ライフサイエンスコーパス: subdominant

1 ted to four epitopes (three dominant and one subdominant).

2 cing responses to all epitopes, dominant and subdominant.

3 then combined a subset of these dominant or subdominant Ags with a Th1 augmenting adjuvant, glucopyr

4 se to AChR and its dominant alpha146-162 and subdominant alpha182-198 peptides through epitope spread

5 residues that flank the C termini of several subdominant and cryptic epitopes are often suboptimal fo

6 We have found that the delivery of subdominant and dominant epitopes on separate dendritic

7 nt clonotype in one subject, and by multiple subdominant and minor clonotypes in the other.

8 are maintained in concert with more numerous subdominant and minor clonotypes.

9 direct immunodominant responses to otherwise subdominant and often more vulnerable viral targets.

10 heating) in the liquid oceans; I show that a subdominant and previously unconsidered tidal force due

11 able in both, whereas all new responses were subdominant and remained so.

12 ine efficacy, confirming the hypothesis that subdominant and weakly antigenic M. tuberculosis protein

13 To test the hypothesis that subdominant and/or weak M. tuberculosis Ags are viable v

14 bacterial genera (7 were dominant and 7 were subdominant) and 202 WAT genes changed after RYGB.

15 SpyCEP may be poorly immunogenic (cryptic or subdominant), and it would be to the organism's advantag

16 t WNV target was apparent, two epitopes were subdominant, and three demonstrated little CTL reactivit

17 a priori knowledge of the immunodominant and subdominant antigenic epitopes, as well as the MHC backg

18 broadens immunity by augmenting responses to subdominant antigens and improving the survival of the C

19 nd dramatically enhanced CD8(+) effectors to subdominant antigens.

20 Their infected infants target an otherwise subdominant B27-restricted epitope and fail to contain H

21 These data enabled the discovery of subdominant binding motifs and an integrative analysis q

22 blished tumors when targeting the apparently subdominant but not the dominant epitope.

23 ce of which dampens the immune response to a subdominant but protective epitope in region 3.

24 minant CD8 T cell epitope; the response to a subdominant CD8 T cell epitope was modestly less diverse

25 responses during infection and identified a subdominant CD8 T cell response that is numerically and

26 rchy in part through selective inhibition of subdominant CD8(+) T cell proliferation.

27 viral clearance, and a protective effect of subdominant CD8(+) T cell responses.

28 nding underscores the difficulty of inducing subdominant CD8(+) T cells by vaccination and demonstrat

29 he acquisition of cytokine responsiveness by subdominant CD8(+) T cells precedes their development of

30 served a significant expansion of functional subdominant CD8(+) T cells, resulting in significantly i

31 ulation with antigen, the HA210-219-specific subdominant CD8(+) T lymphocytes give rise to daughter c

32 Subdominant CD8(+) T-cell responses contribute to contro

33 nd the levels of small subsets of previously subdominant CD8+ T cells expanded up to 2,500-fold above

34 It is likely that subdominant CD8+ T-cell populations play a key role in m

35 otential (granzyme B(+) CD107a(+)) targeting subdominant CE epitopes, compared with the responses eli

36 CII610-618 (GPAGT AGA R) within CB10 and the subdominant CII445-453 (GPAGP AGE R) within CB8.

37 es, the relapse clone could be identified as subdominant clones in the diagnostic sample in 8 of 14 p

38 These subdominant clonotypes do not efficiently enter germinal

39 The subdominant clonotypes emerge with similar dynamics to t

40 al epitopes and suggest that cross-reactive, subdominant clonotypes may retain greater capacity to su

41 with peptides representing variant epitopes, subdominant clonotypes produce higher relative levels of

42 In contrast, subdominant clonotypes were characterized by lower intri

43 sion and lower C127 expression compared with subdominant clonotypes, and TCR avidity positively corre

44 ing H1 influenza viruses that the previously subdominant, conserved lateral patch had become immunodo

45 (ISPRTLNAW) epitope of Gag, while generally subdominant, correlated with delayed progression to dise

46 ped an immunodominant response to a normally subdominant, cross-reactive epitope (nucleoprotein resid

47 Subdominant CTL recognition of conserved HIV-1 epitopes

48 We have identified the immunodominant and subdominant CTL responses and subsequently assessed the

49 First, it shows that subdominant CTL responses can be protective, and second,

50 general experimental approach for uncovering subdominant CTL responses in vivo.

51 rol was associated with responses to several subdominant cytotoxic T lymphocyte epitopes, whereas the

52 e augmentation of responses specific for the subdominant D(b)-restricted KV9 epitope.

53 o acids 82 to 90 (K(d)M2(82-90)) than on the subdominant D(b)M(187-195) epitope response, indicating

54 e with less illness, whereas mutation of the subdominant D(b)M(187-195) response resulted in overcomp

55 the role of a dominant (K(d)M2(82-90)) and a subdominant (D(b)M(187-195)) epitope of respiratory sync

56 epitopes have been classified as dominant or subdominant depending on the magnitude of the CTL respon

57 ntroduction of a dibasic motif adjacent to a subdominant determinant enhances the presentation of thi

58 dition of excess naive T cells targeting the subdominant determinant.

59 The enhanced response to one of the subdominant determinants (PB1F2(62-70)) correlates with

60 Little is known about how immunodominant and subdominant determinants are distinguished by the TCD8+

61 drop precipitously, whereas responses to two subdominant determinants are greatly enhanced.

62 The immunogenicity of subdominant determinants is often limited by immunodomin

63 Subdominant determinants may be expressed at or above le

64 revealed that the poor immunogenicity of two subdominant determinants reflects limitations in T cell

65 inority of T(CD8+) responding to a number of subdominant determinants.

66 r the poor immunogenicity of just one of the subdominant determinants.

67 ively suppress the expansion of dominant and subdominant effectors simultaneously but, in some few ca

68 6-214)-specific CD8(+) T cell specificities (subdominant effectors) in response to pMHC-coated nanopa

69 se of peripheral blood CD8(+) T cells to the subdominant Env epitopes were not as great as those to t

70 mmunization, CD8(+) T cells specific for the subdominant Env p15m and p54m epitopes and/or the domina

71 s study, we generated dominant Gag p11C- and subdominant Env p41A-specific CD8(+) T-lymphocyte respon

72 model and found that the previously defined subdominant Env-specific CD8(+) T cells are endowed with

73 quired additional direct presentation of the subdominant epitope by T Ag-transformed cells and was on

74 a QGPRG core sequence, which was found in a subdominant epitope CII (906-916).

75 ptive transfer of a CTL clone against such a subdominant epitope cured mice bearing EL4 lymphoma grow

76 ns was bound to class II DR4 compared with a subdominant epitope from this same Ag.

77 in BALB/c mice, the GP(283-291) epitope is a subdominant epitope in BALB/c mice that becomes dominant

78 rchies, as seen by the detection of only one subdominant epitope in Mamu-A*01(+) vaccinees.

79 ified a new RSV-specific, H-2K(d)-restricted subdominant epitope in the M2 protein, M2(127-135) (amin

80 response also eliminated the response to the subdominant epitope in the protein.

81 The response to a subdominant epitope is less obvious after secondary chal

82 minant ovalbumin epitope SIINFEKL (ova8) and subdominant epitope KRVVFDKL, using either vaccinia viru

83 later emerging CTL response specific for the subdominant epitope may contribute to the control of vir

84 proteins may obviate the need for additional subdominant epitope modifications.

85 +) T lymphocytes specific for a dominant and subdominant epitope of influenza hemagglutinin using act

86 e eliminated, whereas T cells specific for a subdominant epitope on the same protein preferentially e

87 However, the dominant and subdominant epitope sequences differ among virus strains

88 g-transformed cells, we demonstrate that the subdominant epitope V is weakly cross-presented relative

89 when the C-terminal flanking residues of the subdominant epitope were attached to S-L.

90 However, memory CTLp specific for this subdominant epitope were induced at frequencies approach

91 virus infection, memory CTLp specific for a subdominant epitope were selectively primed by vaccinati

92 resulted in effective viral clearance by the subdominant epitope with less illness, whereas mutation

93 e show that memory CD8 T cells specific to a subdominant epitope within the RSV fusion (F) protein fa

94 -38 (HDIILECV; restricted by B4002), and one subdominant epitope, E6 52-61 (FAFRDLCIVY; restricted by

95 ted CD8(+) T cells directed against only one subdominant epitope, regardless of the vaccination regim

96 oss-reactive T-cell responses to LCMV, and a subdominant epitope, VV-a11r198, did generate cross-reac

97 For the subdominant epitope, we identified an optimal nine-amino

98 uggest that the limited clonal repertoire of subdominant epitope-specific CD8(+) T-lymphocyte populat

99 loy TCRs with multiple CDR3 lengths, whereas subdominant epitope-specific cells employ TCRs with a mo

100 for its ability to elicit both dominant and subdominant epitope-specific CTL responses in rhesus mon

101 Immunodomination, or diminution of subdominant epitope-specific responses by dominant epito

102 These subdominant epitope-specific T cells can also recognize

103 V-1 epitope is more efficient than that of a subdominant epitope.

104 n B (gB498-505-Tet(+)) and cells reactive to subdominant epitopes (gB-Tet(-)).

105 f low-frequency CD4+ T cells targeting other subdominant epitopes appeared in blood several weeks lat

106 trate that potent secondary CTL responses to subdominant epitopes are rapidly generated following a p

107 on cytokine profiles, CTL specific for these subdominant epitopes are Tc2, in contrast to CTL for the

108 the constellation of chemically dominant and subdominant epitopes as a whole, and did not discriminat

109 to account for weak CD8(+) CTL responses to subdominant epitopes at the level of CD8(+) T lymphocyte

110 y be due to the coexpression of dominant and subdominant epitopes by the same antigen-presenting cell

111 omeningitis virus model, we demonstrate that subdominant epitopes can be more reliably identified by

112 data indicate that memory CTLp specific for subdominant epitopes can be primed by Sendai virus infec

113 CD8+ T cells specific for both dominant and subdominant epitopes can be rendered tolerant.

114 emonstrating that memory CTLp primed against subdominant epitopes can participate in an immune respon

115 mice vaccinated using the vaccine targeting subdominant epitopes caught up with the conventionally v

116 immunodominance did not shift to other known subdominant epitopes despite the capacity of these mice

117 Vbeta repertoire, whereas those specific for subdominant epitopes employ a dramatically more focused

118 e concentrations, while T cells specific for subdominant epitopes expand maximally to high peptide co

119 CD8 T cell responses to dominant as well as subdominant epitopes following infection with lymphocyti

120 effector CTL and memory CTLp to dominant and subdominant epitopes following Sendai virus infection of

121 nt epitopes form stable complexes, while the subdominant epitopes form less stable complexes with H2-

122 Importantly, these data identify subdominant epitopes from AFP that can activate high-avi

123 ion, and avidity of the T cells specific for subdominant epitopes from AFP.

124 We identified a series of immunodominant and subdominant epitopes from alpha fetoprotein (AFP), restr

125 dramatically suppress the immunogenicity of subdominant epitopes in the context of gene-based vaccin

126 nting a minimum of four to seven dominant or subdominant epitopes in these conserved N and C termini.

127 DNA vaccines encoding isolated dominant and subdominant epitopes induce equivalent responses, confir

128 pitope hierarchies by enhancing responses to subdominant epitopes induced by recombinant modified vac

129 (498-505) nor the dominance hierarchy of the subdominant epitopes is due solely to MHC or TCR affinit

130 To determine whether CTLp memory to subdominant epitopes is functional in the context of Sen

131 estingly, CTL function towards both of these subdominant epitopes is restricted by the H-2D molecule,

132 However, CD8(+) T cells specific for subdominant epitopes lose functionality, whereas those s

133 RT1(u)-restricted immunodominant and several subdominant epitopes on CII often share a QGPRG-like mot

134 and characterized an immunodominant and five subdominant epitopes on CII, which stimulate RT1(u)-rest

135 onstration that coexpression of dominant and subdominant epitopes on the same antigen-presenting cell

136 an Ad vector lacking most of the E1 region, subdominant epitopes outside this region were recognized

137 CD8(+) T lymphocytes (T(CD8)) responding to subdominant epitopes provide alternate targets for the i

138 virus encodes approximately 150 dominant and subdominant epitopes restricted in by HLA-A*0201.

139 FN-gamma(+) cytotoxic effector cells against subdominant epitopes that were either absent or in low f

140 th cases, whereas compensation by five other subdominant epitopes was minimal.

141 phocytes specific for the immunodominant and subdominant epitopes were maintained to a remarkable deg

142 In contrast, when two subdominant epitopes with intermediate MHC binding affin

143 These findings indicate that subdominant epitopes with low major histocompatibility c

144 opes in C57BL/6 mice, 19 (gB(498-505) and 18 subdominant epitopes) stimulated CD8(+) T cells in the s

145 One of the subdominant epitopes, GP283-291, conferred partial prote

146 d more sustained CTL responses against these subdominant epitopes, suggesting that subdominant respon

147 future vaccines should preferentially target subdominant epitopes, the idea being that this should al

148 he development of responses directed against subdominant epitopes.

149 the production and antigenicity of otherwise subdominant epitopes.

150 the production and antigenicity of otherwise subdominant epitopes.

151 ific CD8+ T cells to both immunodominant and subdominant epitopes.

152 gies can be utilized to enhance responses to subdominant epitopes.

153 O and delivery by L. monocytogenes revealing subdominant epitopes.

154 ar immunity elicited is broad and extends to subdominant epitopes.

155 ession of CD8 T cell responses to the weaker subdominant epitopes.

156 l responses targeting at least two otherwise subdominant epitopes.

157 berately shifting the immune response toward subdominant epitopes.

158 asured the T-cell responses to the remaining subdominant epitopes.

159 e followed by new CTL responses specific for subdominant epitopes.

160 ent of all transfectants in presenting these subdominant epitopes.

161 to the recognition of five otherwise silent subdominant epitopes.

162 ues 283-291 from the viral glycoprotein, are subdominant epitopes.

163 , whereas the other half are specific for 18 subdominant epitopes.

164 the virus nucleoprotein, of two overlapping subdominant epitopes: one presented by L(d) and the othe

165 response, they may be considered as typical "subdominant" epitopes.

166 he SIV Gag p11C (dominant) and SIV Pol p68A (subdominant) epitopes that are consistently generated in

167 nalyzed, the immunodominant response and the subdominant F and HN responses were comprised of both hi

168 In tapasin-deficient mice, responses to subdominant fast off-rate peptides were clearly favored.

169 fusion proteins based on strongly protective subdominant fusion proteins.

170 d strongly lytic for targets coated with the subdominant gp276 epitope.

171 gly due to compensatory responses of several subdominant grass species.

172 memory CD8(+) T lymphocytes directed to the subdominant HA210-219 epitope results in the generation

173 ntly increased cytotoxic T cell responses to subdominant highly conserved Gag epitopes and maximized

174 icularly attractive immunogens for targeting subdominant HIV-1 envelope V1V2-neutralizing antibody-pr

175 D8+CD127+ memory T cell pools specific for a subdominant HLA-A2-restricted Env(121-129) epitope (KLTP

176 e studied human CD8+ T cell responses to the subdominant HLA-A2-restricted epitope TV9 (Gag p24(19-27

177 y is substantially more efficacious than the subdominant HLA-B*14-restricted Gag response.

178 A subdominant HLA-B*14-restricted response targets Gag (DR

179 Here, we studied the subdominant HLA-B27-restricted epitope, NS5B(2936-2944)

180 ent mice, in effect rendering these epitopes subdominant; however, responses to these epitopes are in

181 OMPs is consistent with the hypothesis that "subdominant" immunogens are required for vaccine-induced

182 -specific CTL response was low frequency and subdominant in both SHIV-infected monkeys and in monkeys

183 is consistently immunodominant and the other subdominant in infected persons.

184 ominant and NAb responses against fiber were subdominant in sera from vaccinated mice, vaccinated hum

185 We find that T(CD8+) responses to three subdominant influenza virus determinants are reduced to

186 esentation of the immunodominant but not the subdominant kappa epitope; Ag refolding restored kappa e

187 t IgG-derived epitope, kappaI, relative to a subdominant kappaII peptide.

188 ses to 2 A2-restricted peptide epitopes: the subdominant latency membrane protein-2 (LMP2) peptide CL

189 patients; however, responses to some of the subdominant latent proteins will be needed to target oth

190 ary CD8 T cell response to both dominant and subdominant LCMV CTL epitopes was approximately 2- to 3-

191 itope sequence, M57727-734, and the normally subdominant LCMV epitope L2062-2069, indicating a profou

192 utative MCMV epitope sequence and a normally subdominant LCMV epitope.

193 ic CD8(+) T cell responses especially to the subdominant MAA epitopes.

194 have a higher reproductive success than the subdominant males.

195 ubdominant" vaccine retain both dominant and subdominant memory cells.

196 t epitope-specific T(CD8) contributes to the subdominant nature of a tumor-specific epitope.

197 ing both immunodominant (NP(324-332)/Kb) and subdominant (NP(324-332)/Db) epitopes.

198 for both the dominant (NP324-332/Kb) and the subdominant (NP324-332/Db) epitopes of NP.

199 mmunodominant epitope and destruction of the subdominant one.

200 nant CD8 T-cell epitopes as well as those of subdominant ones if present.

201 of four C-terminal residues that flank other subdominant or cryptic epitopes in OVA reduced the prese

202 ows high-avidity CD8(+) T cells specific for subdominant or cryptic epitopes to persist while effecti

203 the immune system, particularly for cryptic, subdominant, or marginally antigenic peptides.

204 processes are also involved in generating a subdominant OVA peptide KVVRFDKL (K-L).

205 se of two dominant (p11C and p199RY) and two subdominant (p68A and p56A) epitopes.

206 rexpression of PAR4 in T. cruzi enhanced the subdominant PAR4-specific CD8(+) T cell response, result

207 dy we define and quantitatively monitor four subdominant PCC-specific clonotypes that express Valpha1

208 hat both the N- and C-terminal flanks of the subdominant peptide are suboptimal for Ag presentation.

209 e hypothesized that immunizing patients with subdominant peptide epitopes derived from HER-2/neu, usi

210 We find the immunodominant and subdominant peptide-specific T cells to be differentiall

211 hat cause diminished CD4 T cell responses to subdominant peptides after such multipeptide immunizatio

212 rimary T(CD8+) response to five dominant and subdominant peptides.

213 cessed and presented PLP139-151, but not the subdominant PLP178-191, PLP56-70, or PLP104-117 epitopes

214 ated animals, developed CTL responses to the subdominant Pol epitope that were detectable only after

215 Memory CTL responses to a subdominant Pol epitope were undetectable in these anima

216 a previously unrecognized role played by the subdominant Pol-specific KY9 response in HLA-B 2705-medi

217 demonstrating proviral insertions at CISs in subdominant populations in the tumor mass.

218 ect evidence that demonstrates the growth of subdominant populations to dominance in the absence of a

219 vidity for pMHC, whereas T-bet(int)Eomes(hi) subdominant populations were characterized by higher pMH

220 Furthermore, in both dominant and subdominant populations, lytic activity declines more ra

221 However, the subdominant response directed against the epitope presen

222 Together with a subdominant response to amino acids 57 to 60, these two

223 Two tamarins also made a subdominant response to an epitope of the matrix (M1) pr

224 With the exception of an additional subdominant response to the polymerase (PB2) protein in

225 by vaccination (where IFN-gamma was by far a subdominant response) vs natural infection; in addition,

226 We compare the kinetics of the dominant and subdominant responses after vaccination with those follo

227 epitopes eliciting either immunodominant or subdominant responses after viral challenge.

228 In addition, we demonstrate that subdominant responses are actively suppressed by dominan

229 These data suggest that subdominant responses can contribute to in vivo viral co

230 hereas conserved epitopes generally elicited subdominant responses during both primary and chronic in

231 To address the function of subdominant responses in human immunodeficiency virus in

232 these subdominant epitopes, suggesting that subdominant responses might play a role in clearance of

233 e memory population, as well as of transient subdominant responses that were not detected at the memo

234 epitope present in the viral M protein, and subdominant responses were directed against epitopes pre

235 D8(+) response expands more rapidly than the subdominant responses, but after virus infection is clea

236 supporting the superiority of dominant over subdominant responses, immunodominant epitopes represent

237 hesis that dominant T-cell responses inhibit subdominant responses, we eliminated the two dominant ep

238 of dominant T-cell responses did not enhance subdominant responses.

239 ude from large, dominant responses to small, subdominant responses.

240 hile p60 449-457 and mpl 84-92 elicit minor, subdominant responses.

241 in a reproducible hierarchy of dominant and subdominant responses.

242 oriolis force, and the Lorentz force plays a subdominant role; this has led to conclusions that these

243 ral gap--defined as the distance between the subdominant RP resonance and the unit circle--plays a ma

244 with smaller-magnitude responses are termed subdominant (SD).

245 D8(+) T cells specific for both dominant and subdominant Sendai virus epitopes persisted for many wee

246 This subdominant sequence confers immunity as effective as th

247 he challenge of identifying an uncertain and subdominant signal in the presence of uncertain backgrou

248 zoites demonstrated that this CTL epitope is subdominant since it is not recognized in the context of

249 these animals recognized a broader array of subdominant SIV epitopes in the cytolytic assay.

250 xes-the immunodominant SVG9 (E protein), the subdominant SLF9 (NS4B protein), and the immunorecessive

251 ivers of the poor proliferation observed for subdominant specificities showed that the immunodominanc

252 tionally impaired, helpless CD8 T cells of a subdominant specificity had increased numbers and enhanc

253 precursor frequency might be related to the subdominant status of the M1(128) epitope.

254 In studying the subdominant status of two cysteine-containing influenza

255 A roughly equal fraction of peptides have subdominant status, i.e. they induce weak-to-nondetectab

256 In contrast, the immunogenically subdominant stem region of HA is highly conserved and re

257 genetically diverse population with multiple subdominant strain lineages.

258 but fails to induce T(CD8) specific for the subdominant T Ag epitope V.

259 display of class II-restricted dominant and subdominant T cell epitopes.

260 with broad specificity for both dominant and subdominant T cell epitopes.

261 By allowing the escape of subdominant T cells, this process still preserves a rela

262 This strategy can be used to identify subdominant T-cell responses in other systems.

263 This is an important question because subdominant TCD8 are more likely than immunodominant clo

264 The selective increase in subdominant TCD8 clonal size was due to their enhanced s

265 PD-1 blockade increased the size of subdominant TCD8 clones at the peak of their primary res

266 variants revealed that anti-PD-1 invigorates subdominant TCD8 responses by relieving their lysis-depe

267 LAG-3, TIM-3), PD-1 was highly expressed by subdominant TCD8, which correlated with their propensity

268 , and proliferation profiles of dominant and subdominant TCR clonotypes to evaluate the relationship

269 Although NA is immunologically subdominant to HA, and clinical studies have shown varia

270 ce, but not in WT mice, thereby representing subdominant, tolerance-inducing epitopes of ML-M.

271 ed to recognition of the dominant TSKB20 and subdominant TSKB18 TS epitopes.

272 ar frequencies of immunodominant TSKB20- and subdominant TSKB18-specific CD8+ T cells following T. cr

273 cognizing the dominant TSKB20 (ANYKFTLV) and subdominant TSKB74 (VNYDFTLV) trans-sialidase gene (TS)-

274 e partly because of the weak activity toward subdominant tumor antigens (TAg) and to tumors expressin

275 the basis for the lack of priming against a subdominant tumor epitope following immunization of C57B

276 tein-reactive V beta 8.2(+) T cells, but not subdominant V beta 13(+) T cells.

277 ambda L chains instead of allowing otherwise subdominant V2-glycan broadly neutralizing Abs to develo

278 ion, mice which had been immunized with the "subdominant" vaccine retain both dominant and subdominan

279 ly CD8 T cell responses to both dominant and subdominant VACV epitopes, correlating with its strong i

280 ry CD8 T cell responses to both dominant and subdominant VACV epitopes.

281 opment of strong memory to both dominant and subdominant VACV epitopes.

282 cell response directed against dominant and subdominant VACV-WR Ags, followed by a CD4 T cell and Ig

283 residues 159 to 166 [VP3(159-166)]) and/or a subdominant viral epitope (VP3(173-181)) of susceptible

284 compatibility complexes (pMHC) compared with subdominant virus-specific T cells expressing lower leve

285 against one dominant (VP3(159-166)) and two subdominant (VP1(11-20) and VP3(173-181)) capsid protein

286 ) to T lymphocytes specific for M2(127-135) (subdominant) were approximately 3:1 in the spleen and 10

287 ele frequencies may drive the elimination of subdominant yet effective epitopes from circulating vira