ライフサイエンスコーパス: subpopulation

1 it is consistent with a short integration MT subpopulation.

2 (+) ENG(-) (CD105)(-) LY6A(+) (SCA1)(+) BMSC subpopulation.

3 d evaluation of anti-EGFR antibodies in this subpopulation.

4 (low)) and memory phenotype (MP, CD44(high)) subpopulations.

5 he V-SVZ niche and can regulate specific NSC subpopulations.

6 ation to prevent emergence of resistant cell subpopulations.

7 eralised to other countries as well as other subpopulations.

8 ites that play a critical role in connecting subpopulations.

9 st stable normalizer for comparing these two subpopulations.

10 er cell lines and iii) cancer stem-like cell subpopulations.

11 populations into two geographically distant subpopulations.

12 factors that show different activities among subpopulations.

13 ally responsive areas and fell coarsely into subpopulations.

14 nt of isotypic exclusion in separated B cell subpopulations.

15 sequencing in resolving these minor variant subpopulations.

16 F must be attained to suppress LDV-resistant subpopulations.

17 ut a means of perturbing individual cells or subpopulations.

18 he U.S. population and ethnic- and age-based subpopulations.

19 eby facilitating the identification of novel subpopulations.

20 ivity against susceptible and drug-resistant subpopulations.

21 altering relative abundances of erythroblast subpopulations.

22 d ketamine of overlapping but distinct NMDAR subpopulations.

23 due to the emergence of drug-resistant tumor subpopulations.

24 fied different optimal protocols for various subpopulations.

25 cells and macrophages, and different T-cell subpopulations.

26 two phenotypically distinct epicardial cell subpopulations.

27 d separate meta-analyses for each of these 3 subpopulations.

28 , and variation in type fitness between host subpopulations.

29 on-high risk among 0-19, 20-64 and 65+ years subpopulations.

30 is, proliferation, and stemness, and a minor subpopulation (19%) with many overexpressed cancer genes

31 In the metastatic subpopulations, a gene signature was defined (MET-75) th

32 phages (TAMs) to differentiate into distinct subpopulations according to local levels of ischemia and

33 inase (PI3K) increased both in 5-FU-tolerant subpopulations according to the 5-FU dose, and in gastri

34 Yet, it is unknown to what extent subpopulations adapt to location-specific selective pres

35 ased on the mRNA content found in the B cell subpopulations, an order of L chain gene activation is s

36 inhibitors due to emergence of heterogeneous subpopulations and activation of FGFR-3.

37 ding were then compared across the high-cost subpopulations and by individual ACSCs.

38 of spatial analysis in identifying high-risk subpopulations and evaluating candidate risk factors.

39 and emphysema (PRM(EMPH)) in the SPIROMICS (Subpopulations and Intermediate Outcome Measures in COPD

40 the COPD status of 917 participants from the Subpopulations and Intermediate Outcome Measures in COPD

41 mong the infected macrophages, we find three subpopulations and we show evidence for a linear progres

42 ve map of gene expression for all taste cell subpopulations and will be particularly relevant for cel

43 development of decision trees to define EoE subpopulations and, consequently, will facilitate indivi

44 ogical sample, infer cell identities of each subpopulation, and discover distinguishing features such

45 ows how aspects of food intake differ across subpopulations, and can be applied to determine how eati

46 ration, the ALDH1(+) and CD44(+)/CD24(-) CSC subpopulations, and mammosphere formation, indicating th

47 ransmission patterns, high-risk settings and subpopulations, and the effectiveness of infection contr

48 general cell types rather than granular cell subpopulations, and they do not explain the developmenta

49 p38 MAPK signalling pathway and have shown a subpopulation- and phase-specific pattern of activation

50 These subpopulations are continuously generated during adultho

51 Drug-tolerant cancer cell subpopulations are responsible for relapse after chemoth

52 2012 due to forest loss and degradation and subpopulations are significantly more fragmented.

53 on of species-restricted miRNAs, two notable subpopulations are splicing-derived mirtrons and testes-

54 racks the evolution of the morphology of WBC subpopulations as a patient transitions from a healthy t

55 arkers CD25, CD26, and IL1RAP is high in all subpopulations at diagnosis but downregulated and uneven

56 and mutation profiles, we identify a unique subpopulation based on addiction to the high-affinity gl

57 Classification of RMP subpopulations based on CD11b/CD11c expression demonstra

58 08, 2009-2010, and 2011-2012, overall and by subpopulations based on household composition, race/ethn

59 demonstrate that cells can be separated into subpopulations based on their protein-mRNA expression pr

60 stigated this phenomenon by stratifying cell subpopulations based on transcriptome profiling of 144 s

61 We used novel subpopulation-based visualization methods to interpret t

62 Relatively isolated subpopulations benefit little from high surrounding popu

63 3 inhibitor eliminated the upregulated STAT3 subpopulation, but left a large surviving subpopulation

64 y contribute to inhibition of distinct NMDAR subpopulations by memantine and ketamine and help to exp

65 mechanistically relevant circulating T-cell subpopulation calibrated to pretreatment disease burden,

66 ent, high-risk groups of the three age group subpopulations can be prioritized for vaccination, and t

67 tensity of wildfires, evidence on vulnerable subpopulations can inform disaster preparedness and the

68 ountries that have both low- and high-income subpopulations can provide a proxy measure for the impac

69 In humans, a MSC subpopulation carrying markers for endothelial and peric

70 Macrophage subpopulation cell-surface expression of immunological m

71 ealed the presence of a divergent progenitor subpopulation characterised by an early senescent phenot

72 report on identification of a specialized LD subpopulation characterized by a unique proteome and a d

73 n our understanding of the habitat range and subpopulation complexity of founding strains, as well as

74 Subpopulation Considerations: Preeclampsia is more preva

75 Subpopulation Considerations: Studies show that screenin

76 SuM(vglut2) neurons include a subpopulation containing both glutamate and GABA (SuM(vg

77 patial evolutionary processes acting on edge subpopulations contributed less.

78 eratin(+) cells in the bone marrow, this MSC subpopulation could prove useful in determining the risk

79 cting PL neurons (PL-NAc), but not the other subpopulations, decreased the preference for a social ta

80 letion of PDK1 remarkably diminishes ALDH(+) subpopulations, decreases stemness-related transcription

81 The pattern replicated across subpopulations defined by parity, latitude (region), fet

82 Although vcrA-containing Dehalococcoides subpopulations depend on synergistic interaction with ot

83 aminidase inhibitor-sensitive and -resistant subpopulations detected within the isolate.

84 es concerning combining multiple samples for subpopulation discovery, and these issues can be quickly

85 One subpopulation displayed stem-like features with a slower

86 ionally heterogeneous after activation, with subpopulations distinguished by expression of proliferat

87 ips between various stem and progenitor cell subpopulations driving mammary gland morphogenesis and h

88 oma and found that the emergence of specific subpopulations during tumor progression corresponded wit

89 wean farms over time, demonstrating that pig subpopulation dynamics are important to better understan

90 In this subpopulation, estimated glomerular filtration rates at

91 n consortia composed of multiple D. mccartyi subpopulations, even when other competing electron accep

92 when a population is split and the resulting subpopulations evolve independently, accumulating mutati

93 a previous full-body skin examination in any subpopulation examined.

94 Cryptic minor variant mycobacterial subpopulations exist below the resolving capability of c

95 Conditional KO of Prlr from neuronal subpopulations expressing the neurotransmitters GABA or

96 Notably, infants are a sensitive subpopulation for PFAA's developmental effects and recei

97 ess the need for generating more homogeneous subpopulations for study and use.

98 d mechanism ensures that cells in the motile subpopulation have a tenfold enhanced likelihood of ente

99 mRNA expression profiles, and that different subpopulations have distinct correlation coefficient val

100 to coarse approximations of only a few cell subpopulations, however.

101 hich resulted in selection for the modA2 OFF subpopulation in an ex vivo survival assay.

102 ted in specific elimination of the Kras(mut) subpopulation in primary and metastatic tumors, leading

103 is the highest among the high-risk 65+ years subpopulation in the catastrophic influenza pandemic, an

104 t is the highest in the high-risk 0-19 years subpopulation in the catastrophic, strong and moderate i

105 the highest among the high-risk 20-64 years subpopulation in the catastrophic, strong and moderate i

106 We found a neuronal subpopulation in the mouse preBotzinger complex (preBotC

107 , and highest among the high-risk 0-19 years subpopulation in the strong and moderate influenza pande

108 the question of whether children represent a subpopulation in which a higher risk of leukemia is asso

109 sing these features, users can identify cell subpopulations in a heterogeneous biological sample, inf

110 Epigenomic subpopulations in cancer impact drug sensitivity and the

111 Here, we identified four distinct Mf subpopulations in human small intestine (SI).

112 as established to detect different viral RNA subpopulations in infected cells.

113 ogression events occurring among common bean subpopulations in Mesoamerica and across hemispheres.

114 ownregulated and unevenly distributed across subpopulations in response to TKI treatment.

115 naling across subtypes and within tumor cell subpopulations in vivo.

116 mum (PM10) on hospitalization, by cause and subpopulation, in the Kathmandu Valley, an understudied

117 These processes generate diverse H. pylori subpopulations, in which BabA's adaptive evolution contr

118 two distinct neuron classes within this L4B subpopulation, including a rare novel neuron type, sugge

119 l effect of mandatory communication for some subpopulations, including African American individuals.

120 d to image traditionally hard-to-see protein subpopulations, including nascent polypeptides being tra

121 etes duration, and was maintained in various subpopulations, including the subgroup receiving anticoa

122 V-resistant mutants were selected and mutant subpopulations increased as exposure intensity increased

123 Breast cancer stem cells represent the tumor subpopulation involved in metastatic virulence, and ongo

124 , by specifically assessing metastatic tumor subpopulations, likely responsible for disease relapse,

125 eiving treatment varied significantly across subpopulations; lower likelihoods of awareness and treat

126 individuals in large sequence datasets into subpopulations makes the calculation of subpopulation sp

127 0 yeast mutants for loss of targeting of the subpopulation marker Pdr16 and identified Ldo45 (LD orga

128 flow from South to North between neighboring subpopulations, mediated mainly by males.

129 e characterization of the small F508del-CFTR subpopulation might be crucial for CF therapy developmen

130 eta-analyses are needed to determine whether subpopulations might benefit from combination treatment,

131 events on average, it is possible that some subpopulations might have derived benefit.

132 nd Atherosclerosis Risk in Communities Study subpopulations (n=22,158), then combined subpopulation-s

133 A subpopulation of 17.5% of CG neurons was associated with

134 hese results indicate that activation of the subpopulation of 5-HT2CR neurons within the VTA is suffi

135 ce, demonstrating that the PD-L1(+)/PD-L2(+) subpopulation of AAMvarphis originates from blood monocy

136 Moreover, DCs derived from a subpopulation of ALS patients produced higher levels of

137 redominantly produced by the CD1d(hi) CD5(+) subpopulation of B cells.

138 Within this subpopulation of boutons, 35% of observed vesicles exhib

139 ligned collagen matrices is observed for the subpopulation of carcinoma cells with high tumor initiat

140 ed to model drug addiction, we showed that a subpopulation of CD-1 mice demonstrate "addiction-like"

141 and autoimmunity and are enriched among the subpopulation of CD19(neg) human PCs.

142 A distinct subpopulation of CD4(+) effector memory T (TEM) cells th

143 mAb treatment showed that a highly activated subpopulation of CD44(hi)ICOS(hi) intratumoral Tregs wer

144 In addition, we identified a subpopulation of cells (<10%) that exhibited spectrally

145 virus infections DVGs selectively protect a subpopulation of cells from death, thereby promoting the

146 Inhibitory interneurons comprise a diverse subpopulation of cells that are critical to circuit func

147 The NS platform samples from a select subpopulation of cells within a larger culture, allowing

148 ne mechanism contributing to migration via a subpopulation of cells.

149 e they can be expressed strongly in specific subpopulation of cells.

150 We demonstrate that only a subpopulation of colonic enterocytes which are character

151 emove K48-linked ubiquitin conjugates from a subpopulation of damaged lysosomes to promote autophagos

152 is of Jurkat cells, we detect and separate a subpopulation of dead cells in an unsupervised manner an

153 ort an exception to this generality within a subpopulation of Drosophila neural stem cells (neuroblas

154 d in quiescent adult NSCs, is expressed by a subpopulation of embryonic RGCs, in a temporal and regio

155 We localized a subpopulation of excitatory vasopressin neurons in the a

156 r co-treatment restores stability in a small subpopulation of F508del-CFTR Cl(-) channels but that th

157 id and transient NPAS4 expression in a small subpopulation of FOS-positive neurons in the NAc.

158 1212-1227) demonstrate that one subpopulation of glioblastoma cells expressing a mutant

159 Within these tumours exists a subpopulation of highly plastic self-renewing cancer cel

160 We have identified and characterized a novel subpopulation of human NK cells expressing high levels o

161 l lymphopoiesis and is mainly sustained by a subpopulation of ICAM1(+) perivascular stromal cells.

162 derlining the protective role of this unique subpopulation of innate gamma/delta T17 cells in the col

163 d perinatally but reemerges postnatally in a subpopulation of large-diameter GG neurons expressing th

164 inding protein Mex3a labels a slowly cycling subpopulation of Lgr5+ ISCs that contribute to all intes

165 We identified a subpopulation of LHA (GABA) neurons that coexpress the n

166 turally switched off by phosphorylation in a subpopulation of MDM found in a G1-like state.

167 thermore, only the CD11b(+) Ly6G(+) Ly6C(++) subpopulation of MDSC induced by P. gingivalis infection

168 ylase KDM5B (also known as JARID1B)-positive subpopulation of melanoma cells, which are slow-cycling

169 establish an inverse relationship between a subpopulation of mesenchymal stromal cells and cancer ce

170 A subpopulation of mesodermal cells moving ventrally from

171 HQ elicited Ca(2+) influx in a subpopulation of mouse sensory neurons sensitive to the

172 Here, we investigated a distinct subpopulation of NAc FSIs that express the cannabinoid r

173 ial neoplasms (PanIN), and describe a unique subpopulation of neuroendocrine PanIN cells that express

174 These studies identify a GABAergic subpopulation of neurons in the ventral zona incerta tha

175 nally, we identify a physiologically defined subpopulation of neurons with strong tuning-curve alignm

176 Olfactomedin-4 identifies a subpopulation of neutrophils in patients with septic sho

177 e in intracellular Ca(2+) concentration in a subpopulation of OXT neurons, an effect mediated by NPS

178 Our data support the hypothesis, in a subpopulation of patients, DCs recruited at the diseased

179 water channel Aquaporin-1 for targeting this subpopulation of platelets as antiprocoagulant antithrom

180 of IKD in both high-threshold CSNs and in a subpopulation of polymodal nociceptors expressing TRPM8,

181 ng cold discomfort, but it also transforms a subpopulation of polymodal nociceptors signaling pain in

182 CD1c(+) aAPC presenting endogenous lipids, a subpopulation of primary CD4(+) T cells from multiple do

183 We found a subpopulation of rapid, largely concentration-invariant

184 We found a spatially clustered subpopulation of scene-selective units with an associate

185 Within a multi-path environment, a subpopulation of subiculum neurons robustly encoded the

186 Invariant NKT (iNKT) cells are a subpopulation of T lymphocytes that recognize glycolipid

187 A highly resolved subpopulation of these top-down projecting neurons, iden

188 ics of these platelets, which imply a single subpopulation of versatile platelets and thus suggest th

189 Lymphocyte subpopulations of 40 children and adolescents with Down

190 dependence, defining the character or minor subpopulations of androgen-independent cells that are po

191 iment" to explore this hypothesis in several subpopulations of Atlantic killifish that have evolved a

192 ourses lead to high rates of relapse because subpopulations of bacilli can survive despite being gene

193 Here we apply optogenetics to understand how subpopulations of beta-cells control the overall [Ca(2+)

194 amplification at 1q21.3 that is enriched in subpopulations of breast cancer cells bearing characteri

195 of tumors consist of genotypically distinct subpopulations of cancer cells.

196 perform survival analysis on drug-stratified subpopulations of cancer patients.

197 45RA, CD25, and CD127 expression to identify subpopulations of CD4CD127CD25 cells.

198 hat the Tbx15(Hi) preadipocyte and adipocyte subpopulations of cells are highly glycolytic, whereas T

199 nship between target and movement tuning for subpopulations of cells defined by the temporal duration

200 gorithms, we identified molecularly distinct subpopulations of cells during reprogramming.

201 esting that they had differentiated into the subpopulations of cells that support CSC self-renewal.

202 and in-depth analysis of mRNA dynamics from subpopulations of cells undergoing differentiation.

203 ram in which expression is displayed in rare subpopulations of cells.

204 rrent injections and synaptic stimulation in subpopulations of dopamine neurons grouped according to

205 therapy in part because the biofilms contain subpopulations of dormant antibiotic-tolerant cells.

206 Subpopulations of E. coli PI-7 expressed genes related t

207 endothelial markers using flow cytometry, 3 subpopulations of endothelial cells could be identified

208 cades ago through the identification of rare subpopulations of engrafting cells in xenotransplantatio

209 2J mice, enabling sample stratification into subpopulations of good and poor treatment responders to

210 ug candidates are also attractive targets in subpopulations of individuals with neurodegenerative dis

211 This has been observed in clonal subpopulations of larger size, especially when genomic i

212 lis infection induced the expansion of three subpopulations of MDSC (Ly6G(++) Ly6C(+), Ly6G(+) Ly6C(+

213 DSC); however, little is known regarding the subpopulations of MDSC expanded by P. gingivalis infecti

214 tum from patients with tuberculosis contains subpopulations of metabolically active and inactive Myco

215 The different subpopulations of microparticles could be determined via

216 and synaptically evoked inhibitory pauses in subpopulations of midbrain dopamine neurons.

217 Subpopulations of mitochondria from young and old mouse

218 we examined gene expression in two distinct subpopulations of mouse taste cells: Tas1r3-expressing t

219 Levels of TREM-1 and of subpopulations of MVs were not different between groups.

220 Pafah1b1(+/-) on the function of individual subpopulations of neurons and ultimately brain circuits

221 Here, the authors find evidence for three subpopulations of nonthermal carriers which arise from a

222 nd the ability of individual drugs to enrich subpopulations of receptor conformations to selectively

223 rogeneity of VTD responses reflects distinct subpopulations of sensory neurons.

224 ty, we examined the drug effect in different subpopulations of SKBR3 breast cancer cells, and compare

225 Alveolar and interstitial macrophages had subpopulations of small and large macrophages based on s

226 apical or basolateral RPE surfaces, and two subpopulations of small EVs including exosomes, and dens

227 exhibits two kinetic phases and at least two subpopulations of ternary complexes.

228 Signalling entropy identifies known cell subpopulations of varying potency and drug resistant can

229 s oxidative and glycolytic metabolism within subpopulations of white adipocytes and preadipocytes.

230 e and results in two phenotypically distinct subpopulations, ON and OFF.

231 he purchases of US households overall and by subpopulations.On the basis of nutrition label data from

232 polymorphic sites that we used to define 10 subpopulations, one of which appeared in the gut after 1

233 omic regions of high differentiation between subpopulations, one of which coincides with a cluster of

234 Neuronal Sxl acts additively in 2 neuronal subpopulations, one of which corresponds to 7 median neu

235 dly, we found two mutually exclusive altered subpopulations: one with STAT3 upregulation and another

236 alyzed were either unselected for a specific subpopulation or phenotypically defined as undifferentia

237 Moreover, highly contractile platelet subpopulations present in healthy controls are conspicuo

238 to resolve molecular heterogeneity and cell subpopulations, provoking new questions about the role o

239 erior colliculus (SC) reveals that SC neuron subpopulations receiving corticocollicular projections f

240 ion therapies and reveals characteristics of subpopulations resistant to this treatment.Significance:

241 hared inputs are differentially processed in subpopulations resulting in distinct downstream dopamine

242 evealed central gland hypertrophy in the Bx- subpopulation, resulting in significant volume and poste

243 etically partitioned into inland and coastal subpopulations, separated by a central region dominated

244 es extending to differentially PAH-resistant subpopulations showed organismal level bioenergetic shif

245 Compared with PBMos, Mf subpopulations showed reduced responsiveness to proinfla

246 noma is a heterogeneous tumor with different subpopulations showing different proliferation rates.

247 ng the network structure into interconnected subpopulations simplified access to the locations of int

248 lthough infant mortality has improved in all subpopulations since Israel was founded in 1948, infant

249 COPD lung macrophages include distinct subpopulations; Small interstitial and small alveolar ma

250 into subpopulations makes the calculation of subpopulation specific allele frequency possible, which

251 udy subpopulations (n=22,158), then combined subpopulation-specific results in a fixed-effects, inver

252 ribution and diversity of IAVs among the pig subpopulations studied.

253 dence for a linear progression through these subpopulations, supporting a model in which these three

254 The study identified vulnerable subpopulations that could benefit from targeted interven

255 abled sorting of heterogeneous beta cells to subpopulations that exhibited marked differences in GSIS

256 ute stress preferentially activates neuronal subpopulations that express the neuropeptide gene Cck.

257 distinct but interconvertible malignant cell subpopulations that fuel metastatic spread and therapeut

258 or the induction of T-cell responses, the DC subpopulations that induce Th2 cells in the intestine ar

259 rly-eluting fractions represent different G1 subpopulations that progress through the cell cycle with

260 Stratification of patient subpopulations that respond favorably to treatment or ex

261 ntains anatomically and molecularly distinct subpopulations that target three downstream regions that

262 be inadvertently aggregating over different subpopulations that use very different processes.

263 which defines a distinct ratio between these subpopulations; this in turn leads to distinct infection

264 ous studies, we found the somata of this L4B subpopulation to reside predominantly outside blob colum

265 ious arms of the circuit through specific DA subpopulations to assess: (1) whether the circuit connec

266 elective resistance of cancer stem cell (SC) subpopulations to molecularly targeted cancer therapies.

267 ons, however, the recruitment order of these subpopulations to the injured brain largely remains unkn

268 oach to classify single cell populations and subpopulations using SIMS profiling of lipid and metabol

269 emonstrate the importance of undervaccinated subpopulations, using an existing dynamic poliovirus tra

270 useful normalizer for cancer stem-like cell subpopulations versus subpopulations without stemness pr

271 imaging as well as enrichment of RNA in cell subpopulations via selective irradiation.

272 the overall level of differentiation between subpopulations was low, indicating high levels of gene f

273 Although tonic firing is similar in these subpopulations, we find that their responses to dopamine

274 Using eQTLs from three major immune subpopulations, we found shared effects in only approxim

275 cTFH cells and other lymphocyte subpopulations were characterized.

276 Two distinct porcine cDC subpopulations were FACSorted CD1(-) cDC (Lin(-)CD172(+)

277 ed a higher energetic cost for PAH-resistant subpopulations when seeking an optimum habitat.

278 We define an undamaged HG/CD42b(+) MK subpopulation, which endocytoses fluorescently labeled c

279 8(+)CD28(-) T cells are a heterogeneous cell subpopulation whose function ranges from immunosuppressi

280 nstrated that CD28(+)CD151(+) T cells form a subpopulation with a distinct molecular baseline and act

281 T3 subpopulation, but left a large surviving subpopulation with downregulated SMAD2/3.

282 We identified a CAF subpopulation with elevated expression of alpha-smooth m

283 fined an IGHE score of >/=37.5 for a patient subpopulation with increased esophageal allergic inflamm

284 pared the observed genetic diversity of each subpopulation with other brown bear populations in the r

285 prespecified analysis of EGFR FISH-positive subpopulation with squamous cell histology, overall surv

286 limp1 expression defines a mammary stem cell subpopulation with unique functional characteristics.

287 in vivo selection to isolate malignant cell subpopulations with a higher propensity for metastasis t

288 s are presumed to be implemented by neuronal subpopulations with different tuning functions.

289 ment in mice and humans consists of distinct subpopulations with differing effector functions.

290 When subpopulations with established foraging traditions for

291 ctor and central memory CD4 T cells comprise subpopulations with highly divergent rates of turnover,

292 and decreased activities against tumour-cell subpopulations with low targeting receptor levels.

293 s with CKD, but serial measurements identify subpopulations with rising levels and exceptionally high

294 03, 95% CI, 0.02 to 0.04, n=724) and smaller subpopulations with slowly (slope=0.14, 95% CI, 0.12 to

295 PBP) and A8 (retrorubal field, RRF) neuronal subpopulations, with additional inputs to the dorsal A9

296 preventable spending varied across Medicare subpopulations, with the majority concentrated among fra

297 l clustering reveals five spatially distinct subpopulations within the chick dorsal neural tube.

298 that considers a network of individual viral subpopulations within the host, with differing infection

299 (TIC) represent cancer stem-like cell (CSC) subpopulations within tumors that are thought to give ri

300 cancer stem-like cell subpopulations versus subpopulations without stemness properties.