ライフサイエンスコーパス: substantive

1 composition seems to be more structural than substantive.

2 "optimize" binding affinity at the DAT, the substantive activity found for the n-propyl derivative (

3 r repair (numbers needed to harm, four), and substantive adjunctive interventions are needed.

4 ssful or, at a minimum, will have to undergo substantive adjustments before it can be successful.

5 ins an important goal of modern medicine and substantive advances are occurring.

6 use neither gp49B1 nor alpha(v)beta3 exhibit substantive allelic variation, their newly appreciated i

7 In contrast, loss of xylosylation produced a substantive alteration in the binding behavior of only o

8 V leads to a trunk elongation defect without substantive alteration of cell migration.

9 These findings imply substantive alterations in splanchnic blood flow control

10 all major patterns of temporal expression, a substantive amount of gene expression divergence.

11 ylcarnitine pool) in ischemic hearts without substantive amounts of [3H]eicosenoyl residues in the fa

12 ment protocols had marked heterogeneity, and substantive amounts of data about important outcomes and

13 Substantive and consistent elevations in accommodative l

14 nctional and burden of illness measures were substantive and interrelated.

15 neral moderate, in some families the risk is substantive and likely to be the consequence of unidenti

16 that DED is a progressive condition that has substantive and measurable impacts not only on the ocula

17 structural stability, power laws, and other substantive and methodological issues.

18 The incidence magnitude was substantive and persistent throughout follow-up.

19 physicians develop an understanding of basic substantive and procedural law; first, so that their pra

20 Overall, macrophages make substantive and prolonged contributions to fracture heal

21 plementation of these techniques experiences substantive and technical complications (due mainly to t

22 ed and contribute to delirium in independent substantive, and cumulative ways.

23 r constituents directly on three dimensions: substantive attitudes regarding policy issues, attributi

24 detection of gasoline adulteration and opens substantive avenues for applications in related fields o

25 chieved in this proof-of-concept study opens substantive avenues for characterization and quantificat

26 onic states of Si(2)H(3) and Si(2)H(4), with substantive basis sets.

27 es, and a paucity of baseline data to enable substantive before and after comparisons for affected po

28 Sites with substantive bioinformatics operations are challenged to

29 acts, clinicians and policymakers require a substantive body of evidence on which to base interventi

30 ng most of the neurosciences, has provided a substantive body of evidence supporting this role of sle

31 A large number of studies offer a substantive body of evidence supporting this role of sle

32 A substantive body of research exists on the psychometric

33 f ZnF-1 led to a partial growth defect and a substantive breakdown of the L-complex, whereas disrupti

34 t that optimizing glycemic control remains a substantive challenge requiring interventional paradigms

35 Biomedical manuscripts undergo substantive change as a result of the peer review and ed

36 ts receiving the low dose of NP2 reported no substantive change in pain.

37 urveys, the trends may be harbingers of more substantive changes in less abundant, more sensitive tax

38 o determine if an intervention that produces substantive changes in the daily living environment will

39 ases over Earth history can be used to infer substantive changes to the Earth's surface environment,

40 ted standard institutional language, with no substantive changes to the protocol.

41 erase components (hTR and hTERT) revealed no substantive changes, which suggests a nontranscriptional

42 ests that these restrictions may not reflect substantive clinical differences.

43 onary, and skeletal muscle physiology into a substantive composite assessment.

44 observations, it is clear that there are no substantive compromises accompanying the use of extensiv

45 We found substantive concentration differences among three major

46 rameter estimates and hence in contradictory substantive conclusions.

47 the knowledge needed for clinicians to have substantive conversations with patients.

48 ead, analysis of the 11 mutations revealed a substantive correlation between the effect of the amino

49 tatin on CRP was observed, nor was there any substantive correlation between the magnitude of change

50 The paper thereby contributes to both substantive debates on the Muslim experience in Europe a

51 Failure to detect substantive dephosphorylation of activated PKCalpha was

52 There was no substantive deviation in postnatal growth trajectory or

53 e and mutants subunit 6 failed to reveal any substantive difference of the wild type and mutant prote

54 Few substantive differences among the methods were observed,

55 These data argue against substantive differences between men and women in the lar

56 rioles of the retractor muscle indicate that substantive differences can exist in the nature of signa

57 There were no substantive differences in clinical performances between

58 aining variables, indicating that subtle but substantive differences in microbial communities occur w

59 minated only after oral training, indicating substantive differences in the processing of these stimu

60 year of clinical fellowship training in CCM, substantive differences in training requirements exist a

61 ity estimates across racial groups found few substantive differences.

62 pport autoregulation of the vicRKX operon or substantive direct regulation of fatty acid biosynthesis

63 during appetitive behaviors, though there is substantive disagreement about the specific purpose of t

64 hreshold of 3-10 microm, but failed to evoke substantive discharge in TRPV1-/- C-fibres.

65 hose surgeon recommended against CPM with no substantive discussion (14.5%; n = 37).

66 dustry representatives, provided much of the substantive discussion from which this VARC-2 consensus

67 legislation has the potential to reduce the substantive disease burden associated with second-hand s

68 rical, and methodological advances across 10 substantive domains of application.

69 this decline primarily to the initiation of substantive dust-borne iron fertilization of the Souther

70 in games in which individual actions exert a substantive effect on the environmental state.

71 identify rare disease-causing variants with substantive effects on cancer risk from preexisting geno

72 molecular species of each phospholipid have substantive effects on membrane passive ion permeability

73 Although many antioxidants have shown substantive efficacy in cell culture systems and in anim

74 Substantive efforts over the last three decades have foc

75 s need to combine biomarker development with substantive epidemiologic studies to improve on this ini

76 tly identified new items unlikely to trigger substantive episodic retrieval.

77 On the basis of substantive ethics, clinical practice, policy, and other

78 Overall, there appear to be few substantive ethnic differences in either systolic or dia

79 ssible long-term benefits observed support a substantive evaluation of this community programme.

80 human genome: 47% (35 of 74) of genes showed substantive evidence for a hot spot, and many more showe

81 We conclude that there is no substantive evidence for deforestation at Chaco and no o

82 Our findings provide substantive evidence for RNA G-quadruplex formation in t

83 Together these findings provide substantive evidence for the formation of G-quadruplex s

84 There are limited data with substantive evidence of outcome ascertainment bias, and

85 based recommendations on ECG interpretation, substantive evidence on the training needed to obtain an

86 In addition, we provide substantive evidence that the inhibition of mGluR1/mGluR

87 t of gp78 in Insig-1 degradation, we find no substantive evidence to support roles for either gp78 or

88 -1 in muscle cells, these findings provide a substantive expansion of our understanding of IGF-1 acti

89 intragenerational social mobility provides a substantive expected benefit for adult members to stay i

90 ture coevolution is a framework within which substantive explanations of human evolution must be loca

91 xamples of their application in a variety of substantive fields.

92 fertilization and improved maize seed, with substantive gains in productivity for millions of farmer

93 Substantive genetic and phenotypic differences have emer

94 f-report fluctuates due to causes other than substantive health changes.

95 prosecute top Khmer Rouge leaders and began substantive hearings in March 2009.

96 However, the substantive heterogeneity in the studies' results and de

97 ires at least 27 separate hybridizations for substantive HPV-type discrimination.

98 imental parameters in LIBS studies present a substantive hurdle for robust classification, even when

99 well tolerated and were not associated with substantive immunologic or virologic changes.

100 latter may lead to an underestimation of the substantive impact of VI on mortality.

101 Similarly, the work should have a substantive impact on how genetic variation contributes

102 Ventilator-induced lung injury has substantive impact on mortality of patients with acute r

103 leading cause of untreatable blindness with substantive impact on the quality of life of affected in

104 wever, has been underappreciated despite its substantive impact on the sensing performance.

105 Key conceptual and substantive implications are outlined in relation to bot

106 These results have substantive implications for calculation of recurrence r

107 the origins of the research question and the substantive implications of the debate.

108 a dosage of 30 mg 3 times daily resulted in substantive improvement by increasing the rate of saliva

109 cancer is an ongoing challenge with minimal substantive improvement in patient outcomes despite many

110 n with formal inference systems, can produce substantive improvements in performance over surface-for

111 ed here indicate that it is possible to make substantive improvements in the development of women's c

112 Post-RT SM depletion was more substantive in competing multivariate models of mortalit

113 Running on adulterated fuel leads to a substantive increase in air pollution, because of increa

114 esity epidemic" is paralleled by a rapid and substantive increase in our understanding of molecular p

115 brain complexity, glial cells have undergone substantive increases in cell number, diversity, and fun

116 ttransplant renal function may contribute to substantive increases in resource use, with some variati

117 Neither new algorithm provided substantive information about women at very low risk bas

118 attendant risk estimations, can provide more substantive information for the individual patient for b

119 ntigenic challenge with vaccines can provide substantive insight into the status of human immune func

120 m outcome and therapeutic response, yielding substantive insights into mechanisms of hematopoietic tr

121 We conducted a substantive, interdisciplinary literature review focused

122 ompared with 15 percent of those for whom no substantive interventions were made (P<0.001).

123 Forty-six percent of the patients for whom substantive interventions were made changed their minds

124 eated chronically with losartan suggest that substantive intrarenal actions of Ang II can be maintain

125 Two substantive issues are relevant to discussions of the ev

126 first on the variety of research designs and substantive issues to which SEM can be applied productiv

127 this general overview briefly addresses the substantive law of medical malpractice, informed consent

128 Moreover, we explore a substantive link between large deviation bounds for tail

129 -term graft survival may be possible without substantive long-term immunosuppressive treatment of the

130 d ACR-1, -4, or -5 (aa 447-454), resulted in substantive loss of biochemical activity.

131 n a model of acute pancreatitis, we observed substantive luminal acidification and provide evidence t

132 nce for g in nonmammalian species, for which substantive material exists.

133 There are few substantive methods to measure the health of the immune

134 king both Yme1 and Taz1 function, there were substantive mitochondrial ultrastructural defects, ineff

135 Thus, any further substantive mouse Y-gene functions in spermatogenesis ar

136 ter symptoms had developed did not result in substantive neurologic improvement.

137 In the presence of FIB, substantive non-covalent interactions occurred between r

138 also expressed as a self-protein, additional substantive obstacles are operative within the tumor mic

139 0.05) and was treated as a covariate with no substantive outcome effect.

140 y managed, and how MPA management influences substantive outcomes remain unknown.

141 he tetracene core is planar and there exists substantive overlap among neighboring pi-conjugated back

142 Substantive overlap with human CCA specimens was reveale

143 tion, the physician implemented at least one substantive palliative intervention, such as control of

144 Substantive palliative interventions lead some--but not

145 vel evidence of a very rapid time course for substantive perceptual changes in tactile location perce

146 ll as the role of theory testing, studies of substantive phenomena, and relevance in consumer researc

147 (two untreated and one preconditioned), and substantive platelet aggregates containing porcine leuko

148 come countries are unlikely to narrow unless substantive policy interventions occur.

149 These results show the first substantive post-exposure protection by a small-molecule

150 and memory of plants to abiotic stress holds substantive potential for improving agriculture.

151 e postoperative pulmonary complications as a substantive public health concern demanding national att

152 This article reports the findings of two substantive qualitative studies, both examining similar

153 gant application of theoretical methods to a substantive question.

154 elieve our data constitute a mechanistic and substantive rationale for clinical trials of selected MT

155 ased apoptosis, impaired angiogenesis, and a substantive reduction in the number of invasive carcinom

156 is factor alpha (TNFalpha) blockade provides substantive reduction of the symptoms of rheumatoid arth

157 with ACEI versus no ACEI was associated with substantive reductions of risk of nonfatal events (adjus

158 science and progressing through a series of substantive research and intervention domains that chara

159 The substantive results were consistent across all models; t

160 The purposes of this substantive review of alternatives assessment frameworks

161 We conducted a substantive review of EBPH, identified a consensus EBPH

162 full occupancy by water molecules, requires substantive revision.

163 e, the Update Panel concluded that no major, substantive revisions to the 2006 American Society of Cl

164 the relationship of disclosure to patients' substantive rights, and the impact of disclosure on trus

165 clusion HL survivorship is associated with a substantive risk of a second cancer.

166 , addiction to nicotine continues to carry a substantive risk of recidivism.

167 channel activity in bipolar cells suggest a substantive role for an endogenous cannabinoid signaling

168 of NK cells in PAH and suggests a novel and substantive role for innate immunity in the pathobiology

169 esults indicate that the LDN does not play a substantive role in either the generation or the stabili

170 Our results indicate that NPAS2 plays a substantive role in maintaining circadian behaviors in n

171 These findings provide further support for a substantive role of in utero infection or inflammation i

172 n male meiosis, with AtKIN14a playing a more substantive role.

173 ensitivity of the diagnostic test all having substantive roles.

174 ptically detected magnetic resonance (ODMR), substantive room-temperature magnetoelectroluminescence

175 Simple yet substantive separations of organic reaction mixtures are

176 ant throughout the life course, although the substantive size of associations indicated by simulation

177 the Asgard archaea superphyla has provided a substantive step toward addressing this evolutionary que

178 The brain undergoes substantive structural and functional changes with a dif

179 In this update, we report substantive structural annotation improvements for A. ni

180 As predicted, FBXL5-Hr undergoes substantive structural changes when iron becomes limitin

181 These studies provide substantive support for a unique clinical management of

182 the adjacent peptide bond, thereby providing substantive support for the mechanism of HCF-1 processin

183 merging epidemic of CD in the area, giving a substantive support to the World Gastroenterology Organi

184 onetheless, the finding is not without other substantive support.

185 Substantive systematic evidence is needed to clarify thi

186 Our analysis thereby has substantive, theoretical, and methodological implication

187 are in widespread use and have demonstrated substantive therapeutic efficacy.

188 creasing obesity past 51 years of age pose a substantive threat to future gains in life expectancy.

189 The discovery of substantive top-down effects of cognition on perception

190 ations and methods, and identifying emerging substantive trends.

191 ent of children in high-income countries, no substantive trials have been done of the interventions a

192 al targets whose inactivation will lead to a substantive tumor growth arrest.

193 There were no substantive untoward consequences accompanying these hem

194 esults highlight the importance of releasing substantive updates at regular intervals during a crisis

195 esence did not benefit glycemic control in a substantive way.