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1 he PVTD did not associate with several known subnuclear addresses but was almost always perinucleolar
3 target gene regulatory enhancer regions to a subnuclear architectural structure that serves as an und
5 the nucleolus in spermatocytes, implicating subnuclear architecture in the regulation of terminal di
6 that it interacts with proteins involved in subnuclear architecture, notably nucleophosmin, a 38-kDa
8 myelinated fibers, we were able to correlate subnuclear areas in the mouse habenula to subnuclei, whi
9 A1 mutation in SNU-251 cells inhibited BRCA1 subnuclear assembly for DNA-damage repair and increased
10 ein transduction domain 4 (PTD4)], inhibited subnuclear assembly of RAD51 recombinase, and sensitized
11 f any one of the five paralog genes prevents subnuclear assembly of recombinase at damaged sites and
15 EAT1 (Menepsilon/beta) to form paraspeckles, subnuclear bodies that alter gene expression via the nuc
18 urons adopt medial (dHbm) and lateral (dHbl) subnuclear character at very different frequencies on th
19 ations in chromatin structure and changes in subnuclear chromatin localization in regulating var gene
20 iae found that this local silencing required subnuclear clustering of the tRNA genes near the nucleol
21 RNA polymerase II promoters is dependent on subnuclear clustering of the tRNA genes, but genetic ana
22 revealed that AGO4 and AGO6 differ in their subnuclear co-localization with RNA polymerases required
23 A large number of proteins found in this subnuclear compartment have no identifiable tie either t
24 of how and why these proteins end up in this subnuclear compartment remain unanswered and are the foc
25 , large-scale chromosome folding involving a subnuclear compartment switch of inaccessible chromatin.
26 ing that the Barr body represents a discrete subnuclear compartment that is not freely accessible to
27 RAG-1-RAG-2 complex nucleates a specialized subnuclear compartment that we call the 'V(D)J recombina
28 e neuroblast nuclear periphery, a repressive subnuclear compartment, precisely when competence to spe
30 A structure, specific histone modifications, subnuclear compartmentalization and primary DNA sequence
32 smic signal transduction, nuclear import and subnuclear compartmentalization, DNA repair, and transcr
34 Coilin protein scaffolds Cajal bodies (CBs)-subnuclear compartments enriched in small nuclear RNAs (
35 be a subset of global NER, restricted to the subnuclear compartments or chromatin domains within whic
36 otein (PML) nuclear bodies (NBs) are dynamic subnuclear compartments that play roles in several cellu
37 ns in vivo is their appropriate targeting to subnuclear compartments where their target genes are loc
38 nd directed accumulation of NHPX in distinct subnuclear compartments, and define a novel mechanism fo
39 chromatin modifiers, formation of RNA-based subnuclear compartments, and regulation of transcription
40 late the disposition of FOXP3 into different subnuclear compartments, leading to enhanced chromatin b
48 mer in vivo, but is found within 150-700 kDa subnuclear complexes, which co-migrate with the nuclear
50 ence loss in photobleaching experiments show subnuclear concentrations of MCM-chromatin interactions
51 this study in the C57BL/6J mouse provides a subnuclear cytoarchitectonic parcellation (Nissl stain)
54 on genotoxic damage, which may modulate APE1 subnuclear distribution and enzymatic activity in vivo.
56 and coimmunoprecipitation to examine how the subnuclear distribution and protein-protein interactions
61 d at the nuclear periphery, we evaluated the subnuclear distribution of recombination-activating gene
62 SOX9-transfected COS-7 cells showed that the subnuclear distribution of SOX9 became more diffuse in t
65 es between monosynaptic and PRV cases in the subnuclear distribution or proportions of retrogradely l
67 sulted in prolonged retention of DDB2 at the subnuclear DNA damage foci within micropore irradiated c
68 family, is concentrated in the nucleolus, a subnuclear domain disparate from the sites of mRNA trans
69 or interchromatin granule clusters (IGCs), a subnuclear domain enriched in pre-mRNA processing factor
70 n as the protein marker of the Cajal body, a subnuclear domain important to the biogenesis of small n
71 locytic leukemia protein (PML) and Daxx in a subnuclear domain, nuclear domain 10 (ND-10), when ectop
72 cation of phytochromes from the cytoplasm to subnuclear domains called photobodies and the degradatio
75 s the marker protein for Cajal bodies (CBs), subnuclear domains important for the biogenesis of small
76 Runx2, through its PY motif, recruits YAP to subnuclear domains in situ and to the osteocalcin (OC) g
77 Cajal bodies (CBs) are prominent interacting subnuclear domains involved in a number of crucial aspec
78 ntly, recruitment of the YAP co-repressor to subnuclear domains is abrogated and expression of the en
79 ompensation, providing new insights into how subnuclear domains of coordinate gene regulation are for
81 leus is compartmentalized into nonmembranous subnuclear domains that regulate key nuclear functions.
83 hysical location of these damages within the subnuclear domains, determined the cellular ability to r
84 phingolipid species are localized in various subnuclear domains, including chromatin, the nuclear mat
89 other protein components of CBs and related subnuclear domains; however, only a few have examined in
93 s act in DNA repair, recombination and RAD51 subnuclear dynamics, though not equivalently, while muta
94 and anabolic functions of osteoblasts as the subnuclear effector of multiple signaling axes (e.g. tra
95 chromatin at DSBs establishes an accessible subnuclear environment that facilitates DNA damage signa
96 tional group of genes, suggesting that these subnuclear environments are not organized to respond to
99 ifferent families colocalize within the same subnuclear expression site, indicating that the role tha
100 and p220 are targeted to, and colocalize at, subnuclear foci (Cajal bodies) in a cell cycle-dependent
101 colocalize at histone gene loci in dedicated subnuclear foci (histone locus bodies) that are distinct
102 replication machinery localize into discrete subnuclear foci after DNA damage, where they play requis
103 ically active, localized in discrete dynamic subnuclear foci and associates with DNA during cell divi
105 activation of TAF1, ATR rapidly localized to subnuclear foci and contributed to the phosphorylation o
106 In addition, PRR5 recruits TOC1 to large subnuclear foci and promotes phosphorylation of the TOC1
107 report that 1) Sp2 localizes largely within subnuclear foci associated with the nuclear matrix, and
112 various fluorescent derivatives form similar subnuclear foci in plant cells and that homologous inter
113 ed processes, BLAP75 colocalizes with BLM in subnuclear foci in response to DNA damage, and its deple
115 ERCC1 translocation to DNA damage-induced subnuclear foci is markedly impaired in USP45 knockout c
116 e gene-specific transcription factor NPAT in subnuclear foci, including Cajal bodies that associate w
117 ing hinge region also prevented formation of subnuclear foci, structures potentially important for ep
128 ntified by Western blot analyses in purified subnuclear fractions (e.g., nucleoli and nuclear matrix)
130 roblasts undergo a developmentally regulated subnuclear genome reorganization to permanently silence
131 lvinar and the mediodorsal nucleus displayed subnuclear heterogeneity in their driver assemblies.
133 that might contribute to the characteristic subnuclear KSHV microdomains ("LANA speckles"), a hallma
134 GFP:N fusion, co-localized with DsRed:P in a subnuclear locale in agreement with our previous observa
136 ed COS-1 cells, the RD3-fusion protein shows subnuclear localization adjacent to promyelocytic leukem
139 lation, histone acetylation and methylation, subnuclear localization and DNA replication timing.
140 research addresses the relationship between subnuclear localization and gene expression in fission y
141 y on the Msx1 homeoprotein by regulating its subnuclear localization and proximity to target genes.
142 sine 9 of histone H3 (MeK9H3) to examine the subnuclear localization and replication timing of chroma
143 lf-life of NPHP7/Glis2, but also altered the subnuclear localization and the transcriptional activity
144 issing its C-terminal domain restores normal subnuclear localization and toxicity in C. elegans and C
146 AR2 differ in both their ability to modulate subnuclear localization as well as to promote site-selec
147 f abolish self-interaction or cause aberrant subnuclear localization but do not abolish interaction w
148 nsive alterations to chromatin structure and subnuclear localization have been shown to play key role
151 eat in the N-terminus of the RS domain while subnuclear localization is controlled by phosphorylation
152 functions, and suggest that its nuclear and subnuclear localization is highly dependent on direct or
155 show that Thr-58 phosphorylation alters the subnuclear localization of c-Myc, enhancing its localiza
157 hromosomal organizational structures and the subnuclear localization of chromosomes as they relate to
158 ay muscle-specific defects linked to altered subnuclear localization of heterochromatin, leading to a
159 site mutations affected the subcellular and subnuclear localization of ICP0, its ability to alter th
161 screen to identify determinants required for subnuclear localization of phyB resulted in several phyB
162 tightly correlated with phosphorylation and subnuclear localization of retinoblastoma protein (Rb).
164 ke modifier (SUMO) conjugation regulates the subnuclear localization of several proteins; however, SU
165 etermine signals controlling the nuclear and subnuclear localization of the 18-kDa FGF-2, its full-le
166 ynamics during elongation or disruption, the subnuclear localization of the MUC4 loci, the cohesion o
168 trafficking within the cell, we analysed the subnuclear localization of wild-type and mutant p53 in h
169 ferent light conditions and define four phyB subnuclear localization patterns: diffuse nuclear locali
173 ological activity of Runx2, dependent on its subnuclear localization, in promoting early events of br
180 ins (SIRT1, SIRT6, and SIRT7) show different subnuclear localizations: SIRT6 and SIRT7 are associated
182 clustering of the genes, we have probed the subnuclear location of five different tRNA gene families
184 hen expressed alone but was relocalized to a subnuclear locus when coexpressed with the MFSV N protei
185 sor protein that is associated with distinct subnuclear macromolecular structures called the PML bodi
187 atin-remodeling events and rapid assembly of subnuclear microenvironments that activate histone gene
188 gerin sequesters NRF2 and thereby causes its subnuclear mislocalization, resulting in impaired NRF2 t
190 on and suggests that additional steps (i.e., subnuclear mobilization or uncoating) limit successful A
191 tal regulator relocalizes a locus into a new subnuclear neighborhood that is permissive for high leve
199 potential center of an "anti-reward system." Subnuclear organization and connectivity of the LHb are
204 ropose that Son is essential for appropriate subnuclear organization of pre-mRNA splicing factors and
205 revealing some interesting insights into the subnuclear organization of RNA processing machineries am
208 formation is prohibited by the fact that the subnuclear organization of the habenular complexes in mo
209 us and provide a model for understanding the subnuclear organization of tissue-specific regulatory pr
210 ells treated with hinokiflavone show altered subnuclear organization specifically of splicing factors
213 role of SUMO binding in this context is the subnuclear partitioning of the active form of Ubc9 (SUMO
214 portant signaling roles by targeting PHYB to subnuclear photobodies and interacting with PIF3 to trig
217 wever, G9a loss did not significantly affect subnuclear position or replication timing of any non-per
220 n signal sequences, and regulated changes in subnuclear positioning may influence locus recombination
223 inactive X chromosomes localize to different subnuclear positions and adopt distinct chromosomal arch
224 l DNA to the nucleus and subsequently to the subnuclear promyelocytic leukemia protein bodies, sugges
225 etinopathy-associated RD3 protein is part of subnuclear protein complexes involved in diverse process
226 rrest, promotes a specific reorganization of subnuclear protein localization, and modulates splicing
228 ngly, the molecule inhibits the formation of subnuclear RAD51 foci in cells following DNA damage, whi
230 ins associated with nucleosomes in different subnuclear regions in both ES cells and fibroblasts.
231 stered binding sites in spatially restricted subnuclear regions, suggesting that topological structur
233 end-joining (NHEJ) processes in specialized subnuclear repair centres; cells have a broad variety of
234 C inhibition caused a complete inhibition of subnuclear repair foci in response to ionizing radiation
236 cellular nucleolar protein nucleolin in the subnuclear replication compartments in which viral DNA r
237 nuclear PI3K signaling, which regulates its subnuclear residency, cell proliferation, and mRNA expor
239 required for the concentration of BFRF3 at a subnuclear site and the N-terminal 65 amino acids contai
240 association of Tax with this multifunctional subnuclear site results in disruption of a subset of the
241 ntial activities, the FBPs traffic to shared subnuclear sites and regulate many common target genes,
242 on of Runx2-YAP transcriptional complexes at subnuclear sites to attenuate skeletal gene expression.
246 novel evidence of the in vivo occurrence and subnuclear spatial localization of both exogenously expr
249 F65, creates Tat inhibitors that localize to subnuclear speckles, sites where pre-mRNA processing fac
250 iana OXS3 proteins in plant cells revealed a subnuclear speckling pattern related to the nucleosome i
251 vels in a "goldilocks" region for the proper subnuclear storage of an SR protein splicing factor.
252 and only when DNA damage was concentrated in subnuclear stripes, generated by partially shielded ultr
253 lular functions, such as gene transcription, subnuclear structure formation, viral infection, and cel
255 staged assembly and modification of a unique subnuclear structure that coordinates initiation and pro
256 e a molecular pathway linking the actions of subnuclear structure-specific ncRNAs and nonhistone prot
259 e formation of replication compartments, the subnuclear structures in which the viral DNA genome is r
260 3D configuration and chemical composition of subnuclear structures of pyramidal cells in the CA2 regi
261 nd the nucleus, where it concentrates in two subnuclear structures termed Cajal body (CB) and gems.
262 s of proteins, which associate with specific subnuclear structures, is critical to understanding euka
269 wash mutant and knockdown nuclei disrupt subnuclear structures/organelles and exhibit the abnorma
270 We therefore addressed the relevance of AML1 subnuclear targeting and associated functions that resid
271 aining DNA binding activity, display loss of subnuclear targeting and associated transactivation func
273 ation of a RUNX2-SMAD osteogenic complex and subnuclear targeting are structurally and functionally i
274 ssor in primary diploid osteoblasts and that subnuclear targeting contributes to Runx2-mediated tumor
277 minus of AML1 with the ETO protein, modifies subnuclear targeting of AML1 in acute myeloid leukemia (
280 pin RNA-Runx2 or a mutant Runx2 deficient in subnuclear targeting resulted in reversion of acini to m
285 The dsRBMs of ADAR2 are interchangeable for subnuclear targeting, yet such motif alterations do not
291 e developed a previously undescribed in situ subnuclear trafficking assay that generates transcriptio
293 ar chaperone involvement in steroid receptor subnuclear trafficking was provided by the ATP-dependent
296 ization to the nucleoplasm and disrupted the subnuclear transport of vRNP, abolishing vRNP nuclear ex
298 ax TSLS mutant rescued the nuclear entry and subnuclear TSS targeting of both proteins, demonstrating
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