ライフサイエンスコーパス: submandibular

1 y glands (parotids, 0.031 +/- 0.011 mSv/MBq; submandibular, 0.061 +/- 0.031 mSv/MBq).

2 of 50 and 8 of 50 otic, 14 of 47 and 4 of 47 submandibular, 18 of 58 and 10 of 58 superior cervical,

3 a2+ release channels in pancreatic acini and submandibular acinar and duct cells.

4 2+)](i) were nearly abolished in P2X(7)(-/-) submandibular acinar and duct cells.

5 The current study tested whether submandibular acinar cell function also relies on these

6 e activity appears to be directly related to submandibular acinar cell loss in NOD-scid mice involvin

7 were also observed in freshly dispersed rat submandibular acinar cells but not in three immortalized

8 The membrane potential of submandibular acinar cells from wild-type mice remained

9 We found that the K(+) currents in submandibular acinar cells have the biophysical and phar

10 cusing on the membrane potential in isolated submandibular acinar cells revealed mechanistic details

11 ed that NOD-scid mice develop severe loss of submandibular acinar cells with concomitant appearance o

12 t ion channels in individual mouse and human submandibular acinar cells.

13 p progressive histopathologic lesions of the submandibular and lachrymal glands similar to NOD mice,

14 vere chronic periductal inflammation in both submandibular and lacrimal glands in contrast to the muc

15 nto several stages: 1) initial injury to the submandibular and lacrimal glands via an environmental i

16 The similar neonatal submandibular and parotid gland expression patterns obse

17 ry hypofunction is correlated with decreased submandibular and parotid gland sizes.

18 Saliva from the submandibular and parotid glands contained higher concen

19 d HEK cells and from the native pancreas and submandibular and parotid glands.

20 mucosal tissues, including human gingiva and submandibular and parotid glands.

21 , liver, and gut cells, and the pancreas and submandibular and pituitary glands.

22 higher uptake of (18)F-PSMA-1007 in muscle, submandibular and sublingual gland, spleen, pancreas, li

23 cin secreted by mucous acinar cells in human submandibular and sublingual glands.

24 ack of differentiated mucous acinar cells in submandibular and sublingual glands.

25 Similar results were obtained with submandibular and sublingual secretions.

26 virus-specific IgG2a was restricted to NALT, submandibular, and mesenteric lymph nodes.

27 e cranial ciliary, pterygopalatine, lingual, submandibular, and otic ganglia--arise from glial cells

28 to compare the susceptibilities of lacrimal, submandibular, and parotid cells to viral invasion.

29 progressively expanding lingual, sublingual, submandibular, and submental hematomas have the tendency

30 into the rat glioma cell line C6B4, the rat submandibular cell line RSMT-A5, and the rat pancreatic

31 operties of the conductances in lacrimal and submandibular cells were similar, e.g. halide selectivit

32 lar TNUR, 2-45 min; parotid DF, 20%-99%; and submandibular DF, 27%-98%.

33 rotid artery (eICA) stenoses, detectable via submandibular Doppler sonography and cervical magnetic r

34 s are co-expressed in the apical membrane of submandibular duct cells, consistent with the significan

35 Exogenous FGFs added to submandibular epithelial rudiments cultured without mese

36 chronic dermatitis with extensive facial and submandibular erosions.

37 termine variations in stimulated parotid and submandibular flow rates over 6 hours and to define sali

38 e mouse superior cervical ganglion (SCG) and submandibular ganglion (SMG) to examine the assembly of

39 pre- and postganglionic neurons in the mouse submandibular ganglion in vivo, focusing on the mechanis

40 maged nerve terminals in the parasympathetic submandibular ganglion.

41 Silencing Cav1 in human submandibular gland (HSG) cells decreased plasma membran

42 The culture of human submandibular gland (HSG) cells on laminin-1 induces aci

43 contribute to [Ca(2+)](i) increases in human submandibular gland (HSG) cells.

44 H+ exchanger (NHE) isoforms expressed in the submandibular gland (SMG) acinar and duct cells and thei

45 l-]i and the Cl- current in the rat salivary submandibular gland (SMG) acinar and duct cells was used

46 ned miRNAs expressed in the mouse developing submandibular gland (SMG) and found that miR-200c accumu

47 y studies have been done to understand mouse submandibular gland (SMG) branching morphogenesis, littl

48 a critical role for heparanase during mouse submandibular gland (SMG) branching morphogenesis.

49 Parasympathetic innervation is critical for submandibular gland (SMG) development and regeneration.

50 -inducible Cre recombinase Ela-CreERT in the submandibular gland (SMG) ductal cells, was established

51 Here, our results show that in primary mouse submandibular gland (SMG) epithelial cells, P2X7R activa

52 The mouse submandibular gland (SMG) epithelium undergoes extensive

53 f the vector to the parotid gland (PTG), the submandibular gland (SMG) or to the liver via the tail v

54 y the latter two develop inflammation in the submandibular gland (SMG), a critical target of Sjogren'

55 ery (BA), middle cerebral artery (MCA)], the submandibular gland (SMG), and pineal gland was quantifi

56 infiltration and caspase-3 activation in the submandibular gland (SMG), production of antinuclear and

57 being found only in the acinar cells of the submandibular gland (SMG).

58 nd the Cl- current were measured in isolated submandibular gland acinar and duct cells to characteriz

59 int of the Ca(2+)-activated Cl(-) current in submandibular gland acinar cells from Best2-deficient mi

60 In contrast, submandibular gland acinar cells from Tmem16A(-/-) mice

61 ected HEK293 cells and from the pancreas and submandibular gland also coimmunoprecipitated EBP50.

62 tive, non-vasomotor sympathetic axons in the submandibular gland and at the base of piloerector hairs

63 1 IFNR (IL14alphaTG.IFNR(-/-)) had the same submandibular gland and lacrimal gland injury as did the

64 lized in the plasma membrane region of human submandibular gland and Madin-Darby canine kidney cells.

65 sly and exogenously expressed TRPC1 in human submandibular gland and Madin-Darby canine kidney cells.

66 glands, specifically in acinar cells of the submandibular gland and palatine minor glands, as well a

67 termined by recording salivary flow from the submandibular gland and temperature changes on the tongu

68 SMGC is expressed in the submandibular gland at high levels through postnatal day

69 cover that decreasing MT-MMP activity during submandibular gland branching morphogenesis decreases pr

70 required for branching morphogenesis of the submandibular gland but not the lung.

71 g ClC-3, and ClC-3 protein, was found in rat submandibular gland by RT-PCR and Western analysis.

72 , htrp3, and Trp1 were detected in the human submandibular gland cell line (HSG).

73 ty fractions of Triton X-100-extracted human submandibular gland cell membranes.

74 tro stimulation with a muscarinic agonist of submandibular gland cells isolated from mice treated wit

75 Stimulation of human submandibular gland cells with carbachol, inositol trisp

76 In human submandibular gland cells, carbachol (CCh) induced flick

77 th or adhesion of B16-F10 melanoma and human submandibular gland cells.

78 regulating Ca2+ signaling in pancreatic and submandibular gland cells.

79 ivary gland cells as well as dispersed mouse submandibular gland cells.

80 Six patients had submandibular gland disease: three with primary neoplasm

81 renergic receptors) in pancreatic acinar and submandibular gland duct cells, respectively, evoke a Ca

82 and membrane current were measured in human submandibular gland ductal (HSG) cells to determine the

83 PC3 was detected in the apical region of rat submandibular gland ducts, whereas TRPC6 was present in

84 The most common manifestations were submandibular gland enlargement, macroglossia, and carpa

85 show that calcineurin is required for normal submandibular gland function and secretion of digestive

86 the question of a role for 5-HT in mammalian submandibular gland function was re-addressed, using iso

87 The mouse submandibular gland has been used as a model for major s

88 Submandibular gland lysates were examined by Western blo

89 ations of this stem cell population into the submandibular gland of irradiated mice successfully rest

90 tic ductal cells were injected into the left submandibular gland of the same hamsters.

91 Expression of TAg in the submandibular gland of transgenic mice from the time of

92 ional significance of FGFR1 was confirmed by submandibular gland organ culture.

93 measurements from time-lapse images of mouse submandibular gland organ explants to construct a tempor

94 chain reaction studies in cells of mammalian submandibular gland origin using consensus sequence prim

95 or agonists induced salivation in an ex vivo submandibular gland preparation.

96 ped large ductal-type adenocarcinomas in the submandibular gland region, where islets were transplant

97 ike the induced pancreatic tumors, all three submandibular gland tumors that were examined had the mu

98 bulated solid mass was detected in the right submandibular gland with similar sonographic findings.

99 or full-length hTrp1alpha in the HSG (human submandibular gland) cell line.

100 transcripts also are found in the pancreas, submandibular gland, and adult spleen.

101 ively influences gene expression in the male submandibular gland, and that many of the sex difference

102 f androgen control of gene expression in the submandibular gland, and to explore the degree to which

103 s observed in cultured cells in vitro and in submandibular gland, cortex, and caudate nucleus for as

104 ion of adenylyl cyclase and, at least in rat submandibular gland, involved in modifying the volume an

105 ncreased by LPS-induced periodontitis in the submandibular gland, returned to control values after HU

106 ce lacked comparable defects in the lung and submandibular gland, suggesting that MT1-MMP acts via me

107 Of the different cells isolated from the submandibular gland, this specific population, Lin-CD24+

108 ean dose, 0.26 Gy/GBq, was seen in the right submandibular gland, whereas the lowest mean dose, 0.029

109 nd correlated with acute inflammation in the submandibular gland.

110 ndrogens have profound effects on the murine submandibular gland.

111 tubule) cells of the neonatal rat and mouse submandibular gland.

112 anted, but none developed tumors in the left submandibular gland.

113 ression for all 10 known active genes is the submandibular gland.

114 at is essential for saliva production by the submandibular gland.

115 eptor regulates fluid secretion in the mouse submandibular gland.

116 15 and 5-lipoxygenase) is expressed in mouse submandibular glands (mSMG), using qPCR and Western blot

117 generation in a wound-healing model of mouse submandibular glands (mSMGs).

118 93), spinal cord (PRP, 64%; mean SUV, 2.12), submandibular glands (PRP, 53%; mean SUV, 2.11), parotid

119 ctive of this study was to determine whether submandibular glands (SMG) from ALX/FPR2(-/-) mice displ

120 sequently, this DC subset became resident in submandibular glands (SMGs) and nasal passages (NPs) in

121 Using ex vivo cultured embryonic mouse submandibular glands (SMGs) as models to study branching

122 issues such as the nasal passages (NPs), the submandibular glands (SMGs), and nasopharyngeal-associat

123 Salivary glands, such as submandibular glands (SMGs), are composed of branched ep

124 equired for branching morphogenesis of mouse submandibular glands (SMGs).

125 ated the function of laminin alpha5 in mouse submandibular glands (SMGs).

126 e acinar cells in developing rat parotid and submandibular glands and are also products of the sublin

127 s re-addressed, using isolated, perfused rat submandibular glands and dispersed-cell aggregates from

128 ved in cells isolated from mouse and opossum submandibular glands and rat sublingual and parotid glan

129 ein occurred in the nasal lamina propria and submandibular glands and the frequencies of CD11c+CD8+ d

130 When AdhAQP1 was administered to rat submandibular glands by retrograde ductal instillation,

131 , we report that ex vivo branching of intact submandibular glands decreases when either FGFR2 express

132 Immunohistochemical stainings of submandibular glands from C57BL/6.NOD-Aec1Aec2 mice and

133 Submandibular glands from NOD-scid mice exhibited the gr

134 alivation was suppressed by more than 70% in submandibular glands from P2X(7)-null mice.

135 cells as well as lymphocytic infiltrates in submandibular glands from patients with pSS demonstrated

136 F, and administration of beta-NGF from mouse submandibular glands induced ovulation in llamas.

137 t adenoviral-mediated gene transfer to mouse submandibular glands is possible by intraductal cannulat

138 Branching morphogenesis of mouse submandibular glands is regulated by multiple growth fac

139 respectively), AdhAQP1 administration to rat submandibular glands led to a two- to threefold increase

140 an hamsters were transplanted into the right submandibular glands of 50 female hamsters that were or

141 of immunoglobulin A (IgA) was studied in the submandibular glands of anaesthetized rats by stimulatin

142 on was upregulated upon radiation therapy in submandibular glands of both mice and humans.

143 y of a replication-deficient adenovirus-5 in submandibular glands of C57BL/6 mice through retrograde

144 Temporal expression of IL-17 and IL-23 in submandibular glands of C57BL/6.NOD-Aec1Aec2 mice correl

145 d enriched the number of functional acini in submandibular glands of irradiated animals and enhanced

146 The exocrine pancreas, liver, and submandibular glands of the rat were used to express and

147 rt a RCC case with metastasis to parotid and submandibular glands that has the same sonographic and s

148 pine-stimulated in vivo fluid secretion from submandibular glands was essentially normal in double-nu

149 diffuse lymphocytic infiltration was seen in submandibular glands, a major target of pSS, by age 6 wk

150 ences in ABPs secreted by mouse lacrimal and submandibular glands, and in ABPs secreted by male and f

151 This activity appeared in the submandibular glands, but not in the parotid glands.

152 caspase-3, lack of leukocyte infiltration of submandibular glands, reduced synthesis of disease-assoc

153 DNA levels were lower in the spleen than in submandibular glands, the number of individual viral gen

154 al saliva obtained from both the parotid and submandibular glands, with highest levels of activity pr

155 crease in NOS and BH4 biosynthetic enzyme in submandibular glands.

156 OC, of acinar and ductal cells in intact rat submandibular glands.

157 zed a stem cell population from adult murine submandibular glands.

158 on of the cannulated main excretory ducts of submandibular glands.

159 receptors were found in cell lines from the submandibular (HSG) and parotid (HSY) salivary glands.

160 and was removed under general anesthesia via submandibular incision.

161 These results demonstrate that the submandibular LN is the primary site for early clonal ex

162 e day 3 accumulation of KJ1-26+ cells in the submandibular LN was inhibited if the eye was removed wi

163 cells accumulated primarily in the draining, submandibular lymph node (LN) within 3 days.

164 25(+)FOXP3(+) cells and CD4/CD8 ratio in the submandibular lymph node (p < 0.05).

165 ng OVA peptide in vivo was only found in the submandibular lymph node and not in other lymph nodes, s

166 rP(Sc), was first detected in the tongue and submandibular lymph node at 1 to 2 weeks following inocu

167 anced STAT6 and decreased STAT4 induction in submandibular lymph node cells.

168 ll clonal expansion was only observed in the submandibular lymph node following conjunctival applicat

169 Subconjunctival and submandibular lymph node macrophages in mice given local

170 0(+) macrophage infiltration of gingival and submandibular lymph node tissues and significantly (p <

171 ease in F4/80(+) macrophages in gingival and submandibular lymph node tissues.

172 he a.c. OT-I T cells increased 9-fold in the submandibular lymph nodes and 3-fold in the spleen follo

173 Nasal mucosa-associated lymphoid tissue and submandibular lymph nodes initially accumulated PrP(d) a

174 ad bronchial tree-associated lymph nodes and submandibular lymph nodes that were 5-10 times larger th

175 including teeth and surrounding tissues, and submandibular lymph nodes were obtained for histomorphom

176 The animals were sacrificed, the submandibular lymph nodes were removed for FACS analysis

177 ity in the spleens, superficial cervical and submandibular lymph nodes, and inoculated eyes peaked at

178 in the spleen, the superficial cervical and submandibular lymph nodes, and the inoculated eye by lys

179 ans, including hypertrophy of the spleen and submandibular lymph nodes, glomerulonephritis, and periv

180 antigen was detected in the lung, hilar and submandibular lymph nodes, spleen, and colon.

181 8(+) T cells first appeared in the draining (submandibular) lymph node on day 5 and were detectable i

182 eful landmark in determining the origin of a submandibular mass.

183 Thirteen patients with 14 palpable submandibular masses, surgical and histologic confirmati

184 22-kilodalton protein was isolated from the submandibular (mental) gland of the male terrestrial sal

185 s indicated that the direct contact of mouse submandibular (mSMG) cell clusters and hHF-MSCs was not

186 These results indicate that a decrease in submandibular NO-BH4 protein expression may provide insi

187 andibular PP, 4%-31%; parotid NUR, 2.2-16.0; submandibular NUR, 1.4-16.2; parotid TNUR, 8-45 min; sub

188 causing intense burning rectal, ocular, and submandibular pain and flushing.

189 In contrast, GFRalpha1-deficient submandibular parasympathetic neurons retain normal resp

190 xpression of SLPI transcripts was evident in submandibular, parotid, and minor salivary glands from b

191 g ranges were observed: parotid PP, 22%-49%; submandibular PP, 4%-31%; parotid NUR, 2.2-16.0; submand

192 mbryonic cells are tagged by AID(cre) in the submandibular region, where conditional deletion of the

193 In addition, the introduction of the mouse submandibular renin (mRen-2d) transgene into Sprague-Daw

194 The submandibular saliva proteases were shown to be sensitiv

195 Human submandibular saliva reduces human immunodeficiency viru

196 dentify the salivary protein(s) responsible, submandibular saliva was fractionated by anion- exchange

197 In the present study, we have analyzed submandibular saliva, collected without contaminating ce

198 and stimulated glandular (i.e., parotid and submandibular) saliva flow rate and composition alterati

199 orted to affect electrolyte transport by the submandibular salivary gland (adrenaline, carbachol, iso

200 Cleft formation is the initial step in submandibular salivary gland (SMG) branching morphogenes

201 d H(+) and HCO3- transport mechanisms in the submandibular salivary gland (SMG) ducts of wild type, N

202 e-dependent regulatory role during embryonic submandibular salivary gland (SMG) morphogenesis.

203 The submandibular salivary gland (SMG), a major site of pers

204 ly, SERCA2b was found in the luminal pole of submandibular salivary gland acinar and duct cells.

205 pared the properties of native CaCC in mouse submandibular salivary gland acinar cells to the Ca(2+)-

206 were observed in both rat lacrimal gland and submandibular salivary gland acinar cells.

207 Cleft formation during submandibular salivary gland branching morphogenesis is

208 ifferentiation in early developing embryonic submandibular salivary gland buds.

209 e in mobilizing Ca2+ from internal stores of submandibular salivary gland but not pancreatic acinar c

210 ession of ryanodine receptor was detected in submandibular salivary gland cells but not pancreatic ac

211 ClC-3 was examined in rat lacrimal gland and submandibular salivary gland cells using RT-PCR and West

212 n profiles at five different stages of mouse submandibular salivary gland development provide insight

213 During murine submandibular salivary gland development, the vasculatur

214 The mouse submandibular salivary gland first appears as a single m

215 asympathetic innervation of the lacrimal and submandibular salivary gland is dramatically reduced in

216 T cells in nude mice receiving sham (submandibular salivary gland) or pituitary grafts alone

217 s of the small intestine and in cells of the submandibular salivary gland.

218 ration of tissue structure in the developing submandibular salivary gland.

219 urce of immature T cells in parotid (PG) and submandibular salivary glands (SMG) were studied in Fisc

220 In the present study we investigated whether submandibular salivary glands (SMGs) in F508 mice (Cftr(

221 ntly fewer focal inflammatory infiltrates in submandibular salivary glands and kidneys.

222 he role of LIMK signaling in mouse embryonic submandibular salivary glands using ex vivo organ cultur

223 re inoculated by retrograde perfusion of the submandibular salivary glands via Wharton's duct with tc

224 ithelial basal periphery in developing mouse submandibular salivary glands, and that ROCK inhibition

225 ical secretory tracks were also found in the submandibular salivary glands.

226 ove AAV-mediated gene transfer to the murine submandibular salivary glands.

227 iltration and parenchymal cell damage in the submandibular salivary glands.

228 ntly and focally in forming cleft regions of submandibular salivary-gland epithelia, accompanied by a

229 opoietin (hEPO) directly to individual mouse submandibular SGs.

230 Individual DLN (submandibular [SM]; superficial cervical [SC]; and inter

231 , namely parotid (PAG), sublingual (SLG) and submandibular (SMG) glands.

232 major salivary glands: the parotid (PG), the submandibular (SMG), and the sublingual glands (SLG).

233 cator space - 31 patients (82%), followed by submandibular space - 27 patients (71%).

234 ently involves masticator space, followed by submandibular space.

235 ranial parasympathetic ganglia including the submandibular, sphenopalatine and otic ganglia.

236 y(A)+ RNA isolated from harderian, lacrimal, submandibular, sublingual, and parotid glands and the li

237 s to blots of SDS-PAGE-separated parotid and submandibular-sublingual (SM-SL) saliva.

238 ory activity was present in whole saliva and submandibular-sublingual saliva, but it was essentially

239 35%), stimulated parotid (47%), unstimulated submandibular/sublingual (23%), and stimulated submandib

240 bmandibular/sublingual (23%), and stimulated submandibular/sublingual (39%) saliva.

241 ates for unstimulated whole and unstimulated submandibular/sublingual (SMSL) saliva as well as citrat

242 Removal of the submandibular/sublingual glands and changes in diet cons

243 sucrose diets, removal of the parotid or the submandibular/sublingual glands, and diets in powder or

244 bserved for protein secretion in parotid and submandibular/sublingual glands, and that the secretion

245 A digested submandibular/sublingual saliva sample was used for the

246 Parotid and submandibular/sublingual saliva samples and xerostomia q

247 microbial proteins in stimulated parotid and submandibular/sublingual saliva were determined.

248 encoded by MUC7), a major component of human submandibular/sublingual saliva, is a bacterial receptor

249 cin MG1 and other salivary proteins in human submandibular/sublingual secretion (HSMSL) could have a

250 Protein samples from parotid secretion, submandibular/sublingual secretion, whole saliva, and pe

251 en compared with the proteomes of parotid or submandibular/sublingual secretions.

252 cleavage of parotid secretory protein in the submandibular tissues.

253 bular NUR, 1.4-16.2; parotid TNUR, 8-45 min; submandibular TNUR, 2-45 min; parotid DF, 20%-99%; and s

254 Here we describe the under-investigated submandibular "whisker trident" on the rat's chin.