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3 ogical actions of GIP in glucose metabolism, subcutaneous abdominal adipose tissue blood flow (ATBF),
5 ith no association seen between DeltaLAV and subcutaneous abdominal fat (P=0.47) or lower body fat (P
7 nib (5 mg twice daily) plus methotrexate, or subcutaneous adalimumab (40 mg every other week) plus me
9 for the use of SGBS vis-a-vis primary human subcutaneous adipocytes as a human white adipocyte model
11 mmation, elevated adiponectin, mulitilocular subcutaneous adipose tissue (inguinal WAT) with upregula
12 effect of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) area on metabolic synd
16 ups receiving high perinatal n-6/n-3 ratios, subcutaneous adipose tissue in 14-day-old wild-type pups
17 ait locus (eQTL) analyses by using abdominal subcutaneous adipose tissue of 770 extensively phenotype
18 insulin sensitivity, and losing superficial subcutaneous adipose tissue remained neutral except for
21 ted with improved lipid profile, losing deep subcutaneous adipose tissue with improved insulin sensit
22 zed by a thin superficial layer of abdominal subcutaneous adipose tissue, increased visceral adipose
24 munoglobulin preparations for intravenous or subcutaneous administration are the cornerstone of treat
27 een, and liver) under Cu deficiency and that subcutaneous administration of Cu to these animals resto
30 HCV genotypes 1, 3, and 4 received a single subcutaneous administration of RG-101 at 2 mg/kg (n = 14
33 ografts in NOD/SCID-gamma mice after oral or subcutaneous administration; D538G tumors were more pote
35 ousness of the biosensor performance towards subcutaneous alcohol monitoring was substantiated by the
39 years of treatment with either sublingual or subcutaneous allergen immunotherapy has been shown to be
41 Participants were randomly assigned to daily subcutaneous anakinra, 100 mg (n = 25), or placebo (n =
42 distribution) of the same materials in mouse subcutaneous and dog tibia implant models, we demonstrat
43 ivity, chemoresistance, and tumorigenesis in subcutaneous and intrabursal mouse xenograft models of h
44 rapies for hepatoblastoma (HB) is limited to subcutaneous and intrasplenic xenograft models that do n
45 motive behavioral changes following repeated subcutaneous and intravenous heroin challenges in mice a
46 he tissue mimics matched expected values for subcutaneous and muscle tissue, and that the compliance
47 labeled SC16 antibody enabled delineation of subcutaneous and orthotopic SCLC tumor xenografts as wel
48 re-clinical data help prove the concept that subcutaneous and subconjunctival injection of HC-HA/PTX3
51 Adipocyte numbers were decreased in both subcutaneous and visceral adipose tissue of TRPC1 KO mic
52 ression and increased Wnt expression in both subcutaneous and visceral adipose tissues and impaired a
53 macokinetics shows that both intravenous and subcutaneous applications are viable routes for the deli
57 ma were randomly assigned (1:1:1) to receive subcutaneous benralizumab 30 mg, either every 4 weeks or
59 To evaluate the ability of a novel, weekly, subcutaneous buprenorphine depot formulation, CAM2038, t
60 ditary angioedema, the prophylactic use of a subcutaneous C1 inhibitor twice weekly significantly red
61 nts were randomly assigned to receive single subcutaneous canakinumab 150 mg or placebo injections fo
65 mic (18)F-FDG measurement of a mouse bearing subcutaneous colon cancer and validated using histology.
66 hieved by administering the antagonists as a subcutaneous continuous infusion for 2 weeks compared to
67 the efficacy and safety of self-administered subcutaneous CSL830 in patients with type I or type II h
68 nner - low systemic Cu increases ATP7A while subcutaneous Cu administration decreases ATP7A suggestin
69 dose of 60 mg once daily (edoxaban group) or subcutaneous dalteparin at a dose of 200 IU per kilogram
72 model-predictive control algorithm to direct subcutaneous delivery of rapid-acting insulin analogue w
73 ere randomly assigned (1:1) to receive 60 mg subcutaneous denosumab or placebo every 6 months for 3 y
74 ed under the kidney capsule (KC) or into the subcutaneous deviceless (DL) site at a marginal islet do
77 HIV-positive men were randomised to a single subcutaneous dose of C34-PEG4-Chol at incrementing doses
79 Patients were randomly assigned (3:1:3) to subcutaneous dupilumab 300 mg once weekly (qw), dupiluma
82 once daily for 35-42 days) or standard-dose subcutaneous enoxaparin (40 mg once daily for 10+/-4 day
83 he effects of atorvastatin (80 mg daily) and subcutaneous evolocumab (420 mg every 2 weeks) for 8 wee
84 her amount of total body fat (p < 0.001) and subcutaneous fat (p < 0.001) than those without NAFLD.
85 d by a layered closure of the ischioanal and subcutaneous fat and skin similar to the control interve
87 ed waist circumference (11-13 cm), abdominal subcutaneous fat mass (1650-1850 cm(3)), visceral fat ma
91 ction on DNL, liver fat, visceral fat (VAT), subcutaneous fat, and insulin kinetics in obese Latino a
98 Accurate identification of the agents of subcutaneous fungal infection is essential to guide appr
99 eive standard care (control), treatment with subcutaneous G-CSF (lenograstim) 15 mug/kg for 5 days, o
101 travenous group and 95 (48%) patients in the subcutaneous group (mainly grade 1 or 2 local injection-
102 intravenous group vs 189 [96%] of 197 in the subcutaneous group); the frequency of adverse events of
108 ke was studied in nude BALB/c mice bearing a subcutaneous HER3 overexpressing H441 non-small cell lun
109 infused into immunocompromised mice bearing subcutaneous human U87 glioblastomas expressing EGFRvIII
110 randomized within 6 hours of presentation to subcutaneous icatibant 30 mg or placebo at 0 and 6 hours
116 ponse in Allergic Rhinitis to Sublingual and Subcutaneous Immunotherapy (GRASS) trial demonstrated th
117 and monthly placebo injections), 36 received subcutaneous immunotherapy (monthly injections containin
121 ted that sublingual immunotherapy (SLIT) and subcutaneous immunotherapy (SCIT) would be considered co
122 r by comparing with other therapies, such as subcutaneous immunotherapy (SCIT), or other pharmacother
123 gic changes during 2 years of sublingual and subcutaneous immunotherapy and for 1 year after treatmen
124 Three years of continuous treatment with subcutaneous immunotherapy and sublingual immunotherapy
129 iomyopathy (HCM) ECG make it a challenge for subcutaneous implantable cardioverter-defibrillator (S-I
131 aluate 4 different implant techniques of the subcutaneous implantable cardioverter-defibrillator.
134 om lung and breast cancer) were developed by subcutaneous implantation of patient tumor fragments.
135 ible alternatives to the standard 3-incision subcutaneous implantation, and the 2-incision technique
138 nce levels of the steroid were controlled by subcutaneous implants, thus suggesting actions related t
139 he pneumonia model but high virulence in the subcutaneous infection model, suggesting that the virule
140 rophil recruitment and systemic infection in subcutaneous infection of mice by MGAS315, a hypervirule
143 Thus, GAS RocA mutants can be selected in subcutaneous infections in mice and exhibit gene express
145 and Parathyridaria percutanea cause similar subcutaneous infections, but these infections lack the d
146 murine cardiac injury model was performed by subcutaneous infusion of either saline or Angiotensin II
148 f fatty acid-binding protein 4 and increased subcutaneous inguinal adipose tissue expression of adipo
151 that beige adipocytes formed postnatally in subcutaneous inguinal white adipose tissue lost thermoge
155 e limitations of current DHE formulations in subcutaneous injection and nasal spray such as pain, adv
156 r 300 mg in METREO) with placebo, given as a subcutaneous injection every 4 weeks for 52 weeks in pat
157 6h in chemical-induced diabetes mice, while subcutaneous injection failed to maintain blood glucose
158 g-dose trial of inclisiran administered as a subcutaneous injection in patients at high risk for card
161 enerated randomisation schedule to receive a subcutaneous injection of 7.5 mg, 22.5 mg, 75 mg, or 225
162 eceiving an anti-myostatin PINTA745 (n = 12; subcutaneous injection of 7.5 mg.kg(-1) PINTA745 immedia
163 puter-generated random sequence to receive a subcutaneous injection of 80 mg ixekizumab every 4 weeks
164 assessed by comparison with intradermal and subcutaneous injection of antigen using a 27G needle and
165 We randomly assigned patients to receive a subcutaneous injection of either erenumab, at a dose of
166 d participants (1:1) by country to receive a subcutaneous injection of either mepolizumab 100 mg or p
167 r results indicated that subconjunctival and subcutaneous injection of HC-HA/PTX3 preserved tear secr
168 mg per deciliter in a 3:1 ratio to receive a subcutaneous injection of inclisiran or placebo in eithe
173 g/m(2)) was given as an intravenous bolus or subcutaneous injection on days 1, 4, 8, and 11 of 21-day
174 local skin inflammatory reaction limited to subcutaneous injection site and elicited no other toxic
175 nergy expenditure in mice was measured after subcutaneous injection with vehicle, 1 mg norepinephrine
176 t hardly penetrated into the lungs following subcutaneous injection, as opposed to pulmonary delivery
177 1 inhibitor preparation that is suitable for subcutaneous injection, resulted in functional levels of
178 nificantly different (p>0.05) as compared to subcutaneous injection, with a relative bioavailability
182 scid)Il2rg(tm1Wjl)/SzJ (NSG) mice were given subcutaneous injections of AMC-EAC-007B cells and also g
184 ease were randomly assigned (1:1) to receive subcutaneous injections of exenatide 2 mg or placebo onc
185 previous cardiovascular disease, to receive subcutaneous injections of extended-release exenatide at
187 ose group) were randomly assigned to receive subcutaneous injections of placebo or an antisense oligo
188 assigned a total of 166 patients to receive subcutaneous injections of risankizumab (a single 18-mg
190 bution and PET studies after intravenous and subcutaneous injections showed similar patterns and kine
194 t meal-time insulin boluses) or conventional subcutaneous insulin delivery according to local clinica
195 multiple daily injections (MDI), continuous subcutaneous insulin infusion (CSII) and islet transplan
196 uous glucose monitoring (CGM) and continuous subcutaneous insulin infusion can be used to improve the
197 itiation of insulin pump therapy (continuous subcutaneous insulin infusion; CSII) in patients with ty
198 is safe and effective compared with standard subcutaneous insulin therapy in patients with type 2 dia
199 of early versus delayed treatment (DT) with subcutaneous interferon (sc IFN) beta-1a 44 mug in patie
200 izumab at a dose of 600 mg every 24 weeks or subcutaneous interferon beta-1a at a dose of 44 mug thre
203 dines was reflected in lipid accumulation in subcutaneous layer and visceral fat and not in the liver
207 n schedule with no stratification to receive subcutaneous liraglutide (3.0 mg) or placebo, with stand
208 telephone or web-based system, to once-daily subcutaneous liraglutide 3.0 mg or matched placebo, as a
209 f different fat depots (deep and superficial subcutaneous, liver, pericardial, muscle, pancreas, and
210 ere randomized to receive adalimumab, 80-mg, subcutaneous loading dose followed by 40 mg every other
214 on-Hodgkin lymphoma and a B16 mouse model of subcutaneous melanoma are used to extract a snapshot of
215 effect of an intensified dosing schedule of subcutaneous methotrexate in patients with moderate to s
216 a favourable 52 week risk-benefit profile of subcutaneous methotrexate in patients with psoriasis.
218 Treatment with exendin-4 (Ex-4) delivered by subcutaneous micro-osmotic pumps 48 hours prior to or 2
220 uscle tissue, and that the compliance of the subcutaneous mimics increased linearly with water conten
221 ul alternative to parenteral opioids such as subcutaneous morphine (SCM) to treat severe cancer pain
222 Although transplantation of cardiac MSCs and subcutaneous MSCs from LVD and sham hearts did not impro
225 radermal injection using the jet injector or subcutaneous needle injection exhibited comparable immun
226 omly assigned participants (1:1:1) to either subcutaneous once-weekly 0.5 mg or 1.0 mg semaglutide (d
230 ecies from confirmed cases of eumycetoma and subcutaneous pedal masses, previously formally identifie
231 with 250 mg intravenous REP 2139 and 180 mug subcutaneous pegylated interferon alfa-2a once per week
233 was investigated in animal fats (butter fat, subcutaneous pig back-fat and subcutaneous ham fat).
234 e web-based voice response system to receive subcutaneous placebo or benralizumab 30 mg injections ev
235 Patients were randomly assigned (3:2:2) to subcutaneous placebo, erenumab 70 mg, or erenumab 140 mg
240 show the pharmacokinetic non-inferiority of subcutaneous rituximab to intravenous rituximab in folli
241 375 mg/m(2) intravenous rituximab or 1400 mg subcutaneous rituximab, plus chemotherapy (six-to-eight
243 interactive voice response system to receive subcutaneous romosozumab (210 mg once monthly) or subcut
244 igned them in a 1:1 ratio to receive monthly subcutaneous romosozumab (210 mg) or weekly oral alendro
245 he intramuscular route is preferred over the subcutaneous route for vaccine administration and that t
247 l relationship between intramuscular (IM) or subcutaneous (SC) drug depot morphology and distribution
249 (PKs) of methylone and its metabolites after subcutaneous (sc) methylone administration (3, 6, 12 mg/
251 atment group 1 [T1], n = 20); eleven 5 mg/kg subcutaneous (SC) VRC01 (treatment group 3 [T3], n = 20)
253 (dosage-dependent range, -0.7% to -1.9%) and subcutaneous semaglutide (-1.9%) and placebo (-0.3%); or
254 age-dependent range, -2.1 kg to -6.9 kg) and subcutaneous semaglutide (-6.4 kg) vs placebo (-1.2 kg),
255 lutide with placebo (primary) and open-label subcutaneous semaglutide (secondary) on glycemic control
256 lacebo (n = 71; double-blind) or once-weekly subcutaneous semaglutide of 1.0 mg (n = 70) for 26 weeks
257 ional intrahepatic transplantation site, the subcutaneous site requires a large number of islets to a
261 e web response system (stratified by age) to subcutaneous TDV injection (one 0.5 mL dose containing 2
263 blind, placebo-controlled trial, we compared subcutaneous tezepelumab at three dose levels with place
264 ith semaglutide, and others such as skin and subcutaneous tissue disorders (eg, rash, pruritus, and u
265 verse events (AEs) included nausea, skin and subcutaneous tissue disorders (SSTD), diarrhea, and fati
268 These data demonstrate the importance of subcutaneous tissue on microneedle performance and the n
269 ontent (67, 80, 88 and 96%) to represent the subcutaneous tissue, and a type of ballistic gelatine, P
270 ed multiple hypermetabolic lesions involving subcutaneous tissue, muscle osseous structures, and bone
271 251 patients, in a 2:1:1:1 ratio, to receive subcutaneous tocilizumab (at a dose of 162 mg) weekly or
275 lly, exogenous expression of JMJD2B enhanced subcutaneous tumor growth of colon cancer cells in a p53
279 D scid gamma-(NSG) mice were inoculated with subcutaneous tumors engineered to either be constitutive
282 ced durable and complete remissions of large subcutaneous tumors without detectable side effects.
287 ctivated early (2 hours) in both BAT and the subcutaneous WAT depots, with the most striking change b
288 have highlighted differences in visceral and subcutaneous WAT thermogenic metabolism and demonstrate
289 s reduces blood flow and (18)F-FDG uptake in subcutaneous WAT, indicating that the physiologic respon
293 ith alemtuzumab induction (15-30 mg, 1 dose, subcutaneous), whereas 35 nonsensitized patients receive
295 in obesity whereas preferential expansion of subcutaneous white adipose tissue (WAT) appears protecti
298 showed that the knockdown of LAMB1 or K19 in subcutaneous xenograft mouse models resulted in signific
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