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1 nd the cargo-binding alphabeta'epsilon-COP B-subcomplex.
2 on of CENP-HIKM and of CENP-TW, another CCAN subcomplex.
3 hich along with APC1 form the APC/C platform subcomplex.
4 ic F1 region via rotation of a central rotor subcomplex.
5 d the trimeric Atg17-Atg31-Atg29 scaffolding subcomplex.
6 s a bridge between VPS34 and the ATG14:BECN1 subcomplex.
7 e Xeroderma pigmentosum B (XPB) and a kinase subcomplex.
8 for connecting the stalk to the catalytic F1 subcomplex.
9 king site for the formation of eIF3(a:b:i:g) subcomplex.
10 ecessary for the formation of the CSN4-5-6-7 subcomplex.
11 vacuolar Q(a) SNARE, leaving behind a Q(bc)R subcomplex.
12 n is further regulated by the 19S proteasome subcomplex.
13 nchored to the cell envelope by the membrane subcomplex.
14 063w, which is also a component of the Cef1p subcomplex.
15 tory IC138 phosphoprotein and its associated subcomplex.
16 ex of the CSN, we reconstituted a CSN4-5-6-7 subcomplex.
17 sis of the EcoP15I holoenzyme and the Mod(2) subcomplex.
18 fy the interplay between BamA and the BamCDE subcomplex.
19 interactions with the Nup107-160 nucleoporin subcomplex.
20 cific subunits, Vps39 and Vps41, also form a subcomplex.
21 3 endonucleases associate with the insertion subcomplex.
22 ing modulators that target SF3B1 in the SF3b subcomplex.
23 complex with the human VPS29-VPS35 retromer subcomplex.
24 e-embedded VO region via rotation of a rotor subcomplex.
25 ith a 315-kDa subassembly, forms the 550-kDa subcomplex.
26 ents efficient formation of this midassembly subcomplex.
27 orting Pex10 and Pex12, but with the docking subcomplex.
28 he cytosolic V1 and the integral membrane V0 subcomplex.
29 ts than deletion of single MICOS subunits or subcomplexes.
30 fferent nucleoporins, typically organized in subcomplexes.
31 hilus with those of its membrane and soluble subcomplexes.
32 between IFT88/70/52/46 and IFT81/74/27/25/22 subcomplexes.
33 lex and the Nup93 complex, two conserved NPC subcomplexes.
34 einhardtii IFT70/52 and Tetrahymena IFT52/46 subcomplexes.
35 but finite exchange of even its most stable subcomplexes.
36 arity and structural independence of the IFT subcomplexes.
37 origins of the IFT-A, IFT-B, and the BBSome subcomplexes.
38 ic protein, C3orf1, were associated with the subcomplexes.
39 nto separate cavin1-cavin2 and cavin1-cavin3 subcomplexes.
40 Complex I is put together from preassembled subcomplexes.
41 mposed of 13 proteins, which assemble in two subcomplexes.
42 s and consequently the masses of the various subcomplexes.
43 icles (19S RPs) subdivided into base and lid subcomplexes.
44 the interaction between the BamAB and BamCDE subcomplexes.
45 Nuclear pore complexes consist of several subcomplexes.
46 The RP is divisible into base and lid subcomplexes.
47 res that the SNAREs assemble into functional subcomplexes.
48 rtners the APH-1/nicastrin and PS1-NTF/PEN-2 subcomplexes.
49 alyses of isolated FlaH and archaellum motor subcomplexes.
50 s are released as individual molecules or as subcomplexes.
51 ghts into the structure and function of FoF1 subcomplexes.
52 he Rpc82/34/31 and Rpc53/37 Pol III-specific subcomplexes.
53 g the mutually exclusive composition of PRC2 subcomplexes.
54 e carrier protein, NADH dehydrogenase 1alpha subcomplexes 2 and 3, translocase of inner mitochondrial
55 osphate carrier or NADH dehydrogenase 1alpha subcomplexes 2 or 3 in 3T3-L1 cells results in decreased
56 nds on two evolutionarily conserved modules, subcomplexes A (IFT-A) and B (IFT-B), to drive ciliary a
58 etry, crystal structure of the CPSF160-WDR33 subcomplex and biochemical assays, we define the molecul
59 comet)-dependent disassembly of a Cdc20-Mad2 subcomplex and identify it as Thyroid Receptor Interacti
60 complex, comprising the Mis18alpha:Mis18beta subcomplex and M18BP1, is crucial for CENP-A homeostasis
61 VET-specific subunits, Vps3 and Vps8, form a subcomplex and physically and genetically interact with
62 elix domains that form the eIF2Bgammaepsilon subcomplex and propose a model for domain interactions b
64 nally, we discovered the presence of a CcoNQ subcomplex and showed that CcoN is the required anchor f
65 Importantly, the presence of the Nup84 pore subcomplex and Slx5/8 suppresses CAG repeat fragility an
66 s through a mechanism involving the shoulder subcomplex and the cytoskeletal-associated protein glyci
67 sponsible for the formation of eIF3(a:b:i:g) subcomplex and, because of mutually exclusive nature of
68 aled the presence of active CcoNQO and CcoNO subcomplexes and also showed that the CcoP subunit is no
71 m mitochondria lacking gRNA-bound RNP (gRNP) subcomplexes and identified REH2-associated cofactors 1
72 cose-dependent manner, positioning V1 and V0 subcomplexes and orienting the V1 C subunit to promote a
74 CI subunits demonstrated rapid generation of subcomplexes and revealed that their specific abundance
76 unfolded GLFG repeats as Velcro to link NPC subcomplexes and thus add a new layer of connections to
78 mass spectrometry measurements of complexes, subcomplexes, and subunits are necessary to build comple
79 ow that inactive EGFR, LAPTM4B, and the Sec5 subcomplex are required for basal and starvation-induced
82 into CI and CI+CIII(2), indicating that the subcomplexes are productive intermediates of assembly.
83 phic data obtained from the E1p-E2p didomain subcomplex as well as with other biochemical and NMR dat
84 e 26 S proteasome comprises two multisubunit subcomplexes as follows: 20 S proteasome and PA700/19 S
85 HoxEFUYH, HoxFUYH, HoxEFU, HoxFU, and HoxYH subcomplexes as well as association of the immature, unp
86 or interaction with the membrane-embedded Fo subcomplex, as its transmembrane helix can be removed.
90 atalysis requires interaction of the protein subcomplex (BchX)2 with the catalytic (BchY/BchZ)2 prote
92 in a gamma-CA mutant is consistent with this subcomplex being a key initiator of CI assembly in plant
93 We here report the crystal structure of a subcomplex between E1p and an E2p didomain containing a
97 ility was discovered in the E1p-E2p didomain subcomplex, both of which probably have consequences in
98 S proteasome from 20 S proteasome and PA700 subcomplexes but has no effect on in vitro activity of t
99 ized roles and normally function in distinct subcomplexes but retain the ability to substitute for on
100 tinating histone H2B, which is mediated by a subcomplex called the deubiquitinating module (DUBm).
101 also found evidence suggesting that the WRAD subcomplex catalyzes weak H3K4 monomethylation within th
108 SC activity and that UBAP2L is part of a PcG subcomplex comprising BMI1, we propose a model in which
109 are carried out by a lagging strand-specific subcomplex comprising DnaG, DnaEBs and DnaC, which stimu
110 netically and biochemically define a minimal subcomplex comprising just three proteins (FANCB, FANCL,
111 ochemical characterization of influenza RdRP subcomplex comprising PA, PB1, and N terminus of PB2, wh
113 nce, is composed of inner and outer membrane subcomplexes, connected by an alignment subcomplex compo
115 r's tail module is highly dynamic and that a subcomplex consisting of Med2, Med3, and Med15 can be in
116 Cells lacking NDUFA9 contained a complex I subcomplex consisting of membrane arm subunits but not m
117 found that components of the inner membrane subcomplex consisting of PilMNOP were not essential for
118 Here we describe a heterotrimeric TFIID subcomplex consisting of the TAF2, TAF8 and TAF10 protei
119 of proteins called the divisome, of which a subcomplex consisting of three bitopic inner membrane pr
121 the daughter cell requires members of an NPC subcomplex containing Nsp1p and its interacting partners
125 ETd1A/B, which all interact with a conserved subcomplex containing WDR5, RbBP5, Ash2L, and DPY-30 (WR
128 0-subunit yeast TFIIH and of a nested set of subcomplexes, containing 5, 6, and 7 subunits, have been
131 ected via Mic19, which functions to regulate subcomplex distribution, and thus, potentially also cris
132 The VPS34 catalytic domain and BECN1:ATG14 subcomplex do not touch, and it is unclear how allosteri
133 s, prefabrication of a native-like r-protein subcomplex drives efficient and accurate construction of
134 observations support that the 19S proteasome subcomplex enhances the targeting of co-activator at the
135 our data demonstrate that the 19S proteasome subcomplex enhances the targeting of NuA4 HAT to activat
136 ndividual components, we reconstituted a PLC subcomplex, excluding the Transporter Associated with An
137 ing sites, which are on different proteasome subcomplexes, explains the specificity of Ecm29 for prot
140 t the reconstitution and characterization of subcomplexes formed by the cytoplasm-exposed synaptotagm
144 ble nanoscale organization of these separate subcomplexes, forming individual striations on the surfa
146 Electrophysiology studies show that the Ton subcomplex forms pH-sensitive cation-selective channels
147 tic and biochemical evidence that a PTIP-PA1 subcomplex functions independently from the MLL3/MLL4 co
149 in mammalian cells, the individual retromer subcomplexes have functionally diverged to organize mult
151 structures of individual MAC components and subcomplexes; however, the molecular details of its asse
155 comparing the structures and composition of subcomplex Ibeta and complex I, supported by comparisons
156 esolution X-ray crystallography structure of subcomplex Ibeta, a large portion of the membrane domain
157 mass spectrometry revealed that the largest subcomplex (IIa) represents the succinate dehydrogenase
159 corporation of new subunits into the 200-kDa subcomplex in a gamma-CA mutant is consistent with this
161 e providing a new role of the 19S proteasome subcomplex in establishing a specific regulatory network
165 approach to explore the role of Sec71-Sec72 subcomplex in post-translational protein translocation.
167 However, the role of the 19S proteasome subcomplex in transcriptional activation of the TFIID-de
168 atin-remodeler form an abundant and distinct subcomplex in vivo and stimulate INO80-mediated activity
170 d our understanding of this highly conserved subcomplex, in part by demonstrating a direct interactio
171 reduced by phosphomimetic mutations on both subcomplexes, in an additive manner, indicating that bot
174 import showed the further assembly of these subcomplexes into CI and CI+CIII(2), indicating that the
175 s the first structure of an E1p-E2p didomain subcomplex involving a homodimeric E1p, and the results
181 The results indicate that the IC138 IC/LC subcomplex is necessary to generate an efficient wavefor
188 ) coactivator, which contains a four-protein subcomplex known as the deubiquitinating (DUB) module.
191 3/5/7 within NuA4 came from mutations in the subcomplex leading to approximately 40% reductions in H4
192 molecular architecture and roles of the NPC subcomplexes, little is known about the regulation of NP
193 in an additive manner, indicating that both subcomplexes make independent contributions to attachmen
194 ents captured for both intact assemblies and subcomplexes match expected values from available X-ray
195 of MICOS and identify two independent MICOS subcomplexes: Mic27/Mic10/Mic12, whose assembly is depen
197 es the major microtubule-binding kinetochore subcomplexes, Ndc80 and (in yeast) Dam1, to promote rele
198 ionally relevant form of the proteasome is a subcomplex of 19S base proteins, which functions as an A
199 n particular, the S-shaped Atg17-Atg31-Atg29 subcomplex of Atg1 is critical for phagophore nucleation
201 rtant for the maintenance of the MRPP1-HSD10 subcomplex of RNase P and that loss of HSD10 causes impa
202 not affect Wapl-Pds5 binding to the cohesin subcomplex of sister chromatid cohesion protein 1 (Scc1)
205 h along with APC4 and APC5 form the platform subcomplex of the APC/C, is an additional target of the
206 structure and assembly of a CSN5-containing subcomplex of the CSN, we reconstituted a CSN4-5-6-7 sub
208 ough a mechanism dependent on the Nup107-160 subcomplex of the nuclear pore complex and is modulated
210 ted, CMG unloading is inhibited, and a large subcomplex of the vertebrate replisome that includes DNA
211 cking, suggesting that vesicles derived from subcomplexes of COPII coat proteins have a role in the s
212 dings of eIF3a and eIF3j to eIF3b, different subcomplexes of eIF3 likely exist and may perform noncan
213 It is also not clear whether or not some subcomplexes of MCC inhibit the APC/C and whether Mad2 i
218 ed differences in the subunit composition of subcomplexes of ovine complex I as compared with bovine,
221 We have previously proposed a model where subcomplexes of vRNA are exported from the nucleus and a
222 , Fap7 ATPase activity unloads the uS11:eS26 subcomplex onto its rRNA binding site, and therefore ens
224 r pilin PilE depends on the putative priming subcomplex PilVWX and the non-pilin protein PilY1 for in
225 at mutant ESCs assemble atypical hybrid PRC2 subcomplexes, potentially accounting for enhancement of
226 a major component of an adaptor nucleoporin subcomplex proposed to link the NPC coat with the centra
228 ory particle, consisting of the lid and base subcomplexes, recognizes and processes polyubiquitinated
230 lar waveforms reveals that loss of the IC138 subcomplex reduces shear amplitude, sliding velocities,
235 For these exceptions, we find that distorted subcomplexes result from extreme disruption conditions,
236 ndant functions as the absence of both MICOS subcomplexes results in more severe morphological and re
237 n amc1, -2, -5-7, the detection of a 700 kDa subcomplex retaining NADH dehydrogenase activity indicat
239 liberated upon dissection of complex II into subcomplexes, SDH6 and SDH7 also add some hydrophilic ma
240 ated by association with different accessory subcomplexes: SecYEG (forming SecYEG dimers) or SecDF-Ya
242 ein 3, NADH dehydrogenase (ubiquinone) 1beta subcomplex subunit 8, and NADH dehydrogenase (ubiquinone
243 fied NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9 (NDUFA9) and inosine-5'-monophospha
244 , and NADH dehydrogenase (ubiquinone) 1alpha subcomplex subunit 9 of respiratory complex I, and decre
245 d find additional functions of the Top3-Rmi1 subcomplex that are critical for the completion of meios
246 complex I and probably stabilizes a 400-kDa subcomplex that forms the initial nucleus of the periphe
248 eatments, the holo complex is dissected into subcomplexes that are analyzed by a three-dimensional ge
249 romatin-modifying complexes are organized by subcomplexes that harbor unique and distinct activities.
250 ase-resistant EMRE mutants produce uniporter subcomplexes that induce constitutive Ca(2+) leakage int
251 y mutants and isolated histidine-tagged PSII subcomplexes that Psb27 associates with the "unassembled
252 active minimal complexes, we identify stable subcomplexes that, through newly defined protein-protein
255 plex (NDH-C) is assembled from five distinct subcomplexes, the membrane-spanning (subM) and the lumin
257 The 26S proteasome can be divided into two subcomplexes: the 19S regulatory particle and the 20S co
259 The APC/C assembly comprises two scaffolding subcomplexes: the platform and the TPR lobe that togethe
260 hat F(O)F1 is assembled in a modular way via subcomplexes, thereby preventing the formation of a func
261 aging, and budding of peroxisomal importomer subcomplexes, thereby preventing their premature assembl
262 is the core component of the inner membrane subcomplex thought to be involved in both recognition of
263 solating mitochondria, we have identified CI subcomplexes through differences in (15)N incorporation
264 rmational switch in both FtsA and the FtsBLQ subcomplex to de-repress septal peptidoglycan synthesis
265 that with FimU, PilE may couple the priming subcomplex to the major pilin PilA, allowing for efficie
266 PilXNm and PilVNm, likely connects a priming subcomplex to the major pilin, promoting efficient assem
267 Here we used heterologously expressed BBSome subcomplexes to analyze the complex architecture and to
268 quiring 66 subunits distributed over several subcomplexes to associate in a coordinated fashion.
270 ators include components of the spliceosomal subcomplex U1 small nuclear ribonucleoprotein (U1 snRNP)
272 ammadelta)(4) kinase core, because a beta(4) subcomplex was observed through both chemical cross-link
273 Proper fractionation of PSII super- and subcomplexes was achieved by critical selection of eluti
275 d throughout the extremely stable Nup107-160 subcomplex, we refined our understanding of this highly
276 try of the FtsQpBpLp complex and the FtsQpBp subcomplex were determined in complementary surface plas
277 mutations in the conserved PilMNOP alignment subcomplex were previously shown to have distinct effect
278 ver, intact PA700 accumulated as an isolated subcomplex when cellular 20 S proteasome content was red
279 ften more compact and reflect native protein subcomplexes when compared with unmodified complexes act
280 EPB7, and KREPB8 associate with the deletion subcomplex, whereas the KREN1, KREN2, and KREN3 endonucl
282 ith the highly conserved YidC and SecDF-YajC subcomplex, which facilitates translocation into and acr
283 DNA repair, while the CDK-activating kinase subcomplex, which includes the kinase activity of CDK7 a
285 (Arf1):GTP-binding betagammadeltazeta-COP F-subcomplex, which is related to the adaptor protein (AP)
287 an mRNA-associated ribonucleoprotein (mRNP) subcomplex with editing substrates, intermediates, and p
288 somal central protuberance, assembles into a subcomplex with MrpL7 (uL5), Mrp7 (bL27), and MrpL36 (bL
289 on display reduced affinity to form a stable subcomplex with NFS1, and thereby fails to prevent NFS1
290 of RNA polymerase II (RNAP II) that forms a subcomplex with Rpb7, play important roles in transcript
291 paring the CD spectrum of an alphagammadelta subcomplex with that of the native (alphabetagammadelta)
294 I disrupted the assembly of the complex, and subcomplexes with masses of 550 and 815 kDa accumulated.
295 ions suggest that the complex is composed of subcomplexes with RNA-dependent and independent interact
297 n distinct conformations of the Rpn1-p28-AAA subcomplex within the p28-bound RP at subnanometer resol
298 e determined the structure of a four-protein subcomplex within the SWI/SNF remodeler that comprises t
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