ライフサイエンスコーパス: substance P receptor

1 ceptor, angiotensin II type 1A receptor, and substance P receptor.

2 we constructed chimeras between PAR1 and the substance P receptor.

3 tail sequestered and recycled like wild-type substance P receptor.

4 th high (nM) affinity and specificity to the substance P receptor.

5 amina I spinal cord neurons that express the substance P receptor.

6 were equally effective at desensitizing the substance P receptor, a classic reversibly activated GPC

7 study, the effects of microinjections of the substance P receptor agonist, [Sar9.Met(O2)11]-substance

8 h a cell maintains responsiveness to PAR1 or substance P receptor agonists over time.

9 Substance P receptor and the P/S chimera showed little d

10 dicative of pain, the internalization of the substance P receptor, and c-Fos expression in lamina I n

11 ify NALCN as the cation channel activated by substance P receptor, and suggest that UNC-80 and Src fa

12 5-HT3 label was only present in small GABA-, substance P receptor-, and calbindin-containing neurons

13 cribes an asymmetric synthesis of the potent substance P receptor antagonist (+)-CP-99,994 from 4-phe

14 Administration of a substance P receptor antagonist in mice.

15 The substance P receptor antagonist, CP-96,345, not only blo

16 The nonpeptide, substance P receptor antagonist, CP96-345, significantly

17 Administration of a specific substance P-receptor antagonist (CP-96,345) reduced toxi

18 e P release and pretreatment with a specific substance P-receptor antagonist blocked LTB4-induced sub

19 The effect of a specific substance P-receptor antagonist was also studied.

20 oduced by NMDA were significantly reduced by substance P-receptor antagonists or by elimination of su

21 By contrast, wild-type PAR1 and a substance P receptor bearing the cytoplasmic tail of PAR

22 5'ET4 cells, nor was DAB389 GRP cytotoxic to substance P receptor-bearing cells.

23 n cells stably transfected with the bullfrog substance P receptor (bfSPR).

24 In the present study, substance P receptor binding was localized in the dorsal

25 thyrotropin-releasing hormone receptor, and substance P receptor) bound both betaarrestin isoforms w

26 the radiolabeled peptides in the presence of substance P receptor caused covalent attachment of the p

27 mitations in the Ag-specific CTL response in substance P receptor-deficient mice could result from lo

28 Furthermore, substance P receptor-deficient mice showed a reduced CTL

29 , wild-type animals were markedly reduced in substance P receptor-deficient mice.

30 rmeable AMPA receptors are expressed by some substance P receptor-expressing (NK1R+) neurons in lamin

31 We focused on substance P receptor-expressing (NK1R+) projection neuro

32 ing protein saporin that specifically target Substance P receptor-expressing cells.

33 The importance of substance P receptor expression in vivo was further sugg

34 fact by investigating the contribution that substance P receptor expression makes toward immunity ag

35 The ability of Salmonella to induce substance P receptor expression on cultured macrophages

36 stration that mice, genetically deficient in substance P receptor expression, showed an increased vir

37 ntibody constant region (Fc) receptor or the substance P receptor fail to produce a model inflammator

38 ability of macrophages to express authentic substance P receptors (i.e., NK-1 receptors) has been in

39 la (BLA) are reported to specifically lesion substance P receptor immunoreactive (SPR-IR) interneuron

40 dies demonstrate that genetic elimination of substance P receptors in mice results in an increased ga

41 stimulation of the medial amygdala activates substance P receptors in the medial hypothalamus, thus t

42 gical methods to determine the role of NK(1)-Substance P receptors in the midbrain periaqueductal gra

43 results demonstrate a major requirement for substance P receptors in the pathogenesis of acute infla

44 rated the presence of: (1) high densities of substance P receptors in the ventromedial hypothalamus,

45 Wild-type substance P receptor internalized and recycled after act

46 ut also a large-scale internalization of the substance P receptor into dorsal horn neurons, as well a

47 estioned the contribution that expression of substance P receptors makes to the protective response f

48 The distribution of substance P receptors may reconcile apparent mismatches

49 ella induced rapid and dramatic increases in substance P receptor mRNA expression within Peyer's patc

50 o acid identity to the tachykinin receptors (substance P receptor, neurokinin A receptor, and neuroki

51 Both fluoxetine and the substance P receptor (NK(1)R) antagonist (SPA) L-0007607

52 Gene-targeted disruption of the substance P receptor (NK-1R) protected the lung from imm

53 y altering the trafficking fates of PAR1 and substance P receptor, one can dictate the efficiency wit

54 on; PAR1 bearing the cytoplasmic tail of the substance P receptor (P/S) behaved similarly.

55 rneurons, identified with immunostaining for substance P-receptor, parvalbumin, and mGluR1a-receptor,

56 amina I spinal cord neurons that express the substance P receptor play a pivotal role in the transmis

57 ssion rather than basket cell death, because substance P receptor-positive interneurons, some of whic

58 phosphorylate purified and reconstituted rat substance P receptor (rSPR).

59 A chimeric PAR1 bearing the substance P receptor's cytoplasmic carboxyl tail sequest

60 ggest that the cytoplasmic tails of PAR1 and substance P receptor specify their distinct intracellula

61 that loss of spinal neurons that possess the substance P receptor (SPR) attenuated pain and hyperalge

62 The substance P receptor (SPR) gene is expressed at high lev

63 on and ligand-induced internalization of the substance P receptor (SPR) in the spinal cord in acute,

64 The substance P receptor (SPR) is a G protein-coupled recept

65 ndogenous substance P (SP) activation of the substance P receptor (SPR) on enteric neurons in the rat

66 The striatal distribution of the substance P receptor (SPR) protein was examined in relat

67 soactive intestinal peptide receptor (VIPR), substance P receptor (SPR), and gastrin-releasing peptid

68 Substance P receptor (SPR), which plays a key role in pa

69 Substance P receptor (SPR)-expressing spinal neurons wer

70 The recent finding that Substance P receptors (SPRs) are expressed exclusively i

71 Unexpectedly, however, antagonists to the substance P receptor (the NK1 receptor) could achieve th

72 anisms responsible for this improvement, the substance P receptor was blocked in mice after traumatic

73 xin, DAB389 SP, directed to cells expressing substance P receptors, was not cytotoxic to 5'ET4 cells,

74 s individually expressing neuropeptide Y and substance P receptors were mixed in the same well.

75 Activation of substance P receptors, which are coupled to Galpha(q), i

76 belong to peptide receptor subfamily (e.g., substance P receptor), with more distant relationship to