ライフサイエンスコーパス: substance

1 ia was well above the odour threshold of the substance.

2 veloped in a complex extracellular polymeric substance.

3 ow the same response as the hazardous target substances.

4 verlapping of peaks corresponding to various substances.

5 D) is a compound that solubilizes lipophilic substances.

6 tion about 1000 times higher than the target substances.

7 lecular assemblies thought to exist in humic substances.

8 ed group-specific similarities for petroleum substances.

9 in, and urinary thiobarbituric acid-reacting substances.

10 with known nonspecific toxicity to chemical substances.

11 and tea mate), all of them rich in bioactive substances.

12 ns, in addition to binding to PCh-containing substances.

13 ability to respond to multitudinous foreign substances.

14 luded number of days of use of other illicit substances.

15 verification of public exposure to chemical substances.

16 abolized native and uniformly labeled tracer substances.

17 nsport and potential health effects of these substances.

18 reactions in the synthesis of novel organic substances.

19 s may help explain how stress contributes to substance abuse and how it can disinhibit automatic beha

20 s significantly influence susceptibility for substance abuse and mood disorders.

21 by the model included both well-known (e.g., substance abuse and psychiatric disorders) and less conv

22 triatal CREM mediates impulsivity related to substance abuse and suggest that CREM and its regulated

23 Sleep disorders and substance abuse are highly comorbid and we have previous

24 diagnostic categories assessed, psychoactive substance abuse conferred the highest risk for all-cause

25 [aOR], 1.35; 95% CI, 1.21-1.49), alcohol and substance abuse disorders (aOR, 1.34; 95% CI, 1.05-1.72)

26 attention-deficit hyperactivity disorder and substance abuse disorders.

27 nt avenue for advancing our understanding of substance abuse disorders.

28 cocaine addiction and a DSM-V criterion for substance abuse disorders.

29 Substance abuse history was the strongest predictor of O

30 Substance abuse is a pressing problem with few therapeut

31 ve class, carotid stenosis intervention, and substance abuse referral for alcohol.

32 ic stress disorder, depression, anxiety, and substance abuse) on this association.

33 tanding psychiatric disorders, in particular substance abuse, schizophrenia, and the potential antide

34 minorities, but less likely to abstain from substance abuse.

35 flect vulnerability of prodromal patients to substance abuse.

36 al method for determination of banned doping substances, achieving limits of quantitation below the m

37 listic estimation of impacts of thousands of substances across multiple media, including non-toxicolo

38 During reward outcome, individuals with substance addiction showed increased activation in the v

39 drinking users (MAD), and users of all three substances (ALL).

40 were performed across all addictions and for substance and gambling addictions separately.

41 ifferences between technology addictions and substance and gambling addictions.

42 ship between the temperatures of the working substance and heat reservoirs that the maximum-work effi

43 lcathinone (methylone) is a new psychoactive substance and the beta-keto analog of 3,4-methylenedioxy

44 epot did not suggesting that the active drug substance and/or related particle was a key driver for d

45 Prenatal exposure to perfluoroalkyl substances and adiposity in early and mid-childhood.

46 Early-life exposure to perfluoroalkyl substances and childhood metabolic function.

47 The mucoadhesion between polymeric substances and mucosal membranes, widely exploited in th

48 for sites contaminated with polyfluoroalkyl substances and perfluorocarboxylic acids.

49 educed production of important antimicrobial substances and responses, is a common feature of many fo

50 erm abstinence from heroin and other illicit substances and should be considered as a treatment optio

51 The concern about these substances and the recent legal restrictions of China in

52 the removal/formation of selected indicator substances and their transformation products (TPs), (ii)

53 ods of screening and quantitating controlled substances and therapeutic drugs in biofluids typically

54 cked repeating units, but the aforementioned substances are able to bind only a few of them.

55 h much higher concentrations than the target substances are shown.

56 cimicifugolide, five previously undescribed substances, aruncins C, D, and E, and aruncides D and E,

57 th respect to the temperature of the working substance at a special instant along the cycle.

58 Biological substances based on proteins, including vaccines, antibo

59 These substances belong to five chemical groups: derivatives o

60 w rates of transcytosis to limit the flux of substances between blood and CNS.

61 balances on the level of goods and selected substances (C, Cd, Cr, Cu, Fe, Hg, N, Ni, P, Pb, Zn) are

62 2-MIB with time, it was concluded that this substance can still be detected in wine and can induce,

63 A prolonged and combined use of these substances can alter normal brain wiring in different wa

64 ry to 2-(hetero)arylpyridines, an attractive substance class in drug discovery.

65 Injections of neuroactive substances combined with running-wheel assays suggested

66 resholds positively correlate with competing substances' competitive effect and negatively correlate

67 ees C for 4-6 min removed all sorbed organic substances completely.

68 Honey is a complex biological substance, consisting mainly of sugars, phenolic compoun

69 After 40 years, the 1976 US Toxic Substances Control Act (TSCA) was revised under the Fran

70 results suggest that existence of the active substance could be successfully determined at the levels

71 ctions from seal and sea lion pups for Nissl substance, cytochrome oxidase, and vesicular glutamate t

72 t GSK598809 may remediate reward deficits in substance dependence.

73 ividuals) but not with conduct disorder in a substance-dependent sample (950 male individuals and 138

74 addiction: high motivation to seek addictive substances, despite adverse consequences, and high relap

75 SM-IV mood, anxiety, disruptive behavior and substance disorders before random traumas.

76 ed interference from extraneous (nonanalyte) substances (e.g., ions of heavy metals).

77 on (P<0.001) in thiobarbituric acid reactive substances, effective inhibition of protein oxidation (P

78 nventory and the most important O3-depleting substance emitted in this 21st century.

79 r, the production of extracellular polymeric substances (EPS) was significantly increased as compared

80 We observed that the dust concentrations of substances exclusively transferred via air were similar

81 is 15-year period, there were 962,222 single substance exposures to the 48 medications studied.

82 cture of products, but it does not cover all substances formed in the production processes.

83 The identification of a bioactive substance from probiotic bacteria could circumvent this

84 Bumblebees secrete a substance from their tarsi wherever they land, which can

85 We used petroleum substances from four petroleum substance manufacturing s

86 cells by the regulated release of cytotoxic substances from granules at the immunological synapse.

87 emi-allogeneic antigens from maternal cells, substances from ingested amniotic fluid, food antigens,

88 ere conducted to investigate the transfer of substances from products into dust due to direct and air

89 series of new aroma compounds from different substance groups were identified that have hitherto not

90 We concluded that all of the substances have an impact on brain connectivity, but the

91 sible risks from combined exposures to these substances have not been evaluated.

92 ertified for its content of the two priority substances hexachlorobenzene (HCB) and hexachlorobutadie

93 ides (PS), nucleic acids (NA) and humic-like substances (HS) in the STAD system within the initial 2

94 ic dissolved organic matter (CDOM) and humic substances (HS) remains poorly understood and yet to be

95 the high stability of peatland-derived humic substances (HS).

96 Humic-like substances (HULIS) in particulate matter such as biomass

97 photosensitizer species, such as humic-like substances (HULIS), may contribute more significantly to

98 d compounds, often referred to as humic-like substances (HULIS), which influence particle properties

99 ck by the peptide inhibitor blood depressing substance I (BDS-I).

100 urons, blockade of Kv3.4 by blood depressing substance II suppresses axon growth via an increase in t

101 c acid (MPA) is the active immunosuppressive substance in both mycophenolate mofetil and mycophenolat

102 Correct identification of a chemical substance in environmental samples based only on accurat

103 the user provides a measured spectrum of the substance in which the (13)C labeling is known a priori.

104 tion and elemental speciation of radioactive substances in a nondestructive manner with very small am

105 In 2010, the Directive on undesirable substances in animal feed entered into force and for the

106 EEK) mesh that can rapidly detect prohibited substances in biofluids via direct analysis in real-time

107 cokinetics of per- and polyfluorinated alkyl substances in humans.

108 of aflatoxins could be associated to matrix substances in plants.

109 masking ozone recovery from ozone-depleting substances in some regions and will increasingly affect

110 id space as potential access points allowing substances in the CSF to enter the perivascular space.

111 stressor due to the release of a plethora of substances, including cytokines, chemokines, and growth

112 uded all persons who received a diagnosis of substance-induced psychosis between 1994 and 2014 (N=6,7

113 32.2% (95% CI=29.7-34.9) of patients with a substance-induced psychosis converted to either bipolar

114 tive probabilities for the conversion from a substance-induced psychosis to schizophrenia or bipolar

115 Self-harm after a substance-induced psychosis was significantly linked to

116 d the homogenous distribution of biochemical substances inside the bioreactor.

117 Formulating a poorly water-soluble drug substance into nanocrystals offers many advantages.

118 ld, contradicting previous reports that this substance is unstable in wine and must.

119 The safe handling of category A infectious substances is a unique challenge in this environment.

120 selective and sensitive analysis of odorous substances is required.

121 ity and that some species of coral secrete a substance known as palytoxin, a potent vasoconstrictor t

122 Hydrophobic solid substances like graphite and carbon nanotubes are smooth

123 sed petroleum substances from four petroleum substance manufacturing streams and evaluated their chem

124 riteria were the use of illicit psychotropic substances, mental confusion, hepatic encephalopathy, he

125 We think that exposures to hazardous substances migrating from FCAs require more attention.

126 Substance misuse contributed most to the increased risk

127 ls with mental disorders, and programmes for substance misuse prevention and treatment.

128 Targeting of comorbid substance misuse would have particular effect on reducti

129 status, socioeconomic status, education, and substance misuse) for BBV infection.

130 applications and the nonintentionally added substances (NIAS) that may migrate into food.

131 o active compound was detected in 4 (9%) and substances not listed on the label were contained in 11

132 to be the largest group of new psychoactive substances (NPS) monitored by the European Monitoring Ce

133 rom the NW region of Spain showed that these substances occur in raw wastewater up to ca. 1.6 mug L(-

134 Substances of Unknown or Variable composition, Complex r

135 The effect of such substances on the foraging behaviour of pollinators is p

136 ew widely used product or the ban on certain substances, on the flows of nanomaterials to the environ

137 drenergic stimulation), hydrocortisone, both substances, or a placebo to healthy young men.

138 Among other substances, oxaliplatin causes CIPN in up to 80% of trea

139 ions, and 10 chloride and contains a single Substance P (SP) [SP + 3H](3+) ion (SP(3+); amino acid s

140 Substance P (SP) is an undecapeptide present in the CNS

141 Substance P (SP) is linked to itch and inflammation thro

142 in part, by inhibiting GABAergic input onto substance P (SP) neurons in the ventral tegmental area (

143 ne PanIN cells that express the neuropeptide substance P (SP) receptor neurokinin 1-R (NK1-R).

144 IP), calcitonin-gene related peptide (CGRP), substance P (SP), neuropeptide tyrosine (NPY), and the n

145 y activation of the neurokinin-1 receptor by substance P decreases sepsis survival through multiple m

146 lated peptide but increases the neuropeptide substance P in LPS-treated mice.

147 with the potential to release both 5-HT and substance P is necessary for normal respiratory dynamics

148 tion channel subfamily V, receptor 1 (TRPV1)-substance P nociceptive signaling pathway.

149 or Gal, Penk, and Adcyap1, and receptors for substance P, orexin, serotonin, and ATP.

150 Substance P, the principal ligand for the neurokinin-1 r

151 Substance P-like immunoreactive free nerve endings were

152 complex, the patterns of calbindin-like and substance P-like immunoreactivity, and the organization

153 in corneal epithelial nerve regeneration and substance P-positive nerve density in both wounded and u

154 tes modulatory responses to the neuropeptide substance P.

155 ptive neuronal markers IB4, TRPV1, CGRP, and substance P.

156 It includes substances passing biological wastewater treatment plant

157 Smart regulation of substance permeability through porous membranes is highl

158 Several per- and polyfluoroalkyl substances (PFAS) are ubiquitous anthropogenic pollutant

159 Perfluoroalkyl substances (PFAS) are ubiquitous in the environment, inc

160 Perfluoroalkyl substances (PFAS) are ubiquitous, persistent chemicals t

161 Certain perfluoroalkyl and polyfluoroalkyl substances (PFAS) are widespread, persistent environment

162 Perfluoroalkyl substances (PFAS) may affect body mass index (BMI) and o

163 Up to 46 per- and polyfluoroalkyl substances (PFASs) and precursors were identified.

164 products containing per- and polyfluoroalkyl substances (PFASs) and their presence has been reported

165 idence that certain poly- and perfluoroalkyl substances (PFASs) are associated with negative human he

166 Poly- and perfluoroalkyl substances (PFASs) are persistent, bioaccumulative anthr

167 at are treated with per- and polyfluoroalkyl substances (PFASs) are sources of human and environmenta

168 Perfluoroalkyl substances (PFASs) are synthetic chemicals that may pers

169 More than 3000 per- and polyfluoroalkyl substances (PFASs) are, or have been, on the global mark

170 esence of perfluoroalkyl and polyfluoroalkyl substances (PFASs) commonly associated with aqueous film

171 le it is known that per- and polyfluoroalkyl substances (PFASs) contained in AFFFs pose a potential e

172 ionic, and cationic per- and polyfluoroalkyl substances (PFASs) enter the environment.

173 The bioaccumulation of perfluoroalkylated substances (PFASs) in plankton has previously been evalu

174 and newly identified per and polyfluoroalkyl substances (PFASs) in the benthic fish white sucker (Cat

175 whether prenatal exposure to perfluoroalkyl substances (PFASs) is associated with childhood adiposit

176 ostnatal exposure to perfluorinated alkylate substances (PFASs) is associated with lower serum concen

177 Exposure to perfluoroalkyl substances (PFASs) may increase risk for metabolic disea

178 transport for poly- and perfluorinated alkyl substances (PFASs) reaching the Arctic Ocean is not well

179 Analysis of legacy Per- and polyfluoroalkyl substances (PFASs) revealed a marked increase in concent

180 nd-sea transport of per- and polyfluoroalkyl substances (PFASs) through riverine discharge into coast

181 (AFFFs), containing per- and polyfluoroalkyl substances (PFASs), are released into the environment du

182 nation by perfluoroalkyl and polyfluoroalkyl substances (PFASs), juvenile Eurasian perch were dietari

183 Per- and poly fluorinated alkyl substances (PFASs), notably perfluorooctanoic acid (PFOA

184 n discovery collections that are enriched in substances possessing less desirable properties (high li

185 arking with CTPs for other nanoparticles and substances present in the USEtox database, while large d

186 surface adhesins (PrgA, PrgB or Aggregation Substance, PrgC) and the Prg/Pcf type IV secretion syste

187 maltose-binding protein (MBP), N-utilisation substance protein A (NusA), human protein disulphide iso

188 of reversibility of TSLR due to short-lived substances provides insights into physical processes: se

189 f consciousness induced by three psychedelic substances: psilocybin, ketamine and LSD.

190 chips for multiplexed analysis of different substances reaching very good detectability.

191 Somatic symptom disorder, substance-related and addictive disorders, feeding and e

192 oreover, male patients had 19% lower odds of substance-related events 2 years after medication period

193 ), and female patients had 14% lower odds of substance-related events 2 years after medication period

194 s between pharmacological ADHD treatment and substance-related problems remain unclear.

195 es, and for attention-deficit/hyperactivity, substance-related, and mood disorders.

196 itude, no influence of humidity or any other substance relevant to the off-gas analysis, as well as a

197 hese devices alone, some common and harmless substances show the same response as the hazardous targe

198 Both substances smell citrussy, fresh and floral.

199 Using International Humic Substances Society standards, Suwannee River fulvic acid

200 osition similarity based on high-dimensional substance-specific quantitative parameters including m/z

201 ry signaling platforms that detect microbial substances, sterile environmental insults, and molecules

202 s to helminths and an array of environmental substances such as allergens.

203 rgence, mediates the transport of apoplastic substances such as Ca into the xylem.

204 tion was attributed to the presence of polar substances such as p-hydroxybenzoicacid, procyanidin B1

205 netics and tissue distribution of xenobiotic substances, such as perfluorooctanoic acid (PFOA), in or

206 Similar behavior with humic substances suggests that they and BrC share a common lin

207 0.21mug/ml) and thiobarbituric acid reactive substances (TBARS) (2.56mug/g) within 28days, and provid

208 pectroscopy and thiobarbituric acid reactive substances (TBARS).

209 ents that need to be assimilated and harmful substances that need to be expelled.

210 There are broad-spectrum substances that prevent the first step of virus-cell int

211 In the brain, astrocytes secrete diverse substances that regulate neuronal function and viability

212 colonies and secrete extracellular polymeric substances that surround the individual cells.

213 analyzed 5036 concentrations of 22 chemical substances that were measured between 1986 and 2014 at 3

214 ittle is known about the properties of other substances, that are mainly used as a foodstuff, for con

215 variety of artificial surfaces and biologic substances, the plasma proteins factor XII (FXII) and pr

216 the criteria which would be expected from a substance to be released in response to RIPC and to prot

217 valuating the efficacy of a chemotherapeutic substance, underscoring the potential of the system for

218 ommon causes were cardiovascular (10.9%) and substance use (9.8%).

219 with genes implicated in the neurobiology of substance use (DRD2, PDE4B).

220 Further adjustment for adolescent risky substance use and antisocial behaviour attenuated the re

221 populations of PLWH, including persons with substance use and mental health disorders.

222 the domains of mental state, behaviour, and substance use are likely to be most successful in helpin

223 Chronic substance use can disrupt the reward function of the ant

224 534 samples were grouped according to their substance use combination as controls (CTR), smokers (SM

225 f integrated care to address psychiatric and substance use comorbidities; and electronic data tools f

226 of homelessness, imprisonment, sex work, or substance use disorder (excluding cannabis and alcohol u

227 Having a comorbid personality or substance use disorder also increased the risk of suicid

228 trong associations were observed between any substance use disorder diagnosis and the polygenic risk

229 merican College of Physicians maintains that substance use disorder is a treatable chronic medical co

230 t that comorbidity between schizophrenia and substance use disorder is partially attributable to shar

231 y is most consistent with a general risk for substance use disorder rather than specific risks for in

232 a blurred boundary between schizophrenia and substance use disorder.

233 7), conduct disorder (97.1 [0.82]; P = .02), substance use disorders (alcohol abuse, 96.5 [0.67]; P <

234 isorder (AOR: 1.8; 1.4-2.2), although not of substance use disorders (AOR: 1.2; 0.9-1.5).

235 everal neuropsychiatric disorders, including substance use disorders (SUDs).

236 rized by neural hyperexcitability, including substance use disorders (SUDs).

237 er rather than specific risks for individual substance use disorders and adds to increasing evidence

238 Substance use disorders are major contributors to excess

239 , millions of individuals need treatment for substance use disorders but few receive it.

240 episodes and Wave 2 depression, anxiety and substance use disorders controlling for background chara

241 Substance use disorders involving illicit and prescripti

242 f clinical overlap of mania with anxiety and substance use disorders provide a basis for re-examining

243 g the opioid epidemic, insurance coverage of substance use disorders treatment, education and workfor

244 unipolar depression, anxiety disorders, and substance use disorders).

245 eating disorders, autism spectrum disorder, substance use disorders, anxiety disorders, and personal

246 on deficit hyperactivity disorder (ADHD) and substance use disorders, are characterized by deficits i

247 sion: homeless populations, individuals with substance use disorders, sex workers, and imprisoned ind

248 e is associated with Parkinson's disease and substance use disorders.

249 ng high rates of mental health disorders and substance use disorders.

250 ariety of adverse health outcomes, including substance use disorders.

251 ion, schizophrenia, cognitive disorders, and substance use disorders.

252 resents a viable target for the treatment of substance use disorders.

253 ing disorders that is comorbid with mood and substance use disorders.

254 opment in adolescents' natural resilience to substance use disorders.

255 have mainly focused on the risk side of the substance use equation: escalation of substance use.

256 ment for adolescent antisocial behaviour and substance use measures.

257 ests investment in evidence-based adolescent substance use prevention programs in any additional stat

258 k score, each 1-point increase in a friend's substance use risk score increased a respondent's odds o

259 After adjustment for a participant's substance use risk score, each 1-point increase in a fri

260 periencing sexual violence (SV) and friends' substance use risk scores predicted whether adolescents

261 Experiences of SV and substance use within adolescent girls' friendship networ

262 eneration (eg, violence, mental illness, and substance use).

263 recocious sexual activity, bullying, illicit substance use).

264 ely) after adjustment for sociodemographics, substance use, and human immunodeficiency virus status.

265 d a broad range of fear, distress, behavior, substance use, and other disorders.

266 d self-reports of ADHD symptoms, impairment, substance use, and other mental disorders, with consider

267 atory factors such as socioeconomic factors, substance use, depression, and sexual behaviours, and wh

268 medications and confounding factors, such as substance use, previous adverse birth outcomes, and demo

269 ting risks of health outcomes, consisting of substance use, sexual health, mental health, weight and

270 of the substance use equation: escalation of substance use.

271 morbid disorder, or the cognitive effects of substance use.

272 ccurring exclusively in the context of heavy substance use.

273 isorders such as depression and anxiety, and substance use.

274 ch as treatment with medication and maternal substance use.

275 rrent adolescent mental health disorders and substance use.

276 stimulant that has recently been linked to a substance-use disorder and 'pharmacoterrorism' in the Mi

277 hol-use disorder (AUD) is the most prevalent substance-use disorder worldwide.

278 like behavior in rats.SIGNIFICANCE STATEMENT Substance-use disorders are often characterized as "habi

279 Individuals suffering from substance-use disorders develop strong associations betw

280 ith those from prior neuroimaging studies in substance-use disorders, thus raising the possibility th

281 ates in the second wave as a function of key substance-use outcomes in wave 1.

282 We considered the changes in substance-use outcomes over a 3-year period among young

283 ets for interrupting the virus life cycle in substance using hosts.

284 Substance-using youths, aged 14 to 24 years, seeking ED

285 dy was conducted in a single ED and involved substance-using youths.

286 ps according to thiobarbituric acid reactive substances values after 9days of display.

287 ificantly as the concentration of one of its substances varies: for example, blood permittivity depen

288 fluencing the detoxification of co-occurring substances via biotransformation.

289 (2) D was found to decrease when the tested substance was (13)C labeled, and this isotopic effect al

290 The identity of seven substances was confirmed by authentic reference standard

291 Transformation and sorption of these substances were assessed in targeted batch experiments u

292 Phenolic substances were compared in crude, semi-purified extract

293 wed that under all tested conditions organic substances were leached out of the 1C-PU coating.

294 nd several other perfluorobutane sulfonamido substances were present as well.

295 Quantified substances were theobromine, theophylline, caffeine, cat

296 luorescence indexes related to tyrosine-like substances were well correlated with the concentrations

297 ain vast amounts of Sphagnum-derived organic substances which can act as powerful chelators for disso

298 epsy pharmacotherapeutics include controlled substances with abuse potential or drugs with undesirabl

299 An increased separation of four substances with similar low field ion mobility is shown:

300 m triclosan, triclocarban, and antimicrobial substances with similar properties and effects.