ライフサイエンスコーパス: submicromolar

1 (100-17,000 Da), and concentration (neat to submicromolar).

2 helical peptide (THP) when the substrate was submicromolar.

3 mean-graph midpoint (MGM) GI50 values in the submicromolar (0.033-0.630 muM) range.

4 ic folic acid can promote DNA damage by UVA, submicromolar 5-MTHF inhibits photosensitization-induced

5 n A inhibited the viral entry process with a submicromolar 50% inhibitory concentration (IC50) (IC50

6 array of in vitro assays, we have identified submicromolar (600 nM) N1L antagonists belonging to the

7 We show herein that RS67333 is also a submicromolar acetylcholinesterase (AChE) inhibitor and

8 However, a submicromolar active agent could be derived from 1 by th

9 were the most potent derivatives exhibiting submicromolar activities; among them monoesters are part

10 Compounds had submicromolar activity against Mycobacterium tuberculosi

11 most potent compounds, 7g and 13, exhibited submicromolar activity against the replicating bacteria

12 A number of compounds demonstrated submicromolar activity in a cell line model of prion dis

13 n-JNK inhibitors were identified that showed submicromolar activity in a cellular assay.

14 very of potent and selective inhibitors with submicromolar activity in cells and clear mechanism of a

15 roach afforded a series of compounds showing submicromolar activity in HCV replicon assays.

16 inhibit Shp2 over Shp1 and PTP1B with low to submicromolar activity.

17 We demonstrated submicromolar affinities for 2-OG and ferrous iron and H

18 in produces highly selective MRI probes with submicromolar affinities for small molecules.

19 approach led to macrocyclized peptides with submicromolar affinities for TNKS and high proteolytic s

20 aled two nipecotic acid derived binders with submicromolar affinities.

21 proinflammatory cysteinyl leukotrienes with submicromolar affinities.

22 in both bound alongside actin filaments with submicromolar affinities.

23 the full-length Gag, binds the membrane with submicromolar affinities.

24 ns the myo-inositol ligand, which binds with submicromolar affinity (0.76 +/- 0.08 muM).

25 regions on the target guanylate cyclase with submicromolar affinity (apparent KD-values of 663 +/- 12

26 2a-CRIg dimer bound C3b-coated surfaces with submicromolar affinity (KD).

27 e ZA loop of Brd4, leading to compounds with submicromolar affinity and cellular target engagement.

28 remained bound to the side of F-actin with a submicromolar affinity and did not nucleate actin polyme

29 s PHD, binds Lys4-trimethylated histone 3 in submicromolar affinity and has been reported to have the

30 less complex than ritonavir have comparable submicromolar affinity and inhibitory potency for CYP3A4

31 ed linked molecules that bind to RPA70N with submicromolar affinity and minimal disruption of RPA's i

32 5) inhibitor sildenafil was found to possess submicromolar affinity for AA2AR.

33 The PPAR-alpha agonist fenofibrate exhibited submicromolar affinity for both receptors (pKi CB1, 6.3

34 col was developed, which led to ligands with submicromolar affinity for FKBP51 and FKBP52.

35 cule database searches to identify hits with submicromolar affinity for the metastin receptor.

36 in MlcB binds the sole IQ motif of MyoB with submicromolar affinity in the absence and presence of Ca

37 n's disease, binds copper(II) ion (1:1) with submicromolar affinity in vitro.

38 Starting from Val-Pro-NHBu, a dipeptide of submicromolar affinity that had previously been generate

39 I J-protein family, bound DnaK2 or HtpG with submicromolar affinity, and HtpG bound DnaK2 with microm

40 e compound, termed VU590, inhibits ROMK with submicromolar affinity, but has no effect on Kir2.1 or K

41 se soluble construct binds the receptor with submicromolar affinity.

42 point for the development of inhibitors with submicromolar affinity.

43 ) and heparin is mainly enthalpy driven with submicromolar affinity.

44 en activators, plasmin, and plasminogen with submicromolar affinity.

45 on constants for all 12-mer sequences having submicromolar affinity.

46 -methylated at lysine 9 (H3K9me3/H3K9me2) in submicromolar affinity.

47 l fragment associates with microtubules with submicromolar affinity.

48 the C-terminal portion of the MIIA rod with submicromolar affinity.

49 mal glycoprotein that binds cholesterol with submicromolar affinity.

50 e cytoplasmic domain of ATP1A1 and FGF2 with submicromolar affinity.

51 roline-rich (PxxP) motif of Aplip1/JIP1 with submicromolar affinity.

52 e EF-Tu switch I region bound to AbDsbA with submicromolar affinity.

53 ychotic, although it displays only moderate (submicromolar) affinity for the dopamine D(2) receptor.

54 that rTp34 bound human lactoferrin at high (submicromolar) affinity.

55 VU590 was the first publicly disclosed, submicromolar-affinity (IC50 = 0.2 muM), small-molecule

56 e discovery and characterization of VU041, a submicromolar-affinity inhibitor of Anopheles (An.) gamb

57 anced, multifunctional profile consisting of submicromolar ALR2 inhibitory efficacy (IC50=0.99+/-0.02

58 -V27A and A/M2-L26F mutant ion channels with submicromolar and low micromolar IC50, respectively.

59 ory activity toward BChE with IC50 values in submicromolar and micromolar range and exhibited selecti

60 Instead, several gold analogues show submicromolar and selective antimicrobial activity again

61 high CBR affinity with Ki values within the submicromolar and subnanomolar ranges with interesting m

62 NO coordinates tightly to CYP125 and CYP142 (submicromolar) and with a lower affinity (micromolar) to

63 features, including low nanomolar InhA IC50, submicromolar antimycobacterial potency, and improved ph

64 ed a group of fluorine-substituted SBAs with submicromolar antiviral activity against HBV in human he

65 The six-residue cPT 9 (AAR029b) exhibited submicromolar antiviral potencies in inhibiting cell inf

66 usly and rapidly phase-separate from dilute (submicromolar) aqueous solutions into characteristic 'FG

67 Ti surface from dilute aqueous solution with submicromolar binding affinities as determined by ELISA

68 long as the individual ligands had at least submicromolar binding affinities, they could be linked w

69 This is the first time that submicromolar binding affinity has been achieved for thi

70 the name of O-methylcorypalline), displayed submicromolar binding affinity toward the alpha4beta2 nA

71 th ERCC1 to form a stable complex exhibiting submicromolar binding affinity.

72 e and surface plasmon resonance studies show submicromolar binding of copper/iron to NEILs but not OG

73 rthodox i,i+6 stapled peptide with improved, submicromolar binding to Ctf4.

74 from the rod photoreceptor is stimulated by submicromolar Ca(2+) and exhibits an unusually shallow d

75 esicles by hindering premature exocytosis at submicromolar Ca(2+) concentrations, whereas the N-termi

76 In bilayer experiments, at submicromolar [Ca2+], the purified VDAC or isolated OMM

77 We show that MmaK is indeed gated by submicromolar cAMP and approximately 10-fold higher conc

78 sulfamoylphenyl)-purine derivative exhibited submicromolar CDK2-inhibitory activity by virtue of engi

79 M2 and MDMX with nanomolar affinities, shows submicromolar cellular activities in cancer cell lines i

80 imH in a fluorescence polarization assay and submicromolar cellular activity in a hemagglutination (H

81 dine derivatizations provided compounds with submicromolar cellular FAK inhibition potential.

82 r cholesterol 27-hydroxylation either in the submicromolar (clevidipine, delavirdine, etravirine, fel

83 nable to image nuclear DNA in fixed cells at submicromolar concentration ([TP-2Bzim] = 100 nM) and to

84 ompounds inhibited tubulin polymerization at submicromolar concentration and inhibited cell growth at

85 d interrupts the lytic cycle of T. gondii at submicromolar concentration by targeting ASP3.

86 termination of trihalomethanes (THMs) at the submicromolar concentration level in water.

87 he NW sensors were found to be sensitive for submicromolar concentration of DA.

88 well-folded protein substrates using only a submicromolar concentration of enzyme.

89 inhibition of HDAC6 with IC50 values in the submicromolar concentration range.

90 ensitivity toward RSNO concentrations in the submicromolar concentration range.

91 adiolabeling studies showed that macropa, at submicromolar concentration, complexed all (225) Ac (26

92 generation and to stimulate fibrinolysis at submicromolar concentration.

93 In slice cultures, submicromolar concentrations (0.001 microm) of C11 produ

94 In support, Cd(2+) at submicromolar concentrations (50-100 nm) enhanced lock-u

95 phenol (4-MmC)] inhibits channel activity at submicromolar concentrations (IC(50) = 0.34 +/- 0.08 muM

96 layed potent antiproliferative properties at submicromolar concentrations (IC50 values; 100-500 nM),

97 At submicromolar concentrations 24(S)-HC potentiates NMDAR-

98 ion-dependent self-association that began at submicromolar concentrations and proceeded to dimer and

99 We find that BID BH3 peptide alone at submicromolar concentrations cannot activate BAX or comp

100 s (HCV) NS5A protein is virocidal for HCV at submicromolar concentrations in vitro.

101 We determined that CDDO analogues at submicromolar concentrations induce apoptosis of culture

102 recombinant neurexin to cultured neurons at submicromolar concentrations induced the same suppressio

103 n release ATP at levels that account for the submicromolar concentrations measured in the cochlear fl

104 dependence of calpain on calcium exceeds the submicromolar concentrations normally observed in cells.

105 ls that the 5-HT(5A) current is activated by submicromolar concentrations of 5-HT, is inwardly rectif

106 1252-resistant strains remained sensitive to submicromolar concentrations of AFN-1252, which blocked

107 Moreover, submicromolar concentrations of AZ-TAK1, a novel ATP-com

108 c integrity at either dose, however, whereas submicromolar concentrations of C11 did not interfere wi

109 Moreover, we demonstrate that addition of submicromolar concentrations of C1ql proteins to culture

110 Physiologic submicromolar concentrations of DIM protected cultured c

111 2, revealed significantly improved growth at submicromolar concentrations of exogenous heme.

112 th 24p3R or distal tubule cells internalized submicromolar concentrations of fluorescence-coupled pro

113 ear polarization allows for the detection of submicromolar concentrations of fluorinated small molecu

114 ose parallel with stomatal closure evoked by submicromolar concentrations of H2S.

115 PMCAs use energy derived from ATP to extrude submicromolar concentrations of intracellular Ca2+ ([Ca2

116 and catalase activities (Hpx(-)) accumulate submicromolar concentrations of intracellular H(2)O(2).

117 Herein, we demonstrate that submicromolar concentrations of palmitoyl-CoA inhibit gl

118 human plasma and milk were found to contain submicromolar concentrations of protein N-linked Hcy, wh

119 In the present study submicromolar concentrations of taxol, mimicking concent

120 Submicromolar concentrations of the bisindenoisoquinolin

121 ptors in that they are potently inhibited by submicromolar concentrations of zinc and copper.

122 ating lack of NR2B subunits, and no block by submicromolar concentrations of zinc, consistent with NR

123 ontaining the KA1 subunit being sensitive to submicromolar concentrations of zinc.

124 which was alleviated by supplementation with submicromolar concentrations of Zn.

125 sts were cocultured with gammadelta cells in submicromolar concentrations of ZOL, we show that Vgamma

126 ress rimantadine resistance polymorphisms at submicromolar concentrations, and show activity against

127 bits growth of cancer cell lines in vitro at submicromolar concentrations, and significantly suppress

128 At submicromolar concentrations, E-12-NO2 derivatives were

129 Prefibrillar Abeta42 was active at submicromolar concentrations, several-fold below those r

130 ulin and inhibited tubulin polymerization at submicromolar concentrations.

131 ch appears to stabilize this G-quadruplex at submicromolar concentrations.

132 r l-allo-Ile inhibited carboxypeptidase A at submicromolar concentrations.

133 e entry of cell culture grown HCV (HCVcc) at submicromolar concentrations.

134 es not undergo dissociation upon dilution to submicromolar concentrations.

135 ophilin is dimeric in the cytoplasm, even at submicromolar concentrations.

136 fungal activity against filamentous fungi at submicromolar concentrations.

137 TR human bronchial epithelial (hBE) cells at submicromolar concentrations.

138 in some AML cell lines, induced apoptosis at submicromolar concentrations.

139 e shown to potently inhibit HCV infection at submicromolar concentrations.

140 cancer cells with K-Ras mutations at low or submicromolar concentrations.

141 he viability of several lung cancer lines at submicromolar concentrations.

142 C 724998 exert antiproliferative activity at submicromolar concentrations.

143 ytopathic effect of HIV-1RF and HIV-1IIIB at submicromolar concentrations.

144 only selectively depolarizes mitochondria at submicromolar concentrations.

145 t the human prostate cancer cell line PC3 at submicromolar concentrations.

146 , as well as malaria parasites in culture at submicromolar concentrations.

147 2-induced monomethylation of p53 Lys(370) at submicromolar concentrations.

148 ii is susceptible to hBD-2 and -3 killing at submicromolar concentrations.

149 that shows in vitro cytotoxic activities at submicromolar concentrations.

150 clinically relevant mycobacterial species at submicromolar concentrations.

151 rated in buffer and in serum with associated submicromolar detection limits as low as 190 nM (buffer)

152 ncentration method to boost sensitivity with submicromolar detection limits for iodide (S/N approxima

153 of ISEs, yielding functional electrodes with submicromolar detection limits.

154 d at physiologically relevant micromolar and submicromolar DIM concentrations when cells were exposed

155 , and by the quantitative measurement of the submicromolar dissociation constant Kd (0.2 muM) of the

156 sugar were essential for achieving a low-to-submicromolar dissociation constant that was only slight

157 a biphasic response, as they accumulated at submicromolar doses and then decreased with increasing A

158 Submicromolar doses of S-norfluoxetine (S-NFLX) that are

159 ld-type and splice variant isoforms of AR at submicromolar doses.

160 e than half of the compounds tested showed a submicromolar EC(50) against these parasites.

161 ative activity in K562 and MV4-11 cells with submicromolar EC(50) values.

162 Several compounds from this study exhibited submicromolar EC50 values against S31N-containing A/WSN/

163 isotherms generated using DIS272(2AP) yields submicromolar EC50 values for paromomycin (0.5 +/- 0.2 m

164 t yielded a number of potent antivirals with submicromolar efficacy against several human clinical is

165 vokes endocannabinoid release in response to submicromolar elevation of dendritic calcium that transi

166 omatic substitution did yield compounds with submicromolar enzymatic inhibition.

167 in the identification of a lead series with submicromolar enzyme inhibition, high ligand efficiency,

168 ided the optimization of the series yielding submicromolar enzyme inhibitors with promising cellular

169 l half of ZO-1 form stable homodimers with a submicromolar equilibrium dissociation constant.

170 Analogues such as 9a, b and 12a, d yielded submicromolar GI50 values in both cell lines; however, n

171 Surprisingly, submicromolar H(2) O(2) poisoned the Isc machinery, ther

172 enhanced activity profiles, including 6 with submicromolar half maximal inhibitory concentrations.

173 nt that low concentration (few micromolar to submicromolar), highly turbid subglacial meltwater could

174 Structural modification of the submicromolar hit compound 3 led to the potent 3-methoxy

175 o the identification of MtGS inhibitors with submicromolar IC(50) values and promising antituberculos

176 them, 13 compounds were identified as having submicromolar IC(50) values.

177 mpound 90, which inhibited the enzyme with a submicromolar IC50 (0.162 muM), capable of inhibiting th

178 We find that PGG inhibits CMG2 with a submicromolar IC50 and it also inhibits the migration of

179 ylphosphanes, was the most efficacious, with submicromolar IC50 concentrations.

180 a bone marrow-sparing compound, exhibited a submicromolar IC50 in 10 of 10 multiple myeloma cell lin

181 reaching of P-gp inhibitory activity at the submicromolar IC50 level.

182 iguration on cytotoxicity was confirmed with submicromolar IC50 values against HCT116 cells.

183 prostate cancer cells with low micromolar to submicromolar IC50 values as well as markedly enhanced a

184 nd kills G. lamblia trophozoites in vitro at submicromolar IC50 values.

185 M2 V27A mutant ion channel, one of them with submicromolar IC50.

186 techol) substituted thienopyrimidinones with submicromolar in vitro activity against both wild type H

187 h isomeric series) exerted low micromolar or submicromolar in vitro cytostatic activities against a b

188 w structural classes of GPR119 agonists with submicromolar in vitro potencies.

189 rations are able to stimulate physiological (submicromolar) increases in cGMP concentration in an act

190 ow 10 muM, with the best compound exhibiting submicromolar inhibition (IC50 = 0.8 muM).

191 h structural class, CM026 and CM037, exhibit submicromolar inhibition constants but have different me

192 )piperazine-1-carbothioamides, which exhibit submicromolar inhibition of bacterial Sfp-PPTase with no

193 bit low nM inhibition of both LDHA and LDHB, submicromolar inhibition of lactate production, and inhi

194 tural characterization of a highly selective submicromolar inhibitor of ALDH3A1, 1-[(4-fluorophenyl)s

195 ound 16 was identified as a highly selective submicromolar inhibitor of BuChE (huBuChE IC50 = 0.443 m

196 1,4]thiazine-6-carboxamide, 11 (ML276), is a submicromolar inhibitor of PfG6PD (IC(50) = 889 nM).

197 inhibit Tdp1 and identified compound 50 as a submicromolar inhibitor of Tdp1 (IC(5)(0) = 0.87 muM).

198 This compound was also found to be a submicromolar inhibitor of the class C ADC-7 and PDC-3 b

199 Initial fragment hit optimization led to a submicromolar inhibitor, which was cocrystallized with P

200 hibitors of this class of enzymes, achieving submicromolar inhibitors for ERAP2 (IC50 = 237 nM) and I

201 th a (3R)-hydroxyl configuration, are low to submicromolar inhibitors of beta-N-acetylhexosaminidases

202 series of compounds is the first example of submicromolar inhibitors of bromodomains outside the BET

203 Approximately 60% of the submicromolar inhibitors of PfKASIII inhibited in vitro

204 s revealed that four hasubanan alkaloids are submicromolar inhibitors of the N87 cell line.

205 and (SID7970631), were identified as potent submicromolar inhibitors, yielding IC(50) values of 760

206 the PPI between stonin2 and Eps15, producing submicromolar inhibitors.

207 hate pathway, in particular, was poisoned by submicromolar intracellular H(2)O(2).

208 vealed a specific Mn(2+) binding site with a submicromolar K(D).

209 (Cdc4) and makes a major contribution to the submicromolar K(m) of Cdc34 for SCF(Cdc4).

210 rous drug-protein interactions determine the submicromolar Kd of posaconazole for CYP46A1.

211 The aptamer binds to each dye with submicromolar KD values, and the resulting fluoromodules

212 Herein we describe the discovery of submicromolar ketohexokinase inhibitors with promising d

213 ing studies, granting a lead compound with a submicromolar Ki.

214 A round of optimization resulted in 11 new submicromolar KOR binders (best Ki = 90 nM).

215 detection for sulfide and cyanide are in the submicromolar level, with a linear dynamic range up to 1

216 also demonstrated that extracellular ATP at submicromolar levels apparently affected outer hair cell

217 lotriazadisulfonamide (CADA) inhibits HIV at submicromolar levels by specifically down-modulating cel

218 lotriazadisulfonamide (CADA) inhibits HIV at submicromolar levels by specifically down-modulating cel

219 tric detection of S-nitrosothiols (RSNOs) at submicromolar levels in blood samples is of potential im

220 ation of NsrR appeared to be a result of the submicromolar levels of NO released from GSNO and did no

221 At submicromolar levels, FRP-alphabeta was significantly mo

222 several micromolar, followed by recovery to submicromolar levels.

223 ions were scaled up and, after purification, submicromolar ligands based on two scaffolds with no pre

224 iability of PLC5, Huh7, and Hep3B cells with submicromolar median inhibitory concentration (IC(50)) v

225 ation of 70 PDZ domains showed that ~40% had submicromolar membrane affinity.

226 he effort led to more than 10 compounds with submicromolar MICs and desirable physicochemical propert

227 omolar IC(50) values versus E. coli MurB and submicromolar minimal inhibitory concentrations (MIC) ag

228 Several compounds had submicromolar minimum inhibitory concentrations (MIC) ag

229 ese new agents are robust enough to maintain submicromolar PDT in pigmented metastatic melanoma cells

230 anules in the early embryo, with an apparent submicromolar phase boundary comparable to that measured

231 the compound 8a was selected as a selective submicromolar phosphodiesterase-4 (PDE4) inhibitor assoc

232 Molecule 1 had submicromolar photocytotoxicities to cells that were eng

233 wever, this Kd is still much higher than the submicromolar physiological I(-) concentration.

234 iferation, migration and tube formation with submicromolar potencies (IC(50), 0.1-1.0 microM) compara

235 n the first AZT-derived 1,2,3-triazoles with submicromolar potencies against HIV-1.

236 ere later combined to produce analogues with submicromolar potencies, including 6-trifluoromethyl-3H-

237 discovery of multiple PRMT3 inhibitors with submicromolar potencies.

238 13755 (an arylstibonic derivative) displayed submicromolar potency (average IC(50) of 0.59 and 0.93 m

239 ML375 is a highly selective M5 NAM with submicromolar potency (human M5 IC50 = 300 nM, rat M5 IC

240 f P2X4 currents by extracellular BX430, with submicromolar potency (IC50 = 0.54 microM).

241 oacid hybrids, the majority of which exhibit submicromolar potency against 3'-end processing and stra

242 be a selective HCV NS5A inhibitor exhibiting submicromolar potency against both G-1a and G-1b replico

243 es, high activity in cell-free assays, and a submicromolar potency against T315I Bcr-Abl expressing c

244 a series of highly selective mGlu3 NAMs with submicromolar potency and good CNS penetration.

245 acarbocyanine iodide (compound 11), retained submicromolar potency and had calculated physical proper

246 ve compound 13, which unexpectedly displayed submicromolar potency as a partial agonist at PPARalpha

247 otency; we show that diminazene indeed has a submicromolar potency at ASIC1a (IC50 0.3 muM).

248 Compounds 9b and 9c showed submicromolar potency at both human and rat mGluR4.

249 O-B, high hMAO-B over hMAO-A selectivity and submicromolar potency at hAChE.

250 th native and T315I variants of BCR/ABL with submicromolar potency but showed nonspecific cellular to

251 hibit both SPP and gamma-secretase, but with submicromolar potency for SPP.

252 ited melanoma cell growth via apoptosis with submicromolar potency while sparing healthy cells.

253 hereby inhibits fatty acid biosynthesis with submicromolar potency.

254 roisocytosines were efficiently optimized to submicromolar potency.

255 ery of a novel series of GPR40 agonists with submicromolar potency.

256 y, is <100 nM potent against HDACs 2 and 10, submicromolar potent against HDACs 1, 8, and 11, and >50

257 finding a clear concentration dependence at submicromolar protein.

258 by iterative structure-based design to give submicromolar pyrazolopyridines with good ligand efficie

259 s were bactericidal for the export mutant in submicromolar quantities.

260 ith direct enzyme inhibiting activity in the submicromolar range (IC(50): 0.13-0.37 muM) were designe

261 omethyl substituents, with TPI values in the submicromolar range and cytotoxicities in the subnanomol

262 ost promising inhibitor, with an IC50 in the submicromolar range and high selectivity, relative to al

263 nsubstituted subtype 11 inhibited RNase H in submicromolar range and RT polymerase in low micromolar

264 cence sensing technique for glutamine in the submicromolar range based on the glutamine binding prote

265 These inhibitors display K(I) values in the submicromolar range for both sphingosine kinases and, in

266 -2 at median effective concentrations in the submicromolar range in ex vivo lymphoid and cervicovagin

267 inum complexes exhibiting IC50 values in the submicromolar range in the A2780 cell line.

268 with a 1:1 stoichiometry and affinity in the submicromolar range similar to that observed for binding

269 d in vitro potency with IC(50) values in the submicromolar range was attained with electron-withdrawi

270 possess anti-inflammatory activities in the submicromolar range with low cytotoxicity, and that the

271 nc complexes typically reached values in the submicromolar range with low toxicity in the dark (TC50

272 n the physiologically relevant micromolar to submicromolar range with the TGACGTCA canonical motif af

273 nds are highly potent on cancer cells in the submicromolar range without any toxicity on healthy cell

274 ists) but very potent TLR4/MD-2 antagonists (submicromolar range).

275 ese compounds inhibited WNV infection in the submicromolar range, had selectivity indices of greater

276 the presence of hepcidin, with IC(50) in the submicromolar range.

277 yed AC(50) values for PDK1 activation in the submicromolar range.

278 cooperatively with a binding constant in the submicromolar range.

279 n the physiologically relevant micromolar to submicromolar range.

280 tors of beta-N-acetylglucosaminidases in the submicromolar range.

281 strongly self-associates with a K(d) in the submicromolar range.

282 ent inhibition of fusion with an IC50 in the submicromolar range.

283 potent inhibitors having K(I) values in the submicromolar range.

284 ant (K1) P. falciparum strains in the low to submicromolar range.

285 at inhibit ClpP1P2 peptidase activity in the submicromolar range.

286 RNase H and polymerase with IC50s in low to submicromolar range.

287 e growth of the parasite with IC50 values in submicromolar range.

288 ressing Ca(v)3.3, with Ki in a micromolar or submicromolar range.

289 Submicromolar-range activities were observed against wil

290 ics with respect to Ubc5 concentration, with submicromolar [S]0.5 and Hill coefficients of 3-5, sugge

291 Nevertheless, submicromolar S100A1 can alter RyR function, an effect t

292 re performed on both targets, resulting in a submicromolar (sEH IC50 = 0.3 muM/PPARgamma EC50 = 0.3 m

293 diates Ca(2+)-dependent Cl(-) transport with submicromolar sensitivity to Ca(2+), consistent with wha

294 The 1-Zn(II) NDP sensor assay offers submicromolar sensitivity, compatibility with both purif

295 n Ca(2+) signals differ vastly from the slow submicromolar signals routinely observed in bulk cytopla

296 New analogues have been identified with submicromolar SIRT2 inhibtory activity and good to excel

297 d X-ray crystallography, that high-affinity (submicromolar) substrate binding to the OM long-chain fa

298 examined in vitro as a function of time and submicromolar tau concentrations using electron microsco

299 tor, nonsuppressed detection permits LODs of submicromolar to double digit micromolar for a variety o

300 ATP-bound form of myosin IIIA from actin is submicromolar, which agrees well with the low K(actin).