ライフサイエンスコーパス: substantial

1 professional career over the past decade is substantial.

2 contributions from the 6d-orbitals were more substantial.

3 er, but the risk to the fetus and newborn is substantial.

4 in which the unmet therapeutic need remains substantial.

5 Here we report the detection of substantial (8.3 +/- 0.8 per cent from our most conserva

6 icrostructural characterizations reveal that substantial accumulation of phase boundary sliding at me

7 Substantial advances in treatment, such as robotic surge

8 ing NMDA receptors may inadvertently produce substantial adverse consequences for cocaine addiction.

9 combinant attenuated strains, can still show substantial adverse or lethal actions in the brain.

10 That work determined that there was substantial agreement on the need for a mixture of push

11 greement in detecting CC fractures was 0.65 (substantial agreement).

12 terogeneity, their scale has not resulted in substantial alterations to the comet's landscape.

13 confidence, the inter-observer agreement was substantial among the US pathologists (kappa, 0.63; 95%

14 dolycaena marsyas and show that it possesses substantial amorphous gyroid character, demonstrating th

15 dication for anorectal testing, along with a substantial amount of anorectal-only infections.

16 g activity of theta-driving neurons shares a substantial amount of information with the theta wave re

17 HPLC analysis indicated presence of substantial amount of lycopene in soluble fraction which

18 Most eukaryotic genomes contain substantial amounts of repetitive DNA organized in the f

19 The impact of early industry is substantial and rivals more recent metal fluxes, resulti

20 etween sexually antagonistic traits remained substantial and significant even after accounting for al

21 historical data with CRT alone, toxicity was substantial, and LRF still occurs in approximately 20%,

22 hes (order Pleuronectiformes), which display substantial asymmetry of the olfactory organs and forebr

23 that an APDS2 mutation in p85alpha leads to substantial basal activation of p110delta (>300-fold) an

24 Each approach produces substantial benefits and net cost savings relative to th

25 Our study suggests substantial benefits of extending the approach to treatm

26 ate students in scientific research promises substantial benefits, but it is not accessible to all st

27 elective removal of light during nights with substantial bird migration is a viable strategy for mini

28 A substantial body of empirical work and recent computatio

29 Now that a substantial body of research has established the existen

30 Falls result in substantial burden for patients and health care systems,

31 t ART coverage in Botswana, there is still a substantial burden of advanced HIV, with 2013-2014 incid

32 Latin America has a substantial burden of influenza and rising Internet acce

33 ta-download bottleneck more evident, placing substantial burdens on the research community to keep pa

34 The model predicts substantial capital and labor flows from rural to urban

35 now spend 2.4 years and women 3.0 years with substantial care needs, and most will live in the commun

36 investment in the first 1000 days, enabling substantial catch-up from early growth failure, and leve

37 pment used for injecting drug use (IDU) is a substantial cause of disease burden and a contributor to

38 application to greater samples is revealing substantial cell-to-cell variation in expression levels

39 Intra-tumor heterogeneity poses substantial challenges for cancer treatment.

40 However, substantial challenges remain in the scalability, stabil

41 y diagnosed dementia has not been subject to substantial change in the past two decades.

42 ain regulatory factors is conserved, despite substantial change in the specific sites of regulation.

43 A substantial change in trial methodology for solid tumour

44 nd circular dichroism spectroscopy showed no substantial change to the structure of LPS in the presen

45 Substantial changes appear possible, suggesting this is

46 However, the bacterial community experienced substantial changes following ZVI exposure, with more Pr

47 f the intervertebral disc (IVD) demonstrates substantial changes in cell and matrix composition with

48 seous metastatic disease was associated with substantial changes in intended management in Medicare b

49 adolescent growth spurt (10-14 years), when substantial changes place commensurate demands on good d

50 ses of secondary structure elements revealed substantial changes rendering the hybrid de facto nonrea

51 Despite substantial clinical need for TB prevention and treatmen

52 factor binding sites in LCL GM12878 revealed substantial co-localization of EBNA3s with RUNX3-a prote

53 Bangladesh has substantial cold-chain storage and transportation capaci

54 We found evidence for substantial common regulation and conservation of gene e

55 mainly because such networks usually engage substantial computational resources, the handling of whi

56 sponse and illustrates how such data can add substantial confidence to target identification and vali

57 The reduction induces substantial contraction in all bond lengths around the m

58 f a specific objective test has been raising substantial controversy about this entity.

59 gradients inherent to plasma accelerators is substantial correlated energy spread-an obstacle for key

60 f mammals (Carnivora), both of which exhibit substantial craniofacial diversity.

61 Regulation is complex, with substantial crosstalk across these multiple pathways.

62 ICANCE STATEMENT Zika virus (ZIKV) can cause substantial damage to the developing human brain.

63 t epidemic ribotypes and was associated with substantial declines in total C difficile infections in

64 However, substantial declines in total P may drive tropical plant

65 iopsies, while another 2 recipients showed a substantial decrease in C4d scores.

66 well as humans with lipodystrophy, exhibit a substantial decrease in levels of circulating exosomal m

67 arly 2000s and their rise has coincided with substantial decreases in several important fish species.

68 c ribonuclease activity that corresponded to substantial degradation of cellular RNA.

69 We found substantial derangements in both neuronal excitability a

70 We identified substantial differences among CA, AA, and AS populations

71 an represent as much as 35% of fixed N, with substantial differences between cultures using the Mo- a

72 e of ATP are much too small to explain their substantial differences in light scattering.

73 potassium were independently associated with substantial differences in mortality risk.

74 For snail kites, our method reveals substantial differences in movement strategies for diffe

75 he lineage leading to mammals, together with substantial differences in the subcellular location of t

76 of care than white stroke survivors without substantial differences in unmet need.

77 to multiple psychiatric disorders and causes substantial disability.

78 improve clinical care, at present there is a substantial discrepancy between research knowledge and i

79 against CPM and 30.1% (n = 343) reported no substantial discussion about CPM.

80 highly divergent genomic distributions with substantial disruption of bimodal, CpG density-dependent

81 h quantum chemical calculations, suggested a substantial divergence of PxaTPS8 from other TPSs leadin

82 stence of multiple populations, existence of substantial diversity, and similarity of hospital isolat

83 oduction, with negative consequences for the substantial economic, cultural, and ecosystem services t

84 s indicate that the independent factors have substantial effect on the pectin yield.

85 TATION: Education of religious leaders had a substantial effect on uptake of male circumcision, and s

86 ighlight that parental environments can have substantial effects in offspring generations.

87 We anticipate that there could be substantial effects on chronic pathology, natural immuni

88 liver disease is a growing problem that has substantial effects on public health.

89 Substantial efforts had been made to identify significan

90 However, despite substantial efforts, no generally applicable computation

91 Until now, however, the substantial electrostatic disorder of the solid state ha

92 own to elevate CUP1 transcription) lead to a substantial elevation in rate of both interhomolog and i

93 ustrial importance and practically entails a substantial energy penalty, typically necessitating the

94 al properties of ecosystems are experiencing substantial erosion, with potentially pervasive effects

95 ufficient methodological maturity to provide substantial evidence about such representations.

96 Substantial evidence at the subcellular level indicates

97 In the present study, we provide substantial evidence demonstrating that TIM-1 is importa

98 This study provides for the first time substantial evidence for extensive Cu metallurgy already

99 Substantial evidence suggests that breast cancer initiat

100 While there is substantial evidence tying low SES to increased disease

101 (H1N1pdm09) from humans to pigs resulted in substantial evolution of influenza A viruses infecting s

102 sponse to light and temperature, and allowed substantial expansion of its distribution range.

103 panel of experts with knowledge of CBCT and substantial experience in applying CBCT to a broad range

104 to 58.3% (ever e-cigarette use), indicating substantial false-negative rates.

105 rbidities, the risk was reduced but remained substantial for both death by suicide and attempted suic

106 d that the resulting methanol incorporated a substantial fraction (70%) of gas-phase O2 More oxygenat

107 We observed that the 1D MPS exists in a substantial fraction of dendritic regions in relatively

108 A substantial fraction of marine plastic debris originates

109 e led to changes in intended management in a substantial fraction of patients with prostate or other

110 Balaur can securely outsource a substantial fraction of the computation to the public cl

111 A substantial fraction of the proteome is intrinsically di

112 ervosa was 0.20 (SE=0.02), suggesting that a substantial fraction of the twin-based heritability aris

113 sual experience occurs during the day when a substantial fraction of the visual pigment in our photor

114 ults suggest that tarsometatarsi play a more substantial functional role than tibiotarsi and femora.

115 -Centered Outcomes Research Institute offers substantial funding to support this approach, but gettin

116 nge of electronic applications which require substantial gain.

117 ction in China have largely been eliminated, substantial gaps in quality of care persist in both sett

118 and access for persons with chronic disease, substantial gaps remain, particularly for minorities and

119 -related population, which therefore implies substantial genetic continuity in the Levant since at le

120 al genesis and differentiation pathways, and substantial genetic correlations were found between neur

121 losis and Mycobacterium smegmatis, encompass substantial genetic diversity and are commonly temperate

122 Overall our results reveal substantial global epigenomic change in mammalian sperm

123 ity is a heritable trait that contributes to substantial global morbidity and mortality.

124 The last few decades have seen substantial growth in the populations of competitive ath

125 the negative adjustments under the repealed Substantial Growth Rate model.

126 Thus, HRV represents a substantial health care and economic burden for which th

127 Acute Pancreatitis is a substantial health care challenge with increasing incide

128 of the spot sign in any phase was related to substantial hematoma expansion (P < .001 for all compari

129 n presentation, the greater the frequency of substantial hematoma expansion (P = .013).

130 n for full-dose anticoagulation therapy, and substantial hepatic or renal impairment.

131 ge artery atherosclerotic stroke (LAS) shows substantial heritability not explained by previous genom

132 mproving child survival in Africa, there was substantial heterogeneity in absolute levels of under-5

133 netically identical cells frequently display substantial heterogeneity in gene expression, cellular m

134 Furthermore, substantial heterogeneity supports the need for more rob

135 the Southern Hemisphere [4], despite a more substantial history of fossil sampling north of the equa

136 ion and protein analysis indicated that this substantial hypertrophy was associated with both the com

137 This finding implies the existence of substantial ice volume in the Aurora subglacial basin be

138 state cancer, preliminary data demonstrate a substantial impact on clinical management.

139 ber and quality of social relationships have substantial impacts on health, well-being, and longevity

140 itive to changes in climate, which will have substantial impacts on the livelihoods of the more than

141 e, we show that these changes translate into substantial improvement on multiple empirical datasets.

142 ublinearly with the input population size, a substantial improvement on previous implementations of p

143 The Quality Payment Program is a substantial improvement over the negative adjustments un

144 nation beyond traditional predictors, with a substantial improvement prediction of amputation with AC

145 = .7), and when combined multiplicatively, a substantial improvement was seen (IQ-OR, 1.64; 95% CI, 1

146 Substantial improvements in the planning, monitoring, an

147 Fire-driven carbon and nitrogen losses were substantial in savanna grasslands and broadleaf forests,

148 We note substantial inaccuracies with GFT-predicted influenza ac

149 soenergetic replacement does not result in a substantial increase in blood triglyceride concentration

150 Interestingly, we observed a substantial increase in Neto2 Ser-409 phosphorylation in

151 In AIH/AISC we noted a substantial increase in peripheral blood-derived CD4(+)

152 A substantial increase in the abundance of [M + Na](+) add

153 omic integrity in these cells is linked to a substantial increase in the stability of RAD51 at DNA do

154 ) through day 28 (0.20%; P = .14), driven by substantial increases in 2 participants who received BMS

155 into classic fluorophore structures elicits substantial increases in brightness and photostability,

156 Ecological comparisons revealed substantial increases in HPV vaccination during this tim

157 whether repeated shocks of this kind lead to substantial increases in the prevalence of firearm owner

158 leled structural and functional maturations, substantial individual variability, and high vulnerabili

159 ndings show that climatic factors can have a substantial influence on infectious disease patterns, al

160 to be a crucial uncertainty that may have a substantial influence on the life-cycle impacts.

161 at surround proteins and biomolecules have a substantial influence upon their function and stability.

162 This dorsomedial nucleus also showed substantial innervation by trigeminal nerve fibers immun

163 chnology-empowered diagnostics are serving a substantial input to identify biomarkers associated with

164 We begin by reviewing the substantial insight gained from more than 50 years of ex

165 ysis between spinach and sugar beet suggests substantial inter- and intra-chromosome rearrangements d

166 tment at the genomic level must contend with substantial inter-individual natural genetic variation.

167 However, due to substantial interannual variability, a 25% load reductio

168 ting of triplet excitons, which now attracts substantial interest when used in conjunction with singl

169 larly within a short training session, is of substantial interest.

170 Very substantial investments have been made, over 30 years, t

171 This network of global coverage requires substantial investments in laboratory infrastructure, eq

172 The agreement for T stage was good/substantial (k=0.790) and for N stage was moderate (k=0.

173 ntrareader agreement ranged from moderate to substantial (kappa = 0.55-0.67).

174 f biparametric MR imaging interpretation was substantial (kappa = 0.81).

175 d Atg17 complexes are required to overcome a substantial kinetic barrier in the transition to the cup

176 As a result, substantial lead time was needed to resolve procurement

177 rmless bacteria as porogens, and demonstrate substantial Li-oxygen battery performance improvement by

178 This survey revealed substantial lipid profile differences between neurons an

179 RPRETATION: Childhood CSE is associated with substantial long-term neurological morbidity, but primar

180 luding a poor solubility of fatty acid and a substantial loss in the therapeutic activity.

181 We demonstrate a substantial loss of antimicrobial function when the pept

182 ia virus of mice (PVM) resulted in rapid and substantial loss of osteoblasts from the bone surface.

183 Consistently, LIL3-deficient plants exhibit substantial loss of POR as well as CHLP, which is not du

184 observed that ageing in mice started with a substantial loss of these hypothalamic cells.

185 MI) has been shown to effectively identify a substantial low-risk subset of patients possibly safe fo

186 ication of the latter estimate is limited by substantial measurement noise.

187 For a substantial minority of users, the combined effect may b

188 In Ethiopia, there is a substantial mismatch between need and supply of corneal

189 especially in severe forms that might cause substantial morbidity and even mortality, particularly w

190 depressive disorders and is associated with substantial morbidity and mortality, including maternal

191 heart disease is a challenging problem with substantial morbidity and mortality.

192 disorder in the United States, and leads to substantial morbidity, though associated mortality is ra

193 prolonged hospital stay, increased cost and substantial mortality.

194 and transcriptomic dysregulation even after substantial motor dysfunction and pathology were observe

195 CXCL6 and CXCL8 3'-UTRs unexpectedly led to substantial mRNA decreases.

196 ded 218 +/- 8 kcal/d.During CVVH there was a substantial net uptake of both glucose and citrate that

197 Despite these advances, a substantial number of patients with inflammatory arthrit

198 We discovered a substantial number of public CDR3-TCRbeta segments that

199 e, well educated, and economically well off, substantial numbers of harder-to-recruit women also enro

200 Substantial numbers of HSIL would have been missed by st

201 This approach has the potential to spare substantial numbers of women the morbidity of ALND.

202 tential therapies have been taken, there are substantial obstacles that will need to be overcome if C

203 ly 0.010 standard units per decade, which is substantial on an evolutionary timescale.

204 We believe there is a substantial opportunity to improve radiotherapy delivery

205 like other systems with low exchange energy, substantial oscillator strength is sustained at the sing

206 TRPV4 activation despite the absence of the substantial osmotic gradients frequently employed for ac

207 Substantial outbreaks of yellow fever in Angola and Braz

208 We also found that substantial overexpression of CaMK2N2 in dorsal hippocam

209 show that, even when taking into account the substantial overhead of quantum error correction, and th

210 ctrons across each GPNJ, so that the lack of substantial overlap between transmission lobes across su

211 Substantial overlap exists in the clinical presentation

212 This study indicates that a substantial part of the variation in tooth loss is expla

213 DNA variants are suspected to account for a substantial part of undiscovered causes of rare diseases

214 t inhibitors in IDH1 mutant gliomas may have substantial patient benefit.

215 Such hospitalizations are associated with substantial patient, caregiver, and economic costs.

216 is common in both Uganda and the UK, but the substantial phenotypic differences might reflect fundame

217 eveal that myrmecoid clades are separated by substantial phylogenetic distances-as much as 105 millio

218 ester 30 was the only prodrug that achieved substantial plasma levels of 1.

219 ite oxides such as BaTiO3 and PbTiO3 exhibit substantial polarization and stability, but have the dis

220 Our analysis revealed a substantial population of Tfr cells in livers of chronic

221 ined with increasing elevation, resulting in substantial population structure in the higher elevation

222 revealed that fluorotelomer betaines were a substantial portion of the organofluorine in some waters

223 The cloning of Ms2 has substantial potential to assemble practical pipelines fo

224 However, there are substantial practical challenges in applying this approa

225 Substantial preclinical and clinical research into chron

226 h the grey literature suggests that AXO is a substantial problem.

227 Diagnosis of the causative organism has a substantial prognostic importance.

228 There is potential for substantial progress by adapting strategic body mass reg

229 een controversial for several decades and no substantial progress for a practical application has bee

230 istress syndrome (ARDS) was first described, substantial progress has been made in identifying the ri

231 Recently, substantial progress has been made on the characterizati

232 Substantial progress has been made toward the developmen

233 In conclusion, our findings indicate that a substantial proportion of donors have platelets with con

234 A substantial proportion of HPV DNA detections may be depo

235 Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is derived

236 re elevated in surface sediments and bound a substantial proportion of Ni.

237 ociated with permanent shunt dependency in a substantial proportion of patients post-ICH.

238 For a substantial proportion of patients with mild symptoms, g

239 Additionally, a substantial proportion of the adaptive lymphocytes that

240 A substantial proportion of the reads mapping to protein-c

241 existent photocontact allergy occurring in a substantial proportion.

242 he interim assessment that rVSV-ZEBOV offers substantial protection against Ebola virus disease, with

243 Two of the laminarins contained substantial quantities of very low m.w. compounds, some

244 onsequently, such a pK difference could have substantial ramifications for assessing the translocatio

245 tive fashion by increased contractility with substantial reach.

246 Both groups were similar in terms of substantial recanalization (Thrombolysis in Cerebral Isc

247 ed accumulation for HA-treated MSC yielded a substantial reduction in inflammation as demonstrated by

248 ctral sensitivity of these effects and their substantial reduction in melanopsin knockout animals ind

249 r no ESA), ESA therapy was associated with a substantial reduction in mortality [risk ratio (RR) 0.63

250 1/tristetraprolin double knockout mice, with substantial reduction in the number of tumor cytotoxic T

251 Substantial reductions in adult mortality have been obse

252 emia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, i

253 Despite substantial reductions in leaf gas exchange, barley plan

254 -2.4% loss of global croplands by 2030, with substantial regional disparities.

255 riod in development when the brain undergoes substantial remodeling in response to the environment.

256 olar thermal energy conversion has attracted substantial renewed interest due to its applications in

257 Plants divert substantial resources to produce nectar that attracts po

258 hown to act as "aquatic noses," supporting a substantial revision of the current definition of the ch

259 on rhythmic enzyme activities that allow for substantial rhythms in pathway flux and metabolite conce

260 effective, it is still laborious and carries substantial risk of adverse events.

261 ng that the autonomic nervous system plays a substantial role in HSV pathogenesis.

262 nic comorbidities in which alcohol use has a substantial role.

263 There is substantial room for improvement in diet quality in all

264 obal model quality relatively well, there is substantial room for improvement in local quality assess

265 ing polyfluorinated arene building blocks in substantial scale is important.

266 d Ravn virus (RAVV), is difficult because of substantial sequence variability.

267 utine clinical screening, is associated with substantial short- and long-term mortality.

268 s that are mutated in cancers can often have substantial short-term effects, but the emergence of res

269 asite development revealed an unexpected and substantial slowing of parasite maturation in acutely in

270 rop yields have also served as a pathway for substantial soil C sequestration.

271 ide fluxes to the atmosphere, with phases of substantial soil carbon loss alternating with phases of

272 landfills can be a long-term, (potentially) substantial source of PFOS.

273 ngs are poorly characterized but potentially substantial sources of trace metals to the landscape.

274 A substantial stability of functional and morphologic para

275 Despite successfully achieving substantial stabilization, however, almost all mutations

276 Moderate-to-substantial statistical heterogeneity was noted.

277 We found a substantial stiffening of single filaments above a chara

278 organelles have small circular genomes with substantial structural and genetic similarity to bacteri

279 Substantial subsets of these genes exhibited altered exp

280 hese discoveries have been complemented by a substantial suite of experimental studies, now bridging

281 Substantial SUV variations were seen mainly for scan-res

282 NA surface at 20 mM Mg(2+) that is much less substantial than at 20 mM K(+) (-120 mV vs -210 mV).

283 oint blockades, the nanovaccine demonstrates substantial therapeutic effect.

284 This distinction may have substantial therapeutic implications as direct anti-infl

285 Our laboratory experiments demonstrated substantial thermal effects.

286 res further adaptation before representing a substantial threat to public health.

287 We conclude that each scenario poses substantial threats.

288 with 91% reduced use of firewood (p < 0.01), substantial time savings for primary cooks, a 72% reduct

289 of nitrogen-starved yeast cells resulted in substantial transcriptome changes.

290 igh-risk vaccination remains cost-effective, substantial uncertainty exists as to whether low-risk el

291 Up, although the economic analyses indicated substantial uncertainty.

292 sider biphasic pathogen dynamics can lead to substantial under- or overestimation of disease risks an

293 we present STITCHER 2.0, which represents a substantial update to STITCHER.

294 ate (IR) was 11.4 cases/100000 persons, with substantial variation by state (range, 3.1-47.6 cases/10

295 All three models demonstrate substantial variation in cancer risks, by at least 20 or

296 ical and ecological gradients that result in substantial variation in fish total mercury concentratio

297 s that these individuals unexpectedly retain substantial vision in daylight.

298 on of the choroidal neovascular stage before substantial vision loss has occurred and to consider die

299 e burst or lower-frequency tonic APs undergo substantial voltage attenuation as they spread into the

300 leaf vein xylem conduits were embolized, and substantial xylem embolism arose only under severe dehyd