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1 e now being investigated as a vitreous humor substitute.
2 r living organisms and cannot be replaced or substituted.
3 molecular 1,3-dipolar cycloaddition of ortho-substituted 1,1,1-trifluoromethylstyrene-derived nitrone
5 difference in reactivity between differently substituted 1,3-dipoles is driven by distortion, whereas
6 amines 1, affording the appealing and highly substituted 1,4-dihydropyridines 4 with very good result
7 useful symmetrical and unsymmetrical 2-aryl substituted 1,4-diketone building blocks from commercial
9 e adenosine A2A receptor antagonists bearing substituted 1-methylcyclohexyl-carboxamide groups at pos
10 ioselective coupling protocol between 3-aryl-substituted-1,1-diphenyl-2-azaallyl derivatives and viny
11 -1-(trimethylsilyloxy)-1-propene result in 5-substituted-1,3-cyclohexadienes after removal of the met
14 6 literature ligands, known as bpp(X,Y) [X,Y-substituted 2,6-(pyrazol-1-yl)pyridines], which have pro
15 P), we previously identified a series of 4,6-substituted 2-aminopyrimidines that associate with this
16 nical candidate, this structurally related 7-substituted 2-nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazin
17 c elaboration to produce, for example, a CF3-substituted 2-oxa-4,7-diazabicyclo[3.3.0]octan-3-one sys
19 We report here the synthesis of 7-phenoxy-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-di
21 ar heteroannulation of newly synthesized 4,5-substituted 3-amino- or 3-hydroxy 2-functionalized thiop
22 keto counterparts, the 6-desoxo-14-benzyloxy substituted 3a displays significantly increased MOR bind
23 ade is designed for the synthesis of densely substituted 4-alkoxy quinolines via an oxonium ion trigg
25 91/6-31G(d,p)) on terminal and phenylethynyl-substituted 5,6-diethynylquinoxaline and 6,7-diethynylqu
27 hly regio- and enantioselective synthesis of substituted [6]carbohelicenes by sequential Au-catalyzed
28 which function as ready precursors of ortho-substituted 8-aryl BODIPY derivatives by reaction with b
30 cks, we examined high-pressure frozen/freeze-substituted alfalfa root cap cells with electron microsc
31 ted alkene followed by migration of the more substituted alkene during the course of a Pd-induced met
32 at involves selective activation of the less substituted alkene followed by migration of the more sub
33 2)-C2H4)2]2 catalyzes production of 1-phenyl substituted alkene products via oxidative arene vinylati
34 building blocks and 1,1-bis(trifluoromethyl)-substituted alkenes can be prepared under ambient condit
35 The hydroboration of a series of terminally substituted alkenes with BH3 was examined experimentally
37 -catalyzed Heck reaction of alpha-heteroatom substituted alkyl iodides and -bromides with vinyl arene
39 e to yndiamides, a novel class of double aza-substituted alkyne, has been established by the copper(I
41 One property of chemical bonding renders 1,3-substituted allenes chiral, making them attractive targe
42 In the presence of a chiral copper catalyst, substituted allylic iodides couple with alpha-diazoester
43 Interestingly, aryl-substituted and alkyl-substituted alpha-diketones produced different products:
44 thesized from ZnI2-mediated sulfonylation of substituted alpha-methylstyrenes and sodium sulfinates (
46 e risk of ESRD in the general population and substituting alternative sources of protein may reduce t
50 s are difficult to generate, and the alpha-S-substituted analogues are configurationally unstable.
55 unity, and it showed a preference to degrade substituted and non-substituted polycyclic aromatic hydr
56 five chiral resorcin[4]arenes, four tetra-O-substituted and one hepta-O-substituted, have been resol
57 talyse Diels-Alder reactions for a number of substituted and unreactive N-allyl-2-furfurylamines unde
58 s of 1,3-disiloxanediols, including naphthyl-substituted and unsymmetrical siloxanes, has been quanti
60 adipose-derived mesenchymal cells into skin substitutes and found that adipose-derived mesenchymal c
61 osalivation are limited to the use of saliva substitutes and medications that provide only temporary
62 le the developed asymmetric synthesis of C10 substituted anthrones is anticipated to find wider appli
63 ed that dietary Enterococcus Faecalis UC-100 substituting antibiotics enhanced growth and health of w
64 he distal gut of pigs fed E. faecalis UC-100 substituting antibiotics, this study assessed fecal micr
66 e-light irradiation, typical mono- and multi-substituted aromatic olefins could be converted into ket
68 adienes are also formed in the case of ortho-substituted arylalkynes by a metathesis-type process.
71 s of flavonoids, which have a hydroxyl group substituted at the R-3 position on the C ring, have outs
74 is strategy, finding that incorporation of 3-substituted azetidine groups allows rational tuning of t
75 n effective and simple preparation method of substituted azoxybenzenes by reductive dimerization of n
77 tions that the tau torsion of the meta-amino-substituted BDI systems leads to a zwitterionic twisted
79 ed condensation of 6-hydroxy-1-indanone with substituted benzaldehydes and to compare the reaction ac
83 nic esters and a N-activator to afford ortho-substituted benzylic boronic esters with formal 1,1'-ben
85 ming mixtures of Ga-substituted In2O3 and In-substituted beta-Ga2O3 with different degrees of substit
86 BH3 THF with K[N(NO2 )2 ](-) produced a mono-substituted [BH3 N(NO2 )2 ](-) anion, which contains a B
87 is an efficient method for the synthesis of substituted bicyclo[4.3.1]deca-2,4,8-triene-7,10-diols,
89 d bisphenol S (BPS) are increasingly used to substitute bisphenol A (BPA), a widespread environmental
91 hodology allows for the preparation of 1,2,3-substituted borocyclopropanes in high yields and diaster
93 re condensed with oxalyl boronates to afford substituted boryl imidazoles in a regiocontrolled fashio
94 ng to the extra cysteine residue of 1Dx5 was substituted by a cysteine codon through site-directed mu
96 ng oxazolidine-based pseudoprolines (PsiPro) substituted by a trifluoromethyl group, we show that the
97 polar-ion interaction cannot be functionally substituted by aromatic, non-polar, or polar sidechains.
98 tissue-engineered corneal endothelial graft substitute can alleviate this reliance on cadaveric corn
99 e rates of the reactions of the arylsulfonyl-substituted carbanions carrying alpha-chloro and alpha-b
100 those possessing numerous contiguous, fully substituted carbon atoms (i.e., tertiary alcohols and qu
101 on of a partial positive charge on the nitro-substituted carbon in both transition state and product
103 protocol for the synthesis of certain phenyl-substituted carboxylic acids from 2-phenylcycloalkanones
106 uctive cleavage enables the preparation of N-substituted cis 5-amino-3-hydroxypiperidines from a read
107 investigation of structural evolutions of Cu-substituted Co3 O4 supplemented by first-principles calc
108 derivatives have also been discovered: anion-substituted compounds where the complex borohydride anio
112 nt starting materials for the preparation of substituted cyclohexanes; however, the synthetic tools a
113 atalyzed dynamic kinetic resolution of alpha-substituted cyclohexanones has been performed and yields
115 side analogs from common precursors-properly substituted cyclopentanones, which can be prepared racem
117 somers: the former conditions afford 5-alkyl substituted cyclopentenones via beta-carbon elimination,
122 transfer of both P and Cl atoms from chloro-substituted dibenzo-7lambda(3) -phosphanorbornadiene.
123 g is used for the elaboration of the desired substituted dienes which will be involved in the second
127 substituents, halides, isolated mono- and di-substituted double bonds, esters, silyl ethers, and sily
128 e units, 15 elastin-like units, and 1 lysine-substituted elastin-like unit) with GAG GM-0111, we crea
131 atalyzed reactions of beta-triisopropylsilyl-substituted enoldiazo compounds with sulfur ylides.
132 elective rhodium-catalyzed reaction of gamma-substituted enoldiazoacetamide with nitrosobenzene produ
133 A simple method for accessing perfluoroalkyl-substituted enones is described applying a four-componen
135 found to be general for both alkyl- and aryl-substituted enones, providing the corresponding 4-oxopip
136 he kinetics of the reactions of monoacceptor-substituted ethylenes (H2C horizontal lineCH-Acc, 1) and
137 anism in which chain extension with fluorine-substituted extender units switches largely to an acyl c
139 It was found that the reaction with alpha-substituted five- to seven-membered cyclic amines procee
143 vitro, and the mutant prion-like domain can substitute for a portion of a yeast prion domain in supp
144 ey interact and the degree to which they can substitute for each other have not been systematically e
145 the hypothesis that many cancer drivers can substitute for each other in certain contexts and broade
148 se of N-hydroxyquinolinimide as a convenient substitute for N-hydroxyphthalimide in the catalytic aer
151 t, heterologous Oxs1 and Pap1-homologues can substitute for S. pombe Oxs1 and Pap1 to enhance stress
153 audit-based physical disorder measure could substitute for the in-person one with little to no loss
154 ed with advection along vessels is likely to substitute for the lymphatic drainage system in other or
157 beta1D-integrin expression and that Tln1 can substitute for Tln2 in preserving heart function, but th
158 that the daily consumption of cashews, when substituted for a high-carbohydrate snack, may be a simp
160 nder and would impart increased potency when substituted for benzodioxole in paroxetine derivatives.
161 t at pre-primitive streak stages where it is substituted for by P-cadherin We also show that Snail2 a
163 mino acid p-benzoyl phenylalanine (pBzF) was substituted for Tyr72, which led to a catalytically inac
164 ethod (mCIM), in which tryptic soy broth was substituted for water during the inactivation step and t
165 tive currently in phase III clinical trials, substituted for Y-redirected cells and enabled tumor deb
166 hese disease markers that are intended to be substitutes for a clinical outcome and to accurately pre
167 , we show that eYHB-based alleles are robust substitutes for antibiotic/herbicide-dependent marker ge
169 propose that the body of eIF5A functionally substitutes for polyamines to promote general protein sy
171 cation to the development of potential blood substitutes for the rare Bombay blood type that is chara
172 roteins promote resistance by preferentially substituting for EGFR/RAS/ERK signaling rather than ERBB
173 Upon deprotonation of the NH group, a C6F5-substituted formazan undergoes facile cyclization as a r
175 reactive sites were consumed by chlorine, Cl-substituted functional groups (Cl-DOM) are reacting with
181 phile at the alpha-position to provide fully substituted glycolic esters with three contiguous stereo
182 ographs of thirty children with ceramic bone substitute grafting were analyzed using the software fro
183 es, four tetra-O-substituted and one hepta-O-substituted, have been resolved by enantioselective HPLC
185 nd synthesized a collection of novel hydroxy-substituted heteroarylpiperazines and heteroarylhomopipe
188 des, under palladium catalysis, to produce 4-substituted homopropargyl alcohols and 5-en-3-yn-1-ols,
190 s a possibility that hair could be used as a substitute in building the database for the geographical
193 tly with temperature, forming mixtures of Ga-substituted In2O3 and In-substituted beta-Ga2O3 with dif
195 dole and an organo-B(pin) species to provide substituted indoles and indolines with high enantio-, re
197 or V (i.e., Nb and Ta) transition metals are substituted into zeolite *BEA, the metals that form stro
198 via one-pot three-component reactions using substituted isatins, alpha-amino acids, and cyclopropene
199 ently trapped with electrophiles to generate substituted isocyanides incorporating contiguous tri- an
201 a single-cysteine (C16) hVELC construct and substituted it for the VELC of bovine cardiac myosin sub
202 ound to react with perfluorobenzonitrile (2) substituting its para-fluorine atom to form 2-(4-cyanote
203 nation and that an increase in the number of substituted lysines tends to increase APP metabolism.
204 This method allows access to differently substituted (mainly on phenyl ring) indoles and 1-benzot
205 rization-deficient GLUT1 variant in which we substituted membrane helix 9 with the equivalent GLUT3 s
207 yses, we present evidence that SDH6 and SDH7 substitute missing sequence stretches of SDH3 and SDH4 i
208 have used a boundary replacement strategy by substituting modified DNAs for the Fab-7 boundary, which
209 number of steps required to synthesize these substituted molecules, and enabling late stage functiona
213 n characterization of 3,7- and 2,6-dithienyl-substituted NBA molecules and corresponding isomeric NBA
214 FeMo-cofactor in the MoFe protein, either by substituting nearby amino acids or transferring the isol
221 is demonstrated for the synthesis of highly substituted oxazoles from readily accessible ynamides in
222 rapping of the benzylic cations by the ortho-substituted oxygen and nitrogen nucleophilic groups.
230 ), in the meta position of the symmetrically substituted phenyl ring is expected to form axially chir
232 ides a new synthetic route to valuable amino-substituted phosphiranes and phosphirenes, respectively.
234 ted with reduced grapheme oxide (rGO), vinyl substituted polyaniline (VS-PANI) and lutetium Phthalocy
238 The single nucleotide polymorphism rs1143678 substitutes Pro(1146) for Ser in the integrin alphaM cyt
239 This method opens a rapid access to gamma-substituted propyl-1,1-diesters, ketoesters, cyanoesters
240 f amine end-capped polyynes as precursors to substituted push-pull thiophenes was next presented.
241 tively, the regioselective assembly of 3-CF3-substituted pyrazoles can be performed via two-step one-
242 ation, -arylation, and -heteroarylation of 3-substituted pyrazoles have been achieved using K2CO3-DMS
243 c study of the N-substitution reactions of 3-substituted pyrazoles under basic conditions has been un
246 proton donor and acceptor slurry containing substituted pyridinium triflates and the corresponding p
247 for the alpha-C-H alkylation of a variety of substituted pyrrolidines, piperidines, and tetrahydroiso
250 concise and straightforward access to highly substituted pyrrolobenzoxazines with high efficiency and
253 on, whereas the latter result in the 4-alkyl substituted regioisomers with concomitant oxidation at t
256 omplementary strategies: (i) coordination of substituted sodium phenolates to form the substrate-boun
258 adopt an alternative statistical method that substitutes space for time to estimate the temperature s
259 readily generate the bicyclic alkyl-/alkenyl-substituted stannylenes, ArSn(norbornyl) (2a or 2b) and
261 lts of DFT calculations and experiments with substituted styrenes indicate that the coupling proceeds
262 eaction mixture generated mono-, di- and tri-substituted sugar complexes and their hydrolysis product
263 components into a variety of differentially substituted sulfonimidamides containing medicinally rele
264 series of isatin derived difluoronitromethyl substituted tertiary alcohol benzoates and naphthoates w
267 ggested that small localized fluoride anions substituted the hydroxyl anions in hydroxyapatite crysta
268 e observed for small DAT inhibitors, whereas substituting the DAT C terminus with that of SERT affect
269 This mutation alters channel structure by substituting the highly conserved first arginine residue
270 a direct and efficient means of selectively substituting the meta-position of anilines to produce ar
271 the ability to detect small microplastics by substituting the subjectivity of human visual sorting wi
272 inetic isotope effect (KIE) is observed upon substituting the transferred hydrogen atoms by deuterium
273 annot be transformed to mimic one another by substituting the variable cysteine residues at position
274 iscuits, crackers, instant coffee and coffee substitute; the acrylamide content evolution during gast
275 ient chemoselective practical route to fully substituted thiazoles and 2,3-dihydrothiazoles has been
276 ent enantioselective synthesis of quaternary-substituted thiazolines through the organo-catalyzed hal
277 roots of Decalepis hamiltonii are traded as substitute, to meet the international market demand of H
280 ormational analysis suggested that trans-3''-substituted trioxolanes would exhibit Fe(II) reactivity
282 One example is the lack of a blood meal substitute, which accounts for the Wolbachia-specific ph
284 rboxaldehyde (AD half) and a dihydrodipyrrin substituted with a beta-ketoester (BC half) forms a prop
286 locyanine fused in peripheral positions octa-substituted with alkyl linked carbazole has been prepare
289 he consecutive C4-hydroxyprolines (Hyps) are substituted with an alpha-galactose and 1-5 beta- or alp
292 When lysine (Lys) residues of the hD4R are substituted with arginine (Arg) residues, cellular hD4R
293 amenability of the amide nitrogen atom to be substituted with bulky groups, we developed quinazoline-
294 rated with arabinose side chains that may be substituted with ferulic acid, thus limiting depolymeriz
295 two subphthalocyanines (SubPcs) peripherally substituted with hydrogen (H12SubPc) or fluorine atoms (
297 obial decapeptide tyrocidine A, (Tyrc A) was substituted with the d-Phe-2-aminobenzoic acid (2-Abz) m
299 s an optical indicator composed of a bismuth-substituted yttrium iron garnet thin film, and visualize
300 or enantioselective synthesis of fluoroalkyl-substituted Z-homoallylic tertiary alcohols has been dev
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