ライフサイエンスコーパス: submucosal gland

1 reflect a profound decrease in the number of submucosal glands.

2 ononuclear leukocytes and in serous cells of submucosal glands.

3 regular mucosal surface, and (3) presence of submucosal glands.

4 triggers CFTR-dependent ASL secretion by the submucosal glands.

5 h well developed respiratory bronchioles and submucosal glands.

6 NK-1 receptor mRNA was localized to submucosal glands.

7 he surface epithelia and serous cells of the submucosal glands.

8 ay as well as serous and mucous cells of the submucosal glands.

9 did not modulate exocytosis from the deeper submucosal glands.

10 periglandular ganglion plexuses surrounding submucosal glands.

11 secretion via muscarinic M3 receptors on the submucosal glands.

12 olin-stimulated mucus secretion from porcine submucosal glands (75 glands, 7 pigs).

13 onsequent reduction in mucus production from submucosal glands and bronchodilation have been proposed

14 ciliated respiratory epithelium and cells of submucosal glands and ducts.

15 ssociations in airways that contain abundant submucosal glands and goblet cells are uncertain.

16 bsence of goblet cells in tracheal/laryngeal submucosal glands and in the conducting airway epitheliu

17 ted expression of SPLUNC1 in serous cells of submucosal glands and surface epithelial cells of the up

18 way smooth-muscle tone, mucus secretion from submucosal glands and surface epithelial goblet cells, v

19 T is a primary defect in CF, suggesting that submucosal glands and tethered mucus may be targets for

20 ate that AQP5 facilitates fluid secretion in submucosal glands and that the luminal membrane of gland

21 Whereas both mouse and human submucosal glands and their serous acinar cells express

22 chanisms of salt and water secretion by lung submucosal glands, and they suggest that while murine su

23 al membrane of the airway epithelium, airway submucosal glands, and type 1 pneumocytes, where it can

24 Airway submucosal glands are important sites of cystic fibrosis

25 Airway submucosal glands are sites of high expression of the cy

26 In human airways, oxidative stress-induced submucosal gland cell hypertrophy and hyperplasia, histo

27 nels in excised membrane patches from a lung submucosal gland cell line.

28 by luminal hyaluronan (HA), and treatment of submucosal gland cells with X/XO induced HA depolymeriza

29 ypertonic interstitium at all times, and the submucosal glands constantly secrete ions and accompanyi

30 que, we have compared fluid transport across submucosal gland cultures from individuals with and with

31 1 expression alone is insufficient to induce submucosal gland development.

32 The muscarinic M1 receptors localized to the submucosal glands do not appear to be involved with mucu

33 We found that MUC5B emerged from submucosal gland ducts in the form of strands composed o

34 ared with non-CF, MUC5B more often filled CF submucosal gland ducts.

35 2 mRNAs are expressed in excised surface and submucosal gland epithelia from non-CF and CF patients.

36 ed at mucosal surfaces, including airway and submucosal gland epithelia.

37 aCC conductance in human salivary and airway submucosal gland epithelial cells, and IL-4 treated bron

38 d can induce beta2-R function as assessed by submucosal gland exocytosis in vitro.

39 l glands, and they suggest that while murine submucosal gland fluid secretion in response to choliner

40 ding defective airway chloride transport and submucosal gland fluid secretion; variably penetrant mec

41 trate that LEF1 is functionally required for submucosal gland formation in the nasal and tracheal muc

42 Here, we studied individual submucosal glands from 1-day-old piglets in situ in expl

43 It has been proposed that defective submucosal gland function in CF airways is a major deter

44 Our results suggest that defective airway submucosal gland function is an early, primary defect in

45 We tested the hypothesis that submucosal gland function is defective early in CF subje

46 Airway submucosal glands have been proposed as a primary site f

47 osed NHPs developed robust mucus metaplasia, submucosal gland hypertrophy and hyperplasia, airway inf

48 smooth-muscle thickness; (2) goblet cell and submucosal gland hypertrophy and hyperplasia; and (3) ep

49 Goblet cell hyperplasia and submucosal gland hypertrophy are shared with other hyper

50 logy revealed similar size and morphology of submucosal glands in CF and non-CF specimens.

51 The potential role of submucosal glands in cystic fibrosis lung disease is dis

52 o measure SubP-mediated secretion from human submucosal glands in lung transplant tissue.

53 Fluid and macromolecule secretion by submucosal glands in mammalian airways is believed to be

54 Fluid and macromolecule secretion by submucosal glands in mammalian airways is believed to pl

55 he initiation and continued morphogenesis of submucosal glands in the airway.

56 airway epithelium and the epithelium of the submucosal glands in the paranasal sinuses.

57 the alveolar epithelium and the epithelia of submucosal glands in the upper airway and nasopharynx.

58 no increase in the number or size of airway submucosal glands, indicating that ectopic LEF1 expressi

59 These cells localize to proximal airway submucosal glands/intercartilagenous rings, neuroepithel

60 his distal gap segment (which has esophageal submucosal glands) is actually the dilated distal esopha

61 Submucosal gland morphology and density did not differ s

62 irway defenses include reflex stimulation of submucosal gland mucus secretion by sensory neurons that

63 g of fluid droplets secreted from individual submucosal glands near the larynx in living mice showed

64 ar exocytosis, presumably through actions on submucosal gland NK-1 receptors.

65 mmunohistochemical data revealed that within submucosal glands of sinonasal tissues, SPLUNC1 and LPLU

66 in ciliated airway epithelial cells and the submucosal glands of the lung.

67 We found that porcine submucosal glands produce MUC5B, whereas goblet cells pr

68 m, even without hyperviscous secretions from submucosal glands, produces an intrinsically hyperviscou

69 nding factor 1 (Lef1) gene is upregulated in submucosal gland progenitor cells just prior to gland bu

70 nhanced in airway surface epithelium and the submucosal gland region in ovalbumin-induced asthmatic m

71 ublingual gland region of the tongue and the submucosal gland region of the mouse trachea in a normal

72 ulator (CFTR) in airway epithelial cells and submucosal glands results in chronic pulmonary infection

73 The tracheobronchial submucosal glands secrete liquid that is important for h

74 to periciliary liquid depletion; rather, CF submucosal glands secreted mucus strands that remained t

75 ed, abolished the reflex changes in tracheal submucosal gland secretion (n=8); in these dogs mucosal

76 hat PDE3A inhibition augments CFTR-dependent submucosal gland secretion and actin skeleton disruption

77 There is evidence that defective submucosal gland secretion contributes to the airway pat

78 therapeutic approaches to correct defective submucosal gland secretion in CF.

79 IL-4 treated bronchial cells, and stimulated submucosal gland secretion in human bronchi and smooth m

80 teraction was investigated using pig trachea submucosal gland secretion model.

81 ere also exposed to bethanechol to stimulate submucosal gland secretion, when plastered mucus covered

82 d reflex increase in tracheal blood flow and submucosal gland secretion.

83 at regulate the tracheal circulation and the submucosal gland secretion.

84 t reflex increase in tracheal blood flow and submucosal gland secretions are mediated mainly via rele

85 Submucosal gland serous acinar cells are primary sites o

86 Here, submucosal gland serous acinar cells were isolated from

87 Calu-3 human cell line exhibits features of submucosal gland serous cells and secretes HCO(3)(-).

88 Airway submucosal gland serous cells express the cystic fibrosi

89 ignaling, primary cultures of human tracheal submucosal gland (SMG) cells were used to assess EGFR li

90 oride channels causes defective secretion by submucosal glands (SMGs), leading to persistent bacteria

91 ithelial-derived appendages including airway submucosal glands (SMGs).

92 Submucosal glands supply most of the mucus in upper airw

93 lizes to the surface epithelium and MUC5B to submucosal glands, the finding that Muc5b is secreted by

94 minal membrane of serous epithelial cells in submucosal glands throughout the mouse nasopharynx and u

95 n was sufficient for the induction of airway submucosal glands, two additional model systems were uti

96 The mechanism for increased submucosal gland volume in CF deserves further study.

97 c feature in the CF airway is an increase in submucosal gland volume, but serous cell transdifferenti

98 The volume of submucosal glands was fourfold higher than normal (p = 0

99 Secretions from individual submucosal glands were visualized by light/fluorescence

100 By analogy to salivary and submucosal glands, where fluid secretion is aquaporin-5

101 Muscarinic M1 and M3 receptors localized to submucosal glands, whereas M2 receptors did not.