ライフサイエンスコーパス: subepicardial

1 .10+/-0.05 versus -0.04+/-0.05; P<0.05); (2) subepicardial (0.16+/-0.15 versus 0.09+/-0.08; P<0.05) a

2 and subendocardial 20.2%, midwall 33.4%, and subepicardial 20.3%.

3 e most likely related to the same structural subepicardial abnormalities, but the mechanism is differ

4 epicardial attachment to the myocardium and subepicardial accumulation of epicardial-derived cells.

5 ventricular (RV) conduction delay and (2) RV subepicardial action potential shortening.

6 local amplitude dependent upon the immediate subepicardial activity; the combination of these effects

7 to mesenchymal transformation and invade the subepicardial and cardiac matrix.

8 difference in I(pNa) current density between subepicardial and subendocardial cells.

9 I(Ca) was recorded in acutely dissociated subepicardial and subendocardial murine left ventricular

10 ank tests were used for paired comparison of subepicardial and subendocardial MVD and SI within group

11 ively regulate venous differentiation of the subepicardial APJ-negative ECs in the heart.

12 ach facilitated the precise visualization of subepicardial autonomic nerves in the ventricles using w

13 LGE located subepicardial basal inferolateral was detectable in 22%

14 ted with ECG and vectorcardiogram (VCG), and subepicardial biopsies were taken at 5 to 120 minutes an

15 GRK activity was measured in arrhythmogenic subepicardial border zone (EBZ) tissue overlying the inf

16 5 and E10.5 by precocious differentiation of subepicardial cardiac myocytes.

17 shed in Hey2(+/-) mice because of changes in subepicardial cardiomyocytes.

18 tion of FGFR-1 and VEGFR-2 in epicardial and subepicardial cells adjacent to FGF virus-infected myoca

19 s transient outward current (I(to)) than did subepicardial cells.

20 PET subendocardial and subepicardial CFR were in good agreement with the micros

21 ocardial longitudinal shortening at base and subepicardial circumferential shortening at apex continu

22 Pig subepicardial coronary arterioles (50 to 100 microm in d

23 letion results in defective formation of the subepicardial coronary veins, but had no significant eff

24 subendocardial CVR (1.43+/-3) was lower than subepicardial CVR (1.78+/-35; P=0.01).

25 h a left ventricular pressure catheter and 2 subepicardial cylindrical ultrasonic dimension transduce

26 Subepicardial endothelium-dependent microvascular relaxa

27 cardiac injury response by conditioning the subepicardial environment, potentially offering a new th

28 endo), basal midmyocardial (mid), and apical subepicardial (epi) regions of the left ventricular free

29 al cells labeled in ovo with DiI invaded the subepicardial extracellular matrix, demonstrating that m

30 ine ligand binding revealed a subendocardial/subepicardial gradient in normal dogs.

31 ing and a loss in the natural subendocardial/subepicardial gradient, which roughly correlated inverse

32 essels along the atrioventricular groove and subepicardial hemorrhage.

33 of the hearts, transmural in 23.3%, midwall-subepicardial in 23.3%, and midwall-subendocardial in 20

34 is in POH-DCM was severe, subendocardial and subepicardial, in contrast with subendocardial fibrosis

35 was performed in normal rabbit hearts during subepicardial injections (50 muL) of norepinephrine (NE)

36 ions can be explained by the contribution of subepicardial IVEs to optical signals.

37 ients with suitable images, LGE involved the subepicardial layer inferior and lateral wall in 154 pat

38 for distal sympathetic axon extension in the subepicardial layer of the dorsal ventricular wall of th

39 RBP-null cardiac myocytes, especially in the subepicardial layer, display increased cell proliferatio

40 l and midmyocardial layers compared with the subepicardial layer.

41 natural gradient between subendocardial and subepicardial layers in LVH.

42 t infarct age influences EGM duration in the subepicardial left ventricle (LV).

43 l and posterolateral apical right ventricle, subepicardial left ventricular fibrofatty replacements (

44 t, formed a chimeric epicardium, invaded the subepicardial matrix and myocardial wall, and became cor

45 recursors from the proepicardium through the subepicardial matrix where the coronary arteries develop

46 most severe AS (n=15), the subendocardial to subepicardial MBF ratio decreased from 1.14+/-7 at rest

47 early proepicardium, the epicardium and the subepicardial mesenchymal cells (SEMC).

48 r and hypercellular epicardium with abundant subepicardial mesenchyme and a thin compact zone myocard

49 ion of the embryonic epicardium produces the subepicardial mesenchyme that is essential for normal co

50 ex communication between the epicardium, the subepicardial mesenchyme, and the myocardium mediated in

51 emonstrate differences in subendocardial and subepicardial microcirculation and to investigate the re

52 bserved significant transmural APD gradient: subepicardial, midmyocardial, and subendocardial APD80 w

53 Subepicardial, midmyocardial, and subendocardial myocyte

54 A stria LGE pattern with subepicardial/midmyocardial distribution, mostly involvi

55 with ventricular arrhythmias and isolated LV subepicardial/midmyocardial late gadolinium enhancement

56 Because of its subepicardial/midmyocardial location, LV scar is often n

57 d accuracy of quantifying subendocardial and subepicardial myocardial blood flow (MBF) and the relati

58 correlating activation maps of the surviving subepicardial myocardial layer with immunolocalization o

59 Twenty-seven dogs underwent placement of LV subepicardial myocardial markers to measure regional LV

60 myocardium (9.8 +/- 4.6%) and rarely in the subepicardial myocardium (0.32 +/- 0.45%).

61 1 and Scn5a expression remained lower in the subepicardial myocardium of the RVOT than in RV myocardi

62 subendocardial myocytes but is prolonged in subepicardial myocytes (control: endo, 126+/-7 ms; epi,

63 eferential conduction from subendocardial to subepicardial myocytes is lost, and failing myocytes man

64 AP propagation from subendocardial to subepicardial myocytes required less Gc compared with co

65 ural gradient, with faster repolarization in subepicardial myocytes than in subendocardial myocytes.

66 I(Ca) density was significantly larger in subepicardial myocytes than in subendocardial/myocytes.

67 ter in subendocardial myocytes compared with subepicardial myocytes, indicating stress-induced amplif

68 ger in subendocardial myocytes compared with subepicardial myocytes.

69 0.05) smaller I(pNa) than subendocardial and subepicardial myocytes.

70 Basal subendocardial and apical subepicardial regions deform through a characteristic ph

71 ort-lived apex-to-base and subendocardial-to-subepicardial relaxation gradients at the onset of diast

72 Midmyocardial and subepicardial response to dobutamine were predictive of

73 A); and 2) scars restricted to the anterior subepicardial right ventricular outflow tract in 11 pati

74 ribes a novel clinical entity of an isolated subepicardial right ventricular outflow tract scar servi

75 The comparison of mean subendocardial and subepicardial SI within groups revealed significantly mo

76 s of induced VT arose from subendocardial or subepicardial sites distant from areas of marked conduct

77 ion of WT1 and RALDH2 initially populate the subepicardial space and subsequently invade the ventricu

78 tal epicardial explants and engrafted in the subepicardial space in vivo.

79 tant mice, including failed expansion of the subepicardial space, blunted invasion of the myocardium,

80 e cardiac fibroblasts, which localize in the subepicardial space.

81 nfarct and from nonischemic remote-site (RS) subepicardial tissue from the same animal.

82 e mean difference between subendocardial and subepicardial TOTv values versus that in the control reg

83 The subepicardial vascular density was similar in both group

84 we found that cardiomyocytes throughout the subepicardial ventricular layer trigger expression of th

85 ndent action potential characteristics of LV subepicardial versus subendocardial myocytes in differen

86 To test this hypothesis, porcine subepicardial vessels (50 to 100 microm) were isolated,

87 Nonischemic LGE patterns (midmyocardial/subepicardial) were also observed.

88 ys occurred at the border between M-cell and subepicardial zones, where repolarization gradients were

89 abnormalities, typically seen in midwall and subepicardial zones.