ライフサイエンスコーパス: sublethal

1 es and field pesticide exposure is typically sublethal.

2 luence pathogen behaviour at levels that are sublethal.

3 with a HIF-1alpha stabilizer before severe, sublethal 9.0-Gy irradiation improved blood recovery and

4 Here we show that sublethal activation of Caspase-3 plays an essential, fa

5 Moreover, this sublethal activation of caspase-3 promoted persistent DN

6 how that systemic infections with lethal and sublethal amounts of bacteria differentially shape devel

7 Sublethal amounts of the neurotoxin 5,7-dihydroxytryptam

8 We used sublethal and lethal doses of E. coli to examine the mec

9 mine whether inter-specific variation in the sublethal and lethal effects of parasite exposure exist

10 comprehensive, mechanistic understanding of sublethal and lethal thermal tolerances.

11 genesis when the treatment concentration was sublethal, and those mutants were genetically more stabl

12 lts indicate that zebra in ENP often survive sublethal anthrax infections, encounter most B. anthraci

13 We hypothesized that sublethal attack by a co-occurring predator, the spiny l

14 thrax wanes rapidly, subsequent and frequent sublethal B. anthracis infections cause maturation of an

15 ity, providing greater capabilities to clear sublethal bacterial challenges, possibly at the cost of

16 ree silver ion concentration associated with sublethal binding to bacteria.

17 d DCs (pDCs), which downregulate FasL during sublethal, but not lethal, IAV infection, accumulate to

18 Sublethal carbon monoxide (CO) exposure is frequently as

19 e spill, caged embryos at oiled sites showed sublethal cardiac toxicity, as expected from exposure to

20 led 2 y later from oiled sites showed modest sublethal cardiotoxicity but no elevated necrosis or mor

21 re measured at 10 points over 19 days in the sublethal case and at 6 points over 7 days in the lethal

22 ic challenge models, and reduces fever after sublethal challenge in cynomolgus monkeys.

23 ected animals, even following clearance of a sublethal challenge.

24 microtubule cytoskeleton is regulated during sublethal changes to dendrites.

25 Thus, sublethal cognitive deficits elicited by neonicotinoids

26 earance of the virus from older hosts in the sublethal cohort.

27 Interestingly, sublethal complement membrane attack complex formation,

28 Nitric oxide (NO) at sublethal concentration has also been reported to induce

29 to oxidative stress, high temperature and a sublethal concentration of an antibiotic.

30 and of H(2)O(2), ascorbate, and exposed to a sublethal concentration of copper (10 mum) for 24 h.

31 acloprid in the field for several weeks at a sublethal concentration.

32 piration of both plants at a narrow range of sublethal concentrations (e.g., 1 mg/L of 25 nm AgNPs fo

33 effects arising from short-term exposure to sublethal concentrations are unknown.

34 provides clear evidence that imidacloprid at sublethal concentrations has a significant detrimental i

35 evidence that neonicotinoid insecticides at sublethal concentrations have profound effects on social

36 can elicit biofilm dispersal when present at sublethal concentrations in the surrounding medium.

37 ore, the method yields information regarding sublethal concentrations not realized in the traditional

38 Sublethal concentrations of 7KCh resulted in microglial

39 his, we exposed diverse bacterial species to sublethal concentrations of a cell wall biosynthesis inh

40 Here, we show that in PC12 cells sublethal concentrations of aggregated Abeta(25-35) inhi

41 Surprisingly, we find that sublethal concentrations of antibiotics from the most wi

42 and by anaerobic conditions, indicating that sublethal concentrations of antibiotics induce mutagenes

43 d are more sensitive to oxidative stress and sublethal concentrations of antibiotics.

44 Here we show that treating E. coli with sublethal concentrations of antimicrobial peptides cause

45 We found that embryonic exposure to sublethal concentrations of carbaryl induced higher tole

46 during the cell cycle, we treated cells with sublethal concentrations of carbenicillin (Cb) to assess

47 al passage of influenza virus populations in sublethal concentrations of drug.

48 we demonstrate that exposure of S. aureus to sublethal concentrations of H2O2 leads to a specific, do

49 biotransformation and effects of exposure to sublethal concentrations of hexaethylene glycol monodode

50 een antibiotics were tested with and without sublethal concentrations of manuka honey against each of

51 Sublethal concentrations of mixtures of TCDD and endosul

52 We investigated the effects of exposure to sublethal concentrations of the water accommodated fract

53 ane like the addition of SDS or challenge to sublethal concentrations of Zn(2+).

54 At sublethal concentrations, the heat stress response is cr

55 At sublethal concentrations, these CAPs preferentially targ

56 ons but cause bacterial endoreduplication at sublethal concentrations.

57 te Eater-Fc binding to live E. coli, even at sublethal concentrations.

58 s to investigate cellular responses at these sublethal concentrations.

59 different T. cruzi strains under lethal and sublethal conditions and several parameters were measure

60 isruption among aquatic organisms even under sublethal conditions.

61 Encephalitis induced by the sublethal coronavirus JHMV was used to identify when CD4

62 tophagy, a process of cellular adaptation to sublethal damage.

63 Lethal and sublethal DEBtox outcomes and their uncertainty were pro

64 oncentrations of oil causes toxicity that is sublethal, delayed, and not counteracted by the protecti

65 2) showed significant feeding inhibition and sublethal developmental disruption in the cabbage looper

66 Sublethal dosage of NSC 19630 and the chemotherapy drug

67 Sublethal dosage of salubrinal, an eIF2alpha phosphatase

68 e of these that could clear the bacterium at sublethal dosages in all replicate populations, even tho

69 Mice challenged with a sublethal dose (<2.0 x 10(6) CFU) rapidly lost weight, h

70 ed chimerism was established in dogs given a sublethal dose (1-2 Gy) total body irradiation before an

71 Within 1 h of consuming a single sublethal dose (1.34 ng/bee), foragers showed excitation

72 nd MCRR (microcystin-arginine-arginine) at a sublethal dose (10 mug L(-1)) for a period of 30 days.

73 Macrophages pre-exposed to a sublethal dose of anthrax lethal toxin (LeTx) are refrac

74 ive, active-site mutant or pre-exposure to a sublethal dose of antibiotic.

75 Whereas the wild-type mice infected with a sublethal dose of bacteria could resolve the infection w

76 in response to myogenic differentiation and sublethal dose of cisplatin.

77 +CpG DNA, compared with mice infected with a sublethal dose of DENV2 and mice immunized with OVA (neg

78 With a sublethal dose of E. coli, GRK5 knockout (KO) mice exhib

79 Mice were challenged a first time with a sublethal dose of H1N1 2009 pandemic virus and, four wee

80 encephalomyelitis (EAE) were administered a sublethal dose of influenza.

81 bone marrow-derived macrophages exposed to a sublethal dose of LeTx were resistant to LeTx in an HDAC

82 ts in dampened proinflammatory response to a sublethal dose of LPS in vivo, which is dependent on inc

83 cancer cell lines by exposure of cells to a sublethal dose of radiation and screened for lines that

84 These findings demonstrate that a sublethal dose of radiation can enhance the metastatic p

85 Finally, a sublethal dose of several ceramide analogs significantly

86 dividuals challenged with either a lethal or sublethal dose of virus increased the P : C ratio of the

87 antigens, than mice immunized with the same sublethal dose of WT CO92.

88 ed five novel ceramide analogs that act at a sublethal dose to enhance the efficacy of tumor-specific

89 Naja sputatrix venom sublethal dose was injected subcutaneously for 3 consecu

90 bacterial loads in GRK5 KO mice following a sublethal dose, at a lethal dose of E. coli, the bacteri

91 findings show that pDCs from lethal, but not sublethal, dose IAV infections drive elimination of Fas(

92 n was altered within the lethal, but not the sublethal, dose range.

93 hological changes in RAW 264.7 cells, and at sublethal doses (i.e., 10 mg/L) it induced the early exp

94 Moreover, we show that sublethal doses of Abeta(1-42) oligomers enter the nucle

95 on in adult human cortical slices exposed to sublethal doses of AbetaOs.

96 of B. burgdorferi, the results suggest that sublethal doses of antibiotics could negatively impact s

97 d terminally differentiated cells exposed to sublethal doses of carmustine (BCNU), a classic alkylati

98 rimental analyses to identify the effects of sublethal doses of chemotherapy on glial precursor cells

99 ring tumor cells hypersensitive to otherwise sublethal doses of clinically relevant chemotherapeutic

100 xoid or genetically derived CNF1 toxoid plus sublethal doses of CNF1.

101 Finally, sublethal doses of CSE reduced cell motility and gel con

102 Our findings indicate that sublethal doses of doxorubicin and melphalan initiate a

103 Upon exposure to sublethal doses of gamma-irradiation, Parp-2-/- mice exh

104 l deletion of 5' and 3' genetic elements and sublethal doses of histone deacetylase inhibitors demons

105 We studied the effects of sublethal doses of imidacloprid on olfactory learning in

106 Sequential infection with sublethal doses of influenza and H. influenzae resulted

107 ow that codelivery of insulin with otherwise sublethal doses of LPS induced hypoglycemic shock in mic

108 of Dab2 (Dab2fl/fl Lysm-Cre), treatment with sublethal doses of LPS resulted in increased proinflamma

109 Hence, sublethal doses of neonicotinoids might compromise the f

110 Sublethal doses of NMDA can induce robust endogenous pro

111 ially reduced the neuroprotective effects of sublethal doses of NMDA.

112 represented in Daphnia magna (DM) exposed to sublethal doses of presumed narcotic chemicals with log

113 -deficient Gfi-1(-/-) mice were administered sublethal doses of radiation and were then engrafted wit

114 formation is a widely conserved response to sublethal doses of the agent.

115 present in the spleens of mice infected with sublethal doses of the Francisella tularensis live vacci

116 Here we show that sublethal doses of the neonicotinoid imidacloprid impair

117 The occurrence at sublethal doses of this insecticide-induced viral prolif

118 known to induce chromosomal fragmentation in sublethal doses, and yet UV irradiation causes genetic i

119 At sublethal doses, AZT has no significant effect on frame

120 that UV irradiation induces fragmentation in sublethal doses, but the broken chromosomes are repaired

121 abolite when applied to Bacillus subtilis at sublethal doses.

122 nd are unable to control bacterial growth at sublethal doses.

123 However, the sublethal effect of neonicotinoids on S. invicta has nev

124 Pericardial edema was the most sensitive sublethal effect that often preceded embryo mortality, a

125 pesticide concentrations can have subtle or sublethal effects at the individual level, it is not kno

126 e analysis and metabolome analysis indicated sublethal effects consistent with perturbations of calci

127 exposure (up to 120 h) nor consideration of sublethal effects led to a reduced number of outliers.

128 owed the predicted direction indicating that sublethal effects of contaminant exposure can lead to ov

129 For relatively oxidized sediments, sublethal effects of copper to the epibenthic deposit-fe

130 Exploring the sublethal effects of disease outbreaks among natural pop

131 application of molecular profiling to assess sublethal effects of environmental stressors in field-co

132 serve as a quantitative basis for assessing sublethal effects of global change.

133 entage of northern Ontario waterbodies where sublethal effects of mercury on fish can occur may incre

134 We hypothesize that any sublethal effects of neonicotinoid seed dressings on Bom

135 However, the sublethal effects of pesticides on locomotion and moveme

136 ppropriate guidelines for testing chronic or sublethal effects of pesticides used in agriculture.

137 m of this study was to assess the lethal and sublethal effects of the disazo dye Disperse Yellow 7 (D

138 exposure to field-realistic levels can have sublethal effects on bees, affecting their foraging beha

139 To evaluate potential sublethal effects on dolphins, health assessments were c

140 he lethal effects of TFM are well-known, the sublethal effects on fishes are virtually unknown.

141 Here we report on the sublethal effects Pb exposure has on the breeding perfor

142 erns, given their acknowledged potential for sublethal effects to sensitive species and lifecycle sta

143 the sediment-water interface and lethal and sublethal effects to the amphipod Melita plumulosa were

144 of subcellular partitioning of copper on the sublethal effects to two deposit-feeding organisms (41-d

145 DOPO showed only sublethal effects with an EC50 value of 48 mg L(-1) for

146 xposure also revealed significant lethal and sublethal effects, at concentrations 3-5 orders of magni

147 Contrary to models without sublethal effects, our model suggests that modest increa

148 arative species sensitivity, consequences of sublethal effects, potential hazards of greater AR resid

149 s of magnitude, we expect acute mortality or sublethal effects, respectively.

150 te lethality, slow responses may not prevent sublethal effects.

151 may cause mass mortality or result in other sublethal effects.

152 drocarbons (PAHs), which can have lethal and sublethal effects.

153 materials requires studies that address both sublethal end points and multigenerational effects.

154 This study is the first to report on sublethal end points for azo dyes in amphibians, a growi

155 ended) exposure concentrations, inclusion of sublethal endpoints, and different exposure durations fo

156 ith increasing evidence suggesting that this sublethal exposure has implications for pollinator decli

157 e is extreme but also cytoprotective in that sublethal exposure leads to the synthesis of heat shock

158 eutrophilic infiltration.Sublytic EC injury: Sublethal exposure to DSA with EC activation predominate

159 in organisms, and would be induced following sublethal exposure to natural and anthropogenic stressor

160 Cortical neurons preconditioned with sublethal exposure to NMDA or oxygen glucose deprivation

161 Sublethal exposure to QDs stimulated the expression of g

162 aFG pathway was selective, with induction by sublethal exposure to the CAPs, RP-1 (platelets), and po

163 top to test the effects of acute and chronic sublethal exposures to TMX.

164 lower dose of 0.066 microg/adult bee/day) at sublethal, field-realistic doses given over 3 days.

165 inflammatory capacity at early times towards sublethal Ft.

166 tumor cells from one fish to another without sublethal gamma-irradiation.

167 age in human cells in response to a panel of sublethal genotoxic treatments, using other topoisomeras

168 of early-stationary-phase cells exposed to a sublethal H(2)O(2) concentration detected significant (P

169 Treatment with sublethal H(2)O(2) concentrations caused a subset of 41

170 polA1 double mutant following adaptation at sublethal H(2)O(2) levels was decreased 9-fold relative

171 severely attenuated even after adaptation at sublethal H(2)O(2) levels, whereas wild-type bacteria co

172 Sublethal heat treatment skews HCC cells toward EMT and

173 At moderate sublethal histone doses (30 mg/kg), left ventricular con

174 Exposure of N. gonorrhoeae to sublethal hydrogen peroxide revealed that the ng1427 gen

175 To assess the range of cellular responses to sublethal hyperthermia, expression of the gene encoding

176 e translational regulation under control and sublethal hypoxia stress conditions in seedlings of Arab

177 We found that sublethal hypoxia, which elicits tolerance to subsequent

178 Here we demonstrate that exposure to sublethal hypoxia/ischemia increases the neuroserpin exp

179 We have shown previously that a sublethal hypoxic exposure of the nematode Caenorhabditi

180 T mice with a VEEV mutant that induces mild, sublethal illness in immune competent mice.

181 Oxygen limitation affected both lethal and sublethal impacts of warming in each species.

182 eratorPAH50) from the DWH event, significant sublethal impacts were observed ranging from impaired ne

183 tent and/or earlier compared with cells from sublethal infection and showed decreased LPS-induced IL-

184 a lethal disease, anthrax often occurs as a sublethal infection in some susceptible hosts.

185 We analyzed the outcome of sublethal infection of C3H/HeJ mice older than age 10 we

186 nimals fed upon by infected nymphs developed sublethal infection with 27% lethality.

187 eared infection with Eap(+) but succumbed to sublethal infection with Eap- S. aureus.

188 g in enhanced viral clearance, recovery from sublethal infection, and full protection from lethal cha

189 is, contrasting their protective role during sublethal infection.

190 SFR/CD115 in steady state and 72 h following sublethal infection.

191 defect in CD8(+) T cell responses following sublethal infection.

192 iggering host immune responses, these common sublethal infections may act as immunomodulators and aff

193 signaling networks distinguished lethal from sublethal infections.

194 t in resistance to S. aureus pneumonia after sublethal influenza infection.

195 Sepsis was triggered in vivo using a sublethal injection of lipopolysaccharide (O55B5, 10 mg/

196 Sublethal injurious stimuli in neurons induce transient

197 Sublethal injury triggers long-lasting sensitization of

198 Following sublethal inocula (1 x 10(7) CFU), the intra-abscess bur

199 onal antibody (mAb), by immunizing mice with sublethal inocula of a hypervirulent XDR clinical isolat

200 Sublethal inocula of BG2 (1 x 10(8) or 1 x 10(7) CFU) ca

201 When sublethal inocula were used, however, the Deltaplb1-2 mu

202 ngs, liver, and spleen of mice that received sublethal inocula.

203 In contrast, a sublethal inoculum (1 x 10(7) CFU) of BG2 caused less ne

204 well as decreased survival in response to a sublethal inoculum of H. capsulatum The absence of myelo

205 he gamma-H2AX increase occurs in response to sublethal insults.

206 ) subset in spleens and lungs of mice during sublethal intradermal infection with LVS.

207 Here, a sublethal intragastric mouse infection model using wild-

208 njury in wild-type and Nlrc4(-/-) mice using sublethal intranasal inocula of P. aeruginosa strain CHA

209 inetic analyses of progenitor activity after sublethal irradiation and demonstrated that recovery to

210 rescent protein (EGFP) transgenic mice after sublethal irradiation of the recipient.

211 icate that survival of a few neoblasts after sublethal irradiation results in the clonal expansion of

212 long-term suppression of thymopoiesis after sublethal irradiation was primarily due to fewer progeni

213 We previously determined that sublethal irradiation, unlike bleeding or hemolysis, dep

214 d BMT following conditioning with lethal and sublethal irradiation.

215 We observe that a sublethal ischaemic preconditioning insult also leads to

216 Sublethal ischemia in neurons induces calcineurin-depend

217 g is the phenomenon whereby brief periods of sublethal ischemia protect against a subsequent, more pr

218 ing in vivo and in vitro models that, during sublethal ischemia, local neurons rapidly produce interl

219 We showed previously that sublethal ischemia, which renders neurons transiently re

220 steady state and generated during lethal and sublethal L. monocytogenes infection.

221 A mouse model for sublethal Leptospira infection allows understanding of t

222 We found that at sublethal levels a representative NCR peptide specifical

223 We then exposed bumblebee colonies to sublethal levels of a neonicotinoid pesticide.

224 a radical-based molecular mechanism whereby sublethal levels of antibiotics can lead to multidrug re

225 Here, we show that sublethal levels of bactericidal antibiotics induce muta

226 n result in viable viral progeny that harbor sublethal levels of G-to-A mutations.

227 ons and stress responses that are induced by sublethal levels of NCR peptides and other antimicrobial

228 Although sublethal levels of neonicotinoids are known to disrupt

229 Our analysis reveals that exposure to sublethal levels of NMDA does not alter phosphorylation

230 Sublethal levels of oxidative stress are commonly associ

231 R to induce preconditioning, suggesting that sublethal levels of ROS are indeed an important mediator

232 communities that had previously experienced sublethal levels of stress and had been connected by dis

233 ns in vivo are always lethal or can occur at sublethal levels that increase HIV-1 diversification and

234 sticides adversely affect bee health even at sublethal levels.

235 ALPI also affected sublethal life cycle parameters, with an EC50 of 2.8 mg

236 le fibrin limits the bacterial burden during sublethal listeriosis in wild-type mice, FXI-deficient m

237 inflammatory response elicited in mice by a sublethal LPS dose, and protected mice against a lethal

238 o showed enhanced bacterial clearance during sublethal lung infection.

239 Toward this goal, a controlled, sublethal, moderate drought (mDr) treatment system was d

240 In this study, a sublethal mouse MRSA pneumonia model was employed to inv

241 f co-encapsidation with APOBEC3G can promote sublethal mutagenesis of HIV-1 proviral DNA.

242 ormally shown, that APOBEC3G can also induce sublethal mutagenesis, which would maintain virus infect

243 OBEC3F and/or other deaminases may result in sublethal mutations that might facilitate viral diversif

244 opulations to determine how treatment with a sublethal NCR peptide affects the cell cycle and physiol

245 tantial transcriptional response elicited by sublethal NCR treatment that affected approximately 15%

246 te to the spectrum of neuropathology through sublethal neuronal injury.

247 es, decreases the size of varicosities after sublethal NMDA exposure, and protects neurons from NMDA-

248 e morphology and spine number in response to sublethal NMDA-induced excitotoxicity.

249 emicals affecting cardiovascular function at sublethal, nonteratogenic concentrations.

250 d significant cross-protection from either a sublethal or lethal influenza A viral challenge with a d

251 were created by conditioning recipients with sublethal or lethal irradiation, respectively, across di

252 ells expressing phospho-null mutant TRAF2 to sublethal oxidative stress results in a rapid degradatio

253 or necrotic cells we exposed fibroblasts to sublethal oxidative stress.

254 ock protein 70 (hsp70) were characterized at sublethal particle concentrations (25-50 mg/L).

255 We studied the effects of sublethal Pb exposure on immunity, carotenoid-based colo

256 sperm from oxidative stress in the event of sublethal Pb exposure.

257 tages, but we found simultaneous exposure to sublethal pesticide concentrations and Bd had no such ef

258 may affect aquatic ecosystems, we tested how sublethal pesticide concentrations modify body stoichiom

259 Previous studies reported effects of early sublethal pesticide exposure on amphibian Bd sensitivity

260 This study investigated the effect of sublethal physiological stressors on OMV production by P

261 We used an experimental model of sublethal polymicrobial sepsis induced by cecal ligation

262 nt cortical dronc activity is initiated by a sublethal pulse of the inhibitor of apoptosis protein (I

263 We conclude that sublethal radiation is a unique model of endogenous stre

264 ructure, and the inflammatory response after sublethal renal ischemia-reperfusion injury.

265 ature and hydrostatic pressure on lethal and sublethal (respiration rate, antioxidant enzyme activity

266 calanoid copepod, monitoring for lethal and sublethal responses.

267 mice were treated with Dbait alone (n = 20), sublethal RFA (n = 21), three different Dbait schemes an

268 (n = 21), three different Dbait schemes and sublethal RFA (n = 52), or a sham treatment (n = 18).

269 Sublethal RFA or Dbait treatment alone moderately improv

270 oropharyngeal aspiration model of lethal and sublethal S. marcescens pneumonia in BALB/c mice and ext

271 otics must be carefully deployed and not all sublethal sequential treatments succeed.

272 amming into pluripotent cells by exposure to sublethal stimuli, which we call stimulus-triggered acqu

273 investigate how these results can be due to sublethal stress impairing colony function.

274 failures, highlighting an important role for sublethal stress in colony declines.

275 activity remained low; however, exposure to sublethal stress resulted in hyperactive p53 and p53-dep

276 cell cycle arrest that occurs in response to sublethal stress.

277 c to multiple competitors, typically causing sublethal suppression of growth.

278 Conversely, a sublethal surface infection of worms with Verde1 conferr

279 We investigated the effects of sublethal TBI on T cell memory responses to gain insight

280 regulate stress-response systems to tolerate sublethal temperature exposures with climate change, whe

281 Despite the use of sublethal temperatures, all bacteria types were subseque

282 HSP70, an indication of cellular response to sublethal thermal stress.

283 area, by extending the focus from lethal to sublethal thiamine deficiency, and by linking biochemica

284 ciated with growth repression and hence need sublethal to lethal NP doses, which besides stopping fun

285 Sublethal total body gamma irradiation (TBI) of mammals

286 al emergency, we developed a murine model of sublethal total body irradiation (TBI).

287 TLI/ATS/CTX compared with TLI/ATS, lethal or sublethal total body irradiation/ATS/CTX, or CTX/ATS con

288 t C. riparius can indeed withstand long-term sublethal toxicant exposure through phenotypic plasticit

289 ctivity may be a useful complement to screen sublethal toxicity effects of chemicals.

290 method to remove PAHs and reduce lethal and sublethal toxicity in both species.

291 applied to investigate imidacloprid-induced sublethal toxicity in the central nervous system of the

292 rs used for rapidly assessing the lethal and sublethal toxicity of nZVI and its stabilized or oxidize

293 obust repair of DNA double-strand breaks and sublethal-type damage induced by gamma-rays, but not by

294 In response to sublethal ultraviolet B (UVB) irradiation, human keratin

295 In both cases, recurrent sublethal warming decreased embryonic survival and hatch

296 whether oxygen shortages might also underlie sublethal warming effects.

297 Here, we examine impacts of recurrent sublethal warming on development and survival in ecologi

298 compared to models that did not incorporate sublethal warming.

299 vitro clonogenic survival assays and in vivo sublethal whole body irradiation tests showed that Nrf2

300 Sublethal X-irradiation of frogs decreased leukocyte num