgCAM, a cell adhesion molecule

91 enous promoters were utilized to observe the subcellular targeting of Ntg1p and Ntg2p in S. cerevisia

92 Our results show that normal subcellular targeting of p27 is not subverted in E5/E8 c

93 Thus, subcellular targeting of parvalbumin reveals a distinct

94 We demonstrate that subcellular targeting of Pim1 bolsters the distinct card

95 p, determines both enzymatic specificity and subcellular targeting of PIP kinases.

96 We now demonstrate that the subcellular targeting of PKA through association with A-

97 at may allow for selective regulation and/or subcellular targeting of PP1 isoforms.

98 Subcellular targeting of protein kinases and phosphatase

99 These findings provide a mechanism for the subcellular targeting of RGS9-2 in neurons.

100 Interaction with R7BP is important for the subcellular targeting of RGS9-2, which in native neurons

101 the molecular determinants that specify the subcellular targeting of RGS9-2.Gbeta5.R7BP complex are

102 at an important role for Hub1 is the correct subcellular targeting of Snu66, although our data sugges

103 Subcellular targeting of the cAMP-dependent protein kina

104 Subcellular targeting of the components of the cAMP-depe

105 tion is a key determinant for the reversible subcellular targeting of the enzyme to plasmalemmal cave

106 Specific subcellular targeting of the sensor demonstrated rapid i

107 , we conducted a comparative analysis of the subcellular targeting of the two Pd-resident and two unr

108 basis for the transmembrane domain-mediated subcellular targeting of UBC6 was evaluated by lengtheni

109 We subsequently tested the subcellular targeting of yellow fluorescent protein fusi

110 To determine the precise subcellular targets of MOR agonists, immunoreactivity ag

111 in vivo HSP-70 expression, and that specific subcellular targets of PDT (which can differ for various

112 To identify the cellular and subcellular targets of trkB ligands in the adult rat hip

113 t-translational process, which may serve for subcellular targeting or membrane anchoring.

114 gged a series of known proteins with diverse subcellular targeting patterns as well as several protei

115 the stable co-existence of plasmids in which subcellular targeting plays a major role.

116 Here, we identify the subcellular targeting potentials for nine CDPK isoforms

117 ctivation mechanism that may account for its subcellular targeting properties.

118 of C2 domains can account for most of their subcellular targeting properties.

119 In turn, subcellular targeting, protein-protein interactions, or

120 Subcellular target recognition in the CNS is the culmina

121 l function of NRP1 in both axon guidance and subcellular target recognition in the construction of GA

122 ed in BCs, controls both axonal guidance and subcellular target recognition.

123 the relationship between enzyme activity and subcellular targeting remains obscure.

124 t identified an N-terminal signal peptide or subcellular targeting sequence.

125 ot affect phosphatase activity but encodes a subcellular targeting signal.

126 ether, these data show that PKCepsilon forms subcellular-targeted signaling modules with ERKs, leadin

127 uncated Lrmp-EGFP fusion proteins identified subcellular targeting signals in the C terminus of Lrmp;

128 Using two-photon uncaging, we show that this subcellular targeting strongly influences synaptic effic

129 involved in targeting an mRNA to a specific subcellular target such as the germinal granules and sug

130 ontain motifs that serve as "signatures" for subcellular targeting, such as a nuclear localization si

131 PKC is known to participate in the enzyme's subcellular targeting, suggesting an additional mode of

132 Finally, subcellular targeting the CopC protein to plant vacuoles

133 complex were shown to determine its precise subcellular targeting to either the outer segment of pho

134 ferentially regulated by caveolin-1 mediated subcellular targeting to lipid raft/caveolae and in endo

135 structure-guided sensor design or on precise subcellular targeting to presynaptic boutons-allow singl

136 ordination, and the latter leads to specific subcellular targeting to the plasma membrane.

137 ta1-C2 governs its specific Ca(2+)-dependent subcellular targeting to the plasma membrane.

138 al lipid addition, membrane association, and subcellular targeting to the plasma membrane.

139 Subcellular targeting to the vicinity of preferred subst

140 its endocytosis is required to deliver NO to subcellular targets to cause hyperpermeability.

141 inguish between these mechanisms by applying subcellular targeting using a soft X-ray microbeam in co

142 A system named P2SL that infer protein subcellular targeting was developed through this computa

143 Ralpha both were presynaptic, although their subcellular targeting was distinct.

144 g electron-dense contrast agents to specific subcellular targets within intact cells.