ライフサイエンスコーパス: suboptimal

1 nizations, and their implementation has been suboptimal.

2 d where all properties are favoured, even if suboptimal.

3 e evidence that this response is impaired or suboptimal.

4 ilable data for training a classifier may be suboptimal.

5 several years, however, the outcome remains suboptimal.

6 opoietin production in the kidney may become suboptimal.

7 -of-life care for older patients with AML is suboptimal.

8 from their surrounding pancreatic matrix are suboptimal.

9 mprehensive bundled prevention approaches is suboptimal.

10 dose is common but patient stratification is suboptimal.

11 attributed to maternal hyperglycaemia remain suboptimal.

12 ng and is cost-effective, but uptake remains suboptimal.

13 veloped, but the clarity of these reports is suboptimal.

14 ed to propagate virus in vitro may have been suboptimal.

15 y reporting and interpretation of results is suboptimal.

16 uality of ICU-based palliative care is often suboptimal.

17 e current treatment for cryptosporidiosis is suboptimal.

18 eneralized to quantify MRI data where SNR is suboptimal.

19 However, for some cytokines this approach is suboptimal.

20 ogical relevance to in vivo infection remain suboptimal.

21 e size (N < 2000) while other methods become suboptimal.

22 graft-versus-host disease (SR-aGVHD) remains suboptimal.

23 the implementation of this recommendation is suboptimal.

24 eatments for chronic hepatitis B and HCC are suboptimal.

25 t limitations: scale-to-sample targeting was suboptimal, 4 items had disordered response category thr

26 ve docking of the spliceosomal U1 snRNP to a suboptimal 5' splice site.

27 This suboptimal acclimation renders a large portion of residu

28 These techniques have suboptimal accuracy and are time-consuming.

29 CThad suboptimal accuracy for false positivity: 46% of Xpert-p

30 herefore, less TCR/Lck clustering results in suboptimal activation of the downstream signaling events

31 at switch (6.69; 2.49-17.98; P < .001), and suboptimal adherence (3.05; 1.71-5.42; P = .025).

32 Suboptimal adherence (MPR<0.8) was recorded in 35 (51%).

33 were associated with 7% (95% CI, 4%-11%) of suboptimal adherence in this cohort.

34 We evaluated whether suboptimal adherence to combination antiretroviral thera

35 it of detection), more likely among men with suboptimal adherence, is a plausible mechanism.

36 al trajectory of working memory capacity via suboptimal adult neurogenesis in the hippocampus.

37 comparing SD-OCT and HRT measurements showed suboptimal agreement between the techniques.

38 vation and robust BCR responses to otherwise suboptimal amounts of surrogate antigen.

39 physician interpretation of BCID results is suboptimal and can result in ineffective treatment or mi

40 However, this endogenous repair response is suboptimal and may account for the persistently compromi

41 existing computational approaches are still suboptimal and not easy to apply.

42 es for the generation of Hc heterodimers are suboptimal and often suffer from contamination by homodi

43 the problem to identify "correct matches" is suboptimal and propose an alternative, based on optimal

44 urrent definitions of metabolic response are suboptimal and too simplistic.

45 However, this approach leads to suboptimal and unpredictable clinical outcomes.

46 d management of pain in hospital settings is suboptimal, and is a particular challenge in patients wi

47 Existing assays of social interaction are suboptimal, and none measures propinquity, the tendency

48 However, the efficacy of IIVs is suboptimal, and novel approaches are necessary for the p

49 genous thymic repair is possible it is often suboptimal, and there is a need to develop exogenous str

50 urrently available horticultural lighting is suboptimal, and therefore less than ideal for sustainabl

51 ership and understand the societal burden of suboptimal antibiotic use, providing examples of how cou

52 viral load monitoring are feasible to detect suboptimal antiretroviral therapy.

53 bitors with promising antitumor activity but suboptimal aqueous solubility, consequently worth being

54 s that low levels of synthesis capacity were suboptimal, associated with diminished cognitive flexibi

55 n, some intensivists perceive a link between suboptimal attending handoffs, inappropriate treatment,

56 etitive games, it can produce systematically suboptimal behaviors.

57 ter achieves proton selectivity by providing suboptimal binding conditions for rival cations such as

58 d carboxyl-terminus of this cofactor confers suboptimal binding to the proteasome core particle.

59 ORP4L knockdown results in suboptimal bioenergetics, cell death and abrogation of T

60 possibly because of the short half-lives and suboptimal bone marrow exposure of the drugs.

61 in cancers, specifically change splicing of suboptimal BS pre-mRNA substrates.

62 INTERPRETATION: LTC after release is suboptimal but improves when inmates' medical, psychiatr

63 uality of emerging adults in the US remained suboptimal, but some aspects improved marginally over th

64 ides the canonical TTTV PAM, Cpf1 recognizes suboptimal C-containing PAMs.

65 rrelated variables represented indicators of suboptimal cardiovascular and metabolic control and life

66 ith blood cancers have been shown to receive suboptimal care at the end of life (EOL) when assessed w

67 was strongly associated with a persistently suboptimal CD4/CD8 ratio.

68 This also provides a proof of principle that suboptimal CD8 T cell in old organisms can be optimized

69 ation, an elusive form of PutA that exhibits suboptimal channeling.

70 hful to these flowers, even if they become a suboptimal choice in terms of reward.

71 en states were miscoded, rats tended to make suboptimal choices reflecting the miscoding.

72 4; P = .001) greater than controls predicted suboptimal clinical response.

73 Despite suboptimal coalescence in the absence of P, the M and F

74 We propose that suboptimal codon bias, which correlates with low guanine

75 immunologic reconstitution, although it was suboptimal compared with that seen in wild-type bone mar

76 er use general-purpose compressors (gzip) or suboptimal compression schemes that leave significant ro

77 ausation with increased adiposity leading to suboptimal concentrations of circulating vitamin D.

78 groups, adapting to and surviving periods of suboptimal conditions and resuming growth as soon as nut

79 In the most severe exposure hotspots, suboptimal conditions for calcifying organisms encompass

80 However, under suboptimal conditions where [ATP] were varied, we found

81 esponse, and to assess priming for ERD under suboptimal conditions, an antigen dose de-escalation stu

82 Thus, TRIM21 mediates neutralization under suboptimal conditions, whereas induction of immune signa

83 t mutations in the RNA that maximally sample suboptimal conformational space based on the ensemble's

84 In contrast, selective testing is a suboptimal control strategy for anorectal chlamydia, as

85 Suboptimal control was associated with signatures of eos

86 integrate auditory and visual speech in such suboptimal conversational environments are not yet fully

87 allergen when anti-IL-4 was combined with a suboptimal course of grass pollen subcutaneous immunothe

88 IVH), is a common disease usually treated by suboptimal CSF shunting techniques.

89 nths of imatinib 400 mg once daily and had a suboptimal cytogenetic response according to 2009 ELN re

90 omes, our results suggest that patients with suboptimal cytogenetic response are more likely to achie

91 s imatinib dose escalation for patients with suboptimal cytogenetic response on imatinib.

92 onic myeloid leukaemia in chronic phase with suboptimal cytogenetic response remains undetermined.

93 onic myeloid leukaemia in chronic phase with suboptimal cytogenetic response to imatinib according to

94 % confidence interval [CI]: 1.009, 1.07) and suboptimal cytoreduction (P = .03; HR, 2.13; 95% CI: 1.1

95 High anxiety individuals used a suboptimal decision strategy characterized by a higher l

96 aggerated response to uncertainty leads to a suboptimal decision strategy that makes it difficult for

97 ed in higher interval timing uncertainty and suboptimal decisions due to incapability of processing p

98 d to incorporate parameter uncertainties and suboptimal decisions due to market imperfections and inf

99 ed in using their prior knowledge leading to suboptimal decisions when current information is ambiguo

100 slow down responses and can induce impulsive suboptimal decisions.

101 Long-term kidney transplant outcomes remain suboptimal, delineating an unmet medical need.

102 tics formats, sometimes inheriting from them suboptimal design choices; this hinders flexible and eff

103 Suboptimal diet is one of the most important factors in

104 ge of somatic glioma driving alterations and suboptimal disease classification.

105 ulthood in male, but not female, mice when a suboptimal disease-inducing immunization was used.

106 reference genome, and can be used even with suboptimal DNA more easily acquired in conservation and

107 mice, a model of severe SMA, treated with a suboptimal dose of an SMN2 splicing modifier show increa

108 tly, synergy was observed in some cases with suboptimal doses of ADCs, potentially providing an appro

109 ctivity was observed with the combination of suboptimal doses of BMS-986126 and prednisolone, suggest

110 he cotton rat RSV enhanced-disease model, as suboptimal dosing of several RSV F subunit vaccine candi

111 ps that transport the drug out of cells, and suboptimal drug penetration into tuberculosis lesions-ar

112 Eyes with suboptimal early BCVA response showed poorer long-term v

113 A suboptimal early-life environment, due to poor nutrition

114 s distance metric, we iteratively add mutant suboptimal ensembles to converge on a stable 2D map of c

115 is unclear how CSCs maintain stemness in the suboptimal environment outside their niches during invas

116 Suboptimal environmental conditions during early life th

117 stem cells (GSCs) maintain their stemness in suboptimal environments outside their niches.

118 Because tumour cells proliferate in suboptimal environments, and frequently show evidence of

119 apy (AET) for patients with breast cancer is suboptimal, especially among minorities, and is associat

120 However, follow-up is suboptimal, especially in lower socioeconomic groups.

121 Technology was suboptimal, especially in public hospitals.

122 appropriate prophylactic PPI therapy remains suboptimal, especially with low-dose aspirin.

123 risk for receiving disparate care and having suboptimal experiences, including discrimination, throug

124 erance and enhance cereal productivity under suboptimal field conditions.

125 y alters BiP chaperone activity to cope with suboptimal folding conditions.

126 s, we show that although robust averaging is suboptimal for a perfect integrator, it paradoxically en

127 elimination, making the majority of T cells suboptimal for adoptive T-cell therapy (ATT).

128 t of pancreatic cyst fluid aspirate is often suboptimal for analysis, but DNA isolated from lysed or

129 lectin agarose (GNA), but this technique is suboptimal for global production.

130 s of most genetically encoded sensors can be suboptimal for in vivo characterization of frequency ban

131 s generally improved since 2004, but remains suboptimal for many characteristics.

132 tions for these mood disorders are currently suboptimal for many patients; however, specific genetic

133 e turkey vulture to colonize biomes that are suboptimal for scavenging birds and become the most wide

134 centrations of antigen or anti-IgE that were suboptimal for secretion.

135 sities in the habitat of purple bacteria, is suboptimal for steady-state ATP turnover for the benefit

136 ence in host protein ANP32A accounts for the suboptimal function of avian virus polymerase in mammali

137 Suboptimal functioning may foster chromosome missegregat

138 as safe and well tolerated, but efficacy was suboptimal; further research is needed to determine whet

139 nsider all diagnostic categories and provide suboptimal fused representations using the same set of m

140 of large cohorts of individuals have linked suboptimal GI reconstitution to residual inflammation an

141 Achievement of diabetes care goals is suboptimal globally.

142 al glycemic control and 60 T1D patients with suboptimal glycemic control and assessed their tolerogen

143 mutations drive resistance and contribute to suboptimal growth of melanoma cells following the withdr

144 ly caused by culture conditions that support suboptimal growth rates.

145 Individuals in the state of psychological suboptimal health keep increasing, only scales and quest

146 ynamic scans were acquired under optimal and suboptimal heating conditions.

147 ntly faster uptake and washout kinetics than suboptimal heating in all organs for both tracers.

148 ntly faster uptake and washout kinetics than suboptimal heating in all organs for both tracers.

149 515 +/- 35 [mean +/- SD] beats/min), whereas suboptimal heating led to a lower heart rate and a highe

150 515 +/- 35 [mean +/- SD] beats/min), whereas suboptimal heating led to a lower heart rate and a highe

151 owever, 73.2% of deceased donor kidneys with suboptimal histology remained functional at 5 years.

152 associated IFI outbreaks have been linked to suboptimal hospital environmental conditions, transmissi

153 sion to "front-load" project spending can be suboptimal if a delay allows managers to use resources m

154 Our results suggest that suboptimal IL-2 signaling possibly plays a role in reduc

155 ts and parents, induces stress, and leads to suboptimal image quality and avoidance of imaging, thus

156 Several cases of suboptimal image quality were identified along with diff

157 administered in a soluble form have elicited suboptimal immune responses.

158 ge-specific vaccine formulations to overcome suboptimal immunization.

159 Influenza vaccine is known to have suboptimal immunogenicity in transplant recipients.

160 Challenges with the production and suboptimal immunogenicity of malaria vaccine candidates

161 y and onset of eczema, which might reflect a suboptimal implementation of gut microbiota at specific

162 suggest that counteraction by O-Nefs may be suboptimal.IMPORTANCE Previous studies showed that HIV-1

163 undetectable viremia at week 1, but would be suboptimal in general.

164 Adherence to beta-blockers in LQTS is suboptimal in half of those with LQTS 1 and 2.

165 ade among US adults, although the uptake was suboptimal in high-risk groups.

166 delirium prevention and management are often suboptimal in practice.

167 zed that knowledge of allergic conditions is suboptimal in primary care.

168 However, current methods are suboptimal in providing high-speed and accurate OCT atte

169 Images from 7 nevi (14%) were suboptimal in quality.

170 however, currently available GSC markers are suboptimal in sensitivity and specificity.

171 Control is suboptimal in the majority of patients receiving hemodia

172 gnosed diffuse large B-cell lymphoma remains suboptimal in the rituximab era.

173 ose intramuscular (IM) influenza vaccine are suboptimal in this population.

174 Suboptimal in utero nutrition combined with accelerated

175 cer therapy remains elusive, mainly owing to suboptimal in vivo delivery of RNAi therapeutics such as

176 lm matrix, and, in the setting of outbreaks, suboptimal infection control.

177 ostimulation in the context of necrosis to a suboptimal inflammatory milieu in the case of pyroptosis

178 ver, miR-155-deficient macrophages exhibit a suboptimal inflammatory response when exposed to low lev

179 h as lack of drug susceptibility testing and suboptimal initial antituberculosis treatment in setting

180 BACKGROUND & AIMS: There is suboptimal inter-observer agreement, even among expert g

181 There is suboptimal inter-observer agreement, even among expert g

182 ve been found to form only interactions with suboptimal interaction geometries.

183 viruses often suffer fitness defects due to suboptimal interactions among divergent viral components

184 re to grow the molecule and alerting them to suboptimal interactions within the original hit.

185 entation of subsequent treatment, suggesting suboptimal interpretation of RSA results.

186 mental programming of offspring phenotype by suboptimal intrauterine growth.

187 pancy promotes cotranscriptional splicing of suboptimal introns that may otherwise be discarded via p

188 eatment is unsupervised and therefore may be suboptimal, is less well characterised.

189 Irrespective of donor status, suboptimal kidneys came from older donors with a higher

190 t differed significantly between optimal and suboptimal kidneys only in the deceased donor transplant

191 rease discrimination against an AUG codon in suboptimal Kozak context.

192 we found that, in both tasks, observers used suboptimal learning rules.

193 Culture under suboptimal levels of FSS led to intermediate phenotypes,

194 ons in the Mdm2 P2-promoter and thus express suboptimal levels of Mdm2 entirely encoded from the P1-p

195 Stunting malnutrition (suboptimal linear growth) also has long-term negative ef

196 While generally suboptimal, linear tuning may facilitate transitive choi

197 se of preimplant normothermic perfusion of a suboptimal liver from a 57-year-old donor after circulat

198 A similar proportion of eyes demonstrated suboptimal (<5-letter) and robust (>/=10-letter) early r

199 Among suboptimal (<5-letter) responders at 3 months, 6.7% show

200 nt independent predictor of margin status or suboptimal lymphadenectomy (<12 lymph nodes harvested).

201 n, it is underdiagnosed in men, resulting in suboptimal management and less participation of men in c

202 ssessments of the impacts of climate change, suboptimal management outcomes, and the inefficient allo

203 and potential for significant morbidity with suboptimal management, comprehensive clinical guidelines

204 A suboptimal maternal diet during pregnancy might lead to

205 nflammatory injury and two-hit ALI caused by suboptimal mechanical ventilation and injection of throm

206 ge number of readmissions were not caused by suboptimal medical care or deterioration of medical cond

207 ce to the ideal Bayesian learner and several suboptimal models that varied in both computational and

208 ia explains the evolution of competitive but suboptimal N2-fixing strains found in Western Australian

209 ons of RCS in barley (Hordeum vulgare) under suboptimal nitrate, phosphorus, and potassium availabili

210 of ERK2 engagement by Ets-1 and involves two suboptimal noncanonical docking interactions instead of

211 Suboptimal nutrition is a leading cause of poor health.

212 otentially increase the utilization of these suboptimal organs.

213 fluence the decision process to accept these suboptimal organs.

214 Suboptimal outcome was defined as final visual acuity </

215 used to estimate the odds ratios (ORs) of a suboptimal outcome.

216 e clinical factors associated with long-term suboptimal outcomes are not well understood.

217 ve anticoagulation therapy for patients with suboptimal outcomes under any warfarin protocol.

218 f RYGB patients at higher risk for long-term suboptimal outcomes.

219 c total occlusions has improved historically suboptimal outcomes.

220 Suboptimal overlap in outcomes reported in clinical tria

221 ophil-mediated clearance of the pathogen was suboptimal owing to a second subversion mechanism, namel

222 rsal may allow multiple genotypes inhabiting suboptimal peaks to coexist, and recombination at the "s

223 mong adults without known CVD are limited by suboptimal performance and a narrow focus on only athero

224 3D7) and displayed moderate potency but with suboptimal physicochemical properties and poor microsoma

225 bstituted quinoline tau binding ligands with suboptimal physicochemical properties.

226 ined growth of one bacterium, which leads to suboptimal population ratios, and lack of control over b

227 d be very cost-effective or cost-saving, but suboptimal PrEP would erode benefits and increase costs.

228 vival of cancer patients, in part due to the suboptimal properties of NP platforms, such as premature

229 en treatment was initiated at 1 dpi, but the suboptimal protection observed with the 30 minute and 2

230 and most reported inter-person contact with suboptimal protective mask usage.

231 However, because of general suboptimal quality and the heterogeneous nature of the c

232 lorectal cancer incidence in patients with a suboptimal quality colonoscopy, proximal polyps, or a hi

233 Strain can lead to suboptimal quality of care and burnout among providers a

234 vers, particularly those considered to be of suboptimal quality, also known as extended criteria dono

235 ed by quantitative proteomics, cells exhibit suboptimal recovery kinetics in response to nutrient shi

236 Suboptimal recovery may be influenced by disruption of a

237 sed with RR-tuberculosis by Xpert initiate a suboptimal regimen, with information to adjust therapy a

238 ine DST, 101 (40.1%) potentially initiated a suboptimal regimen: 46.8% in the Western Cape and 25.3%

239 that 800 mg administered every 12 weeks is a suboptimal regimen; alternative dosing strategies are be

240 esses, certain kinetic parameters lay in the suboptimal region where their perturbations can improve

241 ATIONALE: Methodological sources of bias and suboptimal reporting contribute to irreproducibility in

242 treatment might offer only modest benefit to suboptimal responders to antipsychotics, if any.

243 In univariate analysis, prior suboptimal response or TKI resistance was the only basel

244 both hematologic and organ R/P, 31%; and (5) suboptimal response to ASCT and second-line therapy as c

245 rednisone in these high-risk patients with a suboptimal response to hormonal induction.

246 l practice may help to identify women with a suboptimal response to osteoporosis treatment.

247 insufficient, considering data demonstrating suboptimal response to other vaccines.

248 (BAT) in patients with myelofibrosis who had suboptimal responses or haematological toxic effects wit

249 ribution to combat transmission hotspots and suboptimal responses to treatment.

250 been designed to improve outcomes, but with suboptimal results.

251 Suboptimal retention is among the biggest challenges to

252 e fraction and the years of life lost due to suboptimal risk factors.

253 lorectal expression patterns, revealing that suboptimal Se status could alter inflammatory signaling

254 esponses and cytoskeleton remodelling in the suboptimal Se status group.

255 or comparison purposes, we also designed two suboptimal search algorithms based on evolutionary algor

256 rge prospective cohort provide evidence that suboptimal selenium status in Europeans may be associate

257 ates with complex biophysical properties and suboptimal serum stability, efficacy, and pharmacokineti

258 -1 stabilizes Sox2 binding to nucleosomes at suboptimal sites through cooperative interactions on DNA

259 d in the open complex increase initiation at suboptimal sites, and uS7-S223D stabilizes TC binding to

260 demonstrate that the combinatorial effect of suboptimal SMN antisense oligonucleotide treatment and P

261 developed and are effective in mice but have suboptimal specificity and sensitivity in humans.

262 At the catalytic stage of splicing, suboptimal splice sites are repressed by the DEAH-box AT

263 he spliceosome must distinguish optimal from suboptimal splice sites.

264 acking H2A.Z is impaired, particularly under suboptimal splicing conditions.

265 osed conformation and promote utilization of suboptimal start codons.

266 n plasma Se = 1.43 muM) and 11 subjects with suboptimal status (mean plasma Se = 0.86 muM).

267 ated Syk or suppression of Syk activation by suboptimal stimulation.

268 any) but not always of those who commit to a suboptimal strategy or who do not commit at all.

269 appropriate for interventions but because of suboptimal stress of the 2/4 protocol in some patients.

270 ing a differential entropic consideration of suboptimal structures.

271 zmann distribution, which generates a set of suboptimal structures.

272 ing viral genomes by numerous synonymous but suboptimal substitutions provides live attenuated vaccin

273 hat most of its primary microRNA domains are suboptimal substrates for Drosha-DGCR8, and therefore re

274 s, it is essential for enhancing cleavage of suboptimal substrates.

275 patients with severe aortic stenosis who are suboptimal surgical candidates.

276 The responsibility for suboptimal surveillance rests with patients, providers,

277 ing high-affinity binding affinities possess suboptimal syntax.

278 othesized that these limitations result from suboptimal T cell help.

279 s obstacles limit T-cell efficacy, including suboptimal T-cell receptor (TCR) activation and an immun

280 ovide new insight into the effect of ITK and suboptimal TCR signaling on CD8(+) T cell function, and

281 T cells to induce expression of FOXP3 after suboptimal TCR stimulation.

282 sustained production of virulence factors at suboptimal temperatures and may play an important role i

283 seen with reduction of insulin transport at suboptimal temperatures as well as with basal-to-apical

284 lis NusA depletion strain, we show that weak suboptimal terminators are the principle NusA substrates

285 but many patients remain undiagnosed due to suboptimal testing and lack of tests for all pathogens.

286 ut currently available prandial insulins are suboptimal: The onset of action is delayed by slow disso

287 , deep brain stimulation can sometimes yield suboptimal therapeutic benefit and can cause adverse eff

288 proportion of patients potentially placed on suboptimal therapy.

289 e primary and secondary prevention of CVD is suboptimal throughout the world, but the evidence-practi

290 Risk factors for poor specimen outcome (suboptimal TME specimen, perforation, and/or R1 resectio

291 onal neural networks to learn a mapping from suboptimal to high-quality histone ChIP-seq data.

292 ive (slow; CT-optimal) vs. neutral (fast; CT-suboptimal) touch.

293 er containment in the C-trap that results in suboptimal trajectories inside the Orbitrap analyzer.

294 trategies for more efficiently escaping from suboptimal traps.

295 al anticancer drugs to the brain, leading to suboptimal treatment in the central nervous system.

296 asthma outcomes, which may contribute to the suboptimal vaccination rates in persons with asthma.

297 yesian inference, but typically show a large suboptimal variability whose origin remains poorly under

298 he course of an influenza season, leading to suboptimal VE during late influenza seasons.

299 he course of an influenza season, leading to suboptimal VE during late influenza seasons.

300 that was compromised, when TCR signaling was suboptimal, was linked to ribosome biogenesis, a rate-li