ライフサイエンスコーパス: substantial increase

1 ach, the NCp7-annealed primer-template has a substantial increase (3- to 7-fold) in the rate of incor

2 ges are likely to have been limited before a substantial increase accompanying the evolution of flowe

3 ation from rRNA-depleted RNA-seq data showed substantial increased accuracy of linear transcript expr

4 After substantial increases between 1998 and 2005 in the propo

5 d to the dose of intraduodenal leucine, with substantial increases during both 0.15 and 0.45 kcal/min

6 This is a substantial increase from the genetic variance identifie

7 This is a substantial increase from the genetic variance identifie

8 ersonal health care and public health showed substantial increases from 1996 through 2013; with spend

9 A substantial increase (>30-fold) in expression of the luk

10 sel vehicles (count/min) was associated with substantial increases (>100%) in in-vehicle concentratio

11 A substantial increase in abundance of the PAO Candidatus

12 phatidylinositol 4,5-bisphosphate leads to a substantial increase in adhesion area of the sessile GUV

13 d marrow and may allow, for some patients, a substantial increase in administered activity and thus t

14 d type 1 diabetic Akita/129 mice exhibited a substantial increase in albumin-to-creatinine ratio (ACR

15 phorylation by the LKB1 complex results in a substantial increase in AMPK activity.

16 These changes were associated with a substantial increase in AMPK and Akt phosphorylation and

17 in transgenic MA, which was accompanied by a substantial increase in angiotensin II-induced constrict

18 Recent studies suggest a substantial increase in ASD prevalence above earlier Cen

19 are specific to each ortholog, as well as a substantial increase in asymmetry in the interactions ob

20 We report a substantial increase in atopy at all ages and in a remar

21 This has resulted in a substantial increase in available habitat and rapid rang

22 Climate change, which generally involves a substantial increase in average temperatures in mountain

23 ate levels in response to prostacyclin and a substantial increase in basal Akt activation.

24 With the substantial increase in BAV utilization and the continuo

25 We observed a substantial increase in biofilm density upon the additio

26 o PHLDA2 into one-cell zygotes resulted in a substantial increase in blastocyst development, whereas

27 soenergetic replacement does not result in a substantial increase in blood triglyceride concentration

28 ater energy and power densities along with a substantial increase in both calendar and cycle life.

29 obligation in EU waters will likely cause a substantial increase in bycatch rates in longliners, at

30 Cells overexpressing Radil show a substantial increase in cell adhesion, as well as in int

31 nditions, only elevated temperature led to a substantial increase in cell maintenance costs.

32 In vivo, Sort1(-/-) mice showed a substantial increase in cellular infiltration of neutrop

33 dia thickness was markedly decreased, with a substantial increase in circumferential wall stress, ind

34 nisotropy experiments, however, results in a substantial increase in complex formation, indicating a

35 no significant trend in droughts, we show a substantial increase in concurrent droughts and heatwave

36 PD and optimized HCD analyses demonstrated a substantial increase in confidence in identification (as

37 tations ranged from very little (R106W) to a substantial increase in conformational sampling (F155S).

38 rve at the neck in rats, which may provide a substantial increase in connections between the contrale

39 reased the rate to 80% to 95%, though with a substantial increase in cost.

40 All scenarios allow for a substantial increase in crop production, using an area 1

41 As well as a substantial increase in data and additions to existing g

42 The substantial increase in education, especially of women,

43 on of sildenafil alone was associated with a substantial increase in EFD score (mean, 7.7 [95% CI, 6.

44 at the method presented here could lead to a substantial increase in efficiency in drug discovery and

45 protein expressed in Escherichia coli with a substantial increase in efficiency over previous methods

46 Consistent with the substantial increase in entropy observed in the course o

47 programme in rural India was associated with substantial increase in equitable contact coverage for d

48 This resulted in a substantial increase in F protein synthesis in infected

49 eas LB1-deficient nuclei exhibit primarily a substantial increase in face area.

50 This subsequently leads to a substantial increase in fibrillization.

51 ries (cod and pollock) that have experienced substantial increase in fishing pressure over the past 6

52 Child health received the most substantial increase in funding since 2003 (286%), follo

53 cocultures, while Western blotting showed a substantial increase in GDNF protein.

54 ent of the samples (90 degrees C) promoted a substantial increase in gel strength due to protein dena

55 reliminary results of Phase 2 studies show a substantial increase in growth rate of ACH children afte

56 poprotein B-containing particles, leads to a substantial increase in HDL-C levels.

57 s predicted that vaccination could lead to a substantial increase in hospitalisation because of dengu

58 (whites, blacks, and Hispanics) experienced substantial increase in hypertension treatment and contr

59 The substantial increase in IHCL seen over this period in bo

60 Despite the substantial increase in internodal length, no significan

61 ovascular glaucoma patient who experienced a substantial increase in IOP associated with severe eye p

62 In a companion study, we demonstrated a substantial increase in Kir2.1 protein occurs in beta-ce

63 ogy, genetics, and imaging has resulted in a substantial increase in knowledge about the development

64 esis in brown adipose tissue is defined by a substantial increase in levels of mitochondrial reactive

65 ling in the liver was also associated with a substantial increase in lipoprotein lipase activity in t

66 fluenza infection has been associated with a substantial increase in local and systemic IFN-gamma con

67 In contrast, there was a substantial increase in long-term mortality after a spon

68 t disease (CHD) and stroke has resulted in a substantial increase in longevity, with subsequent growt

69 The substantial increase in lymphopoietic and hematopoietic

70 atory cells in lungs of IKTA mice revealed a substantial increase in macrophages and lymphocytes, inc

71 RNA-mediated knockdown of TPC2 also caused a substantial increase in melanin content in both MNT-1 ce

72 e, ovarian suppression was associated with a substantial increase in menopausal symptoms, sexual dysf

73 A substantial increase in molecular complexity occurred th

74 ic fatigue syndrome, but our findings show a substantial increase in mortality from suicide.

75 All cities showed a substantial increase in mortality risk associated with m

76 In contrast, males that showed a substantial increase in mPOA DA during precopulatory int

77 genetic defect can be accomplished without a substantial increase in mutational burden.

78 SLIP-GC-deficient mice experienced a substantial increase in mutations at G:C base pairs at t

79 Interestingly, we observed a substantial increase in Neto2 Ser-409 phosphorylation in

80 We specifically show that 27-OHC induces a substantial increase in NF-kappaB binding to the BACE1 p

81 In conclusion, substantial increase in NOAC usage has occurred.

82 among the elderly (increased by 2%) due to a substantial increase in nonvaccine types (NVTs).

83 at elimination of Chop during obesity led to substantial increase in number of adipose tissue T and B

84 geing of the world's population is causing a substantial increase in number of people affected.

85 s a highly energetic event, which requires a substantial increase in nutrient metabolism.

86 The substantial increase in open-circuit voltage and reducti

87 oltage fluctuation conditions that include a substantial increase in overall membrane conductance.

88 The hot solid shows a substantial increase in oxygen disorder around the lambd

89 A substantial increase in papillary thyroid carcinoma (PTC

90 midst of an opioid crisis that has led to a substantial increase in patients at risk for this vision

91 he offshore and coastal reference sites with substantial increase in PCDD/F concentrations in the mid

92 In AIH/AISC we noted a substantial increase in peripheral blood-derived CD4(+)

93 This treatment of polymersomes resulted in substantial increase in permeability for organic compoun

94 Concomitantly, there is a substantial increase in phosphorylation likely tied to c

95 Here, we analyze the substantial increase in platelet count induced by ALA an

96 d consistently small by LSA standards, and a substantial increase in population size is obvious only

97 missense variant in KCNT1, which produced a substantial increase in potassium channel current.

98 rate advantages of the approach, including a substantial increase in power over competing methods.

99 Our findings show a substantial increase in practice consultation rates, ave

100 The substantial increase in prescription and illicit opioid

101 diabetes in all age groups might result in a substantial increase in prevalence of diabetes-related c

102 s protective effect correlated well with the substantial increase in production of KatB, a Mn-catalas

103 ple challenges including the necessity for a substantial increase in production to meet the needs of

104 mono-N-oxide analogue 17a did indeed cause a substantial increase in reactivity of the mustard unit,

105 the predonation value, largely because of a substantial increase in renal blood flow.

106 susceptible, PUSA population (Asia-II-7), a substantial increase in resistant ratios was observed in

107 lts indicate that hippocampal neurons show a substantial increase in responsiveness to task-relevant

108 g 20 mg/day or more of corticosteroids had a substantial increase in risk even after adjustment for d

109 Nevertheless, there is a substantial increase in risk of suicide compared with th

110 hese nine LOF variants was associated with a substantial increase in risk of T2D (OR = 7.22; P = 0.00

111 nally stable atropisomeric alcohol, with the substantial increase in rotational barrier arising from

112 BCL11A knockdown was associated with a substantial increase in S/G2-phase human HSCs after engr

113 time available at XFELs and should enable a substantial increase in sample throughput at these facil

114 s with localized surface plasmons allows for substantial increase in sensitivity of chem/bio sensors.

115 y elevated in NAFLD, which correlated with a substantial increase in serum FGF21.

116 , the HL/EL-dko mice exhibited an unexpected substantial increase in small low-density lipoproteins.

117 increase in mortality and morbidity, with a substantial increase in stroke and systemic thromboembol

118 dynamic perturbation by AF considered led to substantial increase in stroke propensity (i.e., 2.5-3.8

119 erived prostaglandin E2 (PGE2) parallels the substantial increase in stroke-mediated blood-brain barr

120 US enlisted Marines have experienced a substantial increase in suicide rates.

121 es and clouds is less frequent, leading to a substantial increase in surface shortwave forcing.

122 ignificantly lower all-cause mortality and a substantial increase in survival for both men and women.

123 on from grassland to shrubland resulted in a substantial increase in terrestrial C sequestration.

124 mation encoded by neuronal firing; and (2) a substantial increase in the ability of both single neuro

125 A substantial increase in the abundance of [M + Na](+) add

126 onstrained experimental conditions demands a substantial increase in the acquisition speed of high re

127 This resulted in a substantial increase in the amount of F protein expresse

128 This reduction in error resulted in a substantial increase in the amount of genetic variation

129 oxygenic photosynthesis, which resulted in a substantial increase in the amount of oxygen in the atmo

130 e assembly of the liquid crystals promotes a substantial increase in the condensation rate of silicic

131 ion of mesothelial ultrastructure revealed a substantial increase in the density of microvilli in DIO

132 d before screening) and more the result of a substantial increase in the detection of small tumors (w

133 er, and (3) multivariate methods may offer a substantial increase in the discovery of genetic variant

134 stacking and lamellar spacing, leading to a substantial increase in the efficiency of bulk heterojun

135 ed in the structural remodeling of KIF and a substantial increase in the elastic modulus of the netwo

136 Compared with their unlocked counterparts, a substantial increase in the emission yield is also obser

137 se in fatty acid (FA) oxidation as well as a substantial increase in the expression of PPARalpha and

138 tration of the drug a decade ago, there is a substantial increase in the failure rate of oral miltefo

139 and contraction force generation, and caused substantial increase in the fibrogenic marker miR-21 exp

140 entify the molecular level mechanism for the substantial increase in the fluorescence signal strength

141 n vivoandin vitro Finally, we demonstrated a substantial increase in the helicity of this region in t

142 Between 2000 and 2009, a substantial increase in the incidence of NAS and materna

143 pharmacologic suppression of FasL produced a substantial increase in the influx of tumor-rejecting CD

144 in the percentage of myelinated axons and a substantial increase in the mean g-ratio of myelinated a

145 in the percentage of myelinated axons and a substantial increase in the mean g-ratio of myelinated a

146 The redesigned rrnDB brings a substantial increase in the number of genomes described,

147 are required for gene silencing, providing a substantial increase in the number of identified compone

148 , the organ donor shortage has resulted in a substantial increase in the number of patients who under

149 s formed among the touching finger tips, the substantial increase in the observed SERS signal was dom

150 complications and wound infection, without a substantial increase in the operative time.

151 Overexpression of AtADS2 resulted in a substantial increase in the percentage of glycerolipid a

152 ine, the 2017 ACC/AHA guideline results in a substantial increase in the prevalence of hypertension,

153 ine, the 2017 ACC/AHA guideline results in a substantial increase in the prevalence of hypertension,

154 recommended for hypertension treatment and a substantial increase in the proportion of adults conside

155 sitive troponin assays will likely lead to a substantial increase in the proportion of detectable tro

156 expanded use of MTBDRplus DST resulted in a substantial increase in the proportion of new cases iden

157 The substantial increase in the proportion of Tregs we found

158 5 mm methyl-beta-cyclodextrin (MCD) caused a substantial increase in the rate of agonist-evoked pore

159 demonstrate that depletion of CALM causes a substantial increase in the ratio of "open" clathrin-coa

160 sulfate reduction, and were accompanied by a substantial increase in the relative abundance of Desulf

161 g prion infection of the OSE could lead to a substantial increase in the release of prion infectivity

162 of the IFN-stimulated gene signature with a substantial increase in the release of proinflammatory c

163 , population-based cohort study suggested no substantial increase in the risk of cardiac malformation

164 are R47H mutation of TREM2 correlates with a substantial increase in the risk of developing Alzheimer

165 ease stages 3 to 5 and are associated with a substantial increase in the risk of ESRD and ACM before

166 with external systems by >90% because of the substantial increase in the separation between the subst

167 severe reactions, MCA can be documented by a substantial increase in the serum tryptase level above b

168 This substantial increase in the server capacity is achieved

169 wist1-Jagged1 double heterozygotes exhibit a substantial increase in the severity of craniosynostosis

170 is approximately 25%, and this results in a substantial increase in the signal-to-noise ratio allowi

171 IFN-gamma induced a substantial increase in the spatial proximity between PM

172 ns, and half-life measurements demonstrate a substantial increase in the stability of most mRNA speci

173 omic integrity in these cells is linked to a substantial increase in the stability of RAD51 at DNA do

174 This paper shows that a substantial increase in the throughput of the TOF MS-bas

175 Between 2006 and 2010, we found a substantial increase in the use of broad-spectrum antibi

176 The substantial increase in the worldwide prevalence of asth

177 or people with Down's syndrome have led to a substantial increase in their longevity.

178 nanopore sequencing technology have led to a substantial increase in throughput and sequence quality.

179 The Dm-dNK-expressing mice showed a substantial increase in thymidine-phosphorylating activi

180 decrease, whereas knockdown of S6K2 caused a substantial increase in TNF-alpha and TRAIL (TNF-related

181 aboveground large wood pools, resulting in a substantial increase in total system carbon.

182 A substantial increase in toxicity (EC(50) approximately 1

183 nsity (BMD), surprisingly caused mainly by a substantial increase in trabecular bone mass, resulting

184 rastic reduction in the B1 B-cell pool and a substantial increase in transitional and marginal zone B

185 orted in the mug/h/cm(2) range, presenting a substantial increase in transport capacity in comparison

186 ome-wide significant loci, each conferring a substantial increase in TS risk (NRXN1 deletions, OR = 2

187 0 nm) revealed that laser treatment caused a substantial increase in tumor temperature, from 37 degre

188 ensitivity (1 ppb) can be achieved through a substantial increase in turn-on emission fluorescence in

189 ation on all three stop codons, to provide a substantial increase in unnatural amino acid incorporati

190 2 in double-negative thymocytes and caused a substantial increase in usage of TRAV12 in Tcrd recombin

191 randomized controlled data, there has been a substantial increase in use of percutaneous mechanical c

192 We find a substantial increase in water-use efficiency in temperat

193 adoption of longer season cultivars caused a substantial increase in yield ranging from 13% to 38% ov

194 diction method for hybrid yield and showed a substantial increase in yield through genomic hybrid bre

195 ) through day 28 (0.20%; P = .14), driven by substantial increases in 2 participants who received BMS

196 Between 1970 and 2010, substantial increases in adult mortality occurred in sub

197 ycardia, PR prolongation, ST depression, and substantial increases in atrial premature beats, sinoatr

198 in contrast, rainfall addition alone caused substantial increases in biomass, whereas fertilization

199 urther demonstrate that dysc mutants exhibit substantial increases in both evoked and spontaneous syn

200 These findings support substantial increases in both short-term and long-term n

201 mmation indicated that only 40 mL/kg induced substantial increases in both, consistent with developme

202 into classic fluorophore structures elicits substantial increases in brightness and photostability,

203 duals that lived between 1960-2000 indicated substantial increases in C3 herbaceous plants in their d

204 y to enhance T cell function has resulted in substantial increases in clinical efficacy.

205 e reduction in the Raoult effect, leading to substantial increases in cloud droplet concentrations.

206 l motor injury (F2 lesion), which results in substantial increases in contralateral M2 labeling in la

207 ly higher amount of repetitive elements, and substantial increases in copy number and diversity of bo

208 ated, because it can result in transient but substantial increases in daytime sleepiness.

209 ka virus (ZIKV) in Brazil has been linked to substantial increases in fetal abnormalities and microce

210 All models predicted substantial increases in fire by midcentury, with fire r

211 position that we observed occurred alongside substantial increases in forest density, and lead to a l

212 This study shows that substantial increases in handwashing with soap can be ac

213 rdiovascular disease risk, despite producing substantial increases in HDL levels.

214 Substantial increases in height have occurred concurrent

215 curse of the converted, whereby gBGC causes substantial increases in hereditary disease risks.

216 but not the training add-on, associated with substantial increases in home dialysis, which were ident

217 and nonvascular events were associated with substantial increases in hospital care costs.

218 Ecological comparisons revealed substantial increases in HPV vaccination during this tim

219 do not cause T cell activation do not induce substantial increases in intracellular HIV-1 mRNA in pat

220 Various studies report substantial increases in intrinsic water-use efficiency

221 ent in California non-Hispanic whites showed substantial increases in invasive melanoma incidence for

222 emical stimulation of DMH/PeF neurons evokes substantial increases in IOP, ICP, and the translaminar

223 by (liquid chromatography) LC/MS identified substantial increases in lactosylceramide in AB-/- mouse

224 These changes in PS resulted from substantial increases in LDL-ApoB-100 FCRs in both group

225 c LSD1 blunted these responses, which led to substantial increases in liver and serum BA levels, seru

226 l Hg was observed in floodwater, followed by substantial increases in MeHg in seston and sediment.

227 after cardiac surgery are common and lead to substantial increases in morbidity and mortality.

228 in node-positive disease was associated with substantial increases in mortality (rate ratios, breast

229 CLP caused substantial increases in mRNAs for IL-1beta and NLRP3 in

230 gene resulted in an enlargement of NMJs and substantial increases in muscle strength and life span.

231 Despite substantial increases in our understanding of the clinic

232 Participation in an FSP was associated with substantial increases in outpatient services and days sp

233 Tobacco use in PAD is associated with substantial increases in PAD-related hospitalizations, c

234 ducation, a few specialised centres have had substantial increases in patient numbers (in some cases

235 arming at high northern latitudes has caused substantial increases in plant productivity of tundra ve

236 These substantial increases in plasma and urinary dopa and dop

237 tivation of plasmacytoid dendritic cells and substantial increases in plasma interferon-alpha2 levels

238 However, concomitant substantial increases in plasma PYY and glucagon may cou

239 r maintained in vitro than in vivo, allowing substantial increases in platelet storage times.

240 iAEs are independently associated with substantial increases in postoperative mortality, morbid

241 d variance-component tests, they can achieve substantial increases in power.

242 inicopathologic characteristics, we observed substantial increases in predictive accuracy for pCR in

243 There were substantial increases in pretreatment NNRTI resistance p

244 s more than 40 million people worldwide with substantial increases in prevalence anticipated.

245 Because of the established health risks and substantial increases in prevalence, obesity has become

246 In contrast, substantial increases in prevalent AVF rates from 30.9 t

247 Substantial increases in proinflammatory, antiinflammato

248 LV replication is only slightly inhibited by substantial increases in readthrough frequency, but as w

249 f cardiovascular disease and cancer followed substantial increases in research funding, and slowing t

250 spect to class of antiretroviral, there were substantial increases in resistance to non-nucleoside re

251 multiple genes (apart from NRXN1) and cause substantial increases in risk to develop schizophrenia (

252 forms with extended anodic potentials showed substantial increases in sensitivity toward the detectio

253 We have previously observed substantial increases in spectral power in the 25-40 Hz

254 These changes caused substantial increases in steady-state photoluminescence

255 Substantial increases in SUMOylated proteins upon variou

256 e blood of unmanipulated mouse fetuses, with substantial increases in T cell trafficking after IUHCTx

257 Increases in efficacy are paralleled by substantial increases in T- and B-cell responses to EBOV

258 was common among the VCs and correlated with substantial increases in the abundance of mRNAs encoding

259 m-SWNT fraction and can be attributed to (i) substantial increases in the active electrode surface ar

260 s process, leukocyte demargination, leads to substantial increases in the clinical white blood cell a

261 Moreover, there were substantial increases in the content of all three cognat

262 y data for breast-cancer screening that show substantial increases in the detection of early-stage no

263 ethylated promoter CpG positions can lead to substantial increases in the expression of endogenous hu

264 main results in: (i) JNK1/2 activation; (ii) substantial increases in the mitochondrial levels of act

265 Despite substantial increases in the number of cases of early-st

266 using the drug praziquantel is resulting in substantial increases in the number of people, mainly ch

267 whether repeated shocks of this kind lead to substantial increases in the prevalence of firearm owner

268 "invisible" supramolecular crosslinks causes substantial increases in the ultimate gel properties wit

269 There were substantial increases in the use of evidence-based medic

270 Despite substantial increases in the use of less invasive ventil

271 es can improve insurance protections without substantial increases in total costs.

272 Overall, substantial increases in vaccine coverage have occurred

273 decreased in a similar fashion to kh despite substantial increases in xylem area.

274 Median changes in confidence were substantial (increases of 25%, 20%, and 13%, respectivel

275 lement to antiretroviral therapy, leads to a substantial increase of all CD4+ T cell subsets in HIV-1

276 Substantial increase of BrC light absorption coefficient

277 oncentration, however, were accompanied by a substantial increase of certain other air pollutants, sp

278 tigated so far, the light stimulus induces a substantial increase of charge delocalization, or in the

279 This resulted in a substantial increase of ectodomain shedding, which was n

280 nscranial magnetic stimulation resulted in a substantial increase of EEB, and so did reducing visuo-t

281 ided during cooling, a liquid will display a substantial increase of its viscosity, and will form a g

282 inter-specific species differences include a substantial increase of MT and CRH immunoreactivity in t

283 with some beneficial effects but also with a substantial increase of risks for harms.

284 The measurements also evidence a substantial increase of the "lifetime" of the electron g

285 ontrol of cell morphology that resulted in a substantial increase of the cell area.

286 Additionally, we observed a substantial increase of the ceratohyal angle of the cran

287 exploit extended causal structures, finding substantial increase of the quantum advantage.

288 tantly, tumors developed in the liver with a substantial increase of the stem/progenitor cells by 6 m

289 A substantial increase of the superfluid density and a lin

290 eleton interaction is weakened, resulting in substantial increase of the tensile stress in the lipid

291 IPMK deletion elicits a substantial increase of VEGF (vascular endothelial growt

292 This response was accompanied by substantial increases of neuronal calcitonin gene-relate

293 Overall, the substantial increases of nutrients (TN >200%, TP >100%)

294 ns over periods of about 20,000 years led to substantial increases of up to 2000 parts per million (p

295 These estimated prevalence rates represent substantial increases over the last 2 decades (relative

296 ta do not support the notion that there is a substantial increased risk of adverse pregnancy outcomes

297 bellar SUVRs in AD patients showed continual substantial increases through 30 min after administratio

298 increased in response to perceived risk with substantial increases to toxicity.

299 Since Natsal-2, substantial increases were noted in attendance at sexual

300 olesterol, and apolipoprotein B demonstrated substantial increases within the 1-year interval before