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1 ed parotid (47%), unstimulated submandibular/sublingual (23%), and stimulated submandibular/sublingua
3 ility decreased by 65% in parotid and 77% in sublingual acinar cells from Aqp5(-)/- mice in response
4 trast, the water permeability in parotid and sublingual acinar cells isolated from Aqp5(-)/- mice is
5 r nature of the Na+-H+ exchange mechanism in sublingual acinar cells, pH regulation was investigated
9 ently practiced, IT involves subcutaneous or sublingual administration of allergens, both methods of
12 endothelium-dependent dilatation), and after sublingual administration of nitroglycerin (an endotheli
19 (RIPK4), were downregulated after a 4-month sublingual AIT course concomitantly with an upregulation
21 en allergy before and after 2 or 4 months of sublingual AIT in parallel with rhinoconjunctivitis symp
22 omized clinical trial, house dust mite (HDM) sublingual AIT was found to be efficacious in moderate,
26 bcutaneous allergen immunotherapy (SCIT) and sublingual allergen immunotherapy (SLIT) are beneficial
27 bcutaneous allergen immunotherapy (SCIT) and sublingual allergen immunotherapy (SLIT) are safe and ef
36 ions the following responses were monitored: sublingual and mean skin temperatures, heart rate, beat-
38 omising observations include the efficacy of sublingual and oral immunotherapy, a Chinese herbal reme
40 ions, and to update recommendations for both sublingual and subcutaneous AIT for respiratory and veno
41 The Gauging Response in Allergic Rhinitis to Sublingual and Subcutaneous Immunotherapy (GRASS) trial
42 rse of immunologic changes during 2 years of sublingual and subcutaneous immunotherapy and for 1 year
44 urrently in clinical trials, including oral, sublingual, and epicutaneous immunotherapy, immunotherap
46 male rabbit harderian, lacrimal, mandibular, sublingual, and parotid glands and from liver, kidney, p
48 lated apple allergy were randomized to daily sublingual application of placebo (n = 20) or 25 mug of
49 s combined with different modes of delivery (sublingual, buccal, or oral) could be used to achieve bo
50 e efficacy and safety of very low dosages of sublingual buprenorphine as a time-limited treatment for
51 d placebo-controlled trial of ultra-low-dose sublingual buprenorphine as an adjunctive treatment.
52 prenorphine implants compared with continued sublingual buprenorphine did not result in an inferior l
54 ere abstinent while taking 8 mg/d or less of sublingual buprenorphine for 90 days or longer, and were
56 hine implants and 64 of 89 (71.9%) receiving sublingual buprenorphine maintained opioid abstinence (h
59 neonatal abstinence syndrome, treatment with sublingual buprenorphine resulted in a shorter duration
60 mited, short-term use of very low dosages of sublingual buprenorphine was associated with decreased s
61 hine implants and 78 of 89 (87.6%) receiving sublingual buprenorphine were responders, an 8.8% differ
62 years; 40.9% female), 90 were randomized to sublingual buprenorphine with placebo implants and 87 to
63 maintaining abstinence with a stable dose of sublingual buprenorphine, the use of buprenorphine impla
64 ltrexone (XR-NTX), an opioid antagonist, and sublingual buprenorphine-naloxone (BUP-NX), a partial op
66 s available if a threshold for rescue use of sublingual buprenorphine-naloxone treatment was exceeded
67 nza challenge model we found that a nasal or sublingual, but not vaginal, DNA prime/protein boost reg
69 centrations ([Mg(2+)](i)) were assessed from sublingual cells through x-ray dispersion (EXA) (normal
70 proach allows straight forward, dose-defined sublingual challenge tests in a high number of birch pol
72 icacy of AIT vaccines using subcutaneous and sublingual delivery pathways in large patient cohorts, e
74 oped for food allergies; these involve oral, sublingual, epicutaneous, or subcutaneous administration
78 ventions included subcutaneous (six trials), sublingual (four trials), oral or intradermal SIT in chi
79 was expressed in a restricted manner in the sublingual gland region of the tongue and the submucosal
81 (18)F-PSMA-1007 in muscle, submandibular and sublingual gland, spleen, pancreas, liver, and gallbladd
82 d 4.2-kilobase transcripts were found in rat sublingual gland, testis, small intestine, colon, and ov
87 attenuates mucous cell expression in murine sublingual glands with corresponding effects on mucin 19
88 removal of the parotid or the submandibular/sublingual glands, and diets in powder or pellet form.
89 otein secretion in parotid and submandibular/sublingual glands, and that the secretion patterns of MG
92 eactivity (both flow-mediated dilatation and sublingual glycerol trinitrate, markers of endothelial d
93 lium dependent) and response to 50 microg of sublingual glyceryl trinitrate (GTN, endothelium indepen
95 evere seasonal allergic rhinitis, 2 years of sublingual grass pollen immunotherapy was not significan
96 the second study, 15 male patients received sublingual GTN (500 microg) 1 h after sildenafil or plac
99 When RD-Ad and SC-Ad were tested by single sublingual immunization in rhesus macaques, SC-Ad genera
101 Thirty-six participants received 2 years of sublingual immunotherapy (daily tablets containing 15 mi
104 f timothy grass (TG) and dust mite (DM) dual sublingual immunotherapy (SLIT) and to begin to investig
107 actors of poor adherence to and dropout from sublingual immunotherapy (SLIT) by verifying patient bac
108 es suggest that oral immunotherapy (OIT) and sublingual immunotherapy (SLIT) for food allergy hold pr
110 017 after the first purchase of the drug for sublingual immunotherapy (SLIT) for Japanese Cedar polli
111 016 after the first purchase of the drug for sublingual immunotherapy (SLIT) for Japanese Cedar polli
112 erged regarding oral immunotherapy (OIT) and sublingual immunotherapy (SLIT) for the treatment of pea
113 y (SCIT) has been the gold standard, whereas sublingual immunotherapy (SLIT) has emerged as an effect
114 Both subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) have demonstrated effect
115 cacy of epicutaneous immunotherapy (EPIT) to sublingual immunotherapy (SLIT) in a model of mice sensi
116 abel study to assess the safety of cockroach sublingual immunotherapy (SLIT) in adults and children;
117 nvestigated efficacy and safety of high-dose sublingual immunotherapy (SLIT) in children allergic to
125 al-world, long-term efficacy of grass pollen sublingual immunotherapy (SLIT) tablets in AR and their
127 sought to compare the safety and efficacy of sublingual immunotherapy (SLIT) with 2 formulations cont
129 placebo-controlled clinical trial of peanut sublingual immunotherapy (SLIT), observing a favorable s
132 o indirectly compare the treatment effect of sublingual immunotherapy (SLIT)-tablets with pharmacothe
133 unotherapy (SCIT)-treated patients (n = 14), sublingual immunotherapy (SLIT)-treated patients (n = 12
135 leted 3 years of treatment with grass pollen sublingual immunotherapy (the SLIT-TOL group; n = 6), pa
139 urrent clinical approaches using peanut oral/sublingual immunotherapy are promising, but concerns abo
144 ebo-controlled randomized clinical trials of sublingual immunotherapy for respiratory allergic diseas
146 of evidence to support the effectiveness of sublingual immunotherapy for the treatment of allergic r
148 to-treat population, mean TNSS score for the sublingual immunotherapy group was 6.36 (95% CI, 5.76 to
149 reatment with subcutaneous immunotherapy and sublingual immunotherapy has been shown to improve sympt
152 ted the safety and clinical effectiveness of sublingual immunotherapy in a group of grass pollen-alle
153 evidence base for the efficacy and safety of sublingual immunotherapy in patients with HDM-induced AA
154 of this study was to determine the safety of sublingual immunotherapy in pregnancy, which has not yet
156 2 major studies have examined the effects of sublingual immunotherapy in subjects with peanut allergi
162 rapy with placebo, pharmacotherapy, or other sublingual immunotherapy regimens and reported clinical
163 edictable through early testing, (6) oral or sublingual immunotherapy show promise but also have cave
164 ore susceptible to adverse events (AEs) with sublingual immunotherapy tablet (SLIT-tablet) treatment,
165 as to investigate the effect of the SQ grass sublingual immunotherapy tablet compared with placebo on
166 ated efficacy and onset of action of the HDM sublingual immunotherapy tablet MK-8237 (Merck/ALK-Abell
169 diagnose, the efficacy of SQ house dust mite sublingual immunotherapy tablets has been demonstrated i
174 One hundred and fifty-five patients received sublingual immunotherapy with either house dust mite (D.
176 ased by more than 40% in 16 of 41 studies of sublingual immunotherapy with moderate grade evidence.
177 rolled trials were included if they compared sublingual immunotherapy with placebo, pharmacotherapy,
179 immunotherapy, including oral immunotherapy, sublingual immunotherapy, and, more recently, epicutaneo
180 ether 2 years of treatment with grass pollen sublingual immunotherapy, compared with placebo, provide
181 different administration techniques, such as sublingual immunotherapy, is common in Europe and is on
183 biological activity of clinically effective Sublingual immunotherapy, we used this method to determi
189 ined tolerability, dose-finding study with a sublingual liquid birch pollen preparation (SB) was cond
190 ere non-dysphagic, or intravenous labetalol, sublingual lisinopril, or placebo if they had dysphagia,
191 n phase is characterized by abnormalities in sublingual microcirculation and peripheral tissue perfus
193 nvestigated the effect of RBC transfusion on sublingual microcirculation in hemorrhagic shock patient
195 this study was to assess the time course of sublingual microcirculation in traumatic hemorrhagic sho
197 sidestream dark-field videomicroscopy of the sublingual microcirculation prior to and 2 hours after s
198 spective observational study to evaluate the sublingual microcirculation using side-stream dark-field
202 tion to standard hemodynamic assessment, the sublingual microcirculation was evaluated using sidestre
204 ite restoration of the macrocirculation, the sublingual microcirculation was impaired for at least 72
206 252 patients with severe sepsis in whom the sublingual microcirculation was visualized using orthogo
207 genation and side-stream dark-field-assessed sublingual microcirculation were unchanged by stopping a
212 supplementation attenuated the impairment in sublingual microvascular perfusion and permeability, whi
215 out the comparative efficacy of oxytocin and sublingual misoprostol, particularly at the recommended
217 sity ratios of oxy- vs. deoxyhemoglobin from sublingual mucosa correlated with co-oximetry values of
220 tate ranged from a high of 95% (avoidance of sublingual nifedipine for patients with acute stroke) to
223 beyond, subjects received repeated doses of sublingual nitroglycerin (0.4 mg) after the last dose of
224 (endothelium-dependent vasodilation) and to sublingual nitroglycerin (endothelium-independent vasodi
225 tation of the brachial artery to flow and to sublingual nitroglycerin (NTG) was recorded (conduit ves
227 ed dilatation (FMD) and the dilatation after sublingual nitroglycerin (NTG, 25 microgram) were measur
229 emodynamic interaction between tadalafil and sublingual nitroglycerin lasted 24 h, but was not seen a
230 4.5] episodes, p = 0.008), as was the weekly sublingual nitroglycerin use (1.7 [95% CI: 1.6 to 1.9] d
231 p to 2 agents, ranolazine reduced angina and sublingual nitroglycerin use and was well tolerated.
232 ersus placebo on weekly angina frequency and sublingual nitroglycerin use in subjects with type 2 dia
234 l artery endothelium-independent dilatation (sublingual nitroglycerin) did not differ among the group
235 eas endothelium-independent dilatation (EID; sublingual nitroglycerin) did not differ between groups.
239 herefore investigated the capacity of nasal, sublingual or vaginal delivery of DNA-PEI polyplexes to
240 udy was to determine the prognostic value of sublingual PCO2 (P(SL)CO2), lactate concentration, and m
241 ual buprenorphine plus 4 placebo implants or sublingual placebo plus four 80-mg buprenorphine hydroch
242 plants and 87 to buprenorphine implants with sublingual placebo; 165 of 177 (93.2%) completed the tri
251 as present in whole saliva and submandibular-sublingual saliva, but it was essentially absent from pa
252 amples from parotid secretion, submandibular/sublingual secretion, whole saliva, and pellicle were su
258 bility of insulin following intranasal (IN), sublingual (SL), intravaginal (I.Vag) and intrarectal (I
262 mulated whole and unstimulated submandibular/sublingual (SMSL) saliva as well as citrate-stimulated p
263 1 to twelve months of daily treatment with a sublingual solution of Dermatophagoides pteronyssinus an
264 tablets, sublingual tablets, buccal tablets, sublingual spray, transdermal ointment, and transdermal
265 to demonstrate the safety and efficacy of a sublingual standardized ragweed allergen immunotherapy l
267 ociated allergic rhinitis were given a daily sublingual tablet containing placebo or STG320 at a dose
268 seasonal treatment with 300IR 5-grass pollen sublingual tablet demonstrated clinically meaningful eff
269 th SQ (standardised quality) house dust mite sublingual tablet for 1 year resulted in a decreased pro
270 ty, and optimal dosage of the 5-grass pollen sublingual tablet for adults and children with grass pol
274 rolled study to receive 300IR 5-grass pollen sublingual tablet or placebo starting 4 months before an
276 ety and efficacy of rBet v 1 formulated as a sublingual tablet were assessed in a multicentre, double
277 from 11% [placebo] to 5% [SQ house dust mite sublingual tablet]) and an increased probability of havi
279 e-based treatment of opiate addiction with a sublingual-tablet formulation of buprenorphine and nalox
281 were assigned to office-based treatment with sublingual tablets consisting of buprenorphine (16 mg) i
282 ed clinical study evaluating the efficacy of sublingual tablets in an allergen exposure chamber over
283 atment using 2000 UA/day monomeric allergoid sublingual tablets is well tolerated and reduces the CPT
284 lve months of treatment with 500IR and 300IR sublingual tablets of HDM allergen extracts was efficaci
286 inary studies have suggested the efficacy of sublingual tablets of house dust mite (HDM) extracts in
287 ss the efficacy and safety of 2 doses of HDM sublingual tablets over 1 treatment year and the subsequ
289 r delivery via several routes: oral tablets, sublingual tablets, buccal tablets, sublingual spray, tr
290 large-scale clinical trials of grass pollen sublingual tablets, polysensitized patients benefited at
293 adigm in the treatment of PAH, using an i.v./sublingual tissue-penetrating homing peptide to selectiv
295 t Mal d 1 might be suitable and relevant for sublingual treatment of birch pollen-related apple aller
297 content of different house dust mites (HDM)' sublingual treatments and to review the evidence on thei
298 at muscarinic-induced mucin secretion by rat sublingual tubulo-acini was dependent upon PLC activatio
299 The questions of the cost-effectiveness of sublingual vs subcutaneous immunotherapy and of the cost
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