ライフサイエンスコーパス: substantiate

1 recombination between HSV-2 strains could be substantiated.

2 atients with metastatic osteosarcoma is well substantiated.

3 o predict the outcome after MI has yet to be substantiated.

4 zj = 2) was theoretically and experimentally substantiated.

5 become available, present knowledge seems to substantiate a concern.

6 Levin et al. builds on prior work to further substantiate a critical role for skin migratory dendriti

7 These findings substantiate a gating mechanism whereby the TRP domain a

8 These data substantiate a key role for compromised endocannabinoid

9 These data substantiate a need for regular broad molecular monitori

10 Furthermore, the present data substantiate a newly emerging concept that the modulatio

11 with mitochondrial respiration and shape and substantiate a pro-survival role of mitochondrial functi

12 estigation using murine gene-targeted models substantiate a role for signaling at the PTH/PTH-related

13 Together, these findings substantiate a role of memantine as a potential pharmaco

14 This study further substantiates a causal link between the V307L KCNQ1 muta

15 cell interactome of Rev and XPO1 and further substantiates a critical role for paraspeckles in the me

16 ontacts to Si solar cells, but the use of Ag substantiates a significant manufacturing cost, and the

17 contribute to modulator recognition, further substantiating a multisite model of allosteric modulatio

18 3 expression and bind to the ASHR3 promoter, substantiating a role for ASHR3 in cell division control

19 asal resistance against bacterial pathogens, substantiating a role for eNAD(+) in plant immunity.

20 iants with high ST6Gal-I expression, further substantiating a role for ST6Gal-I in cell survival.

21 nd longer term follow-up, and if results are substantiated, adjunctive periodontal therapies subseque

22 These results further substantiate an etiologic role of betapapillomaviruses i

23 These findings substantiate an evolutionary basis for the coordination

24 Our findings substantiate an important role for (68)Ga-DOTATATE PET i

25 Here, we substantiate and expand this concept to include polyunsa

26 researchers in the HIV vaccine field seek to substantiate and extend the results by evaluating other

27 occurrence of homicides has been previously substantiated, and confirmed here, in terms of a superli

28 We used a clinically substantiated anxiogenic treatment to induce sustained a

29 This data is intended to substantiate APGC-MS/MS as a comparable technique to GC-

30 we analyzed the accuracy of a theoretically substantiated approximation, which allows the calculatio

31 a canonical BAG domain, and this finding is substantiated biochemically.

32 l effects of clozapine and lithium have been substantiated, but might be less specific than previousl

33 SAR trends identified within the series were substantiated by a molecular modeling study based on a r

34 r alpha1 antitrypsin deficiency has not been substantiated by a randomised, placebo-controlled trial.

35 This was substantiated by a representative sample of US Medicare

36 showed a dependency for basophil-bound IgE, substantiated by a requirement for cell-to-cell contact,

37 ring strain in the phosphacyclic catalyst is substantiated by an observed temperature-dependent produ

38 This correlation is further substantiated by analyzing the first atomic neighbor dis

39 a four-membered intermediate, has never been substantiated by any theoretical or experimental evidenc

40 This was substantiated by applying tractography, yielding a relat

41 ll line-specific changes in mitochondria, as substantiated by changes in mitochondrial mass and DNA c

42 ings in anion binding; this fact was further substantiated by computational methods.

43 phosphonium groups in 1a(2+) and 1a*+, were substantiated by crystallography and theoretical studies

44 This conclusion was substantiated by demonstration of HNRNPL interactions wi

45 io previously unanalysed by theory but amply substantiated by empirical data, warming can cause an in

46 These conclusions were substantiated by EPR data, isotopic labeling studies, an

47 We present evidence, substantiated by evolutionary theory, demonstrating that

48 The latter was substantiated by its comparatively stable C:N ratio and

49 %), whereas a positive result was not always substantiated by LTA (specificity, 67%; positive predict

50 on of emphysema, a finding that could not be substantiated by lung density measurement at FRC alone o

51 ive Hsp90alpha-antagonist, a finding further substantiated by molecular docking and ATPase inhibition

52 ar/nanomolar concentration range and further substantiated by molecular docking studies.

53 CT phenomenon in the solid state, as further substantiated by nuC-O and nuN-O IR bands and solid-stat

54 Finally, the results were substantiated by observing reduced lung pathology upon a

55 The latter idea is substantiated by our biophysical model of nucleosome pos

56 mirrored within the cortico-subcortical loop substantiated by parallel networks.

57 nce of a WHSC1-mediated signaling cascade is substantiated by patient sample analysis in which WHSC1

58 In all, the proposed mechanism herein is substantiated by product distribution studies, kinetic a

59 This is substantiated by simulations of microwave propagation.

60 ling between heartbeat and eye movements was substantiated by the additional finding of a coupling be

61 These initial findings were substantiated by The Cancer Genome Atlas, which identifi

62 ical significance of these findings has been substantiated by the demonstrations that miR-140-5p is f

63 This association mode is substantiated by the dynamics studies with high resoluti

64 towards subcutaneous alcohol monitoring was substantiated by the ex vivo mice skin model analysis.

65 These data were substantiated by the fact that the Deltalpp DeltamsbB do

66 i donation to rhenium; strong pi donation is substantiated by the intraligand bond distances (metrica

67 ce of these systems to pathogenesis has been substantiated by the many bacteria that require them to

68 This is further substantiated by the observation that angiosperm single-

69 e role of nanofiber/nanoparticle carriers is substantiated by the programmed, tailored, or targeted r

70 tyrosine kinases in this process is further substantiated by the rescue effect of the tyrosine kinas

71 This is substantiated by the results of the computational studie

72 sure(s) and the development of asthma can be substantiated by the temporal association between the on

73 recursor in model hydrolysis experiments was substantiated by trapping experiments, thus confirming t

74 (13)C nuclear magnetic resonance signatures substantiate carbon dioxide fixation by polymerization i

75 Children with substantiated cases of physical and sexual abuse and neg

76 Our work substantiates CD73 as a target to combine with current i

77 cific exemplar structures for synthesis; and substantiate claims of potential future applications for

78 vere infections, but there remains a need to substantiate clinical benefit.

79 ion in cognitive functioning, these findings substantiate concerns about the adverse effects of devel

80 , THMs control will become more challenging, substantiating concerns about the impact of global warmi

81 These observations refine and further substantiate current understanding of the mechanisms gov

82 ions for neuromuscular disorder patients has substantiated data from patient surveys.

83 These findings substantiate early clinical reports on the direct correl

84 Review of the medical literature did not substantiate efficacy or, in most cases, any rationale f

85 e the absence of high-level comparative data substantiating efficacy in the postoperative setting.

86 ve implant primary stability, but scant data substantiate either claim.

87 f pollen with its insect vector and provides substantiating evidence that other long-proboscid Mesozo

88 We theoretically substantiate experimental observations of chloride influ

89 Simple, fast, and theoretically substantiated experimental method for determination of i

90 ese landmine and UXO results are not new and substantiate findings from existing research.

91 Controlled studies are needed to substantiate findings.

92 2) whether the teen's child was reported or substantiated for maltreatment before age 5 years.

93 sequence divergence as an additional tool to substantiate functional orthology only partially overlap

94 These results substantiate GABAergic Ube3a loss as the principal cause

95 d by maintaining the plants in elevated CO2, substantiating gas exchange analyses, indicating that th

96 .19, 95% confidence interval: 2.06, 2.33) or substantiated (hazard ratio = 3.19, 95% confidence inter

97 t present in membrane-embedded receptors but substantiate helix interactions within individual subuni

98 fauna using high throughput sequencing which substantiates how little is known on the biodiversity of

99 This finding was substantiated in a meta-analysis.

100 ath, and FICZ photodynamic activity was also substantiated in a murine skin exposure model.

101 hematogenic metastasis of melanoma cells was substantiated in an experimental metastasis model using

102 degenerative spondylolisthesis, has not been substantiated in controlled trials.

103 Our findings need to be substantiated in large, prospective randomised trials, b

104 -resistant oncogene CKS1B, which was further substantiated in primary breast tumors.

105 f race models of voluntary action is thereby substantiated in the human brain.

106 l expert laboratories, which made laboratory-substantiated information available for central analysis

107 l correlates of this general liability would substantiate its importance in characterizing the shared

108 ique promoter of microtubule catastrophe and substantiate its physiological role in cytoskeletal remo

109 conditions and current-voltage relationships substantiated its major role in the rotor drift.

110 n its deprotonation and reprotonation, which substantiates its role as the internal proton donor to t

111 h a photosynthetic transcriptomic signature, substantiating its use by breeders to produce a superior

112 experimental data which, at a minimum, fully substantiate L1 mosaicism in early embryonic development

113 To further substantiate macrophages' role in the pathogenesis of ma

114 crystal structure of Drosophila Orai (dOrai) substantiated many findings from structure-function stud

115 the teen mother had a history of reported or substantiated maternal maltreatment at or after age 10 y

116 In conclusion, this study substantiates memory B-cell characteristics of human IgM

117 ter randomised trial is a feasible method to substantiate or refute this finding.

118 rtunately, such assumptions are difficult to substantiate or validate in this context.

119 win pairs with discordant exposure status to substantiate our findings.

120 The results substantiate our hypothesis, and they are not consistent

121 -based and kinetic studies were performed to substantiate our initial findings.

122 length of each system is used to compare and substantiate our observations.

123 Taken together, these results substantiate our pharmacophore hypothesis and validate o

124 Additional work is needed to substantiate our pilot data, understand the know-do gap

125 The results presented in this report further substantiate our previous evidence and support the suita

126 These data thus substantiate our prior hypothesis that facilitating flux

127 The results substantiate our recently reported dependence on ceramid

128 To substantiate our simulation findings, we show analytical

129 extend on previous observations and further substantiate our understanding of a multisite model for

130 The bioinformatics data substantiated our findings showing that positive correla

131 Here, we have substantiated our models with experimental evidence of M

132 g kinetics and kinase selectivity profiling, substantiates our approach of targeting drug-resistant E

133 This substantiates our hypothesis that usage of structurally

134 This substantiates our theoretical expectation that the link

135 DF reaches a maximum at the resonance point, substantiating our model of rISC.

136 rbon dioxide reductase (HDCR) complex, which substantiates previous claims that the symbiont is capab

137 It substantiates previous conceptual work with evidence fro

138 at rest was instead obtained with beta-tACS, substantiating previous evidence.

139 nt knowledge about potential biomarkers have substantiated proof of effectiveness of this disease-mod

140 ed substantially over a 20 year period; (ii) substantiate proposals that REE may be used as tracers o

141 Evidence to substantiate recommendations for restriction of caffeina

142 Overall, our results substantiate reduced gene transcription as a major mecha

143 linically valid relationships from less well-substantiated relationships, standard guidelines for suc

144 Therefore, uninjured corticospinal neurons substantiate remarkable motor cortical plasticity and pa

145 However, to date there have been no previous substantiated reports of resting state correlations in t

146 the critical need, no previous research has substantiated safe opioid analgesics without abuse liabi

147 Although our experiments did not substantiate Ser(36) phosphorylation by PKCbeta, they in

148 ian alpha- and beta-cell gene signatures and substantiate several genes/pathways.

149 at a similar OCP assembly can occur in vivo, substantiating specific roles of the COCP carotenoid car

150 NMR experiments in vitro substantiate such binding, which occurs during aggregati

151 All of these observations strongly substantiate that a full PP2A complex is present in pero

152 To substantiate that an oscillatory mechanism governs the a

153 These experiments substantiate that EGFR stimulation predominantly activat

154 These data substantiate that genetic susceptibility to GBM and non-

155 the class C receptors, and our results thus substantiate that non-canonical trafficking mechanisms a

156 In the present work, we substantiate that the alkyne polarization via inductive

157 The results substantiate that the IEAP materials are tolerant to lon

158 Moreover, we substantiate that the mitochondrial biogenesis normally

159 Our results thus substantiate that the tetracarbene ligand (L(NHC)) of co

160 Immunohistochemical analysis substantiated that Galectin-1 upregulation is associated

161 aphic planes in these boron carbide datasets substantiates that crystallinity is maintained to the po

162 binding within the central binding site, and substantiates that EL4 has an important role in controll

163 Neutron reflection further substantiates that PlyC penetrates bilayers above a PS t

164 This study substantiates that tissue-associated HIV is present desp

165 The earliest change was astrocytic swelling, substantiating that in MLC the primary defect is in volu

166 These results substantiate the ability of copper to promote the additi

167 Our results substantiate the age-driven decline in NPP, but in contr

168 These findings substantiate the application of proteomics derived metho

169 They also experimentally substantiate the assumed, although not proven, key role

170 rther suggest auxiliary experiments that can substantiate the authors' claim.

171 Our findings substantiate the beneficial profile of fingolimod as a d

172 s experimental and species-appropriate tests substantiate the claims made in the target article.

173 These data substantiate the concept that the continuity of SC endot

174 ry using UPLC-QTOF and PLGS search engine to substantiate the confidence level of the data.

175 clearly indicating the need to establish and substantiate the development of product-specific varieti

176 roader population of patients are ongoing to substantiate the effects reported here.

177 These findings substantiate the elastic energy-saving role of the longi

178 These data substantiate the hypothesis of inter-blastomere differen

179 Our findings substantiate the importance and complexity of a novel de

180 Our data substantiate the important function of CDC37 in chaperon

181 nt of the child because reports increasingly substantiate the important function of gut microbes in h

182 ivomodel inCaenorhabditis elegans.These data substantiate the interaction of clusterin with biologica

183 Taken together, our data substantiate the key role of VSDIV in Nav channel fast a

184 fMRI, MR spectroscopy, and psychophysics to substantiate the link between the cortical neurochemical

185 These data substantiate the long-standing presumption that anatomic

186 Both scenarios substantiate the non-linear dependency between the inten

187 We further substantiate the notion of a neural-independent origin o

188 Ultimately, the results substantiate the notion of stress-free (Maxwell isostati

189 Findings from this study substantiate the notion that disability weights are sens

190 ed of cross-linked biopolymer-like fibers to substantiate the notion that this universality lies in t

191 the Fermi contact term could experimentally substantiate the oxidation states at the manganese cente

192 These results substantiate the possibility of self-reactivity to crypt

193 optera in comparison to other arthropods and substantiate the possible homology of the embiopteran si

194 These findings substantiate the predicted nontraditional mechanism and

195 These findings substantiate the previous concept that deficient feedbac

196 These findings further substantiate the primary role of gravity in the pathogen

197 Moreover, our findings substantiate the proposal that this small protein may ha

198 ncer cell line model, an attempt was made to substantiate the radiogenomic signature with quantitativ

199 Using a FoxO6-directed siRNA approach, we substantiate the requirement of FoxO6 for a correct radi

200 To substantiate the results of the microarray studies, real

201 pMMO intermediates and provides evidence to substantiate the role of Cu(III) in biological redox pro

202 To substantiate the role of immune responses triggered by o

203 To further substantiate the role of STXBP1, we isolated blood outgr

204 These results substantiate the segregation of taste qualities in the c

205 Thus, they directly substantiate the sense/antisense coding ancestry of Clas

206 These findings substantiate the strong familial aggregation for the 2 p

207 theoretical treatments of ORR catalysis and substantiate the subpicometer resolution of electrochemi

208 hotosynthetic rate through leaf venation and substantiate the theory that an increase in the density

209 novel class of CXCR7 inhibitors, we further substantiate the therapeutic relevance of targeting CXCR

210 Our results substantiate the use of a forward-genetics approach for

211 d of exogenous metal contamination, and they substantiate the use of hair Mn levels as a biomarker of

212 everal prospective examples are presented to substantiate the value of this approach.

213 irmation can follow at the same substrate to substantiate the voltammetric results.

214 We substantiated the astrocytic origin of SEPs through pair

215 chondrial membrane dissipation (Deltapsi(m)) substantiated the intracellular pro-apoptotic mechanism

216 al, computational, and spectroscopic studies substantiated the mechanism of triplet energy transfer a

217 nd ongoing clonal adaptation in human tumors substantiated the notion of cancer as an evolutionary pr

218 from the subsequent tensile tests, in turn, substantiated the proposed adhesion mechanisms underlyin

219 Metabonomic profiling substantiated the proteomic findings by identifying chan

220 ur own results and those of one other study, substantiated the results of the trial.

221 Our findings substantiated the significance of adaptor-mediated sorti

222 The discovery of leptin substantiated the usefulness of a forward genetic approa

223 Animal models have substantiated the view that age related neuron vulnerabi

224 ferent lengths (59, 81, and 124 amino acids) substantiates the assignment of these contributions.

225 This work substantiates the association genetics approach for reso

226 Overall, our study substantiates the biological complexity and pathological

227 d nitrate reduction), this discovery further substantiates the connection between flavodoxin/ferredox

228 thioredoxin with RFP, respectively, further substantiates the general applicability of the DI polypr

229 lable evidence from animal and human studies substantiates the hypothesis of an imbalance of the endo

230 Our study substantiates the important cell-intrinsic role of JAK2

231 In reduction, our work substantiates the inverse relationship between protein a

232 nd markers of UTIs in the general population substantiates the link between UMOD variants and protect

233 macological tools in the EAAT field but also substantiates the notion that EAAT ligands not derived f

234 /C molar ratio, in the anthropogenic source, substantiates the photoinduced dissolved inorganic nitro

235 proposed "dormancy continuum hypothesis" and substantiates the physical and molecular relatedness of

236 A diurnal cTnT rhythm substantiates the recommendation that all dynamic change

237 protracted corticosteroid use, this analysis substantiates the request for prudent and restricted use

238 l line data on chromosomes 14 and 22 further substantiates the superior performance of tREX: the cons

239 protein and, in line with previous studies, substantiates the use of complementary theoretical and i

240 This study substantiates the value of high-throughput metabolomics

241 Archaeological evidence substantiates the widely accepted view that the island w

242 ned using a commercial ELISA method, thereby substantiating the analytical merits of this unique meth

243 of MMC in an animal model and a wound model, substantiating the clinical applicability of MMC against

244 del for the alternating-access mechanism and substantiating the close coupling between global structu

245 e, with an emphasis on the level of evidence substantiating the current guideline recommendations.

246 tional activity on androgen-regulated genes, substantiating the finding that CHK2 affects prostate ca

247 (Pyramimonas) isolated from the study site, substantiating the hypothesis that microalgae undertake

248 to secular variations in marine food supply, substantiating the idea that global species richness is

249 ed d-fenfluramine-induced prolactin release, substantiating the importance of alphaCaMKII modulation

250 ed those imparted by the pah1Delta mutation, substantiating the importance of Pah1p dephosphorylation

251 or efficacy and nearly eradicates the tumor, substantiating the importance of the design of size and

252 t effective predictors of transfer efficacy, substantiating the long-standing practice of manual cura

253 llergic reactions and abnormal desquamation, substantiating the notion that allergic manifestations m

254 However, little if any attention is given to substantiating the potential benefits of such treatment

255 ysin can traverse epithelial membranes, thus substantiating the potential of PlyC as an antimicrobial

256 ctures through robust afferentation, thereby substantiating the PrS's critical role in the parahippoc

257 INTERPRETATION: Substantiating the results of the interim analyses of KE

258 multimodality of mammalian granule cells and substantiate their associative capacity predicted in the

259 ally acquired binding-inhibitory antibodies, substantiating their promise as candidate antigens again

260 ults from ongoing studies will be crucial to substantiate these findings across the drug class, but t

261 randomized, controlled studies are needed to substantiate these findings.

262 the variations, there are no experiments to substantiate these models.

263 ts of the mutations on the protein structure substantiate these new findings.

264 To substantiate these preliminary findings, the Center for

265 assification and cross-validation procedures substantiated these items.

266 jects for twenty different organic compounds substantiates these model predictions.

267 If substantiated, they may also highlight a strategy for pr

268 ettings and membrane pore sizes were used to substantiate this approach.

269 To substantiate this claim, we performed a statistical anal

270 ional, and genetic evidence are presented to substantiate this claim.

271 Here, we substantiate this connection and propose a refined theor

272 ost-effectiveness study has been designed to substantiate this hypothesis.

273 We substantiate this idea by observing clear magnetodielect

274 The evidence currently available to substantiate this idea mostly concerns sensorimotor proc

275 liminary molecular modeling was performed to substantiate this interesting photoresponsive supramolec

276 slational studies are, however, warranted to substantiate this mechanism of action of ipilimumab in p

277 surements of VSG in supported lipid bilayers substantiate this possibility, as two freely diffusing p

278 We substantiate this proposal with a theoretical analysis o

279 We substantiate this using three-dimensional phase field mo

280 ver, no directed study has been performed to substantiate this.

281 We substantiated this by showing that under error-prone con

282 ar domains of the gamma2 and gamma1 subunits substantiated this inference.

283 Mutant analysis substantiates this idea.

284 These findings are substantiated through demethylase-dead knockin mutation

285 of the selectrolyte-filled porous domains is substantiated through ionic conductivity measurements us

286 esulted in the loss of TWEAK binding to Fn14 substantiating Tyr(176) as the anchoring residue.

287 Present results must be further validated to substantiate use of (68)Ga-DOTATATE PET/CT in routine fo

288 erial populations, a finding that we further substantiate using numerical simulations.

289 The presence of Me-Cbl was further substantiated using gold nanoparticle (AuNPs) based apta

290 h and, even, teaching laboratories, which we substantiated using the lower-cost Langendorff-perfused

291 This surprising finding is substantiated using three classes of cyclic game models

292 Our model results substantiate Victorian era claims of host evolution base

293 gation of causal relationships are needed to substantiate whether methylation differences at birth in

294 This phenomenon was substantiated with 3,4-O-unproteced galacto- and fucopyr

295 toward atmospheric CO2 measurement has been substantiated with a laser-based optical cavity-enhanced

296 nd mobility, and the experimental trends are substantiated with Born-Oppenheimer molecular dynamics s

297 influence fruit set, but this has yet to be substantiated with molecular or mechanistic data.

298 n mRNA levels under elicitations and further substantiated with protein expression levels by Western

299 The robustness of these results was substantiated with several sensitivity analyses attempti

300 The therapeutic potential of Dex has been substantiated with their development and clinical testin