ライフサイエンスコーパス: substitution

1 ptides to demonstrate the value of thioamide substitution.

2 are required to better characterize generic substitution.

3 rom 1 patient with a germ line NLRP3 p.V198M substitution.

4 tituted beta-Ga2O3 with different degrees of substitution.

5 ilar to that achieved with canonical cis-4'' substitution.

6 mic with -tau f , or by performing the ionic substitution.

7 rs from the major E3 isoform only by a C112R substitution.

8 :RGS protein pair based on single amino acid substitutions.

9 ed with both the p.Tyr245Cys and p.Ala356Thr substitutions.

10 ion through perturbations caused by chemical substitutions.

11 c medications, primarily through therapeutic substitutions.

12 nal peptides with inactivating twin arginine substitutions.

13 20,570 variations totally, including 20,328 substitutions, 88 insertions, and 154 deletions, compare

14 yping indicated that a single non-synonymous substitution (A120G) in the N-terminal region of eIF2Bbe

15 because trimming the Phe by small amino acid substitutions abolished alphaLbeta2 binding with soluble

16 Importantly, a T239D or F240D substitution abrogates the activity of GSDMD consisting

17 ence variants in our cases included missense substitutions adjacent to the PBX1 homeodomain (p.Arg184

18 These amino acid substitutions affect well-conserved residues in the prod

19 olymer-iodide and was subsequently used as a substitution agent in a polar solvent by simply adding t

20 with: phenolics, through dearomatizing ortho-substitution; alkaloids, through Hofmann-type eliminatio

21 These LALA-PG substitutions allow a more accurate translation of resul

22 ional evidence independent of the nucleotide substitution analyses is needed to support a primary rol

23 REE system showed resilience mainly through substitution and increased non-Chinese primary productio

24 The K36M substitution and NSD1 defects converge on altering methy

25 re subject to error-prone repair, leading to substitution and short frameshift mutations, they are bo

26 lactomannan with a high degree of galactosyl substitution and was shown to be endo-acting generating

27 lective pressure accumulate more maladaptive substitutions and are more prone to splicing errors.

28 main, which is highly tolerant of amino acid substitutions and continual addition of glycosylation si

29 Substitutions and deletions of these loops had surprisin

30 provides a practical tool for investigating substitutions and might assist in quality control and in

31 ntial savings of generic or therapeutic drug substitutions and price negotiation.

32 , including different types of skeletons and substitutions, and antibacterial properties of extracts

33 is affected by energy balance, macronutrient substitutions, and diet and lifestyle patterns.

34 ylation site is mutated by single-amino-acid substitution are highly attenuated and nonlethal.

35 d gap shift directions associated with Sb/In substitution arise from different atomic configurations

36 olutionary analysis indicates that the S139N substitution arose before the 2013 outbreak in French Po

37 In contrast, substitutions around the alkene strongly affect the reac

38 e, whereas the cluster of Y981S/G985E/M1056I substitutions, as well as R1150Q/R1150W, augmented Mg-nu

39 ely little effect on quadricyclane lability, substitution at a bridgehead position with a methyl grou

40 The reaction, formally a nucleophilic substitution at an sp(2) carbon atom, allows the direct

41 in exon 3, which causes a leucine to serine substitution at codon 102 (Human Genome Variation Societ

42 A drawback to this approach is that substitution at more than one or two sites often comes a

43 ining an aspartic acid (D) to asparagine (N) substitution at position 405 (D405N) mutant was partiall

44 ene that corresponds to an alanine to valine substitution at position 673 in APP (A673V), or position

45 to genotype at rs117648444, which encodes a substitution at position 70 of the IFN-lambda4 protein a

46 n because of an alanine-to-valine amino acid substitution at residue 188 in NS1.

47 lpha-methylisoserine strongly depends on the substitution at the C and N termini.

48 is of knock-in mice with cysteine-to-alanine substitution at the palmitoylated residues (4CA mice).

49 of activated aziridines with indoles having substitutions at 3- and other positions followed by cycl

50 In contrast, substitutions at alpha4Gln-124 and alpha4Thr-126 reduced

51 s for propofol, other than those modified by substitutions at beta(Y143) and beta(M286).

52 Heterocycle substitutions at C24 were well-tolerated and several tet

53 We also show that amino acid substitutions at residues known to interact with the tri

54 total of approximately 26% single-nucleobase substitutions at the lesion site, whereas replication pa

55 of Tg and Tg analogs with various long-chain substitutions at the O-8 position extensively inhibit SE

56 Previous analysis of leucine and alanine substitutions at the Val-65-equivalent site (Val-64) in

57 We engineered substitutions at their equivalent positions in rat SUR2A

58 3-regulated splicing and that phosphomimetic substitutions at these two residues reduce binding to GU

59 perimentally evaluated effects of amino acid substitutions at toggle positions are binary, while rheo

60 A single amino acid substitution-based adaptive coevolution of the Galpha:RG

61 end: they show no octahedral tilting upon Cs-substitution but only a contraction of the lattice, lead

62 We report that methionine substitution, but not leucine substitution, results in i

63 bout 10% of the AOBr formed through chlorine substitution by bromine.

64 s9D10A nickase promotes efficient nucleotide substitution by gene editing.

65 ndicating that single and double stabilizing substitutions compromise the full inhibition of contract

66 simeprevir, an inhibitor to which the double substitution confers a significant reduction in potency.

67 Since these substitutions correlate to ASP loop residues, an additio

68 Here, an effective strategy combining anion substitution, defect engineering, and the dopant effect

69 rometry (MS) offered in-depth information, a substitution degree up to four NOTAs was still functiona

70 The phosphomimetic S1777D substitution disrupted catalytic activity, most likely b

71 teomics protocols fail to detect them as d/l substitutions do not affect the peptide parent and fragm

72 ree substitutions) or either Km or kcat (one substitution each).

73 For variants with axial ligand substitutions, electronic absorption, near-UV circular d

74 iridium-catalyzed, enantioselective allylic substitution enabled by (phosphoramidite,olefin) ligands

75 Here we show that aza-glycine substitution enhances the stability of an arginine-conta

76 This allelic series revealed that different substitutions exhibit graded severity, in terms of both

77 no effect or increased Vmax Ala but not Glu substitution for Ser-497 increased the Michaelis constan

78 t conditions, we examined alkaline earth ion substitution for two A, i.e., materials of composition A

79 8E progressively increased the Km Double Ala substitutions for Ser-497 and either Thr-500, Ser-510 or

80 Single alanine substitutions for Ser-497, Thr-500, Ser-502, Ser-506, an

81 ypass was accompanied by an increase in base substitution frequency for the base preceding the lesion

82 lso formed as a result of competing aromatic substitution (Friedel-Crafts reaction).

83 Substitution from an enantio-enriched eta(2)-dimethoxybe

84 Although an amino acid substitution from aspartic acid to alanine at position 1

85 s possessed mutations that caused amino acid substitutions from ClO2-labile to ClO2-stable residues i

86 hly mutations leading to a single amino acid substitution (G299V) or a premature stop codon causing s

87 Increased substitution generally increased lambdamax of Cy chelate

88 at atomic level that the hydrophobicity and substitution geometry of lipophilic groups play importan

89 nse polymorphism resulting in the amino acid substitution Glu326Lys.

90 tumors and results in a lysine-to-methionine substitution (H3K27M).

91 d maximal velocity (Vmax), whereas glutamate substitutions had no effect or increased Vmax Ala but no

92 o that of the wild-type gBcyt while arginine substitutions had wild-type-like fusion levels in an in

93 rovides strong evidence that many synonymous substitutions have been selected to optimize translation

94 ssessment predicted that the five amino acid substitutions have damaging effects on DNA binding of EB

95 E310D and E310Q substitutions having longer side chains exhibit lower ov

96 ludes the need for the compensatory V165I IN substitution, highlights a relatively high genetic barri

97 Letter-digit substitution (HR, 1.59; 95% CI, 1.22-2.04), verbal fluen

98 Substitution I2749R attenuates this ability.

99 ns found in ChAc patients causes amino acids substitution I2771R which affects the localization of hV

100 Phenotypic analysis of resistance-associated substitutions identified in NS3 from GT1a-infected patie

101 their WT counterparts, revealing that these substitutions impair gating through a mechanism independ

102 I44A or H54Y substitution in 3A interrupts the stimulation of PI4KB a

103 F3'H is associated with a Thr498 --> Ser498 substitution in a substrate recognition site (SRS).

104 lects effects of a loss-of-function Ala43Thr substitution in APOC3 (rs147210663) and 3 established fu

105 Here we show that Y1F substitution in budding yeast resulted in a strong slow-

106 cient arenes instead undergoing preferential substitution in intramolecular competition with more ele

107 ability was restored by a single amino acid substitution in position 186 (K186E) that resulted in NS

108 Here we identified a two-amino-acid substitution in RORgammat (RORgammat(M)) that 'preferent

109 Fructose substitution in some subgroups resulted in significantly

110 nt Chihuahua, that carries a G574D (p.G736D) substitution in the alpha1 chain of type I collagen.

111 -domain interactions via targeted amino acid substitution in the catalytic site of the C-terminal nuc

112 Furthermore, we show that a substitution in the penultimate MftA Val-29 position cau

113 pH1N1low-1 also had the unique Y66D substitution in the stalk domain, where 66Y was highly c

114 viously, we identified unique NAI resistance substitutions in AIVs of the N3, N7, and N9 NA subtypes.

115 ports regarding the maximal number of fucose substitutions in C. elegans, which in part may be due to

116 We use single amino acid substitutions in DAXX that abrogate formation of the com

117 , these findings demonstrate that amino acid substitutions in Fn-binding repeat-9 can significantly a

118 receded and may have driven the selection of substitutions in H7 that modify H7 receptor-binding prop

119 selection approach, we identified amino acid substitutions in human and mouse Ctr2 proteins that supp

120 so found that the individual N291G and P294K substitutions in human RR additively affect substrate sp

121 uencies of the respective nucleotide triplet substitutions in non-coding regions and in 4-fold degene

122 e-directed mutagenesis studies revealed four substitutions in OsMTP11 that appear to alter its transp

123 ral RNA packaging or DNA synthesis, multiple substitutions in the CTD to mimic either phosphorylation

124 Based on targeted glycine substitutions in the Env fusion machinery, we defined a

125 Likewise, substitutions in the linker domains of GluA2 completely

126 does not bind melanogaster Deadlock, due to substitutions in the rapidly evolving Shadow domain.

127 Consistent with these results, the alanine substitutions in the viral genome caused exaggerated syn

128 five basic residues, and seven UM-associated substitutions, in yeast eIF1A suppresses initiation at n

129 necessary for fusion regulation, as alanine substitutions induced a 440% increase in fusion compared

130 Unexpectedly, T124N/T174I IN substitutions inhibited proteolytic processing of HIV-1

131 Conversely, the p.Tyr64Asp substitution is constitutively active.

132 o arylazoindazoles via nucleophilic aromatic substitution is presented.

133 Similarly, efficient pEtN lipid A substitution is seen in the absence of lipid A glycinyla

134 city, mode and technology shifting, and fuel substitution) is more limited than for other demand sect

135 Amino acid substitutions K599E and T601M conferred no ganciclovir r

136 Fc variant pair dubbed "DEKK" consisting of substitutions L351D and L368E in one heavy chain combine

137 These substitutions led to inhibitors with increased PACE4 sel

138 x decreased linearly (p<0.05) by raising the substitution levels of rice flour with ASF.

139 s increased linearly (p<0.05) by raising the substitution levels of rice with ASF.

140 using alfalfa seed flour (ASF), at different substitution levels to common rice flour (0% as control,

141 The amino acid substitutions lie in two highly conserved loop regions o

142 We isolated substitutions, locating to the transmembrane helix of Ta

143 An amino acid substitution, lysine to glutamine, at position 166 (H3 n

144 study, we first compared a comprehensive 95 substitution matrices reflecting various amino acids pro

145 n method relies on the choice of amino acids substitution matrices.

146 two parameters, a coefficient that tunes the substitution matrix and the maximum length of k-mers tha

147 sed sequence comparison method, depends on a substitution matrix.

148 Other PHCZs with low halogen substitution may form from in situ dehalogenation of PHC

149 sibility that an alternate nucleophilic aryl substitution mechanism was responsible for the rapid rea

150 Substitution modeling yielded significantly lower risks

151 equence alignment and the use of appropriate substitution models in plastid phylogenomics.

152 Additionally, while these substitutions modulate PON1's active site shape, volume,

153 We then made substitution mutants in DnaK residues suggested by the m

154 Spontaneous base substitution mutation rates increased sevenfold upon the

155 ry network, which can be rewired by a single substitution mutation.

156 , and showed that MMS also induces more base substitution mutations in BRCA1/2-deficient cells.

157 Amino acid substitution mutations within a PMS2 C-terminal (721)QRL

158 A single substitution (N145K/R) was sufficient to affect seroposi

159 We find that unique amino acid substitutions occur at sites under positive selection in

160 Half of driver substitutions occur in yet-to-be-discovered cancer genes

161 hich can be independently prepared by ligand substitution of (ONO(Cat))ReO(PPh3).

162 The substitution of 1 serving refined grains/d with an equal

163 scribed a knock-in mouse strain in which the substitution of 2 amino acids of the endogenous TTP prot

164 The electrophilic aromatic substitution of a C-H bond of benzene is one of the arch

165 Substitution of a conserved serine (S270A) interferes wi

166 entified in exon 1 of the TYR gene, with the substitution of a cytosine for a thymine nucleotide (C64

167 ex with the typhoid toxin CdtB subunit after substitution of a single amino acid in ArtA, while ArtB

168 These data demonstrate that the p.P50T substitution of AKT2 influences insulin-mediated GU in m

169 subsequent tryptophan number reduction with substitution of all tryptophan residues ablating dimeriz

170 Substitution of ammonia in ammonium salts was observed n

171 Here, we show that substitution of APP C-terminal lysines with arginine dis

172 yl methyl ethers through direct nucleophilic substitution of aryl C-OMe bond has been described.

173 It was found that substitution of B with 1 at.

174 The push-pull substitution of BDI also leads to sensitive fluorescence

175 has been identified as a beta-1,6-galactosyl substitution of beta-1,4-galactan requiring more than th

176 -level studies suggest that MMLs have led to substitution of cannabis for opioids, and also possibly

177 iable analyses were conducted applying a 1:1 substitution of carbohydrates for protein.The mean +/- S

178 mination leading to Br-Cl-DOM and by bromine substitution of chlorine leading to Br-DOM.

179 The chlorination pathway of electrophilic substitution of Cl at the ortho or para position of the

180 plets grow by Ostwald ripening and also with substitution of different counterions (Na:AOT, K:AOT, an

181 tivity of PEI is also severely diminished by substitution of DNA for shorter nucleic acids such as mR

182 in IAPP self-assembly, whereas simultaneous substitution of four aromatic/hydrophobic residues with

183 nctional theory calculations as follows: the substitution of Ga(3+) by Fe(2+) ions, occurring in Fe-r

184 Substitution of glutamic acid for tyrosine between the S

185 tep-up of current drug therapy, and straight substitution of individual drug components.

186 In HIV-1, substitution of large residues such as histidine or tryp

187 OsMTP11 harbouring a substitution of leucine 150 to a serine fully rescued pm

188 Substitution of Lys51 to Ala in LC3B abrogates binding o

189 s intramembrane proteolysis, as does leucine substitution of residues that overlap or are immediately

190 a-selectivity of the studied donors, whereas substitution of the 4,6-benzylidene acetal with a 4,6-di

191 del potential savings that could result from substitution of the cheapest topical steroid from the co

192 vings and out-of-pocket patient savings from substitution of the cheapest topical steroid within the

193 e O2-evolution activity assays revealed that substitution of the D1 residue at position 87 with alani

194 measured in a co-immunoprecipitation assay, substitution of the His or Cys heme ligands in Rev-erbbe

195 Substitution of the Lys residues to Glu markedly reduced

196 Substitution of the participating group of glycosyl dono

197 Substitution of the thiol proton in cysteine with m-carb

198 nd the CH1 tyrosine residues, and successive substitution of these tyrosines breaks the interaction b

199 Phosphomimetic substitution of Thr-38 with Asp increased co-immunopreci

200 ynthesis of the latter involved nucleophilic substitution of tosyl group in readily available N-[(2-b

201 ATTR can result from substitution of valine for isoleucine at codon 122 of th

202 ood sensory quality could be produced by the substitution of wheat flour by 5% of potato peel powder.

203 By comparison, substitutions of Asn for Ile-136 (I136N) and Thr for Ile

204 Alanine substitutions of key residues in the interface support t

205 We show that substitutions of these residues reduce bulk translation

206 Here, we report that glutamine substitutions of these residues, which preserve polar in

207 bsorption near edge spectroscopy, suggesting substitution on both Ca and Zr sites.

208 razole-5-aldehydes bearing 2,2-dialkoxyethyl substitution on N-1.

209 estigations of the effects of aroyl chloride substitution on reaction rate.

210 While substitution on the aromatic rings had comparatively lit

211 Although the substitution on the donor olefins was initially limited

212 However, the effect of these substitutions on DPOR activity remains unknown.

213 of the shaker-1 mutation, a R502P amino acid substitution, on the motor function is unclear.

214 -optimized gag sequences and found that such substitutions only resulted in a moderate decrease of RN

215 ex mutations comprising multiple nearby base substitutions or insertion-deletions.

216 dependent changes in both Km and kcat (three substitutions) or either Km or kcat (one substitution ea

217 some escape mutants possessing an amino acid substitution other than K166Q showed superior growth to

218 One recurrent site substitution (p.A636T) occurs in a glutamate receptor su

219 ecular dynamics simulations to elucidate the substitution pattern in softwood xylans and to investiga

220 phthoquinone-based meroterpenoids exhibits a substitution pattern of the polyketide-derived aromatic

221 of antimalarial 1,2,4-trioxolanes bearing a substitution pattern regioisomeric to that of arterolane

222 somerization pathways depending on the silyl substitution pattern were found.

223 ene backbone and different alkoxy side chain substitution patterns were synthesized using a cobalt-ca

224 Notable flexibility in the substitution patterns, readily available substrates, sho

225 ng partners give azolopyridines with various substitution patterns.

226 ss to pyrazolo[1,5-a]pyrazines with multiple substitution patterns.

227 e applied to substrates with a wide range of substitution patterns.

228 mutation rate is 2.7 x 10(-6) - 3.0 x 10(-5) substitutions per nucleotide per strand copied (s/n/r).

229 Conversely, uS7-D215 substitutions, perturbing uS7-eIF2alpha interaction in t

230 A single G to A substitution present in the terminal loop of pri-mir-30c

231 Ribosome profiling of NTT substitution R13P reveals heightened discrimination agai

232 primary defect associated with the missense substitutions ranged from inefficient internal scaffoldi

233 ffects of pre-existing resistance-associated substitutions (RAS) on HCV escape from treatment.

234 rehensive analysis for resistance-associated substitutions (RASs) in HCV genes (nonstructural protein

235 teins, the oncogenes E7 and E6 had increased substitution rates indicative of higher selection pressu

236 Overall, annual substitution rates reached 10% of total demand.

237 in the plastid genome (plastome), nucleotide substitution rates were previously shown to be lower in

238 cient to explain the variation of nucleotide substitution rates.

239 odified alcohol content even at higher juice substitution rates.

240 The first step involves a nucleophilic substitution reaction between aryl-BF3K salts (aryl = me

241 es as a "textbook example" of a nucleophilic substitution reaction, the selective mono-alkylation of

242 port a significant expansion to the scope of substitution reactions for the dodecaborate ion, whereby

243 A systematic study of the N-substitution reactions of 3-substituted pyrazoles under

244 l equivalent then undergoes nickel-catalyzed substitution reactions with aryl halides and triflates a

245 uch as reductions and vicarious nucleophilic substitution reactions.

246 The alanine and glutamic acid substitutions reduced actin-activated ATPase activity, s

247 y mass spectrometry, we show that successive substitutions result in an increase in the conformationa

248 All substitutions resulted in altered temperature activity p

249 hat methionine substitution, but not leucine substitution, results in increased open state stability

250 Functional analysis of the R390Q substitution revealed that it did not affect the ability

251 e two iNK TCR types with a single amino acid substitution revealed that the staining intensity by ant

252 mputationally that a proper selection of the substitution scheme can enhance the synthetic scope of a

253 Primary cells revealed one substitution severely impaired OGFOD1-dependent hydroxyl

254 Viruses containing these W237 substitutions show in vitro growth kinetics and plaque m

255 Nucleophilic aromatic substitution (SNAr) is a direct method for arene functio

256 We used an unbiased D-amino acid substitution strategy to determine structure-assembly re

257 phoblast cell lines confirmed that the R834C substitution strongly and selectively reduces WRN helica

258 itial kinetic profiling for the nucleophilic substitution supports an SN1-like (SN2C+) mechanism in w

259 Two IN substitutions (T124N/T174I) directly weaken inhibitor bi

260 showed that these differences resulted from substitution T401A in the 2nd SIA-binding site, indicati

261 mination (3MSE) 4 times and the Digit Symbol Substitution Test (DSST) 5 times.

262 The NHANES measured Digit Symbol Substitution Test (DSST) score and relative DSST impairm

263 Rey Auditory Learning Test and Digit Symbol Substitution Test before and after treatment; subjective

264 Examination orientation items, Digit Symbol Substitution Test, and Category Naming Test) in the modi

265 In a substitution test, cocaine self-administration rats disp

266 Moreover, we identify a single capsid substitution that has been adopted by all pandemic CV-A2

267 is strongly influenced by a highly conserved substitution that regulates receptor binding in differen

268 Base substitutions that disrupt the base triples reduce telom

269 se alternatives all require prior permissive substitutions that do not enhance the derived function,

270 While amino acid substitutions that result in escape from CD8(+) T cell r

271 r a severe disease mutant involving an R155C substitution the NTD equilibrium can be shifted back to

272 The optimization of the aryl substitution then identified a 4'-CN group that improved

273 needle and syringe programmes (NSP), opioid substitution therapy (OST), HIV counselling and testing,

274 skite oxide superlattices with compositional substitution to artificially break the structural invers

275 deficit using principles of receptor silent substitution to present images in which visibility for m

276 minated in the expansion of the scope of the substitution to various heteroatom-based functionalities

277 species level, biased patterns of synonymous substitutions underpin increased codon optimization in a

278 typically associated with craniosynostosis), substitutions uniquely affecting the Glu117 codon were n

279 re was performed to achieve C-2 nucleophilic substitution using several amine types.

280 Strikingly, the addition of the third IN substitution (V165I) restored polyprotein processing, vi

281 The substitutions V31R and T32R abolished TDP-43 activity in

282 stered (Stroop color word test, letter-digit substitution, verbal fluency, and word learning) and a g

283 he high-fidelity introduction of single-base substitutions via HDR following co-delivery with a singl

284 ASP loop residues, an additional Phe to Ala substitution was synthesized and observed to maintain MC

285 ifference in the clinical impact of some NS3 substitutions was investigated.

286 , a series of disulphide bridges and proline substitutions were created in the xylanase by PCR, and t

287 HIV(NL4-3) 5'UTR substitutions were designed to individually stabilize th

288 However, tryptophan substitutions were detrimental at two sites.

289 All but one base substitutions were G:C to A:T, their distribution betwee

290 Out of 86 variants of p145, seven amino acid substitutions were selected and made the basis of the de

291 Alanine and arginine substitutions were used to determine if the positive cha

292 We show that the p.Arg90His substitution, which is reported to cause reduced reactiv

293 idine kinase SaeS has an L18P (T53C in saeS) substitution, which transformed the protein into an FtsH

294 ity of TP53 mutations in tumors are missense substitutions, which lead to the expression of full-leng

295 Third, Ser-3 modification (i.e. substitution with Asp or phosphorylation) "undocks" and

296 Substitution with biologically active factor H could pot

297 oaddition and subsequent palladium-catalyzed substitution with nonstabilized lithium enolates.

298 bed, and the possibility of contamination or substitution with other medications represents a concern

299 Further substitution with Zr decreased the high frequency GMI ra

300 an especially challenging task, with random substitution yielding stabilizing mutations in only appr